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Metabolite-Responsive Hybrid Biomaterials

Researchers have developed a “smart” biomaterial for drug delivery systems capable of responding to signature cancer metabolite concentrations in tumor environments. This response triggers the release of encapsulated drugs at a specific tumor target.

Protein Nanoparticles For Cancer Immunotherapy

Though new therapeutics for the treatment of cancer are constantly being developed, they often show low efficiency for long-term remission, adverse side effects, and low immune response. Scientists at UCI have found a way to combat these issues with a combination therapy delivered by nanoparticle of both a vaccine, to prime the immune system, and a checkpoint inhibitor to shut down anti-cancer immune responses. This has been shown to prolong survival and promote immune response and immunological memory related to long-term survival.

Vaccines Against Herpes Simplex Virus Infection

Herpes simplex virus (HSV) infections affect billions of patients worldwide and can manifest its symptoms as painful blisters or ulcers at oral, ocular or genital locations. Symptomatic patients can currently only alleviate their pains with antiviral medication. These technologies propose a shift in focus toward novel protective epitopes as the foundation for new vaccines.

Transcription Factor Treatment for Schizophrenia and Bipolar Disorder

Current time to diagnosis for Schizophrenia and Bipolar Disorder is extremely lengthy (~6 months), and a delay in treatment greatly increases risk for suicidal thoughts. Once diagnosis has occurred, therapeutic options for both mental illnesses are greatly varied and have numerous side effects. To address both issues, UCI researchers have developed a novel way to diagnose and treat Schizophrenia and Bipolar Disorder by targeting specific transcription factors.

Mobile Microscopy Camera

A portable camera device that combines fluorescent imaging with optical sectioning capability of microscopic samples and wireless data transfer. This 3D sectioning imaging system and fluorescent detection will detect bacteria for ease use in remote areas for on-site diagnosis and will connect to a smartphone. The technology will lead to significant improvements in public health.

Real-time 3D Image Processing Platform for Visualizing Blood Flow Dynamics

Researchers at UCI have developed an image processing platform capable of visualizing 3D blood flow dynamics of the heart in real-time. This technology aims to be a promising tool for looking at areas of the heart that were previously difficult to image and to better understand the dynamics in cardiac dysfunctions.

Flexible Wearable Sensors for Non-invasive Continuous Blood Pressure Monitoring

Researchers at UCI have developed a wearable, wristband sensor that can detect the pressure of the body’s pulse from the surface of the skin at the wrist. They can correlate this measurement to blood pressure and subsequently use this device for long-term continuous monitoring.

Drug Combinations For Treatment Of Tinnitus, Vertigo, and Headache

UC Irvine researchers propose various combinations of medications for treatment of tinnitus and vertigo.