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Self-Locking Optoelectronic Tweezer And Its Fabrication

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel self-locking optoelectronic tweezer (SLOT) for single cell manipulation in conductive buffer over large areas.

Development of a Small Molecule that Blocks Alpha Synuclein Transmission in Neurodegenerative Disorders

There is a strong correlation with aging and the onset of developing a neurodegenerative disease such as Alzheimer’s or Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD) and Creutzfeldt-Jacob disease, Dementia with Lewy Bodies (DLB), Multiple system atrophy (MSA) and others. A universal commonality among these diseases is the presence of misfolded aggregated proteins in the brain or with cells of the brain. Very strong evidence supports a role of spreading of misfolded proteins from cell to cell and across the brain in disease progression. Moreover, these aggregated proteins can take different forms and be used help diagnosis the specific neurodegenerative disease. Parkinson’s disease (PD) is characterized by loss of striatal dopaminergic signaling and the presence of alpha-synuclein-containing Lewy bodies and neurites. Research has shown the importance of alpha-synuclein (α-Syn) from examining people with PD at autopsy and the pathology associated with the disease which contains misfolded and aggregated α-Syn. Moreover, a mutation in the gene encoding α-Syn (SNCA) or simple overexpression of wild-type α-Syn will lead to PD. The misfolding and spread of α-Syn are central to disease initiation and progression. The presence of misfoided α-Syn is also seen in other synucleinopathy diseases including Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB), the two most prevalent progressive dementia diseases and MSA. One of the most common forms of symptomatic treatment for early stages of PD is the use of monoamine oxidase B inhibitors and in later stages the use of dopamine receptor agonists (DRAs) and /or levodopa. The treatment must find a good balance between clinical benefits and risks. Ultimately, these treatments fail to show improvement over the course of 2-5+ years, therefore, new alternative treatments are needed especially those attacking the underlying course of the disease. Small molecule binding to native states of globular proteins has been successfully to block misfolding and aggregation most notably in the case of targeting transthyretin to treat systemic amyloidosis. By contrast, targeting of intrinsically disordered proteins such as native monomeric α-synuclein (α-Syn) with  small molecules has been challenging due to their inherent structural heterogeneity and the absence of persistent structural elements.

Combination of a drug with low level light therapy (LLT) for treatment of wounds

This is a combination of a drug and light technology for the purpose of accelerating the healing of wounds on the skin, ulcers, and elsewhere in the body. Both methods have been shown to accelerate wound healing, and combining the two will potentially result in more rapid healing than either would alone.  

Multimodal food journaling

Researchers at UCI have developed a hands-free, unobtrusive smartphone-based application for automatic food journaling. The app, which operates via voice command, is interactive and highly engaging thereby encouraging long-term user participation.  

Antibacterial Polypeptide with Broad-Spectrum Gram-Positive and Gram-Negative Activity

Researchers at the University of California, Davis have developed a polypeptide that kills pathogenic bacteria.

A New Human-Monitor Interface For Interpreting Clinical Images

UCLA researchers in the Department of Radiological Sciences have invented a novel interactive tool that can rapidly focus and zoom on a large number of images using eye tracking technology.

Dicom/Pacs Compression Techniques

Researchers led by Xiao Hu from the Department of Surgery at UCLA have created a novel and convenient way to compress and query medical images from a PACS system.

Methods Comprising Immune System Modulation With Microporous Annealed Particle Gels

UCLA researchers have developed a novel microporous annealed particle (MAP) scaffold that acts as both a tissue growth scaffold and an immune modulatory system. The technology permits continuous, time-encoded, modulation of the immune system delivered injection/implantation of fabricated scaffold, comprised of the MAP gel technology.

Hydraulically Actuated Textiles

A soft, planar, actuator based on hydraulically actuated textiles.

Preparation Of Functionalized Polypeptides, Peptides, And Proteins By Alkylation Of Thioether Groups

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering Department, have developed new methods for adding different functional groups on polypeptides.  The UCLA researchers have used this method to create a platform to create and modify nanoscale vesicles and hydrogels for use in nanoscale drug delivery particles, injectable drug depots, imaging and detection, industrial biomaterials, and wound management.

A New Mechanism For Hypertriglyceridemia In Humans

UCLA researchers in the Department of Medicine have identified autoantibodies against GPIHBP1, a GPI anchored protein of capillary endothelial cells, which may provide a novel therapeutic strategy for patients with hypertriglyceridemia.

Hydrogel For Endogenous Neuronal Progenitor Cells (NPC) Recruitment

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel hydrogel that aids in neuronal regeneration post stroke or disease.

Immersive Virtual Reality To Manage Pain

Researchers led by Mark Cohen from the Department of Psychiatry at UCLA have developed a virtual reality-based therapy to manage chronic pain.

The Bic Inhibitor Of Cry-Cry And Cry-Cib Oligomerization/ Clustering

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have discovered two Arabidopsis proteins, BIC1 and BIC2, that are capable of inhibiting light-dependent dimerization of cryptochrome (CRY) molecules. These BICs can be used as an improved drug screening platform through controlled, titratable, label-free and reversible protein – protein interactions.

