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Psychoplastogens For Treating Hearing-Related Disorders

Researchers at the University of California, Davis, have developed a novel approach to treat hearing-related disorders with a new type of psychoplastogen that can increase the synapse density in the ear, correlating with hearing ability.

Melt-And-Meld Approaches To Repair Tissue Defects

See patent publication no. US20220001080A1. The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and/or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

Safety Scalpel for Removal of Gastrostomy Tubes

A researcher at the University of California, Davis has developed a safety scalpel for mitigating the challenges associated with the removal of certain types of percutaneous implants, such as gastrostomy tubes having difficult to reduce anchoring elements.

(SD2021-335) Personalized Machine Learning of Depressed Mood using Wearables (software)

Depression is a multifaceted illness with genetic, behavioral, lifestyle, and interpersonal risk factors that may express as overlapping symptoms, which in turn leads to huge interindividual variability in clinical response to the same treatments or behavioral recommendations.In the era of digital medicine and precision therapeutics, new personalized treatment approaches are warranted for depression.

Vascular Anastomosis Device

Researchers at the University of California, Davis have developed a surgical device to facilitate vascular anastomosis procedures with enhanced ease and speed.

Digital Microfluidic Plasmonic Polymerase Chain Reaction (PCR) Device

This technology automates the polymerase chain reaction (PCR) process using digital microfluidics for droplet manipulation. The invention also increases PCR speed and efficiency by combining electrowetting and plasmonic heating in a single device.PCR tests have a wide variety of applications, including the diagnosis of infectious organisms such as viruses and bacterias, as well as cloning, mutagenesis, sequencing, gene expression, and more. The test has become a gold standard for detecting SARS-CoV-2, the virus that causes COVID-19. In the PCR process, a gene or part of the DNA of the infecting organism is amplified exponentially to the extent that it can be detected using conventional methods like gel electrophoresis. This invention addresses the following challenges in current PCR methods: a long sample to answer time; and manual manipulation by humans, which increases the error rate in the tests.  

Positive Allosteric Modulators Target TRPV1 with Analgesic Effects

Researchers at the University of California, Davis have developed de novo positive allosteric modulators (PAMs) that bind to TRPV1 proteins involved with pain-sensing in order to provide analgesic effects.

(SD2021-225) Wireless Contact Force Sensing and Localization

Our sense of touch is critical for understanding and interacting with the world around us. While interacting with the physical world, force-sensitive mechanoreceptors in the skin respond to various vibrations, motions, pressures, and stretching of the skin to provide us with critical information on the location and magnitude of the stimuli. Thus, if we want the next generation of tactile sensors to emulate how our skin reacts to stimuli, we need to both sense the magnitude and location of contact forces acting on the sensing surface.Contact force is a natural way for humans to interact with the physical world around us. However, most of our interactions with the digital world are largely based on a simple binary sense of touch (contact or no contact). Similarly, when interacting with robots to perform complex tasks, such as surgery, we need to acquire the rich force information and contact location, to aid in the task.

Method for Estimating Blood Plasma Water Content Using Portable NMR Relaxometry

Researchers at the University of California, Davis have developed a method of estimating blood plasma water content using nuclear magnetic resonance (NMR) relaxometry.

Medical/Surgical Instrument-Bending Device

Researchers at the University of California, Davis have developed a device that allows needles to be reliably and easily bent to a range of specified and reproducible angles. The device also enables protection of the needle tip and the maintenance of needle sterility during bending.

Neural Network Machine Learning Applied to Diagnose Acute Kidney Injury

Researchers at the University of California, Davis have developed machine learning models to enhance the accessibility and accuracy of acute kidney injury (AKI) testing.

Inter-Brain Measurements for Matching Applications

This technology utilizes inter-subject measurement of brain activity for the purpose of matching individuals. In particular, the invention measures the similarity and differences in neural activity patterns between interacting individuals (either in person or online) as a signature measurement for their matching capabilities. Relevant applications can be in the world of human resources (e.g., building collaborative teams), patient-therapist matching and others. The application relies on the utilization of both custom and commercial devices for measuring brain activity.

Programmable System that Mixes Large Numbers of Small Volume, High-Viscosity, Fluid Samples Simultaneously

Researchers at the University of California, Davis have developed a programmable machine that shakes and repeatedly inverts large numbers of small containers - such as vials and flasks – in order to mix high-viscosity fluids.

