Combination Therapy For CNS Lymphoma

Technology Description

There are currently no effective therapies for CNS lymphoma. Although B-cell malignancies express CD19, few therapeutic modalities (including CAR-T cells and bispecific T-cell engager antibodies) have overcome severe CNS neurotoxicity. New research suggests that CD19 expression at BBB may mediate neurotoxicity.  Our inventor has shown regression of highly refractory CNS lymphoma with tafasitamab and lenalidomide. 

Stage of Development

Phase 2 L-MIND trial in patients with refractory non-Hodgkin lymphoma.

Related Materials

• Tafasitamab at the blood-brain barrier - 01/23/2023

Patent Status

Patent Pending