Learn more about UC TechAlerts – Subscribe to categories and get notified of new UC technologies

Browse Category: Medical > Delivery Systems

Categories

[Search within category]

Use of a Radiation Detector that Combines Virtual Frisch Grid and Cerenkov Readouts

Researchers at the University of California, Davis have developed a radiation detector for high energy photons that employs a transparent semiconductor with a high index of refraction to combine benefits of Virtual Frisch Grid devices and the readout of Cerenkov light.

Method For Temporal And Tissue-Specific Drug Delivery And Induced Nucleic Acid Recombination

UCLA researchers in the Department of Medicine have developed a novel method for tissue-specific drug delivery via a nanoparticle system.

Trehalose Hydrogels For Stabilization And Delivery Of Proteins

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel trehalose hydrogel to help stabilize proteins for drug delivery.

Sustained Intracellular RNA Delivery and Expression

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.

Process For Reducing Sizes Of Emulsion Droplets

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of reducing sizes of droplets in multiple emulsion systems.

Nanoparticles For Specific Detection And Killing of Pathogenic Bacteria

UCLA researchers in the Department of Chemistry and Biochemistry and Department of Medicine have developed novel functionalized mesoporous silica nanoparticles that can specifically identify pathogenic bacteria and deliver on-target drug treatments.

Systems And Methods For Therapeutic Agent Delivery

UCLA researchers at the Department of Physics have developed a system that is capable of delivering a therapeutic agent to a specifically targeted tissue using ultrasound.

Methods Comprising Immune System Modulation With Microporous Annealed Particle Gels

UCLA researchers have developed a novel microporous annealed particle (MAP) scaffold that acts as both a tissue growth scaffold and an immune modulatory system. The technology permits continuous, time-encoded, modulation of the immune system delivered injection/implantation of fabricated scaffold, comprised of the MAP gel technology.

Disulfide Bioconjugation

UCLA researchers in the Department of Chemistry and Biochemistry have proposed a one-step radical mechanism for disulfide bioconjugation that overcomes many concerns associated with the free cysteine residues that result from current bioconjugation techniques.

Integrin Stimulating Materials For The Normalization Of Diseased Vasculature

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel a novel α3/α5β1 integrin binding site integrated endothelial growth factor (VEGF) delivery hydrogel that directs therapeutic vessel regeneration and reduces VEGF induced vascular permeability.

Bacteriotherapy against Propionibacterium Acnes for the Treatment of Acne Vulgaris

Reduction in Propionibacterium acnes (P. acnes) survival correlates with clinical improvement of acne in patients. Systemic antibiotics have been used to treat acne for several decades and are still widely prescribed for acne patients. Topical antibiotics are also helpful, and the oxidizing agent benzoyl peroxide (BPO) has been one of the most frequently used topical medications for acne treatment. Topicals are often used as the first line treatment for patients suffering from mild to moderate acne. However, current antibiotic treatments have major drawbacks. Systemic antibiotics nonspecifically disrupts microbial ecosystem and promote antibiotic resistance. Topical antibiotics are very poor at killing P. acnes on the skin surface, therefore there is a current need for alternative methods for treatment.

Preparation Of Functionalized Polypeptides, Peptides, And Proteins By Alkylation Of Thioether Groups

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering Department, have developed new methods for adding different functional groups on polypeptides.  The UCLA researchers have used this method to create a platform to create and modify nanoscale vesicles and hydrogels for use in nanoscale drug delivery particles, injectable drug depots, imaging and detection, industrial biomaterials, and wound management.

Combination Therapy Approach Using Novel Biguanides For Cancer Treatment

Researchers in the UCLA Departments of Molecular and Medical Pharmacology, Chemistry and Biochemistry, Surgery, and Medicine have developed novel metformin analogues which, when combined with immune checkpoint inhibitors, enhance the therapeutic benefit of these inhibitors in treating triple-negative breast cancer and other malignancies.

