Monoclonal Antibody Against CEP164 (Clone 13)

Tech ID: 25195 / UC Case 2011-388-0

Brief Description

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Full Description

Centrosomal protein 164kDa (Cep164) is involved in a number of cellular pathways. It is important for microtubule organization and maintenance for the formation of primary cilia. Additionally, Cep164 is critical for G2/M checkpoint and nuclear divisions. Cep164 is also involved in DNA damage-activated ATR/ATM signaling through proper phosphorylation of H2AX, RPA, CHK2, and CHK1. Furthermore, by modulating MDC1, RPA, and CHK1, Cep164 is a mediator that maintains genomic stability critical for chromosomal segregation.

The described mouse monoclonal IgG1 antibody binds to human Cep164 and has been described for use in immunocytochemistry/immunofluorescnece, immunoprecipitation, and western blot.

Suggested uses

Immunocytochemistry/immunofluorescence

Immunoprecipitation

Western blot

Advantages

Specific antibody to detect Cep164 by antibody-antigen complex formation.

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Inventors

  • Kim, Yoon
  • Lee, Eva Y H P

Other Information

Keywords

Monoclonal antibody, Centrosomal protein 164kDa, Cep164, Immunocytochemistry/immunofluorescence, Immunoprecipitation, Western blot

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