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Colorimetric Sensing Of Amines

An affordable and easily synthesized indicator that can be applied to monitor reaction progress in a system using only one inexpensive and non-toxic agent.

Apparatus and Signal Processing Technique for Real-Time Label-Free High-Throughput Cell Screening

UCLA researchers in the Department of Bioengineering have invented a novel apparatus for real-time label-free high-throughput cell screening.

Biomarker of Dyskinesia to Customize Medication or Deep Brain Stimulation for Parkinson's Disease Patients

This invention has provided methods for detecting dyskinesia in Parkinson’s disease patients and provided a way to titrate current treatment to maximize benefits while minimizing side effects.

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

UCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K. This probe can also deliver drug molecules to bone resorption sites with high specificity.

Automated Beam Orientation and Scanning Spot Spacing Optimization for Robust Heavy Ion Radiotherapy Therapy

UCLA researchers in the Department of Radiation Oncology have developed a new method to automate and optimize heavy ion beam radiotherapeutic techniques for the treatment of cancer.

Probability Map of Biopsy Site

UCLA researchers in the Department of Radiological Science have developed a technique for generating a probability map on an MRI that indicates the certainty of tissue sampling from a location, which could improve imaging-guided biopsies and their correlation with pathology.

Novel Inhibitor of HIV Replication

UCLA researchers in the David Geffen School of Medicine have discovered a new small molecule inhibitor for HIV-1 replication.

Plasmonic Nanoparticle Embedded PDMS Micropillar Array and Fabrication Approaches for Large Area Cell Force Sensing

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel cell force sensor platform with high accuracy over large areas.

Bidirectional IVC Filter

Researchers at UCLA from the Department of Radiology have developed an improved IVC filter with better filtering performance that is easily retrievable.

Human Resistin for the Treatment of Sepsis

Prof. Meera Nair and her colleagues at UCR have discovered that human resistin may be used as a therapy to treat sepsis.  Using a transgenic mouse model expressing human resistin, researchers showed that  mice expressing resistin had a 80-100% rate of survival from a sepsis-like infection when compared to wildtype mice with the same infection. The researchers also found that human resistin decreased the number of pro-inflammatory and Th1 cytokines.  Through immunoprecipitation assays, human resistin was found to bind to TLR-4 thus blocking the TLR-4 signaling in immune and inflammatory cells. Fig. 1 shows the survival curves for four different mouse models exposed to a sepsis like infection. The red line represents wild type C57BL/6 mice and none of these mice survived the infection. The black line is the background mouse model without the transgene incorporated into its genome. The Tg+ and Tg2+ are two different transgenic mouse models expressing human resistin. Fig. 2 shows that structural modeling predicts that resistin (green/blue) binds TLR4 (red) and blocks binding LPS co-receptor MD2 (grey)

Using DNA Methylation Markers to Predict the Age of Dogs

UCLA researchers in the department of Human Genetics and Biomathematics and Molecular Cell and Developmental Biology have developed a method of determining the biological age of dogs and wolves by examining DNA methylation patterns.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

Mucoadhesive Devices for Oral Delivery of Various Active Agents

Effective and easily accepted system of oral delivery of therapeutic drugs.

A Gene Therapy Strategy To Restore Electrical And Cardiac Function In Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a predominantly genetic-based heart disease characterized by right but also recently left ventricular dysfunction, fibrofatty replacement of the myocardium leading to fatal/severe ventricular arrhythmias leading to sudden cardiac death in young people and athletes. ARVC is responsible for 10% of sudden cardiac deaths in people ≥65 years of age and 24% in people ≤30 years of age. ARVC is thought to be a rare disease as it occurs in 1 in 1000-5000 people, although the prevalence may be higher as some patients are undiagnosed or misdiagnosed due to poor diagnostic markers. Growing evidence also reveals earlier onset since pediatric populations ranging from infants to children in their teens are also particularly vulnerable to ARVC, highlighting the critical need to identify and treat patients at an earlier stage of the disease.At present there are no effective treatments for ARVC nor has there been any randomized clinical trials conducted to examine treatment modalities, screening regimens, or medications specific for ARVC. As a result, treatment strategies for ARVC patients are directed at symptomatic relief of electrophysiological defects, based on clinical expertise, results of retrospective registry-based studies, and the results of studies on model systems. The current standard of care is the use of anti-arrhythmic drugs (sotalol, amniodarone and beta-blockers) that transition into more invasive actions, which include implantable cardioverter defibrillators and cardiac catheter ablation, if the patient becomes unresponsive or intolerant to anti-arrhythmic therapies. However, current therapeutic modalities have limited effectiveness in managing the disease, 40% of ARVC patients (a young heart disease) die within 10-11 years after initial diagnosis, highlighting the need for development of more effective therapies for patients with ARVC.

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Automated titration of vasopressor infusion within predefined guardrails for efficient hypotension management

The invention automatically controls the blood pressure of patients on a continuous basis. It monitors the blood pressure and takes an action, within safety limits, whenever needed. The invention represents a dramatic improvement in the hypotension and critical care management.

Calcified Polymeric Valve and Vessels

A cast molded methodology for creating polymeric heart valves and vessels with calcium apatite inclusions. The heart valves and vessels can then be implanted in animals to test cardiovascular medical device efficacy.

Respiratory Monitor For Asthma And Other Pulmonary Conditions

A patch sensor that is able to continuously monitor breathing rate and volume to diagnose pulmonary function and possibly predict and possibly prevent fatal asthma attacks.

Portable waterborne pathogen detector

The inventors at the University of California, Irvine, have developed an automated, easy-to-use digital PCR system that can be used at the time of sample collection, making it highly effective in microbial pathogen analysis in resource-limited settings and extreme conditions.

Predictive Optimization Of Pharmeceutical Efficacy

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a machine learning platform to virtually screen combinatorial drug therapies.

Plasmon Resonance Enhanced Optical Means for Surface Disinfection

UCLA researchers in the Department of Materials Science and Engineering have developed a novel surface disinfection material for use in hospital coatings.

TREATING TYPE-1 DIABETES BY PRESERVING BETA CELL FUNCTION

This invention proposes the first pharmacological treatment to prevent the onset of Type I diabetes by preventing beta cell destruction. 

Deep Learning Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a novel microscopy analysis that improves resolution, field-of-view and depth-of-field in optical microscopy images.

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