A Novel 3D-Bioprinting Technology Of Orderly Extruded Multi-Materials Via Photopolymerization

Brief Description

POEM is a groundbreaking 3D bioprinting technology enabling high-resolution, multi-material, and cell-laden structure fabrication with enhanced cell viability.

Full Description

The POEM technology is a novel digital light processing (DLP)-based 3D-bioprinting technique that overcomes existing limitations by enabling the rapid and precise fabrication of multi-layer, multi-material structures. It uses photo-cross-linkable hydrogels extruded in a layer-by-layer manner, followed by high-resolution patterning, to create complex, cell-laden tissues and organs with high cell viability and metabolic activity.

Suggested uses

• Fabrication of physiologically relevant cell-laden structures for medical research and therapeutic applications. 
• Construction of complex heterogeneous tissues/organs for transplantation and regenerative medicine. 
• Development of in vitro models for pharmaceutical testing and disease modeling.

Advantages

• Enables the fabrication of complex heterogeneous tissues/organs. 
• High cell viability (≈80%) and metabolic activity for extended periods. 
• Eliminates cross-contamination and cleaning processes required by other techniques. 
• Supports multi-material and multi-layer printing, mimicking in vivo tissue architectures. 
• Uses a support bath to prevent collision and structural deformations during printing.

Patent Status

Patent Pending