Researchers at the University of California, Davis have developed an imaging scheme for two-photon microscopes enhancing speed and resolution in neuroscience research.

Researchers at the University of California, Davis have developed isolated peptides that selectively bind M1 and M2 macrophages to enable precise diagnosis and targeted treatment of macrophage-associated diseases, including cancer.

Researchers at the University of California, Davis have developed an advancement in the field of healthcare technology, specifically in the development and application of silyl lipids for RNA vaccines.

Researchers at the University of California, Davis have developed a potential therapeutic strategy aiming at disrupting intercellular communication of pathogens using quorum sensing molecules and silicon-based pharmacophores.

Researchers at the University of California, Davis have developed a therapeutic use of cannabinoids for the treatment of Neurodegenerative Disorders (NDDs).

Researchers at the University of California, Davis have developed a nanoparticle system combining photothermal therapy and chemotherapy for enhanced cancer treatment.

Researchers at the University of California, Davis have developed a technology that introduces an approach to creating semi-living, non-replicating cellular systems for advanced therapeutic applications.

Researchers at the University of California, Davis have developed a vaccine platform utilizing non-replicating, metabolically active Cyborg Bacterial Pathogens to combat multi-antibiotic-resistant bacteria.

Transcranial focused ultrasound stimulation (TFUS) is a neuromodulation method that aims to change nervous tissue activity non-invasively. TFUS may be applied in an MRI scanner using image-based navigation. There is evidence in animals that the presence of a magnetic field may change the effects of TFUS on brain activity, presumably via Lorentz force effects. The evidence for any such effect in humans is weak and it is usually assumed that the MRI magnetic field does not alter the action of the TFUS. UC investigators provide a new method, Faraday induction-enhanced Focused Ultrasound Stimulation (FIEFUS), of applying ultrasound to nervous tissue (central or peripheral) by utilizing the strong, fringe magnetic field gradients found outside an MRI scanner. The concept is based on the theoretical generation of substantial electromagnetic induction from ultrasound-induced motions within the strong static magnetic field gradient, which could then be used to affect nervous tissue activity. This approach is motivated by the observation that a static, homogeneous magnetic fieldmayalter TFUS effects in animals—possibly through Lorentz forces—suggesting a strong magnetic field gradient could be a controllable experimental variable to induce circulating electric fields localized to an ultrasound target region.

Researchers at the University of California, Davis have engineered dominant negative CD40L mutant polypeptides that inhibit CD40/CD40L-mediated signaling, offering therapeutic potential for inflammatory, immune disorders, and cancer with improved safety profiles.

Researchers at the University of California, Davis have developed a computer-implemented method to identify viral mutations that enhance transmission and predict their prevalence in populations over time.

This invention introduces a novel approach to cardiac tissue stimulation and maturation through the use of photoactive organic and biological material blends.

A fully implantable brain-computer interface (BCI) system that enables direct brain control of lower extremity prostheses to restore walking after neural injury.

POEM is a groundbreaking 3D bioprinting technology enabling high-resolution, multi-material, and cell-laden structure fabrication with enhanced cell viability.

This technology introduces a novel approach for bridging force sensing with wireless communication through direct analog force-to-RF conversion provides lower power consumption and lower costs.

A novel approach to significantly enhance vancomycin's effectiveness against drug-resistant pathogens by conjugating it with a minimal teixobactin pharmacophore.

Innovative cell lines enabling precise genetic modifications to advance research in gene function, disease modeling, and potential therapeutic interventions.

An advanced geometric method for comprehensive 3D cardiac strain analysis, enhancing diagnosis and monitoring of myocardial diseases.

A novel device leveraging centrifugal microfluidics to accelerate bacterial growth and rapidly determine antibiotic susceptibility.

Researchers at the University of California, Davis have developed a Brain-Computer Interface (BCI) technology that enables individuals with paralysis to communicate and control devices through multimodal speech and gesture neural activity decoding.

Nucleic acid therapies hold vast therapeutic potential. FDA approved therapies include mRNA vaccines against SARS-COV2 and CRISPR/CAS9 treatment to treat sickle cell.  Both therapies use non-viral methods to deliver designer nucleic acid therapies to cells. However, a limitation of these approaches is the lack of organ and cell-specific delivery. Controlling gene delivery and expression in various cell subsets is challenging. UC Berkeley researchers have shown that the nanoscale topology of CpG oligodeoxynucleotide (CpG-ODN) motifs can be used to stimulate various immune cell subsets and alter gene expression from exogenously delivered mRNA in distinct immune cell subsets. CpG-ODNs of different classes are known to induce different inflammatory profiles in immune cells based on the structure and nanoscale topology of the short DNA strand. The researchers have found novel nanostructures which can be used to present or deliver CpGs to various cell subsets and regulate gene expression in these subsets.

This invention developed by UC Berkeley researchers provides a novel FRET-Cal Screening Platform to identify positive and negative modulators of membrane signaling proteins. The platform addresses the need for efficient and reliable methods to screen for compounds that can control the activity of these receptors. The technology utilizes a receptor protein with a Förster resonance energy transfer (FRET) pair, composed of a donor and acceptor fluorophore, to screen for candidate compounds. The FRET pair allows for the direct measurement of changes in protein conformation upon binding, providing a highly sensitive and specific method for identifying potential modulators. This platform offers a significant advantage over traditional screening methods by providing a high-throughput, real-time assay for drug discovery and therapeutic development.

Researchers at the University of California, Davis have developed a microscopy system combining optical coherence and confocal fluorescence microscopy for accurate Dry Eye Disease diagnosis.

A novel diagnostic technology offering rapid, accurate, and inexpensive detection, genotyping, and quantification of viral RNA in patient-derived samples, enhancing public health capabilities.

A novel technology for real-time, non-invasive monitoring and adaptive control of electron radiotherapy treatments using acoustic signals.