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Browse Category: Medical > Disease: Central Nervous System

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Wirelessley Powered Stimulator

UCLA researchers in the Department of Electrical and Computer Engineering have developed a battery-less implantable pulse generator with concise circuitry and mm-scale form factor.

Oldest-Old Mri Registration Template

MRI scans of patients/participants can be compared to template scans in order to identify differences or changes in brain anatomy. However, the templates that are used are typically of young brains, which lack the atrophy that naturally occurs in the aged brain. UCI researchers have developed a template for oldest old images (90+ age group) that takes into consideration the natural anatomical changes that can occur with aging.

Effective Repetitive Transcranial Magnetic Stimulation (rTMS) Taking in Account Real-Time Frequency and Phase Of Intrinsic Brain Activity

Current research and practice in the field of therapeutic rTMS is not taking into account 1) inter-individual variability 2) variability between brain areas 3) variability or differences between oscillations in distinct and overlapping frequency bands, 4) existence of high- and low-excitability phase periods in each oscillatory cycle. Clinical treatments with rTMS and experimental research findings show mixed effects, with rTMS protocols inducing variable degrees of brain plasticity over subjects and sessions.

Peptide Mediated Oligonucleotide Delivery to the CNS

Many diseases of the central nervous system (CNS) arise from the accumulation of proteins such as α-synuclein (aSyn) in Parkinson’s Disease (PD) or Aß in Alzheimer’s disease (AD). The ability to regulate the expression at the gene transcription level would be beneficial for reducing the accumulation of these proteins or regulating expression levels of other genes in the CNS. aSyn also accumulates in other neurodegenerative diseases including dementia with Lewy Body (DLB), multiple system atrophy (MSA) and Gaucher’s disease. This means that regulation of aSyn expression may be crucial to the therapeutic control of numerous neurodegenerative diseases.

Biomimetic Conductive Hydrogels

UCLA researchers in the Department of Bioengineering have developed a novel electrically conductive scaffold system with a hyaluronic acid (HA)-based hydrogel for biomimetic research to treat spinal cord and other central nervous system (CNS) injuries.

Blocking Synaptogenesis For Chronic Pain Management

Gabapentin is used for treatment of seizures and hypersensitivity to pain. Researchers at UCI have employed low-dosage gabapentin immediately after injury to block the development of chronic pain.

Brain-Specific Kinase Inhibition to Mitigate Systemic Toxicity

The goal of this invention is to overcome the challenges of previous approaches by selectively targeting treatments to the CNS without peripheral toxicity. Kinase inhibition is targeted to the central nervous system (CNS) by combining brain-permeable kinase inhibitors and a brain-impermeable blocking molecule.

Chimeric Kinase Inhibitors with Increased Activity

This invention describes newly generated kinase inhibitors that demonstrate enhanced and attenuated action over their parent kinase inhibitors. These molecules can be used alone but, when combined with novel blocking molecules, the action of these chimeric kinases can be targeted for action in the central nervous system (CNS).

Technologies that can be Used to Selectively Bind Messenger RNA and Enhance Protein Translation

Control of gene expression is a general approach to treat diseases where there is too much or too little of a gene product. However, while there are many methods which are available to downregulate the expression of messenger RNA transcripts, very few strategies can upregulate the endogenous gene product. The vast majority of gene regulatory drugs which are commercially available or being developed are designed to knockdown gene expression (i.e. siRNAs, miRNAs, anti-sense, etc.). There exist some methods to enhance gene expression, such as the delivery of messenger RNAs; although, therapeutic delivery of such large and charged RNA molecules is technically challenging, inefficient, and may not be practical. There are also classical gene therapy approaches where a gene product is delivered as viral-encoded products (AAV or lentivirus-packaged). However, these methods suffer from not being able to accurately reproduce the correct alternatively spliced isoforms in the right ratios in cells.  

Novel Small Molecules to Prevent Neurodegenerative Diseases

UCSF scientists have developed a novel biophysical-biochemical screening platform to identify small molecules that prevent the oligomerization of alpha-synuclein: the rate-limiting step in the formation of toxic fibrils in the pathologies of Parkinson’s disease, Lewy Body Dementia, and other neurodegenerative diseases. With this technology, novel families of small molecules have been found with the capacity to reverse multiple pathogenic markers of disease progression in cells.

Strategy for in vivo Depalmitoylation of Proteins and Therapeutic Applications Thereof

The neuronal ceroid lipofuscinoses (NCLs), commonly grouped together as Batten disease, are the most common neurodegenerative lysosomal storage diseases of the pediatric population. No cure for NCL has yet been realized. Current treatment regimens offer only symptomatic relief and do not target the underlying cause of the disease. Although the underlying pathophysiology that drives disease progression is unknown, several small molecules have been identified with diverse mechanisms of action that provide promise for the treatment of this devastating disease. On this point, several researchers have reported the use of potential drugs for NCL patient lymphoblasts and fibroblasts, along with neurons derived from animal models of NCL disease. Unfortunately, most of these studies were inconclusive or clinical trials or follow-up results were not available. High concentrations employed and toxicity of the small molecules are clear disadvantages to the use of some of the corresponding derivatives as potential drugs. To circumvent these effects, development of nontoxic alkyl cysteines would be useful for the non-enzymatic and chemo-selective depalmitoylation of S-palmitoyl proteins, which hold good promise as an effective treatment for neuronal ceroid lipofuscinoses.

