Polymeric Vectors For mRNA Delivery

Brief Description

A novel dendronized polypeptide architecture for efficient and safe mRNA delivery, suitable for anti-tumor immunotherapy.

Full Description

This technology introduces a synthetic vector system, based on dendronized polypeptide (denpol) architecture, for the efficient delivery of mRNAs to various cell types, including primary murine dendritic cells (BMDCs). It addresses the challenges of mRNA delivery by providing a non-toxic, highly efficient carrier system, overcoming the limitations of current viral and synthetic vectors.

Suggested uses

• Gene therapy and regenerative medicine. 
• Therapeutic treatment involving mRNA, such as genetic diseases and vaccines. 
• Research applications in gene editing and protein production.

Advantages

• High efficiency of mRNA delivery to a variety of cells, including primary murine dendritic cells (BMDCs). 
• Addresses the immunogenicity and inefficiency issues of viral-based vectors. 
• Overcomes the cytotoxicity and low efficiency problems of current synthetic vectors.

Patent Status

Related Materials

• Oldenhuis, N. J., et al. Guan, Z. (2016). Biodegradable dendronized polymers for efficient mRNA delivery. ChemistrySelect. 1 (15).