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Resonance Assistance and Custom Transmission for Lever-Drive Wheelchair

The technology is a lever-drive wheelchair.With this device, users are able to drive a wheelchair or exercise using impaired arm. The device contains a custom transmission, flexible arm support, elastic members connected between lever and wheelchair frame, and a counterweight for assistance during use and does not contain actuators or powered components.

Genetically Engineered Dendritic Cell-Derived Vaccines

Researchers at the University of California, Irvine have developed a new vaccine which generates a targeted, specific immune response with fewer complications than currently available vaccines.

Scanning Mechanism For Multimodality Intravascular Imaging Catheters

See patent application publication no. US20210282642A16. The present invention is directed to a system for multimodal imaging through the use of a dual-rotational imaging catheter. The system may comprise a swept-source laser for providing a light source for OCT and OCE imaging, and an optical fiber coupler that splits said light source into one for a compensation arm and the other for the imaging catheter. The imaging catheter may comprise a rotary apparatus for a first scanning method, and a distal motor for a second scanning method. The dual-rotational model may allow for optimal performance of multiple imaging modalities. The imaging catheter may utilize optical imaging and acoustic imaging. A balanced photodetector receives input from the destinations of both light sources to offset DC noise. An US pulser/receiver is used for US imaging, a multifunction I/O module, a function generator, and an amplifier are used for generating an acoustic excitation force for OCE imaging.

System Of Epicardial Sensing And Pacing For Synchronizing A Whole Heart Assist Device

See patent publication no. US20210128000A1. A network of electrodes configured to sense and/or pace the heart, wherein the network of electrodes are in contact with an epicardial surface of the heart, within a wrapping sleeve that assist the heart as a whole, wherein the network of electrodes sense the heart by quantifying intrinsic electrical activities of the heart, and wherein the network of electrodes pace the heart by inducing an electrical impulse to the heart to control its contractile activities. The network may be interfaced with a controller system, wherein the controller uses spatial and temporal electrical activities of the heart muscles to generate electrical impulse to synchronize the wrapping sleeve around the heart with the heart. Also disclosed is a system configured to construct space-time mapping of cardiac electrical activities and/or propagation, and sensing effects of a first assist event of a prior beat and controlling a second assist event.

Melt-And-Meld Approaches To Repair Tissue Defects

See patent publication no. US20220001080A1. The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and/or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

Ultrasound-Guided Delivery System For Accurate Positioning/Repositioning Of Transcatheter Heart Valves

See patent publication below. Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.

Percutaneous Heart Valve Delivery System

See patent information below. Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.

Fluidic System For The Rotational Cycle-Determined Release Of Liquid From A Chamber In A Rotor

See patent information below. The present invention relates to a fluidic device. More specifically but not exclusively, the present invention relates to serial siphon valves for a fluidic device. Control of the release of liquid from a fluidic chamber via a spinning rotor is a very important function in the area of centrifuged-based fluidic systems for applications such as immunoassays, nucleic acid analysis, biochemical tests, chemical tests and sample preparation. This is because it is often necessary to mix different reagents together at the appropriate time, either in parallel or in series.   It is a non-limiting object of the present invention to provide a method using a co-radial arrangement of siphon structures each separated by a capillary valve in a fluidic system. Such a method allows saving radial space. This saved radial space can be used, for example, to add more features on a fluidic device. It is a non-limiting object of the present invention to provide siphon structures that enable to sequentially distribute liquids in a fluidic system upon successive centripetal accelerations and decelerations applied to a rotary platform. Sequential fluid distribution can be controlled by the length and number of serial siphon structures. It is a non-limiting object of the present invention to provide a device using a co-radial arrangement of siphon structures each separated by a capillary valve in a fluidic system. Such a device allows saving radial space. This saved radial space can be used, for example, to add more features on a fluidic device.