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Flavonol Profile as a Sun Exposure Assessor for Grapes

Researchers at the University of California, Davis have developed a solar radiation assessment method for grapes that uses a flavonol profile. This method can be done using either HPLC or through the computer processing of the absorption spectra of a purified flavonol extract via a purification kit.

Virtual Reality Visualization Of Dynamic Images Using Deformable Image Segmentation

Researchers led by Tzung Hsiai from the David Geffen School of Medicine at UCLA have developed a way to visualize moving objects using virtual reality.

A New Human-Monitor Interface For Interpreting Clinical Images

UCLA researchers in the Department of Radiological Sciences have invented a novel interactive tool that can rapidly focus and zoom on a large number of images using eye tracking technology.

Dicom/Pacs Compression Techniques

Researchers led by Xiao Hu from the Department of Surgery at UCLA have created a novel and convenient way to compress and query medical images from a PACS system.

Method For Indefinite Storage And Preservation Of Membrane Precursors

UCLA researchers in the Department of Bioengineering have developed a novel strategy for the creation of biomimetic lipid bilayer membrane using a high freezing point lipid-containing solvent.  Using this method, the membrane precursor is frozen/immobilized prior to the completion of the spontaneous process of bilayer self-assembly, and the process can be resumed later by simply thawing and allowing membrane formation to resume.

Method to Reuse Multielectrode Arrays in Rodents

Researchers at the University of California have developed a protocol to enable the reuse of MEA probes.  Using this protocol, the MEA probes can be carefully peeled off undamaged from a protective layer, cleaned with ethanol and stored for re-use.  In addition, at each reuse the measured electrode impedances remain within the normal range set by the manufacturer for every channel and the probes may be reused up to six times.  This protocol is an improvement over the existing published protocols in that (1) these particular MEA electrodes are available commercially in a variety of configurations; (2) the MEA can be reused a number of times in order to record EEG in freely moving mice. Fig. 2 Setup of MEA EEG that allowed for enhanced reusability.

Combination Therapy Approach Using Novel Biguanides For Cancer Treatment

Researchers in the UCLA Departments of Molecular and Medical Pharmacology, Chemistry and Biochemistry, Surgery, and Medicine have developed novel metformin analogues which, when combined with immune checkpoint inhibitors, enhance the therapeutic benefit of these inhibitors in treating triple-negative breast cancer and other malignancies.

The Bic Inhibitor Of Cry-Cry And Cry-Cib Oligomerization/ Clustering

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have discovered two Arabidopsis proteins, BIC1 and BIC2, that are capable of inhibiting light-dependent dimerization of cryptochrome (CRY) molecules. These BICs can be used as an improved drug screening platform through controlled, titratable, label-free and reversible protein – protein interactions.

Thaw Gelation Process for Encapsulating Cell Spheroids

Researchers at the University of California Davis have developed a thaw gelation process for the formation of cell spheroids within a hydrogel shell.

Methods For Modulating And Assaying M6a In Stem Cell Populations

The Xing group at UCLA has discovered a method for modulating and assaying m6A in stem cell populations.

Lipid Bilayer Formation Using Sessile Droplets

UCLA researchers in the Department of Bioengineering have developed a method to form a biologically functional lipid bilayer in a high-throughput and automated fashion.

Predicting the Placebo Response and Placebo Responders in Medicated and Unmedicated Patients Using Baseline Psychometric and Clinical Assessment Score

UCLA researchers have developed a method and model to predict the placebo effect and placebo responsiveness using the 30-item baseline positive and negative syndrome scales (PANSS) scores, within both the medicated and unmedicated Schizophrenia patients.

3D Population Maps for Noninvasively Identifying Phenotypes and Pathologies in Individual Patients

UCLA researchers in the Department of Radiological Sciences have developed a novel computation system that uses large imaging datasets to aid in clinical diagnosis and prognosis.

Method to Direct the Reciprocal Interactions Between the Ureteric Bud and the Metanephric Mesenchyme

Researchers at UCLA have developed an approach to construct an embryonic kidney in vitro for the treatment of end stage renal disease.

Deep Learning Enhanced Mobile-Phone Microscopy

UCLA researchers in the Department of Electrical Engineering have developed an enhancement method via deep learning that improves the quality of images from mobile-phone microscopes.

A Novel Renilla-Derived Luciferase with Enhanced Activity and Stability

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel luciferase variant with enhanced stability and activity.

High Throughput Digital Cell Quantification Of Immune Cell Subsets Via Epigenetic Markers

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel high-throughput method for the quantification of immune cell subtype.

Precise tracking of subsurface tissue probes and objects

The invention is a novel method that tracks the position of probes and objects deep inside tissues, with unprecedented 3D precision. Data obtained from optical techniques are combined with that provided through ultrasound methods, providing accurate localization in the 3D space, along with precise anatomical structure. Such a combined method is crucial for precision-sensitive applications as anesthetic drug delivery.

A Device For Continuous Focusing And Rotation Of Biological Cells And Its Application For High Throughput Electrorotation Flow Cytometer

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel device for high-throughput label-free analysis of cells.

Reagent to Label Proteins via Lysine Isopeptide Bonds

Researchers in the UCLA Department of Chemistry and Biochemistry and the University of Texas-Medical Center, Houston Department of Microbiology and Molecular Genetics have modified the Corynebacterium diphtheriae (C. diphtheriae) sortase enzyme so that it can be used as a bioconjugation reagent in vitro.

Synthetic Algal Promoters as a Tool for Increasing Nuclear Gene Expression in Green Algae

Algae have enormous potential as bio-factories for the efficient production of a wide array of high-value products, and eventually as a source of renewable biofuels. However, tools for engineering the nuclear genomes of algae remain scarce and limited in functionality, in part due to lack of strong promoters.

Using DNA Methylation Markers To Predict Clinically Important Traits In Mammals

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have found association of DNA methylation with metabolic syndrome traits in human adipose tissue samples using epigenome-wide association studies (EWAS).

Label-Free Nanoprobes For Long-Term Imaging Of Organelle Movements In Living Cells

To date, the most widely used technique used to monitor organelle movement in living cells is fluorescent imaging, which requires labelling of organelles. Prior organelle labelling causes disturbance in living cells, which may limit understanding of intracellular organelle movement. Furthermore, conventional fluorescence-based single molecule methods are prone to photobleaching, blinking, and low signal-to-noise ratios.

Multi Layered Microfluidic Devices For In Vitro Large Scale Perfused Capillary Networks

"Organ-on-a-chip” technologies allow recapitulation of organ systems in vitro and can be utilized for drug response and toxicity studies, which are required in preclinical studies. However, current recapitulations via “organ-on-a-chip” technologies are limited because the designs do not fully reflect physiological complexity. To address this, UC Irvine inventors have developed a device to better mimic the vascular network of the circulatory system.

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