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Use of Ozone and Infrared Heating as a Pre-treatment for Drying Fruit

Sequential ozone and infrared pre-treatments prior to hot air drying of fruit inactivates enzymes responsible for fruit browning, and concurrently reduces microbial contamination risk and air drying time.

Group 13 Metals as Anolytes in Non-Aqueous, Redox Flow Batteries

Researchers at the University of California, Davis have identified earth abundant and other relatively inexpensive materials that form the basis of novel molecules (anolytes), with long lifecycles and high energy densities, to be used in redox flow batteries.

Automated Emotion Recognition using Facial Features

Researchers at the University of California, Davis have developed a deep learning-based technology that analyzes facial images to distinguish seven human emotions.

Phased-Locked Loop Coupled Array for Phased Array Applications

Researchers at the University of California, Davis have developed a phased-locked loop coupled array system capable of generating phase shifts in phased array antenna systems - while minimizing signal losses.

Real-time Monitoring Technique for Detecting Insect Activity in Stored Grains

Researchers at the University of California, Davis have developed a wireless imaging technique capable of the real-time monitoring of insect activity in stored grains.

Motion-Corrected, Optical Imaging of Biological Tissue

Researchers at the University of California, Davis have developed a system that displays a real-time image - generated from optical signals - of biological tissue.

Durable, Washable, and Reusable Antibacterial/Antiviral Cotton Fabrics

Researchers at the University of California, Davis have developed a durable and reusable cotton fabric that is antibacterial/antiviral, and has medical, first-responder, and other potential safety and public health applications.

Carbon Nanotube based Variable Frequency Patch-Antenna

Researchers at UCI have developed a patch antenna constructed from carbon nanotubes, whose transmission frequency can be tuned entirely electronically. Additionally, the antenna can be made operable in the microwave to visible frequency regime by simply varying the device dimensions and composition.

Charged Membranes Incorporated With Porous Polymer Frameworks

Ion-exchange membranes have been established for a variety of industrial applications, including energy and environmental technologies related to water treatment, fuel cells, and flow batteries. However, the limited tunability and adverse ion permeability-selectivity tradeoff exhibited by traditional ion-exchange membranes limit their development. To address this limitation, researchers at UC Berkeley developed a new class of composite ion-exchange membrane materials incorporated with highly tunable porous aromatic frameworks (PAFs). The Berkeley researchers show that an assortment of PAF variants can be easily embedded into charged membranes, where the choice of PAF filler can be used to optimize the physical, ion transport, and adsorptive properties of the membrane according to their targeted application. Material characterizations indicate that numerous charged membranes embedded with PAFs exhibit excellent dispersibility, interfacial compatibility, structural flexibility, and pH stability. Proton conductivity and water uptake measurements also indicate that the exceptionally high porosity of PAFs enhances ion diffusion in membranes, while abundant, favorable PAF-polymer interactions decrease non-selective swelling pathways typically observed in highly charged ion-exchange membranes. Furthermore, adsorption experiments demonstrate that ion-selective PAFs can be embedded into charged membranes to tune the ion selectivity of the membrane and also enable their use as membrane adsorbents. Test show promise for technology to improve the general performance and tunability of ion-exchange membrane technologies.

Non Intrusive Workflow Assessment (NIWA) for Manufacturing Optimization

The invention is a smart non-intrusive workflow assessment platform for monitoring and optimizing manufacturing environments. The platform monitors environmental and energy metrics, and provides learning models to classify workers’ activities and relate them to the equipment utilization and performance. Correlating both stream of data enables both workers and supervisors to improve the efficiency of the whole manufacturing process and at an affordable price.

Method for Producing Amphiphilic and Amphoteric Soy Protein Colloids, Sub-Micron Fibers, and Microfibrils

Researchers at the University of California, Davis have developed a method for converting high molecular weight and complex globular proteins such as soy and pea into amphiphilic and amphoteric colloids, sub-microns fibers, and microfibrils important to multiple consumer and industrial applications.

Multifunctional Separations Using Adsorbent-Based Membranes

The selective separation of trace components of interest from various mixtures (e.g., micropollutants from groundwater, lithium or uranium from seawater, carbon dioxide from air) presents an especially pressing technological challenge. Established materials and separation processes seldom meet the performance standards needed to efficiently isolate these trace species for proper disposal or re-use. To address this issue, researchers at UC Berkeley developed a novel separation strategy in which highly selective and tunable adsorbents or adsorption sites are embedded into membranes. In this approach, the minor target species are selectively captured by the embedded adsorbents or adsorption sites while the species transport through the membrane. Simultaneously, the mixture can be purified through traditional membrane separation mechanisms. As a proof-of-concept, the researchers incorporated Hg2+-selective adsorbents into electrodialysis membranes that can simultaneously capture Hg2+ via an adsorption mechanism while desalinating water through an electrodialysis mechanism. Adsorption studies demonstrated that the embedded adsorbents maintain rapid, selective, regenerable, and high-capacity Hg2+ binding capabilities within the membrane matrix. Furthermore, when inserted into an electrodialysis setup, the composite membranes successfully capture all Hg2+ from various Hg2+-spiked water sources while permeating all other competing cations to simultaneously enable desalination. Finally, using an array of other ion-selective adsorbents, the Berkeley team showed that this strategy can in principle be applied generally to any target ion present in any water source. This multifunctional separation strategy can be applied to existing membrane processes to efficiently capture targeted species of interest, without the need for additional expensive equipment or processes such as fixed-bed adsorption columns.

