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Proteoglycan Mimetics For Enhanced Wound Healing Angiogenesis And Vascular Repair

Researchers at the University of California, Davis We have developed proteoglycan mimetics that alters the extracellular environment to promote local vascular repair and wound healing.

Novel Trans-Differentiation Methods for Treatment of Neurodegenerative Disorders

Regenerative medicine has great promise for addressing disorders of cell loss. One approach employs cell replacement, while another utilizes cellular trans-differentiation. Cell replacement has enjoyed remarkable success in treating hematopoietic disorders; but in other diseases, this approach has either shown limited efficacy or is associated with risk of triggering immune responses and/or tumor formation. Given increasing evidence for cellular plasticity of differentiated somatic cells, the trans-differentiation approach for in situ switching of cell fate has gained momentum, which offers an opportunity to treat neurodegenerative diseases, such as Parkinson’s disease since no disease-modifying treatments exist.

Inhibition Of Lipofuscin Aggregation By Molecular Tweezers

UCLA researchers in the Departments of Neurology and Molecular Therapy & Medical Genetics have developed a novel approach toward broad inhibition of lipofuscin aggregation.

Small-Molecule Inhibitors Of Zika Virus Infection

UCLA researchers in the Department of Psychiatry and Biobehavioral Sciences, Department of Radiation Oncology and Department of Pathology have identified small molecules that show anti-Zika activity at low nanomolar and picomolar range.

Disposable and Semi-Disposable Medical Consumables for Infection Control

In the United States lives are lost every year due to the spread of infections in hospitals and healthcare facilities. Thus, healthcare workers must take all precautions to prevent the spread of infectious diseases, especially in surgical spaces. One key step in this process is to control environmental surfaces because certain types of microbial bacteria or fungi are capable of surviving on environmental surfaces for months at a time. A potential solution would be to use consumables that are disposable, or semi-disposable, and offer a platform of products for the purposes of infection control.  

Development of a Diagnostic Test to Differentiate Bradykinin with Normal C1 Inhibitor from Histamine-Mediated Angioedema

Angioedema is a non-itchy, pale swelling of subcutaneous or submucosal tissue that tends to recur chronically and can become life-threatening if the swelling occurs in the upper airways or can be very painful if it occurs in the gastrointestinal tract. Angioedema presenting together with urticarial (hives) usually responds well to antihistamines and corticosteroids, whereas angioedema without urticarial (hives) is frequently resistant to such therapy but may respond to a C1 esterase inhibitor, tranexamic acid, or both therapies that can reduce bradykinin generation. Differentiating bradykinin-from histamine-mediated angioedema is of critical importance to prevent morbidity and mortality. The ability to diagnose bradykinin-mediated angioedema with normal C1 inhibitor (C1INH), however has been severely limited by the lack of any available diagnostic test. Current genetic tests only identify a tiny fraction of the affected patients. Due to the lack of a known biomarker or assay, many patients without bradykinin-mediated angioedema are treated with unnecessary medications (often approaching $1,000,000/year or more in costs).

Scalable Lipid Bilayer Microfluidics for High-Throughput Gene Editing

Researchers led by Paul Weiss from the Department of Chemistry and Pediatrics at UCLA have created a new microfluidic device for high-throughput gene editing of cells.

Strategy for Detecting Residual Host Cell Proteins Using Aptamers

A proposal for the use of aptamers (nucleic acids that are selected for high-affinity binding to target ligands) for the detection of HCPs in recombinant biopharmaceutical products.

Methods And Devices for Continuous Analyte Sensing with Microporous Annealed Particle Gels

UCLA researchers in the Department of Bioengineering have developed novel microporous annealed particle gels for long-term continuous monitoring of blood metabolites.

Airway Manikin With Realistic Mobility

Training for direct laryngoscopy relies heavily on practice with patients. The necessity for human practice might be supplanted to some extent by an intubation manikin with accurate airway anatomy, a realistic “feel” during laryngoscopy, the capacity to model many patient configurations, and a means to provide feedback to trainees and instructors. The realism and mobility of the anatomical features of current models limits the effectiveness of training intubation skills. Current models provide only one set of anatomic features, but patients present innumerable combinations of size, shape, proportion, and tissue stiffness. Thus, a novice who trains on a particular model merely learns how to intubate that particular model, but has minimal ability to transfer the learned skills to the multiplicity of anatomies in patients. Furthermore, most models approximate a normal anatomic configuration that poses no problem for intubation, so novices do not gain experience with difficult situations

System And Method For Automated Image Guided Robotic Intraocular Surgery

UCLA researchers in the Departments of Mechanical Engineering and Ophthalmology have developed a system and method for automated optical surgery.

