Closed-Loop Modulation Of Epileptic Networks

Brief Description

This technology offers a novel approach to treating epilepsy by preventing the spread of epileptic networks and improving memory deficits through targeted electrical stimulation.

Full Description

This technology utilizes closed-loop electrical stimulation, specifically targeting the hippocampal region to counteract interictal epileptiform discharges (IEDs) that disrupt cognitive functions and contribute to the spread of epileptic networks. By inhibiting pathological hippocampal-cortical oscillatory coupling, it effectively prevents the expansion of epileptic networks and mitigates associated memory deficits in focal epilepsy, showcasing a promising avenue for epilepsy treatment and the improvement of neuropsychiatric comorbidities.

Suggested uses

• Treatment of refractory focal epilepsy in both children and adults. 
• Neuropsychiatric interventions, leveraging the modulation of interictal network dynamics. 
• Advanced epilepsy management systems incorporating closed-loop electrical stimulation technology. 
• Potential use in preventing epileptogenesis following brain insult, offering a prophylactic application.

Advantages

• Prevents the spread of the epileptic network, potentially limiting the progression of epilepsy. 
• Ameliorates long-term spatial memory deficits, addressing cognitive comorbidities associated with epilepsy. 
• Offers a targeted intervention that normalizes interictal dynamics, which may improve overall epilepsy outcomes. 
• High translational potential due to non-reliance on viral vectors, genetic modifications, and the established safety of electrical stimulation. 
• Technological advancements enhance the computational capacity and decrease the invasiveness of the required electronic devices.

Patent Status

Patent Pending