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Neural Modulation Of Autonomic Nervous System To Alter Memory And Plasticity Of The Autonomic Network

Researchers at UCLA from the Departments of Medicine and Bioengineering have created a device that modulates the autonomic nervous system to treat heart conditions like arrhythmias.

Predicting Cefixime Susceptiblity Using Molecular Genotyping

UCLA researchers in the David Geffen School of Medicine have developed a novel method to detect the susceptibility of Neisseria gonorrhoeae to the antibiotic cefixime.

Novel Fret Method

Dr. Jiayu Liao and colleagues at the University of California, Riverside have developed a FRET assay using nitrobenzoxadiazole (NBD) and coumarin (CUM) amino acid analogs as a FRET pair.  These fluorophores are genetically encoded into peptides and proteins surrounding a protease cleavage site or ligand binding site and used for FRET-based high throughput screening for enzymes or small molecule inhibitors involved in pathways such as SUMOylation. Researchers have demonstrated FRET for peptides encoded with NBD and CUM separated by 4 and 6 amino acids and excited at 340 nm (Figure 1). Figure 1.  Fluorescent intensity of peptide I (6 amino acids between CUM and NBD) and II (4 amino acids between CUM and NBD) excited at 340 nm.  

Novel Non-Antibody-Based Chimeric Antigen Receptor Against HIV That Also Protects Cells From Infection

UCLA researchers in the Department of Medicine have developed a novel chimeric antigen receptor (CAR) that targets T cells against HIV while protecting T cells from HIV infection.

Novel Protease for Oncology and Inflammatory Diseases

The technology is a novel protease that reduces the ability of cells to respond to the inflammatory cytokine Tumor Necrosis Factor (TNF). High TNF levels have been linked to rheumatoid arthritis, Crohn’s disease and many types of cancers.

Treatment Of Lysosomal Storage Disorders

UCLA researchers in the Departments of Neurology have developed a novel treatment for Lysosomal-storage diseases (LSDs) with neurological impairment.

Novel Sources of Hematopoietic Progenitor Cells

UCLA researchers in the Department of Urology have developed a novel method of collecting hematopoietic stem cells from deceased donors that preserves the donor body and organs for further donations.

Plod3-Targeted Anti-Cancer Treatment

UCLA researchers in the department of Dentistry have developed a novel anti-cancer treatment that directly targets enzyme expression necessary to sustain cancer growth.

A Built-In Mechanism Of Gas Maintenance In Microfeatures On A Submerged Surface

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel superhydrophobic surface for drag reduction and anti-biofouling applications.

CRF Signaling And Hair Growth

UCLA researchers in the department of Medicine have developed a novel method to treat hair loss and potentially circumvent the common complications that rise from current treatments.

New Molecular Tweezers Against Neurological Disorders And Viral Infections

UCLA researchers in the Department of Neurology with an international team of scientists have developed several new molecular tweezer derivatives with novel synthesis methods that significantly improved the therapeutic efficacy and pharmacokinetic characteristics of the drug candidates.

Antibody-Free Protocol For Generation Of Highly Expandable, Non-Fibroadipogenic Mesodermal Precursors from Human Pluripotent Stem Cells For Treatment

UCLA researchers in the Department of Orthopaedic Surgery have developed a novel method to generate mesodermal precursors from human pluripotent stem cells to treat chronic skeletal muscle atrophy and fibrosis.

Massively Parallel High Throughput Single Cell Electroporation (MSEP)

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.

Methods Of Fabricating A Multi-Electrode Array For Spinal Cord Epidural Stimulation

UCLA researchers in the Department of Bioengineering and Department of Integrated Biology & Physiology have developed a novel array for spinal cord epidural stimulation.

Self-Locking Optoelectronic Tweezer And Its Fabrication

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel self-locking optoelectronic tweezer (SLOT) for single cell manipulation in conductive buffer over large areas.

Label-Free, Electrochemical Sensor for Detection of Antibiotics in Protein-based Substances

Researchers at the University of California, Davis have developed a highly sensitive immunosensor for the detection of chloramphenicol (CAP) residues in milk and other protein-based substances.

A Method To Determine Cause Of A Cardiac Arrest And Provide Cause-Specific Decision Support In Real-Time Using Continuous Electrocardiography

Researchers led by Duc Hong Do from the Department of Cardiology at UCLA have developed an algorithm to detect the cause of cardiac arrest in a hospital setting.

Capture And Stimulated Release Of Circulating Tumor Cells On Polymer Grafted Silicon Nanostructures

UCLA researchers in the department of Molecular and Medical Pharmacology have developed a novel capture system of circulating tumor cells for the early detection of metastatic cancer.

Single Circulating Tumor Cell Isolation Using Laser Microdissection And A Polymer Enrichment Assay

UCLA researchers in the department of Molecular and Medical Pharmacology have developed a novel matrix polymer capture system of circulating tumor cells that preserves biomolecular integrity through laser microdissection for the early detection of metastatic cancer.

Stereo Image Acquisition By Lens Translation

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel single-objective lens stereo imaging setup for endoscopic applications.

A New Human-Monitor Interface For Interpreting Clinical Images

UCLA researchers in the Department of Radiological Sciences have invented a novel interactive tool that can rapidly focus and zoom on a large number of images using eye tracking technology.

Machine-Learning-Based Denoising Of Doppler Ultrasound Blood Flow And Intracranial Pressure Signal

UCLA researchers in the Department of Neurosurgery have developed a novel framework to constrain noises in the measurements of vital physiological signals from neurosurgical patients.

Dicom/Pacs Compression Techniques

Researchers led by Xiao Hu from the Department of Surgery at UCLA have created a novel and convenient way to compress and query medical images from a PACS system.

Rapid Detection and Typing Of Bacteria

UCLA researchers in the Department of Material Science and Engineering have developed a novel method for rapid identification of bacteria using a Surface Enhanced Raman Spectroscopy (SERS) based approach.

Equally Sloped (Pseudopolar) Tomography With Applications To Biological And Medical Imaging

UCLA researchers in the Department of Physics and Astronomy and the California NanoSystems Institute have developed a new tomographic imagine technique providing higher spatial resolution at a lower radiation dose.

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