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Methods Of Fabricating A Multi-Electrode Array For Spinal Cord Epidural Stimulation

UCLA researchers in the Department of Bioengineering and Department of Integrated Biology & Physiology have developed a novel array for spinal cord epidural stimulation.

Development of a Small Molecule that Blocks Alpha Synuclein Transmission in Neurodegenerative Disorders

There is a strong correlation with aging and the onset of developing a neurodegenerative disease such as Alzheimer’s or Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD) and Creutzfeldt-Jacob disease, Dementia with Lewy Bodies (DLB), Multiple system atrophy (MSA) and others. A universal commonality among these diseases is the presence of misfolded aggregated proteins in the brain or with cells of the brain. Very strong evidence supports a role of spreading of misfolded proteins from cell to cell and across the brain in disease progression. Moreover, these aggregated proteins can take different forms and be used help diagnosis the specific neurodegenerative disease. Parkinson’s disease (PD) is characterized by loss of striatal dopaminergic signaling and the presence of alpha-synuclein-containing Lewy bodies and neurites. Research has shown the importance of alpha-synuclein (α-Syn) from examining people with PD at autopsy and the pathology associated with the disease which contains misfolded and aggregated α-Syn. Moreover, a mutation in the gene encoding α-Syn (SNCA) or simple overexpression of wild-type α-Syn will lead to PD. The misfolding and spread of α-Syn are central to disease initiation and progression. The presence of misfoided α-Syn is also seen in other synucleinopathy diseases including Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB), the two most prevalent progressive dementia diseases and MSA. One of the most common forms of symptomatic treatment for early stages of PD is the use of monoamine oxidase B inhibitors and in later stages the use of dopamine receptor agonists (DRAs) and /or levodopa. The treatment must find a good balance between clinical benefits and risks. Ultimately, these treatments fail to show improvement over the course of 2-5+ years, therefore, new alternative treatments are needed especially those attacking the underlying course of the disease. Small molecule binding to native states of globular proteins has been successfully to block misfolding and aggregation most notably in the case of targeting transthyretin to treat systemic amyloidosis. By contrast, targeting of intrinsically disordered proteins such as native monomeric α-synuclein (α-Syn) with  small molecules has been challenging due to their inherent structural heterogeneity and the absence of persistent structural elements.

Machine-Learning-Based Denoising Of Doppler Ultrasound Blood Flow And Intracranial Pressure Signal

UCLA researchers in the Department of Neurosurgery have developed a novel framework to constrain noises in the measurements of vital physiological signals from neurosurgical patients.

Glucose-conjugated magnetonanoparticles for visualization and treatment of neoplasms and neurological disorders by MRI

Researchers at the UCLA Semel Institute for Neuroscience and Human Behavior have developed magnetic nanoparticles (MNPs) functionalized with deoxyglucose that can be used as tissue-specific contrast agents for MRI. These novel MNPs can help physicians and researchers to differentiate neoplastic, epileptic, parkinsonian, or Alzheimer tissues from normal tissue based on the metabolic activity of the tissue.

Hydrogel For Endogenous Neuronal Progenitor Cells (NPC) Recruitment

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel hydrogel that aids in neuronal regeneration post stroke or disease.

Method And Substance For The Treatment Of Cerebral Amyloid Angiopathy

UCLA researchers in the Department of Pathology have identified a novel pathway that causes β-amyloid-associated smooth muscle cell loss in Cerebral Amyloid Angiopathy (CAA) cases.

Predicting the Placebo Response and Placebo Responders in Medicated and Unmedicated Patients Using Baseline Psychometric and Clinical Assessment Score

UCLA researchers have developed a method and model to predict the placebo effect and placebo responsiveness using the 30-item baseline positive and negative syndrome scales (PANSS) scores, within both the medicated and unmedicated Schizophrenia patients.

Techniques for Very-Low Power and High Dynamic-Range Delta-Sigma ADCs

Researchers in the UCLA Department of Electrical Engineering have developed an analog-to-digital converter (ADC), to be implemented as part of an implantable and closed-loop neural recording and stimulation system with a linear input range approximately ten times higher than that of existing devices.

Novel Tau Aggregation Inhibitor Peptide

UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel approach to inhibit the aggregation of tau proteins in the brain, which is linked to over 20 dementias including Alzheimer’s Disease and Chronic Traumatic Encephalopathy.

Method to Direct the Reciprocal Interactions Between the Ureteric Bud and the Metanephric Mesenchyme

Researchers at UCLA have developed an approach to construct an embryonic kidney in vitro for the treatment of end stage renal disease.

Minimally Invasive Implantable Brain Stimulation Devices And Methods For Implanting Same

UCLA researchers in the Department of Neurosurgery have developed a novel, minimally invasive deep-brain stimulation device concept.

