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Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

PAC1 Receptor Agonists for Treatment of Obesity, Diabetes, and Fatty Liver Disease

UCLA researchers have developed novel PAC1 receptor agonists (MAXCAPs) that specifically bind and activate PAC1 receptors to induce satiety and treat multiple metabolic diseases.

Label Free Assessment Of Embryo Vitality

Researchers at UC Irvine developed an independent non-invasive method to distinguish between healthy and unhealthy embryos.

Antisense Oligonucleotides and Drug Conjugates for Obesity and Diabetes Treatment

The obesity epidemic is an ongoing issue leading to significant economic and social burden, in part due to its role in the development of diabetes. Only three DFA-approved drugs for obesity treatment currently exist, none of which are without significant side effects and risks. Researchers at UCI have developed a DNA-based approach that activates metabolism, to target genes only in the fat and liver, causing increased energy expenditure and weight loss without affecting other organs. These present a viable approach to obesity treatment with minimal side effects in comparison to current drug treatments.

Hybridoma Producing Antibodies To C1qRp

Individuals with genetic immunodeficiency, as well as patients with HIV, cancer, and those undergoing chemotherapy or high risk surgery, are at increased risk for infection. C1q, an important component of the immune system, is known to enhance phagocytosis (cell ingestion of harmful bacteria or other materials). Scientists at UCI have developed antibodies to the receptor for C1q, C1qRp, to be used as a target for prophylactic treatments in populations at high risk of infection.

Compositions for Enhancing Beta Cell Maturation, Health, and Function

Beta cell failure is the central cause of type-2 diabetes. Researchers at UCI have developed molecules for treating diabetes that target proteins on the surface of beta cells and induce their clustering. This clustering results in an increase in insulin secretion and content and promotion of beta cell maturation. Furthermore, the clustering effect seen with these compositions may promote both proliferation and the reversal of de-differentiation.

Composition and Methods to Treat Osteoporosis

Most FDA-approved treatments for osteoporosis target osteoclastic bone resorption. Only parathyroid hormone (PTH) derivatives improve bone formation, but they have drawbacks, so new bone-anabolic agents are needed. The Nitric Oxide(NO)/cGMP/protein kinase G (PKG) signaling pathway mediates anabolic effects of estrogens and mechanical stimulation in bone cells by increasing osteoblast proliferation and osteocyte survival. Nitrates, which generate NO, reduce bone loss in estrogen-deficient rats and increase bone mineral density in post-menopausal women. However, nitrates are limited by induction of oxidative stress and development of tolerance, and may increase cardiovascular mortality after long-term use.

Compositions and Methods to Diagnose and Treat Chronic Fatigue Syndrome Using Metabolomics

Chronic fatigue syndrome (CFS) is a serious and debilitating systemic disease characterized by diverse symptoms including pain, sleep disturbance, neurologic and cognitive changes, as well as impaired immune and autonomic responses. It affects approximately 1-2 million adults in the US, more often in women than men with peak onset of age 30-50. It is very difficult to reach a conclusive diagnosis due to the subjective nature, range of symptoms, and lack of understanding of the etiology and pathogenic mechanisms of CFS.

Small Molecule Generation of Multinucleated and Striated Myofibers from Human Pluripotent Stem Cells Equivalent to Adult Skeletal Muscle

Researchers in the UCLA Department of Microbiology, Immunology and Molecular Genetics have developed a novel means of generating adult skeletal muscle-equivalent myofibers from human pluripotent stem cells.

Antibodies targeting mammalian Sterol Regulatory Element Binding Proteins (SREBP) 1 and 2

Sterol Regulatory Element Binding Proteins (SREBP) are important factors that control lipid homeostasis in mammals. Researchers at UCI have prepared antibodies that have good affinity and specificity for human SREBP1/2 for use as research tools. These antibodies have application in genetic and immunotherapeutic research areas.

High Performance and Flexible Chemical And Bio Sensors Using Metal Oxide Semiconductors

UCLA researchers in the Department of Materials Science and Engineering have developed a simple method producing thin, sensitive In2O3-based conformal biosensors based on field-effect transistors using facile solution-based processing for future wearable human technologies as well as non-invasive glucose testing.

Enhanced Cell/Bead Encapsulation Via Acoustic Focusing

The invention consists of a multi-channel, droplet-generating microfluidic device with a strategically placed feature. The feature vibrates in order to counteract particle-trapping micro-vortices formed in the device. Counteracting these vortices allows for single particle encapsulation in the droplets formed by the device and makes this technology a good candidate for use in single cell diagnostics and drug delivery systems.

Method of Preventing Bone Loss and Periodontal Disease

A method of controlling mammalian epoxy fatty acids levels in order to regulate the RANK, RANK-L, and OPG anti-inflammatory triad, thereby limiting inflammation, cancer, arthritic disease, and bone loss while promoting bone growth, remodeling, and regeneration.

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Novel Plant Diterpene Synthases And Their Use For Production Of Diteprene Bioproducts

Researchers at the University of California, Davis have developed a diterpene synthase (diTPS) of plant origin that shows a novel enzyme function, and methods for producing natural and novel high-value diterpenoid bioproducts. 

Generation Of Human Beta Cell Equivalents From Pluripotent Stem Cells In Vitro

This invention describes a robust method to generate functional human beta cell equivalents from pluripotent stem cells in vitro for wide applications in basic research, drug and toxicology screens and as a diabetes cell therapy.

