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Polyrotaxane Nanoparticles for Delivery of Large Plasmid DNA in Duchenne Muscular Dystrophy

UCLA researchers have designed, synthesized, and validated a polyrotaxane nanocarrier for targeted delivery of large plasmids for gene therapy applications for treatment of Duchenne muscular dystrophy and cancer.

Methods for Treating and Alleviating Neuropathic Pain Using ApoA-I Binding Protein (AIBP)

Neuropathic pain is a type of persistent pain usually occurring longer than 3 months, associated with peripheral nerve problems, but also can arise from chronic inflammatory diseases like arthritis, chemotherapeutic-induced peripheral neuropathy in the treatment of cancer or a neurodegenerative disease or condition. The chronic pain has an extraordinary negative impact on quality of life. While opiates, NSAIDs, and anticonvulsants can relieve pain for short intervals, they are less effective for chronic therapy, particularly when components of the pain state involve persistent inflammation and/or injury to the peripheral nerve. Aside from efficacy, many of the potent agents are beset with limiting side effects and issues related to dependence and addiction. This relative lack of long-term efficacy of even approved agents is evident from clinical trial results, which often indicate that most subjects complete even successful trials with pain that is sufficiently severe as to permit reentry into the same trial. What is needed is a new treatment modality.

Preconditioned Human Mesenchymal Stem Cells (hMSCs) for Musculoskeletal Tissue Repair

Researchers at the University of California, Davis have developed a preconditioning treatment and delivery method for human mesenchymal stem cell (hMSC) for enhanced bone healing.

Functional Manipulation of the Gut Microbiome Using a Personalized Approach

The use of traditional probiotic microorganisms to provide therapeutic function for the gut microbiome has a number of limitations. Probiotic bacteria do not colonize the gut because they can’t compete with the resident flora that have evolved for that environment. Current probiotics are a single strain which when used in multiple hosts have not had great success in broad populations and are therefore unpredictable. To alleviate the above problem, a new approach is necessary to colonize the human gastrointestinal tract with greater reliability and for therapeutic value to the patient. 

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

UCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K. This probe can also deliver drug molecules to bone resorption sites with high specificity.

High-Throughput Quantification of Nanoparticle Degradation using Computational Microscopy and its Application to Drug Delivery Nanocapsules

UCLA researchers in the Department of Bioengineering have developed a high-throughput imaging technique that monitors the degradation of nanoparticles in real time.

High-Throughput Intracellular Delivery of Biomolecular Cargos via Vibrational Cell Deformability within Microchannels

UCLA Researchers in the Departments of Chemistry and Materials Science & Engineering have developed a novel means of delivering intracellular cargo.

Mucoadhesive Devices for Oral Delivery of Various Active Agents

Effective and easily accepted system of oral delivery of therapeutic drugs.

Automated titration of vasopressor infusion within predefined guardrails for efficient hypotension management

The invention automatically controls the blood pressure of patients on a continuous basis. It monitors the blood pressure and takes an action, within safety limits, whenever needed. The invention represents a dramatic improvement in the hypotension and critical care management.

Calcified Polymeric Valve and Vessels

A cast molded methodology for creating polymeric heart valves and vessels with calcium apatite inclusions. The heart valves and vessels can then be implanted in animals to test cardiovascular medical device efficacy.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Antimicrobial, Stimuli-responsive Polysaccharide

State of the art antimicrobial therapeutics, while effective and promising, remain only short-term solutions to the overall challenge of drug-resistant microbes. UCI researchers have developed a chitosan-based nanoantibiotic that is non-toxic and carries potential for broad spectrum use.

Pressure Based Mechanical Feedback to Safely Insert Catheters

A pressure sensing device that provides feedback during the insertion of a ureteral access sheath to prevent unwanted damage to the wall of the ureter.

Controlled-Release Cysteamine Nanowafer For Treating Corneal Cystinosis

Corneal cystinosis is a rare metabolic disease that causes loss of vision. Researchers at UCI have developed a nanowafer drug delivery system that has demonstrated twice the therapeutic efficacy during in vivo studies in mice.

Active Nanoplatform with High Drug Loading Capacity for the Diagnosis and Treatment of Cancer

Researchers at the University of California, Davis have developed an active nanoplatform (F/HAPIN) for cancer diagnosis and therapy.

Sealed Nanostraw Microdevices For Oral Drug Delivery

This invention is a nanostraw device that is built upon microdevice technology for oral drug delivery. It is the first example of a microdevice for oral drug delivery, with the drug sealed in by a semi-permeable membrane for (1) in-solution drug loading, and tunable drug release, (2) increased bioadhesion for prolonged drug exposure, and (3) protection of drug from outside biomolecules.

Nanowire-Coated Planar Microdevices For Transmucosal Drug Delivery

This invention describes a first-of-a-kind methodology using micro- and nanofabrication techniques to create polymeric microscale devices that are asymmetrically coated with nanowires. The nanowire coating provides an inherent high-throughput, low-waste drug loading mechanism, enhanced cytoadhesion, and may potentially interact with epithelial tissue to enhance drug permeation.

Single Ended Draw Lines For Medical Device Application

Minimizing the movement of deployed transcatheter heart valves and stents during detachment using single ended draw lines.

Novel Nanoliposomal Nitroglycerin Formulation for Cardiovascular Therapies

    To address this major limitation, investigators at UCR have developed a nanoliposomal formulation of NTG, which achieves a 70-fold increase in the anti-inflammatory effect of NTG when compared to NTG. This increase in potency allows lower doses to be effective, which could mitigate the common issues seen with high clinical doses of NTG viz. loss of NTG sensitivity and endothelial toxicity. Fig. 1 Adhesion of U937 monocytes to NO-deficient (L-NIO-treated) ECs is significantly blocked by treating ECs with 5 ug/ml nanoliposomal nitroglycerin (NTG-NL). L-NIO is a selective eNOS inhibitor.  Remarkably, this anti-inflammatory dose of NTG in nanoliposomes is 70-fold lower than the dose of free NTG (5uM) required to achieve a similar effect

Circulatory Cells as Carriers for Photo-Activated Bioregulators

Circulatory cells as carriers for photo-activated small molecule bioregulator releasing compounds and systems.

Breast Milk as a Source, Incubation/Storage Medium, and Delivery System for Infant Mucosal Immunity Bacteriophage

Researchers at the University of California, Davis have developed a method to harvest and enrich symbiotic bacteriophage to promote bacterial immunity.

Preparation Of Functional Homocysteine Residues In Polypeptides And Peptides

UCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for efficient, chemoselective transformation of methionines in peptides and polypeptides into stable, functional homocysteine derivatives. This method provides a means of creation of new functional biopolymers, site-specific peptide tagging, and synthesis of biomimetic and structural analogs of peptides.

Update To Degradable Trehalose Glycopolymers

UCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.

Process For Recycling Surfactant In Nanoemulsion Production

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method to separate and recycle surfactants used in the manufacturing of nanoemulsions.

Patient Initiated Controlled Analgesic Remote Dispenser (PICARD)

Misuse, abuse, and diversion of prescription drugs are a major health problem in the United States, where opioid overdose caused more deaths than suicide and car accidents combined in 2013. The inventors at UCI have developed the Patient Initiated Controlled Analgesic Remote Dispenser (PICARD) system that increases patient adherence to prescribed drug protocols by requiring authentication (such as a fingerprint), dispensing single pills, and recording each event.

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