A soft, implantable electrical access port enables repeatable, direct connections between implanted bioelectronic devices and external instruments.

A highly selective method for producing P-chiral phosphorus(V) compounds, eliminating complex purification steps while enabling the development of pharmaceuticals, agrochemicals, and other bioactive molecules.

A novel method for implementing AI attention mechanism using the natural synchronization of physical oscillators, enabling more energy-efficient computation.

Traditional genome editing relying on double-stranded DNA breaks (DSBs) can cause unintended indels, translocation events, and cytotoxic responses in target cells. To overcome these limitations, a precise site-specific modification technology is required that operates without inducing double-stranded DNA cleavage. Developed by UC Berkeley researchers, this technology utilizes engineered fusion proteins comprising a Cas domain (such as a Cas9 nickase or dCas9) integrated with a nucleic acid-editing enzyme domain, such as a deaminase. The molecular mechanism leverages the RNA-guided targeted binding capability of Cas9 to localize the enzymatic editing domain to a specific genomic locus, facilitating direct nucleotide alterations (e.g., cytidine or adenosine conversions) without introducing double-stranded cuts. This system delivers high-precision target modification, significantly reduces off-target insertion/deletion mutations, and improves cell viability during genomic modifications compared to conventional double-strand cleavage mechanisms.

Innovative synthetic endometrial tissues and uterus-like structures enable advanced in vitro embryo implantation, growth, and culture to model post-implantation stages.

Researchers at the University of California Davis have developed a method to spatially characterize and chemically analyze nanoparticles from biological and environmental samples for enhanced disease diagnosis and pollutant detection.

Researchers at the University of California, Davis have developed a gene therapy that selectively targets KSHV-infected tumors through virus-specific sequences and suicide genes to induce tumor cell death.

Researchers at the University of California, Davis have discovered FOXO inhibition using compounds such as AS1842856 dramatically enhances alpha-defensin expression in human intestinal organoids, restoring antimicrobial peptide levels comparable to native tissue.

Researchers at the University of California, Davis have developed a technology for the treatment of neuropsychiatric and neurological diseases with compounds that enhance neural plasticity without the hallucinogenic effects.

Researchers at the University of California, Davis have developed a machine learning-based platform for early, accurate, and efficient detection of endothelial disease from corneal images assessment.

Researchers at the University of California, Davis have developed an algorithm that uses data from group testing to rapidly provide lifestyle optimizations that improve the health of patients.

Researchers at the University of California, Davis have developed polypeptide compositions of the peripheral nervous system tau isoform ("big tau") that appear to selectively enhance kinesin-3 motor activity and bias intracellular transport toward anterograde direction to treat diseases linked to impaired axonal transport.

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Researchers at the University of California, Davis have developed a treatment method leveraging let-7 microRNA restoration to combat aggressive pediatric diffuse midline gliomas with H3K27M mutations.

Researchers at the University of California, Davis have developed an engineered Escherichia coli platform for efficiently microbial production of lacto-N-tetraose (LNT), an important human milk oligosaccharide, directly from lactose as the sole carbon source. Through metabolic pathway rewiring, optimized lactose utilization, this technology enables a simple, scalable, and cost-effective fermentation process for industrial LNT production.

Researchers at the University of California, Davis have developed methods to treat medulloblastoma by restoring calcium signaling that promotes neuronal differentiation and inhibits tumor growth.

Researchers at the University of California, Davis have developed a compact two-photon miniscope designed to support high-resolution neural activity imaging over an expanded field of view in freely moving animals. The system achieves a favorable balance between imaging performance and device footprint, enabling large-scale neural observations while minimizing interference with natural behavior.

Researchers at the University of California, Davis have developed AAV-mediated gene therapy that delivers the choline acetyltransferase (ChAT) gene to treat presynaptic congenital myasthenic syndromes and related neuromuscular disorders.

Researchers at the University of California, Davis have developed a hybrid system combining Fluorescence Lifetime Imaging (FLIM) and Interferometric Near-Infrared Spectroscopy (iNIRS) within a single optical probe for advanced, multimodal tissue analysis.

Researchers at Louisiana State University, New Orleans and the University of California, Davis have developed neuroprotective compounds that inhibit glutamine transport to reduce excitotoxic glutamate release, offering treatment for neurodegenerative diseases.

Researchers at the University of California, Davis have developed ibogaine-related compounds that promote neural plasticity and treat neuropsychiatric and neurological disorders.

Researchers at the University of California, Davis have developed a class of compounds intended for the treatment of neurodegenerative diseases such as Alzheimer's by inhibiting DYRK1A kinase and modulating 5-HT2Rs.

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Researchers at the University of California, Davis have developed a protein-based composition and method that protects bioactive bacteria from thermal and osmotic stress during dehydration to maintain viability and shelf life.