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Sweat Activated, Shape Changing Fabric

A Liquid-actuated fabric capable of asymetric expansion can be used in apparel to manage body temperature and moisture level.

Engineering Human Proteases for Therapeutic Use

A methodology termed “protease evolution via cleavage of an intracellular substrate” (PrECISE) to enable engineering of human protease activity and specificity toward an arbitrary peptide target. 

Isolation Of A Gene That Regulates The Strength Of Abscisic Acid Signal Transduction

As climate change has an increasingly greater impact on the environment, some regions are likely to get wetter while other regions are going to get drier. Therefore there is need to identify new ways to render agricultural plants more drought tolerant and effective in limiting transpirational water loss. The plant hormone abscisic acid (ABA) regulates a plant’s many important responses to stress. In seeds, ABA is responsible for the accumulation of nutritive reserves, tolerance for desiccation, maturation and dormancy.During vegetative growth, ABA is central in triggering plant responses to drought, salt stress and cold.A rapid response to drought that is mediated by ABA is stomatal closure.Stomata on the leaf surface are formed by pairs of guard cells whose turgor regulates stomatal pore apertures. ABA induces stomatal closure by triggering cytosolic calcium increases, which regulate ion channels in guard cells. Therefore modulating ABA activity in plants can be used to confer drought tolerance on plants.

Hyaluronic Acid-based Gel for Topical and Subcutaneous Applications

A method for producing chemically-crosslinked hydrogels using a biocompatible “click” chemistry for in situ gelation. 

Markers to Identify Primary Cells from Tumor Biopsies

Researchers at UC Irvine have developed a novel immunofluorescent imaging strategy to identify cell subsets of interest, in particular cancer stem cells, endothelial progenitor cells, and other primary adherent cells from tumor biopsies.

Lateral Cavity Acoustic Transducer Based Microfluidic Switch

The ability for on-chip particle/cell manipulation is important for microfluidic applications. Researchers at UC Irvine have developed a technology that exploits the phenomenon of acoustic microstreaming to manipulate fluid flow and suspended cells/particles in a microfluidic environment.

Multilayer High Density Microwells

Researchers at UC Irvine have developed high density, three dimensional (3D) micro-reactors for digital biology applications. The high-density imaging arrays overcome drawbacks associated with existing high density arrays fabricated on a single surface and the more recent 3D droplet emulsion arrays.

A Method For Predicting Glycosylation On Secreted Proteins

Glycosylation is a key post-translational modification that can affect critical properties of proteins produced in biopharmaceutical manufacturing, such as stability, therapeutic efficacy, or immunogenicity. However, unlike a protein's amino acid sequence, glycosylation is hard to engineer since it does not follow any direct equivalent of a genetic code. Despite various attempts to computationally model the process of glycosylation, industrial glycoengineering is still largely carried out using costly and time-consuming trial-and-error strategies and could greatly benefit from computational models that would better meet the requirements for industrial utilization.

Fast Micro- or Nano-scale Resolution Printing Methods and Apparatus

Fast, affordable three-dimensional printing or 3D manufacturing at micron or nano-scale is a holy grail for many high-tech industries. Current state of the art has generally been limited to smallest feature sizes in the 5-10 micron range, with metal-based 3D printer systems held at 100 microns. Another problem is 3D printers are limited to polymer media or require large laser sources. To address these issues, researchers at the University of California, Berkeley, have developed methods and devices to efficiently deposit desirable constituent materials (e.g. metallic, semiconducting, insulating, etc.) with precise micron and nano-scale resolution and without expensive laser requirements. These methods show promise in terms of fast sub-5 micron print speeds, material versatility, and structure sophistication. This is an entirely new fabrication tool, which is unencumbered by the limitations of existing 3D print-like functions, paving the way to arbitrary 2D and 3D nanoscale structures and devices that cannot be fabricated in any other way.

On Demand Vesicle Formation From Vesicle Precursors

A method to circumvent the fragility and short shelf-life of giant unilamellar vesicles by storing them as a double emulsions, and promoting vesicle formation once introduced into an electrolytic solution.

Mouse Cell Lines Mutant For Patched 1 And Patched 2

In mammals, the Hedgehog (Hh) family of proteins is essential for normal embryonic development and crucial for the homeostasis of adult tissues. Aberrant Hh signaling has been implicated in a number of cancers, including ovarian cancer. Sonic Hedgehog (Shh) is the best studied of the Hh proteins, with a well-characterized signaling pathway that involves binding to the receptors Patched 1 and Patched 2. This signaling pathway is activated in basal cell carcinomas and other tumor types.   UC Berkeley researchers have made a cell line mutant for all alleles of Patched 1 and Patched 2. This cell line provides a means to identify agents targeting the Hh pathway, as well as a means to test therapeutics. 

