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Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel biomarker that can be used to diagnose prostate cancer patients for the presence of visceral metastasis with 54% sensitivity and 100% specificity.

Device and Method for Microscale Chemical Reactions

UCLA researchers in the Departments of Bioengineering and Molecular and Medical Pharmacology have developed a passive microfluidic reactor chip with a simplified design that is less costly than existing microfluidic chips.

Chronic Fatigue Syndrome Diagnostic

Chronic Fatigue Syndrome (CFS) is a serious and complex debilitating disease with a wide spectrum of symptoms, including muscle pain and neurocognitive deterioration. At present, the diagnosis of CFS is based on clinical symptoms that vary widely. Clinical therapies can include use of anti-depressants, cognitive therapy, and exercise. A pressing need is for an accurate diagnostic tool, as the symptoms of CFS are so similar to other conditions. UC San Diego researchers have recently developed a new diagnostic methodology, and current data suggest 95% accuracy.

A Built-In Mechanism Of Gas Maintenance In Microfeatures On A Submerged Surface

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel superhydrophobic surface for drag reduction and anti-biofouling applications.

Combination Therapy as Enhanced Antidote to Poisoning

Certain pesticides can be harmful, and there is a need for effective antidotes that can reverse accidental over-exposure by farm workers. UC San Diego researchers have recently developed a therapeutic modality that is a combination of compositions that may be effective as an antidote.

Continuously Variable Inverse Harmonic Drive

A transmission that uses a variable sized drum, a rotating tensioner arm, and a dry adhesive band to create a compact, continuously-variable transmission that behaves like an inside-out harmonic drive.

Novel Clotrimazole Analogs As Blockers Of Intermediate Conductance Kca Channels

Researchers at the University of California, Davis, have developed a method for preparing therapeutically effective amounts of triarylmethane compounds for immunosuppressive treatment of autoimmune disorders, graft rejection, and graft or host disease.

Massively Parallel High Throughput Single Cell Electroporation (MSEP)

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.

Self-Locking Optoelectronic Tweezer And Its Fabrication

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel self-locking optoelectronic tweezer (SLOT) for single cell manipulation in conductive buffer over large areas.

Development of a Small Molecule that Blocks Alpha Synuclein Transmission in Neurodegenerative Disorders

There is a strong correlation with aging and the onset of developing a neurodegenerative disease such as Alzheimer’s or Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD) and Creutzfeldt-Jacob disease, Dementia with Lewy Bodies (DLB), Multiple system atrophy (MSA) and others. A universal commonality among these diseases is the presence of misfolded aggregated proteins in the brain or with cells of the brain. Very strong evidence supports a role of spreading of misfolded proteins from cell to cell and across the brain in disease progression. Moreover, these aggregated proteins can take different forms and be used help diagnosis the specific neurodegenerative disease. Parkinson’s disease (PD) is characterized by loss of striatal dopaminergic signaling and the presence of alpha-synuclein-containing Lewy bodies and neurites. Research has shown the importance of alpha-synuclein (α-Syn) from examining people with PD at autopsy and the pathology associated with the disease which contains misfolded and aggregated α-Syn. Moreover, a mutation in the gene encoding α-Syn (SNCA) or simple overexpression of wild-type α-Syn will lead to PD. The misfolding and spread of α-Syn are central to disease initiation and progression. The presence of misfoided α-Syn is also seen in other synucleinopathy diseases including Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB), the two most prevalent progressive dementia diseases and MSA. One of the most common forms of symptomatic treatment for early stages of PD is the use of monoamine oxidase B inhibitors and in later stages the use of dopamine receptor agonists (DRAs) and /or levodopa. The treatment must find a good balance between clinical benefits and risks. Ultimately, these treatments fail to show improvement over the course of 2-5+ years, therefore, new alternative treatments are needed especially those attacking the underlying course of the disease. Small molecule binding to native states of globular proteins has been successfully to block misfolding and aggregation most notably in the case of targeting transthyretin to treat systemic amyloidosis. By contrast, targeting of intrinsically disordered proteins such as native monomeric α-synuclein (α-Syn) with  small molecules has been challenging due to their inherent structural heterogeneity and the absence of persistent structural elements.

Combination of a drug with low level light therapy (LLT) for treatment of wounds

This is a combination of a drug and light technology for the purpose of accelerating the healing of wounds on the skin, ulcers, and elsewhere in the body. Both methods have been shown to accelerate wound healing, and combining the two will potentially result in more rapid healing than either would alone.  

Multimodal food journaling

Researchers at UCI have developed a hands-free, unobtrusive smartphone-based application for automatic food journaling. The app, which operates via voice command, is interactive and highly engaging thereby encouraging long-term user participation.  

Antibacterial Polypeptide with Broad-Spectrum Gram-Positive and Gram-Negative Activity

Researchers at the University of California, Davis have developed a polypeptide that kills pathogenic bacteria.

A New Human-Monitor Interface For Interpreting Clinical Images

UCLA researchers in the Department of Radiological Sciences have invented a novel interactive tool that can rapidly focus and zoom on a large number of images using eye tracking technology.

Dicom/Pacs Compression Techniques

Researchers led by Xiao Hu from the Department of Surgery at UCLA have created a novel and convenient way to compress and query medical images from a PACS system.

Methods Comprising Immune System Modulation With Microporous Annealed Particle Gels

UCLA researchers have developed a novel microporous annealed particle (MAP) scaffold that acts as both a tissue growth scaffold and an immune modulatory system. The technology permits continuous, time-encoded, modulation of the immune system delivered injection/implantation of fabricated scaffold, comprised of the MAP gel technology.

Hydraulically Actuated Textiles

A soft, planar, actuator based on hydraulically actuated textiles.

Preparation Of Functionalized Polypeptides, Peptides, And Proteins By Alkylation Of Thioether Groups

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering Department, have developed new methods for adding different functional groups on polypeptides.  The UCLA researchers have used this method to create a platform to create and modify nanoscale vesicles and hydrogels for use in nanoscale drug delivery particles, injectable drug depots, imaging and detection, industrial biomaterials, and wound management.

A New Mechanism For Hypertriglyceridemia In Humans

UCLA researchers in the Department of Medicine have identified autoantibodies against GPIHBP1, a GPI anchored protein of capillary endothelial cells, which may provide a novel therapeutic strategy for patients with hypertriglyceridemia.

Hydrogel For Endogenous Neuronal Progenitor Cells (NPC) Recruitment

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel hydrogel that aids in neuronal regeneration post stroke or disease.

Immersive Virtual Reality To Manage Pain

Researchers led by Mark Cohen from the Department of Psychiatry at UCLA have developed a virtual reality-based therapy to manage chronic pain.

The Bic Inhibitor Of Cry-Cry And Cry-Cib Oligomerization/ Clustering

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have discovered two Arabidopsis proteins, BIC1 and BIC2, that are capable of inhibiting light-dependent dimerization of cryptochrome (CRY) molecules. These BICs can be used as an improved drug screening platform through controlled, titratable, label-free and reversible protein – protein interactions.

A Device, Methodology And System For Monitoring, Classifying And Encouraging Activity

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise.

A Novel Mixture for Intravenous Sedation

UCLA researchers from the Department of Anesthesiology and Perioperative Medicine have developed a novel anesthetic mixture which combines anxielytic, narcotic, and sedation effects in a safe, effective solution.

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