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A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Enhanced Fluorescence Readout And Reduced Inhibition For Nucleic Acid Amplification Tests

UCLA researchers in the Department of Bioengineering have developed an enhanced fluorescent detection method for nucleic acid amplification tests.

Method to Control the Spread of Mosquitos Carrying the Zika Virus by a Split Trans-Complementing Gene-Drive System for Suppressing Aedes aegypti Mosquitos

The Aedes aegypti mosquito is known to transmit dengue fever, yellow fever, chikungunya virus, and Zika virus which have a worldwide impact on people’s health. Moreover, both Chikungunya and Zika virus were recently introduced into the western hemisphere and are poised to sweep throughout the areas in the range of mosquitos with the potential of infecting people who live in these broad areas. Attempts to eradicate these diseases by eliminating the Aedes aegypti mosquito by conventional use of spraying insecticides has met with limited success. So, in the absence of effective mosquito abatement, vaccines may provide the best strategy of preventing disease. Currently, there are vaccines for Yellow Fever and Dengue Fever (undergoing further testing); no vaccines exist for either Chikungunya or Zika virus at present. In the absence of such vaccines, UC San Diego researchers have developed a novel approach to control the spread of mosquitos.

Novel method for detection of O-Sulfonation sites on post-translationally modified proteins

Sulfonation of proteins and carbohydrates plays an important role in signaling, transport, and metabolism in the body. The degree to which a molecule is modified and at what positions dictates how that structure interacts within the body. UCI researchers have developed novel methods of detecting and mapping serine and threonine sulfonation of peptides and proteins.

Screening Platform for Anti-influenza Drugs

In addition to their protective functions as lubricants and physical and immunologic barriers, recent work has demonstrated that mucins also provide protection from influenza virus infection by presenting decoy ligands for the virus. In airway passages, target glycans on airway cells are covered with a thick layer of mucus containing dense array of glycosylated proteins (mucins). However, most screens are either overly simplified (and therefore not representative of the natural mucin barrier) or not translatable to a high-throughput platform. Hence, the development of a useful high throughput drug screening method has been hindered by the inability to streamline the process of replicating the complex environment that airborne invaders naturally confront.

Continuous Analyte Sensor Device

Researchers at UCI have developed an implantable medical device for monitoring patient analytes. One application for the device is to continuously measure analytes and oxygen in trauma patients. This biosensor affords rapid and accurate continuous measurements of molecules critical for assessing patient status in clinical settings. This device may also be adapted to measure other analytes, such as glucose, for long-term disease management.  

A Novel Therapeutic Against HIV Using Human T Cell Immunoglobulin Mucin (TIM-3) Ligands to Modulate Immune Response

Blocking human T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) signaling can restore functionality to defective T cells in HIV-1 infected patients. Additionally, measuring TIM-3 provides clinicians with a novel way of evaluating, staging, and monitoring the progression of HIV infections.

Serodiagnostic Test for Acute Typhoid Fever

In the developing countries, typhoid fever continues to be a health challenge. Tests for typhoid fever often requires sophisticated and expensive equipment and long times for analysis. During this time, infection in the patient can spread and cause death. If the patients survives the infection, the patient would likely become asymptomatic Salmonella enterica serovar Typhi (S. Typhi) carriers who can transmit the bacteria indefinitely. Clearly, a serological assay that is simple, sensitive and rapid to detect acute typhoid infection would increase the chance of surviving the infection.

Method to Enrich for Cells Transduced with Chimeric Antigen Receptors

Researchers at UCLA have developed a method to expand chimeric antigen receptor-transduced T cells for use in immunotherapies.

Methods for Disrupting HIV Latency Using Anti-HIV Latency Agents

Researchers at the University of California, Davis have developed methods for reactivating latent viral infection in peripheral blood samples of human immunodeficiency virus (HIV)-infected individuals receiving anti-retroviral therapy and for optimizing the process by including additional reactivation agents.

A New Class Of HIV Inhibitors Targeting Viral Accessory Factor vif

Current antiretroviral agents target enzymatic functions of the virus such as reverse transcription (nonnucleoside or nucleoside reverse transcriptase inhibitors; NNRTI and NRTI), protease processing of viral polyporoteins (protease inhibitors), viral membrane fusion (fusion inhibitors) and viral DNA integration (integarase inhibitors). Drug cocktail (a combination of nonnucleoside and nucleoside reverse transcriptase inhibitors as well as protease inhibitors) is effective in suppressing viral infection into a chronic condition which rarely progresses to AIDS, many of the inhibitors have adverse side effects. For example, NRTIs can interfere with mitochondrial DNA synthesis and cause hypersensitivity, anemia, diarrhea, neuropathy, nausea, and fatigue in patients. NNRTI may cause severe liver damage or psychological disorders such as depression and insomnia. Protease inhibitors may cause numerous drug-drug interaction, elevated lipodystrophy, and elevated risk of heart attack. Lastly, integrase inhibitors only have short and medium term medical outcomes but are not suitable for long-term use. Therefore there is a need to search for a different class of HIV inhibitors that are efficacious and better-tolerated by patients. HIV-1 encodes accessory proteins including vif, vpu, and nef; these proteins counteract cellular antiviral factors that otherwise would restrict viral replication. Necessary for the replication of HIV-1, vif promotes viral replication by targeting host antiviral protein apobec 3 for degradation. Apobec 3 is a cytidine deaminase that introduces catastrophic levels of G to A hypermutations in viral cDNA, thus yielding biologically incompetent viral genomes. As viral replication is absolutely dependent on the ability of vif to neutralize apobec 3, the vif-apobec axis is an attractive antiviral target.  Currently, there are no compounds that target the vif/apobec axis.