Embedded Power Amplifier

Researchers at the University of California, Davis have developed an amplifier technology that boosts power output in order to improve data transmission speeds for high-frequency communications.

Absorptive Microwave Bandpass Filters

Researchers at the University of California, Davis have developed absorptive bandpass filters that enable improved passband flatness and good impedance matching both in-band and out-of-band.

Design For Nesting Height Adjustable Workbenches

Need to transport sturdy adjustable workbenches for use at sea or other temporary work spaces that need anchoring to walls or floors and you can't find a commercially available source?

Laser Additive Manufacturing Method For Producing Porous Layers.

A method of metal additive manufacturing which allows for production of porous products with pore size potentially down to the nanometer-scale.

New And Integrated Method For Continuous Auditory Brain Stimulation

Various examples of delivering continuous auditory stimulation of various kinds (sometimes referred to by the term “entrainment”) have been proposed to modulate brainwaves for therapeutic effect. Current methods of delivering continuous auditory stimulation typically present noises (in the form of clicks, tones, pulses) embedded in music. By modulating the user’s existing audial environment to embed continuous auditory sound stimulation, this technology creates a more tolerable and user-friendly experience that enables prolonged therapeutic stimulation for such neurodegenerative disorders as Alzheimer’s, Parkinson’s and Chronic Traumatic Encephalopathy (CTE).

Monodisperse Emulsions Templated By 3D-Structured Microparticles

UCLA Researchers in the Departments of Bioengineering and Mathematics have developed a method to generate uniform, thermodynamically stabilized microdroplets with digitizable solid structures.

Composition and Methods of a Nuclease Chain Reaction for Nucleic Acid Detection

This invention leverages the nuclease activity of CRISPR proteins for the direct, sensitive detection of specific nucleic acid sequences. This all-in-one detection modality includes an internal Nuclease Chain Reaction (NCR), which possesses an amplifying, feed-forward loop to generate an exponential signal upon detection of a target nucleic acid.Cas13 or Cas12 enzymes can be programmed with a guide RNA that recognizes a desired target sequence, activating a non-specific RNase or DNase activity. This can be used to release a detectable label. On its own, this approach is inherently limited in sensitivity and current methods require an amplification of genetic material before CRISPR-base detection. 

Biosynthetic Production Of L-4-Chlorokynurenine

The non‐proteinogenic amino acid l‐4‐chlorokynurenine (l‐4‐Cl‐Kyn) is a next‐generation, fast‐acting oral prodrug for the treatment of major depressive disorder. Additional studies report that this drug candidate is effective in animal models for the treatment of neuropathic pain, epilepsy, and Huntington's disease.  After active transport across the blood–brain barrier, it is enzymatically converted into the active agent 7‐chlorokynurenic acid, which is a highly selective competitive antagonist of the N‐methyl‐d‐aspartic acid (NMDA) receptor.   Suicide is 2-7x higher in Veterans than non-veterans, and may be related to brain kynurenine pathway (KP) dysregulation and NMDA receptor (NMDAR) hyperactivation.  L-4-Chlorokynurenine (L-4-Cl-Kyn) is a neuropharmaceutical drug candidate that is in development for the treatment of major depressive disorder (Double-Blind, Placebo-Controlled, Phase 2 Trial to Test Efficacy and Safety of AV-101 (L-4-chlorokynurenine) as Adjunct to Current Antidepressant Therapy in Patients With Major Depressive Disorder (the ELEVATE Study)).

Decision Making Spike Time Dependent Plasticity (STDP) Based Neuronal Network Learning

Biologically inspired neural networks are capable of performing sophisticated information processing. Information processing by the brain is multilayered and involves many sequential steps before sensory information can be interpreted and translated into a behavior or action. What makes this cascade powerful is its ability to learn and respond to an ever changing environment based on patterns. Eventually, information gathered from the senses may reach decision centers (such as lateral intra parietal cortex) that govern behavior and are under the influence of reward signals. While a great deal of research has gone into understanding mechanisms of learning at the cellular level, there is still much to discover regarding how learning at the cellular level gives rise to learning on the level of animal behavior. One of the most promising mechanisms of synaptic change for learning is spike time dependent plasticity ("STDP").

Self-Adaptive Architected Materials for Selective Damping of High Amplitude Sounds

Researchers in the UCLA Department of Mechanical and Aerospace Engineering and Department of Electrical and Computer Engineering have developed a responsive hearing protection system that uses self-adaptive architected materials that selectively dampens high amplitude, damaging sounds.

Processes For Microfluidic Fabrication

A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Colorimetric Detoxifying Sensors for Fumigants and Aerosol Toxicants

Researchers at the University of California, Davis have developed a colorimetric sensor than can detect and detoxify fumigants simultaneously. 

Single Conjugative Vector for Genome Editing by RNA-guided Transposition

The inventors have constructed conjugative plasmids for intra- and inter-species delivery and expression of RNA-guided CRISPR-Cas transposases for organism- and site-specific genome editing by targeted transposon insertion. This invention enables integration of large, customizable DNA segments (encoded within a transposon) into prokaryotic genomes at specific locations and with low rates of off-target integration.

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