A Device, Methodology And System For Monitoring, Classifying And Encouraging Activity

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise.

A Novel Mixture for Intravenous Sedation

UCLA researchers from the Department of Anesthesiology and Perioperative Medicine have developed a novel anesthetic mixture which combines anxielytic, narcotic, and sedation effects in a safe, effective solution.

3D Population Maps for Noninvasively Identifying Phenotypes and Pathologies in Individual Patients

UCLA researchers in the Department of Radiological Sciences have developed a novel computation system that uses large imaging datasets to aid in clinical diagnosis and prognosis.

Development of an Antidote for Cyanide and Sulfide Poisoning

Cyanide is a rapidly acting poison, which, along with carbon monoxide, is the major cause of death from smoke inhalation. For treating a large number of casulaties in the field, the best mode of treatment would be intramuscular injection of antidote, preferably by an autoinjector. The two treatments currently approved for cyanide poisoning— hydroxocobalamin (Cyanokit) and the combination of sodium nitrite and sodium thiosulfate (Nithiodote)—must be administered by intravenous injection. Thus, no agent currently exists for rapidly treating a large number of cyanide poisoned persons. Another rapidly acting poison similar to cyanide, is hydrogen sulfide. People are exposed to hydrogen sulfide gas in a variety of occupations, most notably wastewater processing, and agriculture and petroleum industries. Up to 30% of oil workers have been exposed to sufficient amounts of hydrogen sulfide to have symptoms, and fatalities are not uncommon. No specific treatment currently exists for sulfide poisoning, and treatment consists of general supportive care.

Development of Methods and Protocols for Use of Human Cish-/- IPSC-NK Cells for Cancer Therapy

Natural killer (NK) cells are a key component of the innate immune system and are involved in early defense against viruses and cancer cells. NK cells have the ability to lyse cells without prior sensitization  and therefore are the subject of intense interest to be potentially used as immunotherapeutic targets to treat cancer. The crucial element for using NK cells in immunotherapy is the ability to control the signaling and activation pathways. Recent work has shown that the cytokine-inducible SH2-containing protein (CIS), encoded by the Cish gene, can act as a checkpoint in NK activation by inhibiting IL-15 signaling, a major upregulator of NK cell activity. Furthermore, deletion of the Cish gene has been shown to increase the sensitivity of NK cells to IL-15, resulting in mice that are resistant to experimental metastasis.

Multiparametric Imaging with PET Scans Using High Temporal-Resolution Dynamic Data Acquisition and Modeling

Researchers at the University of California, Davis, have developed a method to acquire and model high temporal resolution (1-2 seconds per frame) dynamic data with PET scans.

High Throughput Digital Cell Quantification Of Immune Cell Subsets Via Epigenetic Markers

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel high-throughput method for the quantification of immune cell subtype.

Use of Il-10 Inhibitors as Adjuvants for Vaccination or Immunotherapy

Researchers at the University of California, Davis have developed a process of administering inhibitors of Interleukin 10 (IL-10) signaling concomitantly with a vaccine or other immunostimulus, so that responses to vaccination occur in the absence of such signaling.

Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffold With An Anti-Resorption Factor

Researchers in the Division of Plastic and Reconstructive Surgery at the UCLA David Geffen School of Medicine and the Institute of Genomic Biology at the University of Illinois Urbana Champaign (UIUC) have developed novel methods to incorporate anti-resorption factor into nanoparticulate mineralized collagen glycosaminoglycan scaffold to maximize bone regeneration.

Cyanide, Sulfide, Methane-Thiol Antidote

Cyanide is a highly toxic agent that inhibits mitochondrial cytochrome-c oxidase, thereby depleting cellular ATP. Cyanide exposure contributes to smoke inhalation deaths in fires and could be used as a weapon of mass destruction. Cobalamin (vitamin B12) binds cyanide with a relatively high affinity and is used to treat smoke inhalation victims. Cobinamide, the penultimate compound in cobalamin biosynthesis, binds cyanide with about 1010 greater affinity than cobalamin and is 5-10 times more potent than cobalamin in rescuing animals from cyanide poisoning. Cobinamide is also an effective intra- and extracellular nitric oxide scavenger. Currently, three cyanide antidotes are currently available in the United States: nitrites, thiosulfate, and hydroxocobalamin. All three drugs are approved only for intravenous (IV) administration, and thus are not suitable for treating mass casualties as could occur after a major industrial accident or a terrorist attack. Thus, new formulations for cyanide exposure treatment that are faster and easier to administer are needed.

Improved HEV Nanoparticles for Oral Delivery

Researchers at the University of California, Davis have engineered a functionalized Hepatitis E Niral Nanoparticles (HEVNP) with gold-nanoclusters, enhancing its stability and making it highly biologically accessible, non-toxic, and suitable for oral delivery.

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