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Wearable Voltammetric Monitoring of Electroactive Drugs

UCLA researchers in the Department of Electrical and Computer Engineering have developed a voltammetric wearable device capable of monitoring electroactive drug circulation and abundance in biofluids. This non-invasive monitoring system can be used for electroactive drug therapy management, drug compliance/abuse monitoring, drug-drug interaction studies, and personalized dosing.

Novel Drug Delivery Platform

This invention is a novel method for synthetically designing protein carriers (enFoldin) for small molecules.  

Bioengineered RNA Molecules for Cancer Therapy

Researchers at the University of California, Davis have developed a method to use biologic RNA molecules for cancer research and therapy.

Bioengineered Let-7c Therapy for HCC Treatment

Researchers at the University of California, Davis have developed a bioengineered, RNA-based treatment for advanced liver cancer and hepatocellular carcinoma (HCC).

Training Platform for Transoral Robotic Surgery

UCLA researchers in the Departments of Bioengineering and Head & Neck Surgery have developed a novel robotic platform for the training of transoral surgery.

Photocurable Poly(ethylene glycol) as a Bioink for the Inkjet 3D Pharming of Hydrophobic Drugs

UCLA researchers in the Department of Bioengineering have developed a novel inkjet 3D pharming technique that is fast, customizable, and compatible with hydrophobic drugs.

Exosome-Mimicking Nanovesicles

Researchers at the University of California, Davis have developed a method of synthesizing stem cell-derived, exosome-mimicking, nanovesicles that have the therapeutic potential to rescue apoptotic neurons in culture.

Spray Dry Method for Calcium Cross-linked Alginate Encapsulation of Biological and Chemical Moieties via the Use of Chelating Agents

Researchers at the University of California, Davis have developed a one-step spray dry calcium cross-linked alginate encapsulation process where the calcium is released from a chelating agent.

Design Random Heteropolymer To Transport Proton Selectively And Rapidly

Despite decades of effort, it remains challenging, if not impossible, to achieve similar transport performance similar to natural channels. Inspired by the known crystal structures of transmembrane channel proteins, protein sequence-structure-transport relationships have been applied to guide material design. However, producing both molecularly defined channel sizes and channel lumen surfaces that are chemically diverse and spatially heterogeneous have been out of reach. We show that a 4-monomer-based random heteropolymer (RHP) exhibits selective proton transport at a rate similar to those of natural proton channels. Statistical control over the monomer distribution in the RHP leads to well-modulated segmental heterogeneity in hydrophobicity, which facilitates the single RHP chains to insert into lipid bilayers. This in turn produces rapid and selective proton transport, despite the sequence variability among RHP chains. We have demonstrated the importance of:the adaptability enabled by the statistical similaritythe modularity afforded by monomer chemical diversity to achieve uniform behavior in heterogeneous systems. 

Smart Dialysis Catheter

UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.

Low-Cost Paper-Based Microfluidic Diagnostic Device

Prof. Mulchandani and his colleagues from the University of California, Riverside have developed a new paper-based microfluidic platform for the simple and low-cost fabrication of single-walled carbon nanotube (SWNT)-based chemiresistive nanobiosensor arrays for multianalyte sensing from a single small volume sample that may be used as point-of-care diagnostic for a variety of purposes, including healthcare, food safety, environment, etc. This device is created by utilizing a wax printer to construct well-defined hydrophobic barriers for equal splitting and delivery of fluid and an inkjet printer to fabricate chemiresistors using a water-based SWNT ink on a paper substrate. Currently, the quantitative and selective detection of both human serum albumin (HSA) and human immunoglobulin G (hIgG) simultaneously in urine has been demonstrated by UCR. This paper-based chemiresistive biosensor is easy to fabricate, and designed for cost-effective, rapid, sensitive and selective detection of  analyte(s) of interest. This technology provides a platform for automated, disposable paper-based point-of-care diagnostics with multiplexed detection capability and microfluidic controls. Fig 1: A 3D microfluidic multiplexed paper-based biosensor array device.

Novel microbial species that promote fetal tolerogenic immunity

New therapies to prevent the development of asthma and other chronic inflammatory diseases in infants using natural bacterial modulators of fetal immune development.

Neoantigen-specific antibodies for chemically directed immune targeting of KRAS tumors

UCSF scientists have discovered novel antibodies that can specifically and selectively recognize tumor-derived neoantigens. The antibodies can be used for IgG, BiTE or CAR-T-based targeted immunotherapy and small molecule-based directed immune targeting via combination therapy. This dual therapeutic approach has the potential to specifically recognize and treat KRAS (G12C) cancer cell populations with high specificity, significantly improve cancer treatment outcomes, and overcome risk of treatment resistance in patients.