Predicting Weight Loss And Fat Metabolism Using Optical Signal Changes In Fat

Researchers at UCI have developed a novel use of an emerging functional imaging technology, Diffuse Optical Spectroscopic Imaging (DOSI), for monitoring changes in subcutaneous adipose tissue (“AT” also known as “fat” tissue), structure and metabolism during weight loss. Changes in subcutaneous adipose tissue structure and metabolism have been shown to correlate with the development of obesity and related metabolic disorders. The invention is a diagnostic tool that assesses the structure and function of fat tissue in vivo.

Novel Compounds Targeting LRH-1for Treatment of Inflammatory Bowel Disease, Type II Diabetes, Triple Negative Breast Cancer & Pancreatic Cancer

This technology contains a method for modulating the activity of the nuclear receptor LRH-1 with identified small molecule compounds that may be developed to treat inflammatory bowel disease, Type II diabetes, triple negative breast cancer and pancreatic cancer.

Methods and Compositions of Treating Diabetic Nephropathy and Insulin Resistance

Researchers at the University of California, Davis have developed novel methods and compositions for the treatment of diabetic nephropathy and insulin resistance.

Transposon Vector for Vertebrate & Invertebrate Genetic Manipulation

Background: Therapeutic delivery of genes is a rapidly evolving technique used to treat or prevent a disease at the root of the problem. The global transgenic market is currently $24B, growing at an annual projected rate of 10%. Currently, a variation of this technique is widely used on animals and crops for production of desirable proteins, but this is a heavily infiltrated market. Thus, entering the gene therapy segment is more promising and would enhance the growth of this industry.  Brief Description: UCR Researchers have identified a novel transposon from Aedes aegypti mosquitoes. This mobile DNA sequence can insert itself into various functional genes to either cause or reverse mutations. They have successfully developed a transposon vector system that can be used in both unicellular & multicellular organisms, which can offer notable insight to improve current transgenic technologies as well as methods of gene therapy.

Isolation of Hepatocytes with High Regenerative Capacity for Repair of Liver Injuries

Hepatocyte diversity has long been known, yet it remains difficult to analyze the distinct properties of the various hepatocyte populations under physiological conditions. A unique subpopulation of periportal hepatocytes were recently identified by UC San Diego researchers. These cells are located in the limiting plate and express Sox9 and HNF4alpha, a hepatocyte transcription factor. The cells were termed HypHP (hybrid hepatocytes) and are a hybrid between a hepatocyte and a duct cell. Transcriptomic and immunohistochemical analyses show expression of hepatocyte-specific genes as well as a small number of genes that are preferentially expressed in bile duct cells. In the unchallenged liver, HypHP are quiescent for at least 9 months after birth, but during chronic liver damage they proliferate and serve as a source of new hepatocytes that repopulate the liver. Chronic liver disease remains the leading cause of liver transplantation, an expensive procedure which is a cause of morbidity and mortality. Others have suggested cell transplantation, such as stem cells, as an alternative. However, suitable matches are difficult to find. Hepatocytes can be derived from induced Pluripotent Stem Cells (iPSCs), however, this procedure does not generate fully functioning hepatocytes. Other approaches for cell transplantation use ductal cells, which also does not generate fully functional cells.

Miniature Health-Care Ultrasonic Imaging System

The increasing market of mobile health indicates the growing consumer interest in low-cost and easy-to-use solutions for monitoring personal health. Weight, body-fat percentage and blood pressure are several critical indexes relating to a variety of chronic disease. Weight scale integrated with impedance measuring devices give a coarse full-body measurement on both weight and body-fat percentage but is susceptible to multiple error sources such as humidity. For fitness use, there is also lack of a device to monitor the effectiveness of local muscle building. On the other hand, current blood pressure gauge (sphygmomanometer) is hard to use without calibration and proficiency training. Both the devices are obviously too bulky to be portable and hence not a good solution for personal-health monitoring. Alternatively, ultrasonic imaging, now widely used in medical field, provides accurate and local body-index measuring such as local body-fat assessment by measuring real thickness of body-fat and blood-pressure measuring by Doppler imaging on blood flow speed. The accuracy and local-body part measuring solve the problems of traditional devices but the size, complexity and huge amount of power remains issues to be solved. To meet these challenges, investigators at the University of California, Davis and U.C. Berkeley have jointly developed a novel miniature, ultrasonic imaging system using a combination of microelectronic devices that measures the fat and muscle thickness at a particular human body part for health-care purposes and muscle-training monitoring. The system also has the capability of measuring blood flow and blood pressure. Due to the small size and single, low-voltage power supply of the system, this technology can also be integrated into portable devices for mobile health care.


Therapeutic inhibitors of Urea Transporter A (UT-A) as highly effective diuretics with reduced risk of cardiac and neurological side effects for treatment of cardiovascular and renal disorders

CYP3A4 Epoxygenase Inhibitors for ER+ Breast Cancer Treatment

Small molecule CYP34A inhibitor oncology therapeutics are being developed in collaboration between scientists at UC Irvine and U of Minnesota. These molecules have been shown effective against ER+ xenograft models of breast cancer. Due to their mechanism of action, these molecules may enhance treatment with tamoxifen and paclitaxel to decrease risk of recurrence.

A Rapid, Reproducible, Non-Invasive Predictor of Cadaveric Donor Liver Graft Utilization

Dr. Zarrinpar in UCLA Department of Surgery has demonstrated the applicability of a rapid, non-invasive liver function test for quantitative assessment of cadaveric organ donor graft quality.

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