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Synaptic Resistor With Signal Processing, Memory, And Learning Functions

Researchers led by Yong Chen from the Department of Mechanical and Aerospace Engineering have developed an artificial synapse for neuromorphic chips that have integrated logic, memory, and learning capabilities.

Assay for Oligonucleotides in Serum Without Extraction or RT-PCR

Prof. Ameae Walker’s laboratory at the University of California, Riverside (UCR) has developed an assay to quantify oligos in sub-picomole amounts without the need for sample purification and amplification. This new competitive assay is called an ELOHA (Enzyme-Linked Oligonucleotide Hybridization Assay). The method is illustrated in Fig. 1, below.  Capture Oligos that are to hybridize with an oligo to be measured are covalently linked to a plate (1), a Detection Oligo, with the same sequence as the oligo to be measured, has a conjugated label, such as horseradish peroxidase or biotin.  The Detection Oligo then competes with the oligo of interest for binding to the Capture Oligo (2).  Once the hybridization is complete, the unbound oligos are washed away (3).  A colorimetric readout is produced (4) to inversely quantify the oligo of interest.  Fig. 1 Schematic of the ELOHA assay Fig. 2 shows the use of an ELOHA for amounts of Antimaia in mouse serum. Antimaia is a splice modulating oligomer therapy for breast cancer developed in the UCR lab of Prof. Walker.  

Methods For High-Throughput Screening and Sorting of Hyperproducing Single Cells

UCLA researchers from the Department of Bioengineering have developed a novel approach to screen and sort single cells and colonies while preserving them in viable culture environments. This innovative technology employs a liquid to gel solution that changes phase under mild conditions to compartmentalize biological components.

The Use Of Magnetic Sensors To Prevent Femoral Posterior Wall Blowout During ACL Reconstruction

Researchers led by Andrew Palosaari from the Department of Chemistry and Biochemistry at UCLA have developed a novel way to guide ACL grafts and prevent femoral wall blowout during ACL reconstruction.

Flexible And Stretchable Interconnects For Flexible Systems And Flextrate(Tm)

Researchers led by Professor Subramanian Iyer from the Department of Electrical Engineering at UCLA have developed a novel fabrication technique to create stretchable electronics.

Electrochemical Flash Fluorination and Radiofluorination

Researchers led by Saman Sadeghi from the Department of Molecular & Medical Pharmacology at UCLA have developed a new and simple process to make fluorinated organic compounds.

Upconversion Plasmonic Mapping: A Direct Plasmonic Visualization And Spectrometer-Free Sensing Method

Researchers led by Xiangfeng Duan from the Department of Chemistry and Biochemistry at UCLA have developed a cheap and efficient way to map surface plasmon polaritons in order to detect trace amounts of biomolecules.

Dextrous Hand Exoskeleton

Researchers led by Professor Jacob Rosen from the Department of Mechanical and Aerospace Engineering at UCLA have developed a novel hand exoskeleton that provides sensory information to the user.

A Novel Way To Enhance Soft Tissue Integration And Seal Around Prosthetic Devices

A UCLA researcher from the Weintraub Center at the Department of Dentistry has developed a method to treat prosthetics allowing them to better integrate with the body.

Calcium Scoring Using Parallel Tomosynthesis

Researchers at UCLA in the Department of Radiology have developed a cheaper and safer way to measure coronary calcium levels to predict heart disease.

Joint Pharmacophoric Space through Geometric Features

Pharmacophore analysis through examination of Joint Pharmacophore Space of chemical compounds, targets, and chemical/biological properties.

Air Quality Monitoring Using Mobile Microscopy And Machine Learning

UCLA researchers have developed a novel method to monitor air quality using mobile microscopy and machine learning.

Insect Repellents and Assay

Prof. Anandasankar Ray and his colleagues at the University of California, Riverside (UCR) have developed insect repellants to deter insects from detecting and biting humans. The repellants are comprised of a group of compounds consisting of an aldehyde, mono- or  diketone and an alcohol. Repellants mask the insect’s ability to detect CO2. These repellants can be delivered in a variety of forms and can be used in much smaller concentrations and remain effective for much longer when compared to traditional repellants like DEET. The UCR lab also developed and patented a computational assay to screen and identify mosquito repellents. This assay was used to identify the patented compounds that disrupt CO2 sensing in mosquitos.   Fig. 1 Effect of inhibitory odor, 1-hexanol, on mosquito neuronal CO2 response. The small black bar indicates an 0.5 second exposure to inhibitory odor overlayed with a 3 second response to CO2. The second chart shows how CO2 response is mitigated by the odor   Fig. 2 Effect of pre-exposure to inhibitory odors on long-term reduction to CO2 response. The response to a 0.3% CO2 impulse over 6 minutes was measured every 30 seconds after an initial 3-second exposure to an ‘odor’ mixture (black bars). The odor mixture consisted of 1-hexanolo, pentanal, butanal, and 2,3-butanedione at 10-2 concentration. Paraffin oil (white bars) was used as a control      

Sonification-Facilitated Cognitive Training System to Enhance Visual Learning and Memory

UCLA researchers in the Department of Psychology have developed a new cognitive training tool to enhance visual learning and memory using sound.

dCas9 Epigenome Editing Toolkit

Researchers at the University of California, Davis have developed a dCas9 toolkit for human epigenome editing.

Near-Realistic Sports Motion Analysis and Activity Monitoring

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise in video games.

Apparatus and Signal Processing Technique for Real-Time Label-Free High-Throughput Cell Screening

UCLA researchers in the Department of Bioengineering have invented a novel apparatus for real-time label-free high-throughput cell screening.

The Brightest, Red-Shifted Luciferase-Luciferin Bioluminescent Pairs

Researchers at the University of California, Riverside, have developed several new luciferase-luciferin pairs that have superior brightness and excellent performance in vitro and in vivo. Through directed evolution of the existing NanoLuc Luciferase and the use of diphenylterazine (DTZ) as a substrate, the emission extensity is more than doubled compared to NanoLuc-furimazine. Moreover, red-shifted emission of teLuc-DTZ makes it an excellent tool for in vivo imaging. teLuc-DTZ streamlines a variety of applications to afford high sensitivity and reproducibility. Furthermore, fusing teLuc to a fluorescent protein creates the Antares2-DTZ pair, with emissions further red-shifted to the > 600 nm range and 65 times more photons emitted above 600 nm than FLuc-D-Luciferin. Fig. 1 shows the relative emission intensity and the range of emitted wavelengths of light  

Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

Novel Targets And Use Of Small Molecule BT-2 To Treat Heart Failure, Obesity And Diabetes

UCLA researchers from the Cardiovascular Theme in the Departments of Anesthesiology, Physiology and Medicine have discovered new pathways and potential treatment options for heart failure, obesity, and diabetes

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

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