Novel Multivalent Bioassay Reagents

The guiding principle for the creation of biomolecular recognition agents has been that affinity is essential for both strength and specificity.  Monoclonal antibodies, the dominant workhorse of affinity reagents, have mono-valent affinities in the uM-nM range with apparent affinities that can be sub nM with the bi-valency intrinsic in intact immunoglobulin structure.  The avidin-biotin interaction used ubiquitously for biomolecular assembly is femto-molar and both highly specific and essentially irreversible.  High affinity has been proclaimed the essential goal for the selection of useful specific aptamers, though there has been disagreement about a tight coupling of affinity and specificity.  

Precise Neural Circuit Probe with Reversible Functionality

A neural circuit probe microscope attachment that uses atomic force microscope technology to apply tiny, precisely controlled forces to axons or axon bundles to interfere reversibly with neural transmission on a multielectrode array.

Activating HIV Latency Using Drug Encapsulated Nanoparticles

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.

Dendritic Peptide Bolaamphiphiles for siRNA Delivery

Novel dendritic peptide bolaamphiphiles that are safe and efficient for siRNA delivery.

INFRARED FLUORESCENT PROTEASE REPORTERS FOR DEEP TISSUE IMAGING

This invention includes the design and use of protease imaging reporters which can be detected in deep tissue. These can be used to monitor the effects of protease inhibitors, proteases and protease mediated processes including apoptosis related to the treatment of disease states such as cancer.

Small Volume Liquid Manipulation, Method, Apparatus And Process

Efficient multipurpose device for bulk flow of materials and separation.

Dynamic Equilibrium Separation, Concentration, and Mixing Apparatus and Methods

An apparatus, method and process for manipulating particles and/or solutions through the use of electrokinetic properties. 

The Exocyst As A Novel Drug Target Of Endosidin2 And Application As A Therapeutic

Background: Cancer progression and Diabetes are a few of the diseases that are related to the dysfunction of the exocyst complex, a protein complex that plays a vital part in exocytosis. EXO70, a protein in the exocyst complex, is directly involved in the development of diabetes and cancer, and has been shown to be a target for  therapeutics directed at these diseases. Description: The researchers at the University of California, Riverside have developed a small drug-like molecule that targets the EXO70 protein in both plant and mammalian cell lines. This discovery provides new insights into the novel features of the exocyst complex and also offers a new target for drugs aimed at human diseases.

Stimuli-Sensitive Intrinsically Disordered Protein Brushes

Recent advances in biomedicine and biotechnology are driving the demand for novel surface functionalization platforms for biologically active molecules. Polymer brush coatings form when macromolecular chains are end-tethered to surfaces at high grafting densities. While there have been notable successes integrating polymer brush coatings with proteins to control biological function, such strategies require covalent conjugation of the protein to the polymer, which can be inefficient and can compromise biological function. Moreover, these polymer brushes almost universally feature synthetic polymers, which are often heterogeneous and do not readily allow incorporation of chemical functionalities at precise sites along the constituent chains. To address these challenges, Researchers at the University of California, Berkeley (UCB) conducted experiments with polymer brushes based on nerve cell neurofilaments as the intrinsically disordered protein (IDP). By cloning a portion of a gene that encodes one of the neurofilament bristles, and re-engineering it such that they could attach the resulting protein to surfaces, UCB investigators have developed a biomimetic, recombinant IDP that can assemble into an environment-sensitive protein brush that swells and collapses dramatically with environmental changes in solution pH and ionic strength. Their research demonstrates that stimuli-responsive brushes can be efficiently integrated with proteins without compromising biological function, which could have broad commercial appeal as a new class of smart biomaterial building blocks.

Genome-Scale CRISPR-Mediated Control of Gene Expression

This invention is a novel method of controlling gene expression at genome scale using CRISPRi/a, which provides for highly specific and robust induction or repression of transcription.

Tunable, Modular Control of Multi- Gene Expression Using CRISPR RNA- Mediated Technology

A novel advancement of CRISPR technology which allows tuning the magnitude and direction of gene expression levels independently at each individual gene target.

Pneumatic Digital Computer

Researchers at the University of California, Irvine have developed a computer that is built out of pneumatic valves instead of electronic transistors. The system is built using microfluidics technology and can be employed for integrated control of lab-on-a-chip devices.

A Novel Approach To Asthma Inhaler Compliance Using Breath Measurement Of Tetrafluoroethane

The invention provides a non-invasive method to determine compliance and treatment efficacy of asthma inhalers. The method is divided into two components, which will measure hydrofluoroalkane (HFA) and then analyze the data to estimate pharmacokinetic parameters. Altogether, the HFA levels and estimated parameters will be used to determine the inhaler’s compliance and treatment efficacy.

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