New Inhibitors of the HIV Protease

Drug resistance is one of the key roadblocks towards successful treatment of AIDS. Although numerous drugs have been developed to target various viral proteins, resistant viral strains are selected in the presence of the drug to become dominant in the population, therefore severely impairing drug efficacy and increasing the cost of treatment. There is an unmet need to develop strategies to combat drug resistance.

Novel compounds for the treatment of fungal infections

Treatment of fungal infections remains a medical challenge and better and more efficacious treatments are needed. Antifungal agents provide relief from fungal infections that can potentially infect almost any part of the human body, but, systemic fungal infections can be life threatening. A commonly prescribed antifungal drug for systemic fungal infections is fluconazole. Fluconazole tends to be well tolerated; however there have been reports of various undesirable side effects as well as the emergence of fluconazole resistant fungal strains.

A Gene Expression Panel For Diagnosis Of Ebola Virus Infection

This invention identifies a novel host gene expression panel to screen for the Ebola virus in pre-symptomatic patients.

Small Molecule Targeting HSP70 for Antiviral Therapy

Inhibitors of host Heat Shock Protein-70 (HSP70) as antiviral agents

Methods for Real-Time Sequencing Analysis of Infectious Diseases

A novel point-of-care technology enables real-time analysis and visualization of metagenomic sequence data for pathogen detection using a device that generates long sequencing reads at low cost and high speed with minimal sample preparation and instrumentation.

Erodible Polymer Particle Oral Vaccine Adjuvant

Brief description not available

Preparation and Activity of Novel Photosensitizer Acting as a Broad Spectrum Antiviral Agent Against Enveloped Viruses

Professor Michael Jung’s group at UCLA has developed a novel class of compounds with broad spectrum antiviral activity toward enveloped viruses.

Activating HIV Latency Using Drug Encapsulated Nanoparticles

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.

A Novel Targeting Approach for Selective Delivery of Therapeutic Agents

A novel class of linker/targeting moieties conferring selective release of therapeutic agents in rapidly proliferating mammalian cells or pathogens, leading to reduced drug-associated toxicity in patients and increased therapeutic index.

Identification of Sortases and Methods of Use

UCLA has a portfolio of intellectual property on the composition, methods of screening, and methods of use of the sortase-transamidase enzymes, Sortases A and B.  

Rapid Antigen Detection Test for the Diagnosis of Human Brucellosis

Confirmation of infection with human brucellosis is typically done by culturing of a blood sample and agglutination with a fixed Brucella abortus antigen. Because brucellosis DNA has been found to persist in blood after successful treatment, PCR amplification techniques are not useful when trying to confirm relapse. ELISA assays that detect antibodies to B. abortus are not recommended for diagnosing the human agent because of their limited specificity resulting in false positive results.

Novel Chitosan Derivative as a Systemic Drug Delivery Agent and an Antibiotic Treatment

Researchers at the University of California, Irvine have developed a novel chitosan derivative that may be used simultaneously as a systemic drug delivery agent and a systemic antibiotic treatment.

Novel RNA Biomarkers

Background: Current interest in small noncoding regulatory RNAs and their involvement in the pathology of human diseases has been growing extensively. The potential to grow the known classes of  biomarkers opens the door to better diagnosis and treatment. Description: UCR researchers have discovered  a novel class of circulating small RNAs that may have a broad physiological role. These small RNAs interestingly change in expression with age and are partially mitigated with calorie restriction. These novel RNA biomarkers  may indicate specific disease states, particularly cancer.

Linear Lipopeptides As Treatments For Infectious Diseases

Leishmaniasis is a debilitating disease prevalent across many inter-tropical regions of the world. Caused by over twenty species of intracellular parasite from the genus Leishmania, leishmaniasis can present itself in a number of different clinical manifestations including cutaneous, mucosal and visceral forms of the disease. Both the cutaneous and mucosal forms can cause severe disfigurements to patients including ulcerative skin lesions and the destruction of the mucous membranes of the nose, mouth and throat leading to permanent disfigurement and frequent social ostracization. A shortfall of affordable and clinically efficacious treatments has led World Health Organization to designate leishmaniasis as a category 1 disease, signifying that it is an emerging and uncontrolled global health problem. Human African trypanosmiasis or Sleepign sickness is a parasitic disease of people and animals, caused by protozoa of the species Trypanosoma brucei and transmitted by the tsetse fly. It is estimated that 50,000 to 70,000 people are currently infected. The current standard treatment for first stage trypanosomiasis employs administering intravenous pentamidine (for T.b. gambiense) or intravenous suramin (for T.b. rhodesiense).

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These technologies are part of the UC QuickStart program.