Researchers at the University of California, Davis have developed an approach to improve drug delivery to tumors and metastases in the brain. Their multi-barrier tackling delivery strategy has worked to efficiently impact brain tumor management while also achieving increased survival times in anti-cancer efficacy.

Plant viral nanoparticles (plant VNPs) are promising biogenetic nanosystems for the delivery of therapeutic, immunotherapeutic, and diagnostic agents. The production of plant VNPs is simple and highly scalable through molecular farming in plants. Some of the important advances in VNP nanotechnology include genetic modification, disassembly/reassembly, and bioconjugation. Although effective, these methods often involve complex and time-consuming multi-step protocols.

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Researchers at the University of California, Irvine have developed a guided electrokinetic assembly technique that utilizes dielectrophoretic and electroosmotic forces for micro- and nanomanufacturing. This technique provides a new way for assembling microelectronics and living cells for tissue engineering applications.

Researchers at UCI have developed a patch antenna constructed from carbon nanotubes, whose transmission frequency can be tuned entirely electronically. Additionally, the antenna can be made operable in the microwave to visible frequency regime by simply varying the device dimensions and composition.

UCLA researchers have developed a novel algorithm that can be used to design unique self-assembled molecules and nanostructures.

Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale physical and biological systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and can be integrated seamlessly with disparate probe-based sensing and manipulation technologies. However, conventional AFMs only permit sequential single-point analysis. Widespread adoption of array AFMs for simultaneous multi-point study is still challenging due to the intrinsic limitations of existing technological approaches.

Microfluidic devices have long been touted as a powerful analytical tool with which to characterize a wide range of analytes, including particles, and cells. Despite the apparent convenience of microfluidic technologies for applications in healthcare, such devices often rely on capital-intensive optics and other peripheral equipment that limit throughput, perhaps because the majority of microfluidic devices operate using optics-based principles, which typically require high-speed or sensitive cameras, sophisticated confocal microscopes, vibration isolation tables, and laser excitation systems.

UCLA researchers in the Department of Civil and Environmental Engineering have invented a novel nanofiltration (NF) and reverse osmosis (RO) composite membrane for water desalination applications.

UCLA researchers in the Department of Electrical Engineering have developed a high-responsivity photodetector that utilizes metallo-graphene nanocomposites for superior detection of infrared wavelengths.

UCLA researchers in the Department of Materials Science and Engineering have developed a novel piezoelectric thin film that can control magnetic properties of individual magnetic islands.

Researchers at UCI have developed a fully integrated sample mount for the simultaneous high-resolution imaging and electronic and optical characterization of thin film devices.

UCLA researchers in the Department of Material Science and Engineering have invented a novel and highly stable platinum-based catalyst material for fuel cell technologies.

UCLA researchers in the Departments of Pediatrics and Chemistry & Biochemistry have developed a microfluidic device for delivery of biomolecules into living cells using mechanical deformation, without the fouling issues in current systems.

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel cell force sensor platform with high accuracy over large areas.

UCLA researchers in the department of Electrical Engineering have developed a novel magetoelectric device for use as a spin transistor.

Researchers at UCI have developed a method for enhancing existing hydrogen gas sensors, leading to as much as a 20-fold improvement in sensor response and recovery times.

The invention is a novel method for enhancing the energy, power and performance of lithium ion batteries. It applies a new process for electrodepositing Manganese Oxide in a way that improves the electrical properties as well as the rate at which the battery can operate. Using this method, the energy storage capabilities is boosted significantly; making it faster, more reliable and enabling various applications to become more dependent on electric/battery solutions.

Concurrent control of size, shape, and composition of nanoparticles is key to tuning their functionality with widespread applications in sensing, catalysis, cancer cell ablation, water-splitting, spectroscopy, dye-sensitized solar cells, and more. UCB inventors demonstrate unprecedented precision over the structure and composition of complex nanoparticles by fusing colloidal chemistry with plasmon assisted synthesis.  They show that combining properties of light used for plasmon excitation (wavelength, intensity, and pulse-duration) with the physical properties of nanoparticles (size, shape, and composition) leads to hitherto unrealized core-vest composite nanostructures. Tunable variations in localized temperature distributions >50 degrees C are achieved over nanoparticles as small as 50-100 nm. These temperature variations result in core-vest formations with selective shell coverage that mirrors the local inhomogeneities of the heat distribution. This new class of core-vest nanoparticles (CVNs) allows plasmonic enhancement of nanocomposite functionalities that are inaccessible in typical core-shell geometries.  

Researchers at the University of California, Davis have developed a method to combine individual nanomaterial enhancements to achieve greater X-ray enhancement.

A self-referencing frequency comb based on high-order sideband generation (HSG) that does not require cavities. Applications include "set-and-forget" optical atomic clocks and high-resolution spectrometers for airborne chemicals.