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Antisense Oligonucleotide Therapy for B Cell Mediated Cancers

Researchers at the University of California, Davis have developed a targeted therapy using an antisense oligonucleotide (ASO) to treat precursor B cell (pre-B) acute lymphoblastic leukemia (ALL).

Novel Compounds that Target Her3

UCSF researchers have developed a new class of small molecule ligands that specifically target HER3, a receptor tyrosine kinase implicated in numerous cancers.

Liquid Biopsy Diagnostic for Precursor Lesions of Pancreatic Cancer

These highly specific biomarkers distinguish potentially malignant mucinous cysts from benign nonmucinous cysts in the pancreas to help diagnose precursor lesions of pancreatic ductal adenocarcinoma. The biomarkers can be detected through enzymatic assays with exceptional accuracy and sensitivity.

Polyrotaxane Nanoparticles for Delivery of Large Plasmid DNA in Duchenne Muscular Dystrophy

UCLA researchers have designed, synthesized, and validated a polyrotaxane nanocarrier for targeted delivery of large plasmids for gene therapy applications for treatment of Duchenne muscular dystrophy and cancer.

A Breast Immobilization Device that Improves Radiation Therapy Dosimetry

UCLA researcher in the Department of Radiation Oncology has developed a breast immobilization device that provides structural support for the breast during radiotherapy, which allows for increased patient comfort and accuracy of breast radiation therapy.

Use of Cell-Penetrating Peptides and/or Antibody Drug Conjugates for Tumor Radiosensitization

Tumor resistance to radiotherapy can be an obstacle to patient therapy. On way to overcome radioresistance is via the use of drugs to sensitize cells to ionizing radiation (IR). Although many radiosensitizers have been developed, their clinical benefit is hampered by a failure to improve the therapeutic ratio due to a lack of tumor specific delivery over normal tissue. To overcome this obstacle, activatable cell penetrating peptides (ACPPs) target various cargoes to sites of protease activity in vivo. ACPPs consist of a polycationic cell penetrating peptide attached to a cargo and a polyanionic inhibitory domain with a protease cleavable linker. Probe activation and cargo uptake depends on localized proteolysis of the linker sequence that connects the polyanionic and polycationic domains, which converts the probe to an adherent form. This method provides detection of spatially localized enzymatic activity in living tissues via accumulation of cleaved probe. Recently, the use of anti-tumor drugs conjugated to antibodies has been introduced as a way to increase tumor kill and improve patient outcomes.

Blocking Fragment Of CDCP1

Triple-negative breast cancer (TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or Her2/neu. TNBC is difficult to treat since most hormone therapies target one of these receptors. Researchers at UCI have developed a therapeutic that bypasses these receptors, and instead targets fatty acid oxidation, a process linked to TNBC.

A New Preventive And Therapeutic Strategy For Liver Cancer

While the overall cancer incidences and mortality are decreasing, primary liver cancer, in particular hepatocellular carcinoma (HCC), is increasing rapidly  and has become the second leading cause of cancer-related death worldwide attributing to the rise of metabolic disorders, including alcoholic and non-alcoholic fatty liver diseases, and viral hepatitis. The significance for development of an effective prevention strategy cannot be over-emphasized, given the extremely poor prognosis of liver cancer patients at the advanced stages and the rapidly expanding population with chronic liver diseases and at high risk for subsequent liver tumorigenesis. Unfortunately, this rapid increase of the malignant disease is unmet by more efficient therapeutics in the clinic.

Targeted Inhibition of Human Multiple Myeloma

UCLA researchers in the Department of Medicine have discovered a novel mechanism involving Eph receptor/ephrin ligand interaction, that regulates human multiple myeloma growth and repopulation in vivo.

Technique for Respiratory Gated Radiotherapy using Low Frame Rate MRI and a Breathing Motion Model

UCLA researchers in the Department of Radiation Oncology have developed a novel method to gate radiotherapy using low frame rate MRI sequences to reduce damage to adjacent tissues during radiotherapy.

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

UCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K. This probe can also deliver drug molecules to bone resorption sites with high specificity.

Pegylated Pleiotrophin (PEG-PTN) Promotes Hematopoietic Stem Cell Expansion and Hematopoietic Regeneration

UCLA researchers in the Department of Medicine have developed a novel pegylated recombinant PTN molecule which is capable of unique efficacy as a therapeutic molecule to promote hematopoietic reconstitution in patients.

Automated Beam Orientation and Scanning Spot Spacing Optimization for Robust Heavy Ion Radiotherapy Therapy

UCLA researchers in the Department of Radiation Oncology have developed a new method to automate and optimize heavy ion beam radiotherapeutic techniques for the treatment of cancer.

