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Treatment Of Inherited Retinal Disease

Researchers at UCI have developed a method of treating inherited retinal diseases, such as Leber congenital amaurosis (LCA) and retinitis pigmentosa, by gene therapy of the RPE65 nonsense mutation. This method uses base editor-mediated genome-editing by viral delivery and lead to improved patient treatment through enhanced editing of single base pairs and reduced off-target genomic editing.

Method For Mid-Infrared Imaging In Si-Based Cameras Through Non-Degenerate Two-Photon Absorption

Researchers at UCI have developed a novel method to combine common CCD (charge-coupled device) cameras with mid-infrared (MIR) technology in order to create an affordable and accessible spectroscopic camera for biochemical imaging.

Optimizing Bipolar Membrane Interfaces to Catalyze Water Dissociation

Researchers at UCI have modified current commercial membranes to enhance efficiency of water dissociation at varying conditions for electrochemical technologies geared towards renewable fuel generation.

Electric Ratchet Based Ion Pumps

UCI researchers developed a new device that uses electricity to drive ion separation across a membrane. This device can increase the energy efficiency of various applications such as artificial photosynthesis, water desalination, and chemical separations.

Percutaneous Heart Valve Delivery System Enabling Implanted Prosthetic Valve Fracture

UCI researchers developed a percutaneous heart valve delivery system to deliver and implant a prosthetic valve. This system incorporates the means to fracture a previously implanted prosthetic valve in situ without interfering with the transcatheter valve to be implanted.

Intranasal Delivery of Oligonucleotides for Neurodegenerative Diseases

Delivery of oligonucleotide therapy to the central nervous system remains challenging. Neurodegenerative diseases, such as Huntington’s disease and Spinal Muscular Atrophy, can require intrusive and regular treatments, therefore a non-invasive delivery system would be very beneficial to patients. UC Irvine researchers have proposed a new method of therapeutic delivery utilizing a SARS-CoV-2 pseudovirus. Delivered intranasally, this system has the ability to bypass the blood brain barrier, making it an exciting approach to decrease risk for patients and ease the treatment process.

Advanced Imaging By LASER-Trained Algorithms Used To Process Broad-Field Light Photography and Videography

Diagnosing retinal disease, which affects over 200 million people worldwide, requires expensive and complicated analysis of the structure and function of retinal tissue. Recently, UCI developed a training algorithm which, for the first time, is able to assess tissue health from images collected using more common and less expensive optics.

Method For Rapid In Situ Detection Of Ammonia

This invention, a simple and robust method for ammonia detection, offers high-speed in situ quantification of ammonia concentrations with high sensitivity. The ammonia detection system does not require complex instrumentation, analysis, or labeling, which would allow for widespread adoption in chemistry-based fields and surrounding disciplines.