Physical Multi-Layer Arm Phantom For Body Area Networks

Researchers at UCI have developed an oil-based in vitro phantom that accurately mimics the electrical properties of the human arm. Due to the increased accuracy it affords, this phantom can be used to test the efficiencies of wireless medical devices in body area networks.

A Delivery System for Percutaneous Delivery and Implantation Of Atrioventricular Heart Valves

The invention is a novel delivery system providing a minimally invasive solution for the delivery and implantation of atrioventricular heart valves. Through its novel mechanical structure, the invention delivers and positions the valve accurately with no need for painful surgeries or bulky tools.

Approach For Efficient Protein Incorporation Into Recombinant Vaults

UCLA researchers in the departments of Medicine, Microbiology, Immunology & Molecular Genetics, and Bioengineering have developed a novel method for loading protein payloads into vault nanoparticle carriers.

Multi-Echo Spin-, Asymmetric Spin-, And Gradient Echo Echoplanar Imaging (Message-EPI) MRI

UCLA researchers in the Department of Radiological Sciences have developed a new MRI pulse sequence optimized for brain imaging.

A Transparent, Self-Healing, Highly Stretchable Ionic Conductor

Researchers at the University of California, Riverside have developed a transparent, highly stretchable, self-healing, ionic conductor.  The conductor is comprised of a polar polymer and an ionic salt solution. The material is held together via charge interactions between these two components, which prevents leakage of the ionic solution out of the material. This material can tolerate strains above 5000% and maintains an optical transmittance of 92%. Additionally, the material is spontaneously reversible (goes back to its original shape) for strains under 50%.  When a sample of this material is cut into two pieces and connected together, the sample spontaneously self-healed under ambient conditions within 24 hours.   Fig. 1 Photos of a healed material sample in the non-deformed state and stretched to five times its original length.   Fig. 2 Optical microscope images of a cut material sample after different healing times at room temperature. The damaged sample fully healed after 24 hours. Scale bar is shown at 500 μm.   Fig. 3 Healing efficiency (recovered fracture toughness) at different ambient temperatures

Selective Voltage Gated KV1.3 Potassium Channel Inhibitors

Researchers at the University of California, Davis, have discovered a composition of 5-phenoxyalkoxypsoralens that inhibits potassium channels to treat autoimmune diseases and disorders that involve abnormal homeostasis, body weight and peripheral insulin sensitivity.

Antisense Oligonucleotide Therapy for B Cell Mediated Cancers

Researchers at the University of California, Davis have developed a targeted therapy using an antisense oligonucleotide (ASO) to treat precursor B cell (pre-B) acute lymphoblastic leukemia (ALL).

Lensfree Tomographic Imaging

UCLA researchers in the Department of Electrical Engineering have developed a system for lens-free tomographic imaging.

Inhibition of Pyruvate Oxidation to Promote Hair Growth

UCLA researchers in the departments of Molecular, Cell & Developmental Biology and Biological Chemistry have elucidated a novel mechanism by which pyruvate oxidation can be inhibited in order to promote hair growth.

Algorithm for Diabetes Management and Control

A number of technologies have been developed that optimize the process of managing blood sugar and administering insulin.  

Capture device for small urinary tract stones

The invention is a surgical device designed to remove miniature fragments of uroliths that are less than 2 mm in size. Through the invention’s novel design, such small fragments are captured in the device which will then be easily removed by the surgeon. Removing small stone fragments will reduce the need for future medical procedures.

Obstruction Prevention Airway Collar

Though deep sedation is a routine part of many medical procedures, patients under anesthesia are susceptible to airway obstruction as their throat and tongue muscles relax. Most common methods to prevent obstruction are complicated and carry additional risks. Researchers at UCI have developed a safe and comfortable medical collar that maintains patients’ airways and is entirely adjustable.

Sonification-Facilitated Cognitive Training System to Enhance Visual Learning and Memory

UCLA researchers in the Department of Psychology have developed a new cognitive training tool to enhance visual learning and memory using sound.

Near-Realistic Sports Motion Analysis and Activity Monitoring

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise in video games.

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