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Reducing Risk Of Aerosol-Transmitted Infection From Dental Ultrasonic Instrumentation

Pathogenic transmission of dental aerosol created by ultrasonic scaling is considered a major concern during dental procedures. Researchers at UC Irvine have developed a novel tool/method to address this concern by removing the created aerosol at the source.

Teixobactin O-Acyl Isopeptide Prodrugs

Recently, teixobactin was investigated to treat antibiotic-resistant pathogens, but the drug has yet to reach clinical trial due to its tendency to form gels which prevents accurate dosing. To address this, researchers at the University of California, Irvine have invented a new library of teixobactin related prodrugs which show improved solubility and efficacy versus teixobactin.

High-Throughput Selection Platform to Obtain NMN+-Utilizing Enzymes Through Directed Evolution

Noncanonical redox cofactor-based biotransformation is an attractive low-cost alternative to traditional cell-free reductive biotransformation. However, engineering enzymes to utilize noncanonical redox cofactors has been challenging. Addressing this problem, researchers at UC Irvine have developed a high-throughput directed evolution platform that enables development of such enzymes with ~147-fold improved catalytic efficiency, which translates to an industry-viable total turnover number of ~45,000 in cell-free biotransformation without requiring high cofactor concentrations.

A Broadly Neutralizing Molecule Against Clostridium Difficile Toxin B

Researchers at UCI have developed a family of recombinant protein therapeutics against Clostridium difficile designed to provide broad-spectrum protection and neutralization against all isoforms of its main toxin, TcdB. These antitoxin molecules feature fragments of TcdB’s human receptors (CSPG4 and FZD) which compete for TcdB binding, significantly improving upon existing antibody therapeutics for Clostridium difficile infections.

Medical Device: Electrode for Wearable Point-of-Care Health Monitoring

Researchers at the University of California, Irvine have fabricated a flexible and unobtrusive wearable electrode that can detect glucose at a very low limit of detection.In fact, the detection limits are the lowest ever reported for an enzyme-free sensor. This sensor is applicable for detecting glucose levels in saliva, sweat or tears, and can safely be used at home, especially by diabetic patients without the need to frequently draw blood.

Hollow Core Optical Waveguiding Enabled By Zero-Index Materials

Researchers at UC Irvine have developed a novel optical fiber technology that uses newly developed “zero-refractive index” material as a guiding medium, overcoming the significant limitations of conventional optical fiber where light properties are limited by glass core material. This novel technology will dramatically improve optical communication transmission speed and power by orders of magnitude.

Resonance Assistance and Custom Transmission for Lever-Drive Wheelchair

The technology is a lever-drive wheelchair.With this device, users are able to drive a wheelchair or exercise using impaired arm. The device contains a custom transmission, flexible arm support, elastic members connected between lever and wheelchair frame, and a counterweight for assistance during use and does not contain actuators or powered components.

Genetically Engineered Dendritic Cell-Derived Vaccines

Researchers at the University of California, Irvine have developed a new vaccine which generates a targeted, specific immune response with fewer complications than currently available vaccines.