Probability Map of Biopsy Site

UCLA researchers in the Department of Radiological Science have developed a technique for generating a probability map on an MRI that indicates the certainty of tissue sampling from a location, which could improve imaging-guided biopsies and their correlation with pathology.

Small Molecule Regulators of let-7 MicroRNA Targets in Acute Myeloid Leukemia Cancer Stem Cells

UCLA researchers have identified a class of small molecule phosphodiesterase inhibitors that suppress let-7 target genes and inhibit cell growth in acute myeloid leukemia cancer cell lines.

Mucoadhesive Devices for Oral Delivery of Various Active Agents

Effective and easily accepted system of oral delivery of therapeutic drugs.

A Novel Air/Water Retention Device for Improved Visibility in Colonoscopies

Colon cancer is the third most common cancer diagnosed in men and women in the United States. It is also the third leading cause of cancer-related death in women and the second leading cause in men.  Colonoscopy has been an important tool for screening and prevention of colon cancer. During this procedure, precancerous polyps called adenomas can be removed. Annually, over 15 million colonoscopies are performed each year. A colonoscopy is recommended for adults over the age of 50 in the US to screen for colon cancer. During a colonoscopy, a camera at the end of a flexible tube is inserted into the anus and advanced approximately four feet with the aid of water or air insufflation. Upon withdrawal, the colon is inflated with air to visualize the lining and detect polyps. A good quality exam is dependent on the ability of the anal sphincter muscles to hold water or air in the colon and prevent it from collapsing and obscuring views. There is currently no device available to create a seal in the anus in patients with weak anal sphincter muscles. Weak anal sphincters can occur in patients with history of anorectal surgery, childbirth or increasing age and makes up a growing number of patients undergoing colonoscopy.

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

A New Therapeutic Approach To Create And Exploit Metabolic Vulnerabilities In Malignant Glioma And Other Cancers

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel cancer therapeutic approach that targets both metabolism and cell death signaling pathways, creating a synergistic killing effect that vastly increases treatment efficacy.

Lipoplex-Mediated Efficient Single-Cell Transfection Via Droplet Microfluidics

The invention is an on-chip, droplet based single-cell transfection platform providing higher efficiency and consistency compared to conventional methods. Novel techniques following cell encapsulation yields uniform lipoplex formation, which increases the transfection accuracy. The invention solves the dilemma of the trade-off between efficiency and cell viability, and offers a safe, cell friendly and high transfection solution that is crucial for applications like gene therapy, cancer treatment and regenerative medicine.

Novel Methodology To Convert Magnetic Resonance Imaging Scan Data To Be Used In Proton Beam Therapy

This invention is a novel model that uses magnetic resonance imaging (MRI) information to more accurately determine the irradiation area using proton beam therapy (PBT) for oncological treatment.

17S-FD-895: An Improved Synthetic Splice Modulator mirroring FD-895

The spliceosome, the cellular splicing machinery, regulates RNA splicing of messenger RNA precursors (pre-mRNAs) into maturation of protein coding RNAs. Recurrent mutations and copy number changes in genes encoding spliceosomal proteins and splicing regulatory factors have tumor promoting or suppressive functions in hematological malignancies, as well as some other cancers. Over the past 10 years, a list of natural products, including FD-895, pladienolide B, herboxidiene, and spliceostatin A, have been identified as spliceosome modulators. They have been shown to have anti-cancer effect in vitro and in vivo models. However, these compounds demonstrate poor metabolic stability and short half-lives in vivo, excluding them from entering clinical evaluation. This invention, 17S-FD-895, is an analog of FD-895 and was synthesized through the combination of total synthesis and synthetic methods, demonstrating improved stability and on-target effect. This new spliceosome targeting compound was evaluated in different secondary acute myeloid leukemia models and showed potent efficacy in inhibition of acute myeloid leukemia (AML) LSC and disruption of AML maintenance in vitro and in mouse xenograft models (Crews et al. 2016). The study by Crews et al. indicates the pivotal role of spliceosome in secondary acute myeloid leukemia and the therapeutic potential of targeting leukemia stem cells in this subtype of AML often unresponsive to current therapy.

Novel Covalent Inhibitors Of GTP And GDP-bound RAS

This invention describes a novel class of direct Ras inhibitors that bind and inhibit this oncogene in its GTP and GDP-bound states.

mTORC2 Specific Inhibitors

UCLA researchers have identified and characterized mTORC2-specific inhibitors useful as a novel treatment of glioblastoma.

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