Endogenous Human Protein Nanoparticle-Based Immune-Focusing Antiviral Vaccine

UCLA researchers in the Department of Biological Chemistry have developed a novel nanoparticle based antiviral vaccine capable of targeting many viruses.

New Form Of Hybrid Materials

Advances in science are driven by new discoveries which can pave the way to new create new research directions. For example, crystals by the nature of their order in three-dimensional space, cannot flex or expand, but with the integration of macromolecular ferritin crystals with hydrogel polymers can change their dimensions.

Amphiphilic Derivatives Of Thioether Containing Block Copolypeptides

UCLA researchers in the Department of Bioengineering have developed a new method to generate amphiphilic block copolypeptides.

Chemoselective Side-Chain Modifications Of Methionine-Containing Elastin-Like Polypeptides

UCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for the introduction of various functional groups onto recombinant elastin-like polypeptides (ELPs), creating new compositions of ELPs that may be used for medical therapeutic or diagnostic applications.

Thaw Gelation Process for Encapsulating Cell Spheroids

Researchers at the University of California Davis have developed a thaw gelation process for the formation of cell spheroids within a hydrogel shell.

Targeting Lentiviral Vectors To Specific Cells And Tissues

Researchers in the UCLA Departments of Medicine and Microbiology, Immunology and Molecular Genetics have developed retroviral vectors pseudotyped with a modified Sinbus virus envelope that exhibit reduced tropism and can be used for the targeted transduction of heterologous genes into cells.

BMP Binding Proteins and Prosthetic Surfaces

UCLA researchers have developed a method to attach and enhance the activity of bone growth factors to prostheses through BMP binding proteins to increase the integration of prostheses and bone.

BBP as a Complexed Carrier for Bone Growth Factors

UCLA researchers have identified a BMP binding peptide that binds to bone growth factors to increase their residence time at the site of implantation for treatment of bone defects.

Lentivirus-like Particle Delivery of CRISPR-Cas9 & Guide RNA for Gene Editing

CRISPR-Cas9 is revolutionizing the field of gene editing and genome engineering. Efficient methods for delivering CRISPR-Cas9 genome editing components into target cells must be developed, both for ex vivo and in vivo applications. Current delivery strategies have drawbacks: genetically encoding Cas9 into viruses (ex. adeno-associated virus, adenovirus, retrovirus) leads to prolonged Cas9 expression in target cells, thus increasing the likelihood for off-target gene editing events. This problem can be mitigated by complexing ribonucleoprotein (RNP) Cas9 and guide RNA (gRNA) in vitro prior to administration – however, additional strategies for trafficking RNPs into target cells must additionally be employed.    To address this challenge, UC Berkeley researchers have discovered lentivirus-like particles that deliver Cas9/gRNA RNP complexes into target cells with high efficiency. This delivery strategy combines the ability of viruses to deliver cargo intracellularly with the transient nature of Cas9 RNP complexes. 

Precise tracking of subsurface tissue probes and objects

The invention is a novel method that tracks the position of probes and objects deep inside tissues, with unprecedented 3D precision. Data obtained from optical techniques are combined with that provided through ultrasound methods, providing accurate localization in the 3D space, along with precise anatomical structure. Such a combined method is crucial for precision-sensitive applications as anesthetic drug delivery.

Osterix Specific Peptides for Treatment of Osteoporosis and Reversal of Bone Degradation

Researchers at the University of California, Davis have developed osterix-targeting peptides to prevent premature drug release during circulation, and deliver high concentration and time-depended release of drug treatments to bone defective sites.

Hepatitis E Nanoparticles for the Oral Delivery of Insulin for Diabetics

Researchers at the University of California, Davis have developed a stable, non-infectious orally administered Hepatitis E Viral Nanoparticles (HEVNP) for the delivery of insulin to manage hepatic glucose production in diabetic patients.

  • Go to Page: