Researchers at the University of California, Davis have developed a combinatorial cancer treatment that enhances IL-15 mediated immune activation while inhibiting STAT3 to suppress myeloid-derived immune suppression in bone and soft tissue sarcomas.

Researchers at the University of California, Davis have developed single-chain insulin (SCI) technology, an insulin-based therapeutic approach that may improve treatment for diabetes and cancer by combining insulin, IGF, and integrin signaling properties.

A novel chemically inducible platform that directs arginine methylation to target proteins, enabling their selective lysosomal degradation.

Researchers at the University of California, Davis have developed methods to treat medulloblastoma by restoring calcium signaling that promotes neuronal differentiation and inhibits tumor growth.

Researchers at the University of California, Davis have developed a radiotherapy device that integrates ultra-high magnetic fields with high-energy X-ray beams to precisely target tumors while minimizing radiation exposure to healthy tissue.

Researchers at the University of California, Davis have developed a compact intraoperative sensing solution that helps clinicians identify cancerous tissue during minimally invasive procedures. The technology provides directional insight into the presence of approved molecular imaging tracers during surgery, addressing limitations of existing bulky or surface-limited tools. By offering intuitive, real-time guidance without disrupting surgical workflow, the approach supports more precise and confident tissue removal.

Researchers at the University of California, Davis have developed a compact system for directional detection of gamma rays and X‑rays without relying on heavy mechanical collimators. The approach improves the ability to localize radiation sources while reducing size, weight, and operational complexity compared to conventional solutions. The technology supports faster, more flexible use in clinical and industrial environments where directional radiation information is valuable.

Researchers at the University of California, Davis have developed an innovative platform for creating genetically encoded fluorescent biosensors capable of 1) assessing the formation of GPCR homo and heterodimers, and 2) determining how dimerization impacts protomer conformation in response to ligands.The UC Davis IPN has developed a suite of ~24 biosensors based on GPCR dimers.Collectively called, dimerLights, these modular biosensors have the ability to identify novel dimeric drug targets and assess the impact of ligands on their conformations.In addition to the ~24 biosensors that UC Davis has already developed, the modular platform in principle can easily be adapted to enable the discovery and evaluation of broader GPCR homo/heterodimers than have been tested so far.

Researchers at the University of California, Davis have developed a unique non-sacrificial synthetic peptide substrate designed to inhibit plasmin activity and prevent tumor progression and ascites formation in cancers characterized by elevated plasmin levels.

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An innovative brachytherapy applicator designed to deliver precise radiation to challenging gynecologic cancer sites while sparing healthy tissue.

Researchers at the University of California, Davis, have created a technology that uses engineered polynucleotides to deliver both an antigen and an enzyme that breaks down amino acids. This approach is designed to boost long-lasting memory T-cell responses, providing stronger protection against infectious diseases and cancer.

The core innovation is a dosimetry-driven approach that determines the activity concentration of a radioisotope based on the distance between the cement surface and the target tissue, enabling predictable, volume‑independent radiation dosing.

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A novel method for detecting, diagnosing, monitoring, and treating gastrointestinal cancers by analyzing DNA methylation levels in patient samples.

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