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Somatic loss of Mgat1 as a potential risk factor for Multiple Sclerosis (MS)

Researchers at UCI report the incidence of somatic mutation/ loss in a human gene to increase the risk of some types of Multiple Sclerosis (MS).

Hybricdoma Producing Antibodies To Clqrp

Individuals with genetic immunodeficiency, as well as patients with HIV, cancer, and those undergoing chemotherapy or high risk surgery, are at increased risk for infection. C1q, an important component of the immune system, is known to enhance phagocytosis (cell ingestion of harmful bacteria or other materials). Scientists at UCI have developed antibodies to the receptor for C1q, C1qRp, to be used as a target for prophylactic treatments in populations at high risk of infection.

Substituted quinolone carboxylic acids and potential therapeutic effects in CNS disorders

Substituted quinolone carboxylic acids and their derivatives modulate the effect of γ-aminobutyric acid (GABA). It could be used to ameliorate CNS disorders related to GABA receptors.

Compositions for Enhancing Beta Cell Maturation, Health, and Function

Beta cell failure is the central cause of type-2 diabetes. Researchers at UCI have developed molecules for treating diabetes that target proteins on the surface of beta cells and induce their clustering. This clustering results in an increase in insulin secretion and content and promotion of beta cell maturation. Furthermore, the clustering effect seen with these compositions may promote both proliferation and the reversal of de-differentiation.

Compounds that modulate GABAA receptor

The present invention is related to the discovery that certain substituted enaminones act as enhancers of the GABAA receptor complex (GRC).

Nanowire Building Block

Nanowires have applications as transistors or bioelectronic devices. Current methods to synthesize nanowires lack the ability to precisely control length, sequence, and terminal functionality. Using this invention as a building block, organic nanowires can be made with controlled length, sequence, and terminal functionality. The organic nanowires made with this invention also exhibit zero-resistance and do not degrade with increased length.

Weather Augmented Risk Determination (WARD) System

The inventors have created software for construction project management. The Weather Augmented Risk Determination (WARD) System uses historic weather data and forecasts to determine probability of weather related work stoppage and probabilistic information on labor productivity and project duration.

Soluble Fluorescent DNA Label

Assays or biosensors that utilize electrochemical or fluorescent techniques often employ DNA electrochemical probes. Current probes have drawbacks, as they have either electronic or fluorescent properties, are not readily water-soluble, and are poorly coupled within a DNA strand. This invention is a DNA electrochemical probe that has both electronic and fluorescent properties, is water-soluble, and can readily incorporate into a DNA strand.

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