Growth-Accomodating Transcatheter Pulmonary Valve System

UCI researchers have developed a novel transcatheter pulmonary valve (TPV) that addresses the current lack of options for children with progressive pulmonary valve regurgitation (PVR), which may lead to right ventricular (RV) dysfunction and failure. This TPV allows for implantation into patients of a younger age, preventing the progression of PVR and the RV issues that follow, and can also expand to accommodate the need for a larger pulmonary valve as the patient grows.

Staged Fascial Closure Device

The current invention enables the safe closure of an open abdomen during surgery when the abdominal fascia cannot be closed primarily.

Antibiotic to Fight Gram Negative and Resistant Bacteria

Researchers at the University of California, Davis have developed a gyramide antibiotic which is effective against Gram-negative and fluoroquinolones (FQs) resistant bacteria.

Device for Spinal Dural Repair

Dural tear is a frequent and costly complication of spinal surgery, which can cause cerebrospinal fluid (CSF) leakage, triggering additional, serious post-operative difficulties. Researchers at UC Irvine have developed a new method and device to mitigate dural tears in a rapid, safe, and water-tight manner

Roll-To-Roll Based 3D Printing Through Computed Axial Lithography

The inventor has developed systems and methods for performing continuous 3D roll-based additive manufacturing. This invention is distinct from roll-based micro/nanomanufacturing methods such as imprint lithography, gravure printing, and photo-roll lithography because it enables production of high aspect ratio reentrant features and voids in a single step that are difficult or even impossible with the existing methods.

High Fidelity 3D Printing Through Computed Axial Lithography

The inventor has developed novel algorithms and metrology methodologies, including real-time in-situ imaging of part formation, in computed axial lithography printing (CALP). CALP is a form of continuous 3D roll-based additive manufacturing which is distinct from roll-based micro/nanomanufacturing methods such as imprint lithography, gravure printing, and photo-roll lithography because it enables production of high aspect ratio reentrant features and voids in a single step that are difficult or even impossible with the existing methods.

Protein Inhibitor of Type VI-B CRISPR-Cas System

The inventors have discovered the first protein inhibitor of the type VI-B CRISPR-Cas system. By controlling this CRISPR system, one could possibly ameliorate the toxicity and off-target cleavage activity observed with the use of the type VI CRISPR system. Moreover, these proteins can also serve as an antidote for instances where the use of CRISPR-Cas technology poses a safety risk. Additionally, this technology can also be used for engineering genetic circuits in mammalian cells. This finding is of potential importance to many companies in the CRISPR space. 

Delivery System For Transcatheter Valves

Researchers at UCI have developed a novel medical device for use in transcatheter heart valve replacement surgeries. The device provides physicians with more careful control of the catheter insertion, minimizing complications and adverse effects.

Multifunctional Separations Using Adsorbent-Based Membranes

The selective separation of trace components of interest from various mixtures (e.g., micropollutants from groundwater, lithium or uranium from seawater, carbon dioxide from air) presents an especially pressing technological challenge. Established materials and separation processes seldom meet the performance standards needed to efficiently isolate these trace species for proper disposal or re-use. To address this issue, researchers at UC Berkeley developed a novel separation strategy in which highly selective and tunable adsorbents or adsorption sites are embedded into membranes. In this approach, the minor target species are selectively captured by the embedded adsorbents or adsorption sites while the species transport through the membrane. Simultaneously, the mixture can be purified through traditional membrane separation mechanisms. As a proof-of-concept, the researchers incorporated Hg2+-selective adsorbents into electrodialysis membranes that can simultaneously capture Hg2+ via an adsorption mechanism while desalinating water through an electrodialysis mechanism. Adsorption studies demonstrated that the embedded adsorbents maintain rapid, selective, regenerable, and high-capacity Hg2+ binding capabilities within the membrane matrix. Furthermore, when inserted into an electrodialysis setup, the composite membranes successfully capture all Hg2+ from various Hg2+-spiked water sources while permeating all other competing cations to simultaneously enable desalination. Finally, using an array of other ion-selective adsorbents, the Berkeley team showed that this strategy can in principle be applied generally to any target ion present in any water source. This multifunctional separation strategy can be applied to existing membrane processes to efficiently capture targeted species of interest, without the need for additional expensive equipment or processes such as fixed-bed adsorption columns.

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