Tools To Target Natural And Synthetic Nucleotide-Sensing Pathways

Patent Status

Additional Patent Pending

Brief Description

The invention involves compositions and methods that deploy ddhNTPs (deoxy-dihydro-nucleoside triphosphates) as immunomodulatory therapeutics. These tools are designed to modulate P2 receptors, act as nucleotidase inhibitors, and have a wide range of applications including host-acting anti-infectives, oncolytics, anti-aging treatments, tissue regeneration, and green pesticides targeting plant P2K receptors. This invention represents a significant advancement in the field of nucleotide-sensing pathway modulation, offering innovative solutions for both medical and agricultural challenges.

Suggested uses

●      Immunomodulatory Therapeutics: ddhNTPs can be used to modulate immune responses by targeting P2 receptors, which play a crucial role in various immune functions.

●      Nucleotidase Inhibitors: These compositions can inhibit nucleotidases, enzymes that break down nucleotides, thereby influencing nucleotide signaling pathways.

●      Host-acting Anti-infectives: ddhNTPs can be employed to enhance the host's immune response against infections without directly targeting the pathogens, reducing the risk of resistance development.

●      Oncolytics: The invention can be used in cancer treatment by modulating nucleotide-sensing pathways to induce cancer cell death.

●      Anti-aging Treatments: By influencing nucleotide signaling, ddhNTPs can be used to promote cellular health and longevity.

●      Tissue Regeneration: These tools can aid in the regeneration of damaged tissues by modulating nucleotide-sensing pathways involved in cell growth and repair.

●      Green Pesticides: ddhNTPs can act on plant P2K receptors to provide a sustainable and environmentally friendly approach to pest control.

Advantages

●      Targeted Modulation: The ability to specifically target P2 receptors and nucleotide-sensing pathways allows for precise therapeutic interventions.

●      Broad Applications: The versatility of ddhNTPs enables their use in a wide range of medical and agricultural fields.

●      Reduced Resistance: Host-acting anti-infectives reduce the likelihood of pathogens developing resistance compared to traditional antibiotics.

●      Enhanced Efficacy: By modulating key pathways, ddhNTPs can enhance the effectiveness of treatments for cancer, aging, and tissue regeneration.

●      Environmental Sustainability: The use of ddhNTPs as green pesticides offers a safer alternative to chemical pesticides, promoting ecological balance.

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