Inhibition of the Aggregation of Transthyretin by Specific Binding of Peptides to Aggregation-Driving Segments

UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel process to inhibit amyloid aggregation of Transthyretin, which is associated with three debilitating disorders including senile systemic amyloidosis (SSA), Familial Amyloidotic Polyneuropathies (FAP), and Familial Amyloidotic Cardiomyopathies (FAC).

Surrogate Biomarkers For Amyloid And Neuroinflammation

UCLA researchers in the Department of Neurology and Medicine have developed a novel approach is to detect and measure neuroinflammation.

Allosteric BACE Inhibitors For Treatment Of Alzheimer’s Disease

UCLA researchers from the Department of Neurology have discovered a new class of drug candidates for Alzheimer’s disease. These small molecule compounds can specifically inhibit target enzymes to prevent target protein cleavage through an allosteric mechanism, preventing off-target side effect.

Inhibition Of Lipofuscin Aggregation By Molecular Tweezers

UCLA researchers in the Departments of Neurology and Molecular Therapy & Medical Genetics have developed a novel approach toward broad inhibition of lipofuscin aggregation.

Inhibition Of Stress Granule Formation Through Manipulation Of UBAP2L

Stress granule (SG) formation has been suggested as a two-step process, with initial formation of a dense stable SG ‘‘core’’ followed by accumulation of proteins containing intrinsically disordered regions (IDRs) and low-complexity domains (LCDs) into a peripheral ‘‘shell’’ through a process involving liquid-liquid phase separation (LLPS). Recently, SGs have been associated with human neurodegenerative disorders characterized by the presence of toxic insoluble protein aggregates. This link is most compelling in the case of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where numerous disease-causing mutations are purported to interfere with LLPS-dependent growth and dynamics of SGs.

Integrative Leakage Correction For Contrast Agent Extravasation In Dynamic Susceptibility Contrast (DSC) - MRI

UCLA researchers in the Department of Radiological Sciences have developed a new technique for more accurately estimating relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC) perfusion MRI by improved modeling and correction of contrast agent leakage.

Intelligent Flexible Spinal Cord Stimulators For Pain And Trauma Management Through Neuromodulation

UCLA researchers in the Department of Neurosurgery and Electrical Engineering have developed a novel closed-loop spinal cord stimulator device that is small and flexible.

Antibody Selection to Prevent or Treat Alzheimer’s Disease

Therapeutic antibodies have been developed to prevent or slow the cognitive decline in Alzheimer’s disease (AD) but with limited clinical success to date. These treatment failures suggest that antibodies vary in their therapeutic efficacy and that more effective antibodies or combinations of antibodies need to be identified. To address this issue, researchers at UCI have developed a novel screening platform that can identify antibodies that may prevent or treat AD or other neurodegenerative disorders with high efficacy from human blood.

A Novel Method and Protocol to Induce Pluripotent Stem Cells Toward Astrocyte Differentiation

Rett syndrome (RTT) is a devastating disease that affects 1 in every 10,000 children born in the United States, primarily females. RTT patients undergo apparently normal development until 6-18 months of age, followed by impaired motor function, stagnation and then regression of developmental skills, hypotonia, seizures and a spectrum of autistic behaviors. Rett syndrome is a rare disease that shares certain pathways with major developmental disorders such as autism and schizophrenia, increasing the potential impact. There is no cure for Rett syndrome and the animal model does not entirely recapitulate the human disease. Thus, having the possibility to screen drugs directly in human neurons is a major milestone.

Small Molecule sEH Inhibitors to Treat Alpha-Synuclein Neurodegenerative Disorders

Researchers at the University of California, Davis have developed small molecule inhibitors to prevent or reverse the progression of neurodegenerative diseases or symptoms.

Trainable Filter Emulator For Real-Time Control Systems

Researchers led by Dr. Cong from the Department of Computer Science at UCLA have developed an algorithm that enables real-time control in brain-machine interface applications.

Ultra-Dense Electrode-Based Brain Imaging System With High Spatial And Temporal Resolution

UCLA researchers in the Department of Bioengineering have developed a novel integrated brain imaging system that utilizes an ultra-dense electrode-based device. This system provides high resolution of functional brain images spatially and temporally.

Fabrication Of An Array For Transcutaneous Spinal Cord Stimulation

UCLA researchers in the Department of Bioengineering developed a novel transcutaneous spinal cord stimulation device that employs microneedles to continuously deliver effective and uniform electrical current to spinal cords. The device does not irritate tissues and uses much lower electrical power than conventional devices.

A Cell-Based Seeding Assay for Huntingtin Aggregation

UCLA researchers from the Department of Psychiatry has created a novel cell-based seeding assay for sensitive, specific and high throughput detection of mutant Huntingtin proteins in biological samples.

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