Researchers at the University of California, Davis have developed polypeptide compositions of the peripheral nervous system tau isoform ("big tau") that appear to selectively enhance kinesin-3 motor activity and bias intracellular transport toward anterograde direction to treat diseases linked to impaired axonal transport.

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Researchers at the University of California, Davis have developed a treatment method leveraging let-7 microRNA restoration to combat aggressive pediatric diffuse midline gliomas with H3K27M mutations.

Researchers at the University of California, Davis have developed an engineered Escherichia coli platform for efficiently microbial production of lacto-N-tetraose (LNT), an important human milk oligosaccharide, directly from lactose as the sole carbon source. Through metabolic pathway rewiring, optimized lactose utilization, this technology enables a simple, scalable, and cost-effective fermentation process for industrial LNT production.

Researchers at the University of California, Davis have developed methods to treat medulloblastoma by restoring calcium signaling that promotes neuronal differentiation and inhibits tumor growth.

Researchers at the University of California, Davis have developed a compact two-photon miniscope designed to support high-resolution neural activity imaging over an expanded field of view in freely moving animals. The system achieves a favorable balance between imaging performance and device footprint, enabling large-scale neural observations while minimizing interference with natural behavior.

Researchers at the University of California, Davis have developed AAV-mediated gene therapy that delivers the choline acetyltransferase (ChAT) gene to treat presynaptic congenital myasthenic syndromes and related neuromuscular disorders.

Researchers at the University of California, Davis have developed a hybrid system combining Fluorescence Lifetime Imaging (FLIM) and Interferometric Near-Infrared Spectroscopy (iNIRS) within a single optical probe for advanced, multimodal tissue analysis.

Researchers at Louisiana State University, New Orleans and the University of California, Davis have developed neuroprotective compounds that inhibit glutamine transport to reduce excitotoxic glutamate release, offering treatment for neurodegenerative diseases.

Researchers at the University of California, Davis have developed ibogaine-related compounds that promote neural plasticity and treat neuropsychiatric and neurological disorders.

Researchers at the University of California, Davis have developed a class of compounds intended for the treatment of neurodegenerative diseases such as Alzheimer's by inhibiting DYRK1A kinase and modulating 5-HT2Rs.

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Researchers at the University of California, Davis have developed a protein-based composition and method that protects bioactive bacteria from thermal and osmotic stress during dehydration to maintain viability and shelf life.

Researchers at the University of California, Davis have developed a method that uses phenolic-rich agro-industrial residues to protect and stabilize beneficial microbes for improved shelf life and bioactivity.

Reactive oxygen species (ROS), including hydrogen peroxide and peroxynitrite, play dual roles as essential signaling molecules and high-stress markers of cellular damage. However, imaging these volatile species in live biological systems is often hindered by diffusion and poor signal localization. Researchers at UC Berkeley have developed a "tandem" activity-based sensing and labeling strategy that overcomes these challenges. This technology utilizes selective chemical probes that, upon reacting with a specific ROS, undergo a transformation that simultaneously triggers a fluorescent signal and anchors the probe to nearby cellular proteins. By "trapping" the signal at the site of its production, this dual-action mechanism allows for high-resolution, localized imaging of oxidative stress and signaling events within complex cellular environments.

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Researchers at the University of California, Davis have developed advanced epigenetic methods and systems that detect and assess developmental risks in embryos caused by maternal stress prior to conception.

Researchers at the University of California, Davis have developed a unique non-sacrificial synthetic peptide substrate designed to inhibit plasmin activity and prevent tumor progression and ascites formation in cancers characterized by elevated plasmin levels.

Researchers at the University of California, Davis have developed a method for creating annealed microgel scaffolds using polyethylene glycol-vinyl sulfone, offering improved efficiency and shelf life.

Researchers at the University of California, Davis have developed a method and composition that direct the growth of long, coronally oriented blood vessels in tissue grafts to improve vascularization and clinical transplant outcomes.

The success of gene therapy relies heavily on the ability of delivery vehicles to reach specific cells without being intercepted by the immune system or accumulating in non-target organs. UC Berkeley researchers have developed engineered capsids for recombinant adeno-associated virus that are specifically optimized to target Schwann cells, which are the essential support cells of the peripheral nervous system. While naturally occurring varieties like adeno-associated virus 1 and adeno-associated virus 2 often struggle to infect these cells efficiently or are diverted to the liver, these new variant capsids show significantly increased infectivity in Schwann cells. Furthermore, they are designed to be more resistant to the neutralizing antibodies commonly found in humans, which can often render traditional viral treatments ineffective. This breakthrough enhances both the manufacturing potential and the safety profile of genetic treatments for peripheral nerve disorders.

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Researchers at the University of California, Davis, have created a technology that uses engineered polynucleotides to deliver both an antigen and an enzyme that breaks down amino acids. This approach is designed to boost long-lasting memory T-cell responses, providing stronger protection against infectious diseases and cancer.

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