Organoid/brain slice immobilization for microelectrode arrays (MEAs) and organoid-on-chip platforms have traditionally depended on hydrogels, harp-style grids, or microfluidic confinement, each with its own set of pros and cons with respect to stability, standardization, and impact on electrophysiology. Hydrogels (e.g., Polyethylene glycol or PEG, extracellular matrix like Matrigel) are widely used to immobilize 3D neural tissues on MEAs. These are known to swell, drift, and alter mechanical microenvironments, which in turn modulate network firing, synchrony, and bursting behavior. Mechanical retention via harp slice grids or similar harp devices is a long-standing practice in acute brain slice and organoid electrophysiology. These devices are typically standardized, fragile, and poorly matched to diverse well and tissue geometries. ​Microfluidic organoid chips and specialized 3D MEAs (e.g., e-Flower, organoid-on-chip platforms) have recently emerged to enable hydrogel-free trapping/encapsulation of organoids for imaging and recordings, but they often require bespoke chip designs and overly complex flow control setups. There is a lack of geometry-agnostic devices for mechanically immobilizing diverse organoids on commercial MEAs that feature consistent stability, uniform and/or tailored contact, and with minimal perturbation of electrophysiological readouts.

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Researchers at the University of California, Davis, have created a technology that uses engineered polynucleotides to deliver both an antigen and an enzyme that breaks down amino acids. This approach is designed to boost long-lasting memory T-cell responses, providing stronger protection against infectious diseases and cancer.

An innovative brachytherapy applicator designed to deliver precise radiation to challenging gynecologic cancer sites while sparing healthy tissue.

The invention describes a platform technology that increases MHC presentation of oncogene derived peptide neoantigens that do not normally occur in the cell.  The platform has already been used to identify a method of increasing KRAS G12 D/V derived peptide presentation on MHC- I.

The ability to precisely control gene expression is fundamental to advancing biotechnology and medicine, yet designing functional synthetic promoters for eukaryotic cells remains a complex challenge. UC Berkeley researchers have developed a high-throughput platform for the generation and selection of synthetic transcriptional promoters. This technology utilizes expansive libraries of recombinant expression vectors to identify promoter sequences with optimized performance characteristics. By linking promoter sequence to measurable expression outputs, the method allows for the rapid discovery of highly functional, custom-tuned regulatory elements that are compatible with a variety of eukaryotic host systems.

As global plastic pollution intensifies, the accumulation of microplastics from partial degradation remains a critical environmental threat. To address this, researchers at UC Berkeley have developed a system for the programmable and complete depolymerization of polyesters. By incorporating a nanoscopic dispersion of enzymes directly into the plastic matrix, the technology exploits specific enzyme active sites and enzyme-protectant interactions to ensure processive degradation. This method ensures that the polymer is broken down entirely into its constituent monomers, preventing the formation of persistent microplastics that typically result from traditional degradation processes.

Traditional covalent semiconductor systems, while effective, require energy-intensive and costly synthetic methods for device fabrication. To address these processing challenges, researchers at UC Berkeley have developed a stable, ligand-free zero-dimensional (0D) perovskite semiconductor ink. This ink is composed of vacancy-ordered double perovskite powders (A_2BX_6) dissolved in polar aprotic solvents like dimethyl sulfoxide (DMSO) or N,N-dimethylformamide (DMF). The process stabilizes isolated [BX_6]^{2-} octahedral anions and free A+ cations in solution without the need for organic ligands. These multi-functional inks remain stable for over a year and can be easily patterned onto various substrates—including glass and silicon—where they rapidly recrystallize into the A_2BX_6 phase upon drying.