Liquid Metal Enabled Multi-Functional Neural Probes with Ultra-Large Tunable Stiffness

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel multi-functional neural probe with ultra-large tunable stiffness for electrochemical sensing and chemical delivery in the brain.

Modulation Of Engineered Immune Cell Receptor Translation Using Noncoding Sequence Elements

It would be beneficial to control the expression of engineered immune cell receptors for use in cell-based cancer immunotherapy, known as adoptive cell therapy (ACT), or in other cell-based therapies using engineered regulatory T cells (engineered Tregs) to treat immune dysfunction such as autoimmunity or organ transplant rejection. In these therapies, immune cells such as T cells or natural killer (NK) cells are genetically modified to express an engineered cell surface receptor that directs these immune cells to tumor cells or specific tissues expressing a target ligand recognized by the receptor, thereby leading to tumor cell destruction (ACT) or moderated immune reaction (engineered Tregs). However, it has been found that ACT can suffer from severe toxic side effects due to overactivation of engineered immune cells used in ACT such as CAR T-cells, due to signaling by the engineered cell surface receptor. Conversely, overactive immune cells can become exhausted and lose efficacy over time. Present attempts to regulate CAR expression do not account for control exerted at the level of protein synthesis. It would therefore be useful to be able to tune the activity of immune cells engineered for ACT or for treatment of immune dysfunction, by either increasing or decreasing the protein synthesis of the engineered immune cell surface receptor, i.e. the engineered TCR or CAR. This research describes compositions and methods for selectively increasing or decreasing the protein synthesis of engineered immune cell surface receptors using noncoding sequences in the 3’-untranslated region (3’-UTR) of messenger RNAs (mRNAs) encoding the engineered TCRs or CARs. These 3’-UTR sequences are sensitive to regulation by translation initiation factor eIF3 and can be used to modulate the strength and time duration of TCR or CAR protein synthesis.  

A Wearable Platform for In-Situ Analysis of Hormones

UCLA researchers in the Department of Electrical and Computer Engineering have developed a highly sensitive, wearable hormone monitoring platform.

Ultra-Low Cost, Transferrable and Thermally Stable Sensor Array Patterned on Conductive Substrate for Biofluid Analysis

UCLA researchers from the Department of Electrical Engineering have invented a novel biosensor array that is ultra-low cost and thermally stable. It prolongs the lifetime of electrode modules of sensor products and allows for extended sensing operation in uncontrolled environments.

Wearable Monitor of Attentional Integrity and Mental Strain

UCLA researchers in the Department of Psychiatry & Biobehavioral Sciences have developed a novel brain monitoring device that can be worn inconspicuously.

Titanium Implants with Novel Roughness

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a novel titanium implant with hierarchical multi-scale roughness to promote bone growth.

In-Situ Sweat Rate Monitoring For Normalization Of Sweat Analyte Concentrations

UCLA researchers in the Department of Electrical Engineering have developed a method of in-situ sweat rate monitoring, which can be integrated into wearable consumer electronics for physiological analyses.

Multiplexed Sweat Extraction And Sensing Wearable Interface For Normalized And Periodic Analysis

UCLA researchers from the Department of Electrical Engineering have developed a novel sweat induction and sensing platform to achieve personalized physiological monitoring non-invasively.

Novel Adjustable Caliber Catheter System

UCLA researchers in the Department of Radiological Sciences have designed a new adjustable catheter system for use in embolectomy or thrombectomy procedures.

Stamping-based Method for Microwell Production and Cell Aggregate Formation

Researchers at the University of California, Davis have developed a 3-D printed stamping system (the “Aggrestamp”) with the capability for in-situ production of microwells that facilitate cell aggregate formation.

Use of Machine Learning to Predict Non-Diagnostic Home Sleep Apnea Tests

Researchers led by Robert Stretch from the Division of Pulmonary, Critical Care & Sleep Medicine at UCLA have developed an algorithm that can predict whether a patient will have a non-diagnostic home sleep apnea test based upon data from the electronic health record and a brief questionnaire.

Milk Fat Globules As A Universal Delivery System

Researchers at the University of California, Davis have developed methods that utilize molecules encapsulated in milk fat globules and plant oleosomes to deliver bioactive compounds for a variety of applications.

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