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Systems and Methods for Monodisperse Drop Generation and Use

UCLA researchers in the Department of Bioengineering have developed systems and methods to produce single particle, monodisperse droplets for use in digital assays, targeted drug delivery, and theranostics.

New Classes Of Cage And Polyhedron And New Classes Of Nanotube And Nanotube With Planar Faces

UCLA researchers have developed a novel algorithm that can be used to design unique self-assembled molecules and nanostructures.

Array Atomic Force Microscopy Enabling Simultaneous Multi-point and Multi-modal Nanoscale Analyses

Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale physical and biological systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and can be integrated seamlessly with disparate probe-based sensing and manipulation technologies. However, conventional AFMs only permit sequential single-point analysis. Widespread adoption of array AFMs for simultaneous multi-point study is still challenging due to the intrinsic limitations of existing technological approaches.

Microfluidic Device: Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels

Microfluidic devices have long been touted as a powerful analytical tool with which to characterize a wide range of analytes, including particles, and cells. Despite the apparent convenience of microfluidic technologies for applications in healthcare, such devices often rely on capital-intensive optics and other peripheral equipment that limit throughput, perhaps because the majority of microfluidic devices operate using optics-based principles, which typically require high-speed or sensitive cameras, sophisticated confocal microscopes, vibration isolation tables, and laser excitation systems.

Glucose-conjugated magnetonanoparticles for visualization and treatment of neoplasms and neurological disorders by MRI

Researchers at the UCLA Semel Institute for Neuroscience and Human Behavior have developed magnetic nanoparticles (MNPs) functionalized with deoxyglucose that can be used as tissue-specific contrast agents for MRI. These novel MNPs can help physicians and researchers to differentiate neoplastic, epileptic, parkinsonian, or Alzheimer tissues from normal tissue based on the metabolic activity of the tissue.

Micro- and Nanocomposite Support Structures for Reverse Osmosis Thin Film Membranes

UCLA researchers in the Department of Civil and Environmental Engineering have invented a novel nanofiltration (NF) and reverse osmosis (RO) composite membrane for water desalination applications.

Infrared Detectors And Heat Recycling Cells Based On Metallo-Graphene Nanocomposites

UCLA researchers in the Department of Electrical Engineering have developed a high-responsivity photodetector that utilizes metallo-graphene nanocomposites for superior detection of infrared wavelengths.

Controlling Magnetization Using Patterned Electrodes on Piezoelectrics

UCLA researchers in the Department of Materials Science and Engineering have developed a novel piezoelectric thin film that can control magnetic properties of individual magnetic islands.

Membrane Insertion of Potential Sensing Nanorods

UCLA researchers in the Department of Chemistry have developed inorganic semiconductor nanosensors that measure membrane voltage.

Microfluidic Interfacial Magnetic Separation (MIMS)

UCLA researchers in the Department of Medicine and Bioengineering have developed a novel magnetic method for sorting cells.

Quantitative Deformability Cytometry: Rapid, Calibrated Measurements Of Cell Mechanical Properties

UCLA researchers in the Department of Integrative Biology and Physiology have developed a novel microfluidic device that enables rapid measurement of cell mechanical properties.

In-Situ TEM Holder With STM Probe And Optical Fiber

Researchers at UCI have developed a fully integrated sample mount for the simultaneous high-resolution imaging and electronic and optical characterization of thin film devices.

High Stability PtNiX-M Electrochemical Catalyst

UCLA researchers in the Department of Material Science and Engineering have invented a novel and highly stable platinum-based catalyst material for fuel cell technologies.

High-Efficiency Ion Source

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a miniature direct-current (DC) ion source with the higher power efficiencies and lower erosion rates needed for space propulsion applications.

High-Throughput Microfluidic Gene-Editing via Cell Deformability within Microchannels

UCLA researchers in the Departments of Pediatrics and Chemistry & Biochemistry have developed a microfluidic device for delivery of biomolecules into living cells using mechanical deformation, without the fouling issues in current systems.

Plasmonic Nanoparticle Embedded PDMS Micropillar Array and Fabrication Approaches for Large Area Cell Force Sensing

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel cell force sensor platform with high accuracy over large areas.

Anti-Ferromagnetic Magneto-Electric Spin-Orbit Read Logic

UCLA researchers in the department of Electrical Engineering have developed a novel magetoelectric device for use as a spin transistor.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Accelerating palladium nanowire hydrogen sensors using engineered nanofiltration layers

Researchers at UCI have developed a method for enhancing existing hydrogen gas sensors, leading to as much as a 20-fold improvement in sensor response and recovery times.

Process For Electrodepositing Manganeese Oxide With Improved Rate Capabilities For Electrical Energy Storage

The invention is a novel method for enhancing the energy, power and performance of lithium ion batteries. It applies a new process for electrodepositing Manganese Oxide in a way that improves the electrical properties as well as the rate at which the battery can operate. Using this method, the energy storage capabilities is boosted significantly; making it faster, more reliable and enabling various applications to become more dependent on electric/battery solutions.

System and Method for High Density Assembly and Packaging of Micro-Reactors

High density micro-reactors are fabricated to form an array of wells into a surface for use in high throughput microfluidic applications in biology and chemistry. Researchers at the University of California, Irvine developed a method for increasing micro-reactor densities per unit area using rapidly self-assembled three-dimensional crystalline formation droplet arrays, and a device for performing the same.

Scalable Super-Resolution Synthesis Of Core-Vest Composites Assisted By Surface Plasmons

Concurrent control of size, shape, and composition of nanoparticles is key to tuning their functionality with widespread applications in sensing, catalysis, cancer cell ablation, water-splitting, spectroscopy, dye-sensitized solar cells, and more. UCB inventors demonstrate unprecedented precision over the structure and composition of complex nanoparticles by fusing colloidal chemistry with plasmon assisted synthesis.  They show that combining properties of light used for plasmon excitation (wavelength, intensity, and pulse-duration) with the physical properties of nanoparticles (size, shape, and composition) leads to hitherto unrealized core-vest composite nanostructures. Tunable variations in localized temperature distributions >50 degrees C are achieved over nanoparticles as small as 50-100 nm. These temperature variations result in core-vest formations with selective shell coverage that mirrors the local inhomogeneities of the heat distribution. This new class of core-vest nanoparticles (CVNs) allows plasmonic enhancement of nanocomposite functionalities that are inaccessible in typical core-shell geometries.  

Combined Individual Nanomaterial Enhancements for Total X-Ray Enhancement

Researchers at the University of California, Davis have developed a method to combine individual nanomaterial enhancements to achieve greater X-ray enhancement.

A Cavity-Free Self-Referencing Frequency Comb

A self-referencing frequency comb based on high-order sideband generation (HSG) that does not require cavities. Applications include "set-and-forget" optical atomic clocks and high-resolution spectrometers for airborne chemicals.

Rapid, Portable And Cost-Effective Yeast Cell Viability And Concentration Analysis Using Lensfree On-Chip Microscopy And Machine Learning

UCLA researchers in the Department of Electrical Engineering have developed a new portable device to rapidly measure yeast cell viability and concentration using a lab-on-chip design.

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