Use Of Non-Ionic Copolypeptide Hydrogels For Cell Suspension And Cell And Molecule Delivery

UCLA researchers in the Departments of Bioengineering, Chemistry and Biochemistry, and Neurobiology have developed novel copolypeptide hydrogel formulations for the delivery of cells and molecules to locations throughout the body, including the central nervous system.

Method and Apparatus for Movement Therapy Gaming System

Rehabilitation therapy, while an important tool for the long term recovery of patients affected by brain injury or disease, is expensive and requires one-on-one attention from a certified healthcare professional. UCI researchers have developed a computer-based system that provides arm movement therapy for patients. The system allows patients to independently practice hand and arm movements, improving therapeutic outcomes, while reducing hospital visits and cost for both patients and healthcare providers.

A Method to Prevent the Myelin Abnormalities Associated with Arginase Deficiency

UCLA researchers in the Department of Surgery have developed a gene therapy to prevent dysmyelination (and other CNS abnormalities) as a result of arginase deficiency.

Treatment for Restoring Ureagenesis in Carbamoyl Phosphate Synthetase 1 Deficiency

UCLA researchers in the Department of Surgery have developed a gene therapy to treat carbamoyl phosphate synthetase 1 deficiency.

Treatment Of Lysosomal Storage Disorders

UCLA researchers in the Departments of Neurology have developed a novel treatment for Lysosomal-storage diseases (LSDs) with neurological impairment.

New Drug Class for Treating Multiple Sclerosis

UCLA researchers from the Department of Molecular & Medical Pharmacology have developed a novel drug class for the treatment of multiple sclerosis.

Identification And Development Of Dual nSMase2-AChE Inhibitors For Neurodegenerative Disorders

UCLA researchers in the Department of Neurology, and the Department of Chemistry & Biochemistry have developed small molecule inhibitors of both the neutral sphingomyelinase 2 (nSMase2) and acetylcholinesterase (AChE) as novel therapeutics for neurodegenerative disorders caused by protein aggregation.

Easy to Wear Dry EEG Sensors for Human–Computer Interactions

Measurements based on electroencephalogram (EEG) are made by placing electrodes over a human scalp to apply and receive electrical signals. Various implementations of EEG sensors are available. The electroencephalogram (EEG) has recently gained popularity for use in various non-clinical studies but still lacks any robust, single application outside well-controlled laboratory environments. As the limitations of EEG are mostly due to the low spatial resolution, using multiple bio-sensing modalities proves to be better performing than EEG alone

Carborane-Based Histone Deacetylase (HDAC) Inhibitors

UCLA researchers from the Department of Chemistry & Biochemistry have developed a new class of Histone Deacetylase (HDAC) inhibitors that can be tuned for isoform specificity and other properties.

New Molecular Tweezers Against Neurological Disorders And Viral Infections

UCLA researchers in the Department of Neurology with an international team of scientists have developed several new molecular tweezer derivatives with novel synthesis methods that significantly improved the therapeutic efficacy and pharmacokinetic characteristics of the drug candidates.

Electrical Charge Balancing Scheme For Functional Stimulation Using Pulse Width Compensation

UCLA researchers in the Department of Bioengineering have developed a novel electrical charge cancellation scheme to effectively remove residual charge on an electrode, achieving greater precision for lesser hardware cost, while maintaining a surgically implantable small size without extra pulse insertion.

Methods Of Fabricating A Multi-Electrode Array For Spinal Cord Epidural Stimulation

UCLA researchers in the Department of Bioengineering and Department of Integrated Biology & Physiology have developed a novel array for spinal cord epidural stimulation.

Machine-Learning-Based Denoising Of Doppler Ultrasound Blood Flow And Intracranial Pressure Signal

UCLA researchers in the Department of Neurosurgery have developed a novel framework to constrain noises in the measurements of vital physiological signals from neurosurgical patients.

Glucose-conjugated magnetonanoparticles for visualization and treatment of neoplasms and neurological disorders by MRI

Researchers at the UCLA Semel Institute for Neuroscience and Human Behavior have developed magnetic nanoparticles (MNPs) functionalized with deoxyglucose that can be used as tissue-specific contrast agents for MRI. These novel MNPs can help physicians and researchers to differentiate neoplastic, epileptic, parkinsonian, or Alzheimer tissues from normal tissue based on the metabolic activity of the tissue.

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