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Peptide Inhibitors of Human Voltage Gated Proton Channel hHv1 Activity to Reduce Inflammation

Human voltage-gated proton channels (hHv1) are implicated in a wide range of biological responses, including capacitation of sperm and stimulation of the innate immune response. Human sperm undergo a process called capacitation in the female reproductive tract, whereby intracellular pH rises and stimulates a progesterone-induced Ca2+ influx.  Researchers at the University of California, Irvine have discovered that this calcium influx is controlled by albumin activation of Hv1 voltage-gated proton channels.  Albumin activation of hHV1 in neutrophils also supports production and release of reactive oxygen species and protease during the immune respiratory burst.  These findings demonstrating a stimulatory role of albumin in both sperm and neutrophils has led to new therapeutic approaches to fertility and the treatment of inflammatory diseases.

Laser Photocoagulation To Stabilize Collector Channels To Enhance Aqueous Flows

Inventors at the University of California, Irvine have developed a laser-emitting device that treats glaucoma by enlarging and stabilizing collector channels in order to enhance aqueous outflow and reduce intraocular pressure (IOP).

Growth-Accomodating Transcatheter Pulmonary Valve System

UCI researchers have developed a novel transcatheter pulmonary valve (TPV) that addresses the current lack of options for children with progressive pulmonary valve regurgitation (PVR), which may lead to right ventricular (RV) dysfunction and failure. This TPV allows for implantation into patients of a younger age, preventing the progression of PVR and the RV issues that follow, and can also expand to accommodate the need for a larger pulmonary valve as the patient grows.

High-throughput Microfluidic Research Platform for Performing Versatile Single-Cell Molecular Timed-Release Assays within Droplets

Researchers at UCI have designed a high-throughput, cost-effective microfluidic platform as a research tool for performing genomic, proteomic, single-cell, pharmacological, and agricultural studies across multiple cell types.

Simple, User-friendly Irrigator Device for Cleaning the Upper Aerodigestive Tract and Neighboring Areas

Researchers at UCI have developed a user-friendly consumer medical device capable of cleaning and removing food particles and bacteria that accumulate in and around the back of the throat. Without removal, this accumulation may lead development of halitosis (bad breath) or inflammation that may require more serious medical intervention.

Minimally Invasive Percutaneous Delivery System for a Whole-Heart Assist Device

Researchers at UCI have developed a minimally invasive mechanism to help deliver and implant a cardiac assist device inside the body to help patients with heart failure.

Carbon Dioxide Flow Battery

Inventors at UCI have developed a novel electrocatalyst that reversibly converts carbon dioxide to its reduced form for the power source of a flow battery. The incorporation of this novel electocatalyst allows a common chemical, such as carbon dioxide to be included in the flow battery providing more affordable alternative than what is currently used. Furthermore, this technology has increased solubility, improving the energy density of the battery.

Fabricating Crystallinity Unique Carbon Nanowires (~5nm) with Ultrahigh Electrical Conductivity

UCI engineers have designed a new protocol for the synthesis of technology materials that uses electrospinning to draw polymers into ~5nm carbon nanowires.