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Insect Repellents and Assay

Prof. Anandasankar Ray and his colleagues at the University of California, Riverside (UCR) have developed insect repellants to deter insects from detecting and biting humans. The repellants are comprised of a group of compounds consisting of an aldehyde, mono- or  diketone and an alcohol. Repellants mask the insect’s ability to detect CO2. These repellants can be delivered in a variety of forms and can be used in much smaller concentrations and remain effective for much longer when compared to traditional repellants like DEET. The UCR lab also developed and patented a computational assay to screen and identify mosquito repellents. This assay was used to identify the patented compounds that disrupt CO2 sensing in mosquitos.   Fig. 1 Effect of inhibitory odor, 1-hexanol, on mosquito neuronal CO2 response. The small black bar indicates an 0.5 second exposure to inhibitory odor overlayed with a 3 second response to CO2. The second chart shows how CO2 response is mitigated by the odor   Fig. 2 Effect of pre-exposure to inhibitory odors on long-term reduction to CO2 response. The response to a 0.3% CO2 impulse over 6 minutes was measured every 30 seconds after an initial 3-second exposure to an ‘odor’ mixture (black bars). The odor mixture consisted of 1-hexanolo, pentanal, butanal, and 2,3-butanedione at 10-2 concentration. Paraffin oil (white bars) was used as a control      

Sonification-Facilitated Cognitive Training System to Enhance Visual Learning and Memory

UCLA researchers in the Department of Psychology have developed a new cognitive training tool to enhance visual learning and memory using sound.

dCas9 Epigenome Editing Toolkit

Researchers at the University of California, Davis have developed a dCas9 toolkit for human epigenome editing.

Near-Realistic Sports Motion Analysis and Activity Monitoring

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise in video games.

Apparatus and Signal Processing Technique for Real-Time Label-Free High-Throughput Cell Screening

UCLA researchers in the Department of Bioengineering have invented a novel apparatus for real-time label-free high-throughput cell screening.

High-Throughput Quantification of Nanoparticle Degradation using Computational Microscopy and its Application to Drug Delivery Nanocapsules

UCLA researchers in the Department of Bioengineering have developed a high-throughput imaging technique that monitors the degradation of nanoparticles in real time.

The Brightest, Red-Shifted Luciferase-Luciferin Bioluminescent Pairs

Researchers at the University of California, Riverside, have developed several new luciferase-luciferin pairs that have superior brightness and excellent performance in vitro and in vivo. Through directed evolution of the existing NanoLuc Luciferase and the use of diphenylterazine (DTZ) as a substrate, the emission extensity is more than doubled compared to NanoLuc-furimazine. Moreover, red-shifted emission of teLuc-DTZ makes it an excellent tool for in vivo imaging. teLuc-DTZ streamlines a variety of applications to afford high sensitivity and reproducibility. Furthermore, fusing teLuc to a fluorescent protein creates the Antares2-DTZ pair, with emissions further red-shifted to the > 600 nm range and 65 times more photons emitted above 600 nm than FLuc-D-Luciferin. Fig. 1 shows the relative emission intensity and the range of emitted wavelengths of light  

Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Electrode Agnostic, Supply Variant Stimulation Engine For Implantable Neural Stimulation

UCLA researchers in the Department of Electrical Engineering have invented an innovative universal agnostic electrode for implantable neural stimulation and sensing.

Load Adaptive, Reconfigurable Active Rectifier for Multiple Input Multple Output (MIMO) Implant Power Management

UCLA researchers in the Department of Electrical Engineering have invented a novel full-fledged implant power management unit, which is highly programmable and can process multiple input power deliveries on-chip.

A High Dynamic-Range Sensing Front-End For Neural Signal Recording Systems

UCLA researchers in the Department of Electrical Engineering have invented a novel neural recording chopper amplifier for neuromodulation systems that can simultaneously record and stimulate.

Predictive Optimization Of Pharmeceutical Efficacy

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a machine learning platform to virtually screen combinatorial drug therapies.

High-Efficiency One-Cell-One-Bead Encapsulation In Droplets

A high-efficiency single-cell droplet encapsulation method to improve single cell pharmacological assay throughput.

Scalable Manufacturing Of Superhydrophobic Structures In Plastics

Superhydrophobic surfaces that repel liquid have found a multitude of applications due to their self-cleaning and antibacterial effects, but are often highly surface selective and difficult to produce. Researchers at UCI have developed a new method to reliably mass produce universal superhydrophobic surfaces in a simpler and more cost effective manner.

Drift-Free and Calibration-Free Measurement of Analytes

A method of achieving the calibration- and drift-free operation of voltammetric electrochemical biosensors.

Bacteria from Medicago Root Nodules as Potentialy Useful PPB (Plant Probiotic Bacteria) for Agriculture

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have discovered new species of plant probiotic bacteria to enhance plant growth for agricultural purposes.

Non-Invasive Bladder Volume Sensing Device

Researchers at the University of California, Davis have developed an apparatus and methods for non-invasive bladder volume sensing, to determine when a patient’s bladder is full.

A Way to Genetically Silence Calcium Signaling in Cells and Organisms and Derivates Thereof

UCLA researchers in the Department of Physiology have developed a method of genetically silencing calcium signaling in cells and organisms for use in studying aberrant calcium signaling in disease.

Wireless In Situ Sensors in Stents for the Treatment and Monitoring of Chronic Obstructive Lung Disease (COPD)

UCLA researchers in the Department of Electrical Engineering have developed a novel wireless sensor for external and internal biosensing applications.

Exercise Promotion, Measurement, and Monitoring System

UCLA researchers in the Department of Electrical Engineering have developed a novel wireless sensor and exercise system for real-time exercise promotion and monitoring.

Bispecific Antibodies for Detection and Treatment of Cancers Associated with EGFR Overexpression

This invention identifies novel bispecific antibodies that can be used to detect and/or treat various cancers that overexpress EGFR family of proteins.

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