Methods for treating bone tumors or other target tissues using radioisotopes mixed into a matrix material, most commonly bone cement.

A novel class of bioinspired photo-initiators enabling visible light-driven polymer gelation that improves cell-biomaterial compatibility across thicker tissues.

Researchers at the University of California, Davis have developed a computer-implemented method for accurately classifying congenital heart defects in newborns using pulse oximetry and machine learning.

A novel transparent contact lens device enabling real-time monitoring of corneal curvature during electrochemical vision therapy.

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Professor Iman Noshadi from the University of California, Riverside have developed a choline BIL-functionalized GelMA hydrogel (BioGel) with multifunctional properties for chronic wound treatment. The invention works by enhancing gelatin methacryloyl (GelMA) with a special choline-based bio-ionic liquid, which significantly increases the number of intact vascular tubes compared to standard GelMA. Research results suggest that BioGel can accelerate wound closure, with chronic wounds fully healing in about 21 days. This technology is advantageous over existing treatments because the application of BioGel may accelerate chronic wound closure, reduce biofilm, and promote hair regrowth. 

The next generation pelvic examination device which decreases patient discomfort and enhances visibility to facilitate sample acquisition for diagnostic testing.

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Researchers at the University of California, Davis have developed an innovative Cherenkov-based system for calibrating radiotherapy beams, enabling precise, real-time calibration of radiation dose delivery, including for high-intensity FLASH radiotherapy, improving treatment accuracy and reliability.

The use of standing surface acoustic waves (SSAWs) in microfluidic channels gained significant momentum when researchers demonstrated size-based cell separation (acoustophoresis) using lateral acoustic forces. Using interdigitated transducers (IDTs) positioned on piezoelectric substrates, SSAWs were found to create pressure nodes along the channel width, allowing larger particles to experience greater acoustic radiation forces and migrate toward these nodes faster than smaller particles. Acoustic-based microfluidic devices were successfully applied to circulating tumor cell (CTC) isolation from clinical blood samples in ~2015, demonstrating recovery rates >80% using tilted-angle standing surface acoustic waves, though these systems relied primarily on size-based separation principles. The integration of acoustic methods with microfluidics offered key advantages including label-free operation, biocompatibility, non-contact manipulation, and preservation of cell viability, addressing limitations of earlier methods like centrifugation, FACS, and magnetic separation that could damage cells or require labeling. Despite these advances in acoustic microfluidics, significant challenges persist in affinity-based rare cell isolation, particularly mass transport limitations in microfluidic channels operating at high Peclet numbers (Pe>10⁶) where convective flow dominates over diffusion. In traditional microfluidic affinity capture systems, cells flow predominantly in the center of laminar flow channels where fluid velocity is highest, resulting in minimal interaction with capture agents immobilized on channel walls and requiring extremely long channels or impractically slow flow rates to achieve adequate capture efficiency. The extremely low concentration of CTCs , combined with their phenotypic heterogeneity and the low diffusion coefficients of cells creates a "needle in a haystack" challenge that existing acoustic separation methods based solely on size discrimination cannot adequately address.

This technology offers a novel approach to treating epilepsy by preventing the spread of epileptic networks and improving memory deficits through targeted electrical stimulation.

Achieving precise and tunable control over endogenous gene expression in eukaryotic cells remains a significant challenge, particularly for therapeutic applications or detailed biological studies where fine-tuning is required rather than complete on/off switching. This innovation, developed by UC Berkeley researchers, addresses this by providing a novel, programmable method for transcriptional tuning. The innovation is a two-domain fusion protein comprising the transcriptional repression domain (TRD) of the methyl-CpG-binding domain (MBD) protein MeCP2 linked to a dead Cas9 (dCas9) domain. When combined with a single guide RNA (sgRNA) that targets a specific endogenous gene, this fusion protein partially inhibits, or "tunes," the expression of that gene. Unlike traditional methods like RNAi or full CRISPR interference (CRISPRi), which often aim for complete knockdown, this system offers a highly specific and titratable way to dial down gene expression, providing a distinct advantage in studies requiring subtle modulation of gene dosage or for developing dose-dependent therapeutic strategies.

The challenge in utilizing α-Linolenic acid (ALA) for medical adhesives has been its poor water solubility and the high hydrophobicity of poly(ALA), typically necessitating elevated temperatures, organic solvents, or complex preparation methods for tissue application. UC Berkeley researchers have developed ALA-based powder and low-viscosity liquid superglues that overcome this limitation by polymerizing and bonding rapidly upon contact with wet tissue. The versatile adhesives are formulated using a monomeric mixture of ALA, sodium lipoate, and an activated ester of lipoic acid. These adhesives demonstrate high flexibility, cell and tissue compatibility, biodegradability, and potential for sustained drug delivery as a small molecule regenerative drug was successfully incorporated and released without altering the adhesive's properties. Additionally, the inherent ionic nature of the adhesives provides high electric conductivity and sensitivity to deformation, enabling their use as a tissue-adherent strain sensor.

In PET imaging, patient motion, such as respiratory and cardiac motion, are a major source of blurring and motion artifacts. Researchers at the University of California, Davis have developed a technology designed to enhance PET imaging resolution without the need for external devices by effectively mitigating these artifacts

This technology introduces a flexible, secure, and scalable approach to creating body area networks (BANs) using textile-integrated metamaterials for advanced healthcare monitoring.

This technology offers a significant improvement in the therapeutic application of type E botulinum neurotoxin (BoNT/E) by introducing rationally designed mutations into the receptor binding domain.