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Therapeutic Approach To Prevent Or Alleviate Drug-, Noise- And Age-Related Hearing Loss

UCLA researchers in the Department of Head and Neck Surgery have developed a novel therapeutic approach to treating hearing loss using inflammation-resolving molecules.

Drug Delivery System using Hollow Gold Nanoshells with Precise Drug Release

This drug delivery method eliminates these issues, as NIR irradiation can be applied precisely at the disease spot, and at the intensity required for an appropriately timed release.

Novel Method for the Active Delivery of Drugs Across the Intact Round Window Membrane to the Inner Ear of Mammals

There are many diseases of the inner ear that may be preventable or treatable pharmaceutically or by gene therapy. These include sensorineural hearing loss, “hidden hearing loss” due to neural damage, Meniere’s disease, dizziness, and tinnitus. There are difficulties that could be improved or resolved by local therapies. The bony capsule of the inner ear and the round window membrane that separates the middle ear form the inner hear hamper noninvasive delivery of medications or gene therapy vectors. The round window membrane is passively permeable to some drugs, depending upon size and charge.  However, large molecules and particles cross much less readily. Opening up the cochlea is required for delivery of such potential therapies. Thus, what is needed is an alternative method for delivery of drug across the intact round window membrane.

The Use Of Magnetic Sensors To Prevent Femoral Posterior Wall Blowout During ACL Reconstruction

Researchers led by Andrew Palosaari from the Department of Chemistry and Biochemistry at UCLA have developed a novel way to guide ACL grafts and prevent femoral wall blowout during ACL reconstruction.

Dual-Enzyme Responsive Peptides

UCLA researchers in the Department of Chemistry & Biochemistry have developed a dual-enzyme responsive peptide system that requires sequential digestion by two separate enzymes for cleavage at the C-terminal position of lysine.

A Delivery System for Percutaneous Delivery and Implantation Of Atrioventricular Heart Valves

The invention is a novel delivery system providing a minimally invasive solution for the delivery and implantation of atrioventricular heart valves. Through its novel mechanical structure, the invention delivers and positions the valve accurately with no need for painful surgeries or bulky tools.

New Platform and Methods for Generating Safe Cell Therapeutics

While some cell therapies have experienced success, many current cell therapies fall short in that enough cells do not reach the target tissue and/or the cells are incapable of producing clinically relevant thresholds of desired products sufficient to impact the disease state. Consequently, there is a major fundamental need to genetically engineer therapeutic cells to be more effective and robust using integrating viruses and powerful gene editing technologies like CRISPR, which can target ten to hundreds of genes simultaneously. However, this is highly problematic because the process of genetic engineering introduces dangerous unwanted mutations into the genome that can lead to cancer and other life-threatening diseases, especially if such cells permanently engraft into the body or fuse with host cells, which is common with stem cells. Therefore, the FDA does not readily permit the introduction of new genetic material or the extensive alteration of endogenous genes in cell-based therapies with the exception of CAR-T cells. For this reason, there is a major underlying need in the cell therapy sector to genetically enhance therapeutic cells to express gene products encoding biologics and then render them safe prior to clinical use. 

Approach For Efficient Protein Incorporation Into Recombinant Vaults

UCLA researchers in the departments of Medicine, Microbiology, Immunology & Molecular Genetics, and Bioengineering have developed a novel method for loading protein payloads into vault nanoparticle carriers.

Joint Pharmacophoric Space through Geometric Features

Pharmacophore analysis through examination of Joint Pharmacophore Space of chemical compounds, targets, and chemical/biological properties.

Polyrotaxane Nanoparticles for Delivery of Large Plasmid DNA in Duchenne Muscular Dystrophy

UCLA researchers have designed, synthesized, and validated a polyrotaxane nanocarrier for targeted delivery of large plasmids for gene therapy applications for treatment of Duchenne muscular dystrophy and cancer.

Methods for Treating and Alleviating Neuropathic Pain Using ApoA-I Binding Protein (AIBP)

Neuropathic pain is a type of persistent pain usually occurring longer than 3 months, associated with peripheral nerve problems, but also can arise from chronic inflammatory diseases like arthritis, chemotherapeutic-induced peripheral neuropathy in the treatment of cancer or a neurodegenerative disease or condition. The chronic pain has an extraordinary negative impact on quality of life. While opiates, NSAIDs, and anticonvulsants can relieve pain for short intervals, they are less effective for chronic therapy, particularly when components of the pain state involve persistent inflammation and/or injury to the peripheral nerve. Aside from efficacy, many of the potent agents are beset with limiting side effects and issues related to dependence and addiction. This relative lack of long-term efficacy of even approved agents is evident from clinical trial results, which often indicate that most subjects complete even successful trials with pain that is sufficiently severe as to permit reentry into the same trial. What is needed is a new treatment modality.

Preconditioned Human Mesenchymal Stem Cells (hMSCs) for Musculoskeletal Tissue Repair

Researchers at the University of California, Davis have developed a preconditioning treatment and delivery method for human mesenchymal stem cell (hMSC) for enhanced bone healing.

Functional Manipulation of the Gut Microbiome Using a Personalized Approach

The use of traditional probiotic microorganisms to provide therapeutic function for the gut microbiome has a number of limitations. Probiotic bacteria do not colonize the gut because they can’t compete with the resident flora that have evolved for that environment. Current probiotics are a single strain which when used in multiple hosts have not had great success in broad populations and are therefore unpredictable. To alleviate the above problem, a new approach is necessary to colonize the human gastrointestinal tract with greater reliability and for therapeutic value to the patient. 

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

UCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K. This probe can also deliver drug molecules to bone resorption sites with high specificity.

High-Throughput Intracellular Delivery of Biomolecular Cargos via Vibrational Cell Deformability within Microchannels

UCLA Researchers in the Departments of Chemistry and Materials Science & Engineering have developed a novel means of delivering intracellular cargo.

Noncrushable/Nonabusable Pill Formulations

UCLA researchers in the Department of Chemistry & Biochemistry have developed novel abuse-deterrent opioid formulations from elastomers that resist crushing at room temperature and upon heating or cooling. The formulation also contains a dual-enzyme responsive system whereby sequential digestion by two separate enzymes found in the stomach/intestines together cleave the peptide linkage allowing the drug to be fully released.

Mucoadhesive Devices for Oral Delivery of Various Active Agents

Effective and easily accepted system of oral delivery of therapeutic drugs.

Automated titration of vasopressor infusion within predefined guardrails for efficient hypotension management

The invention automatically controls the blood pressure of patients on a continuous basis. It monitors the blood pressure and takes an action, within safety limits, whenever needed. The invention represents a dramatic improvement in the hypotension and critical care management.

Calcified Polymeric Valve and Vessels

A cast molded methodology for creating polymeric heart valves and vessels with calcium apatite inclusions. The heart valves and vessels can then be implanted in animals to test cardiovascular medical device efficacy.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Antimicrobial, Stimuli-responsive Polysaccharide

State of the art antimicrobial therapeutics, while effective and promising, remain only short-term solutions to the overall challenge of drug-resistant microbes. UCI researchers have developed a chitosan-based nanoantibiotic that is non-toxic and carries potential for broad spectrum use.

Pressure Based Mechanical Feedback to Safely Insert Catheters

A pressure sensing device that provides feedback during the insertion of a ureteral access sheath to prevent unwanted damage to the wall of the ureter.

Controlled-Release Cysteamine Nanowafer For Treating Corneal Cystinosis

Corneal cystinosis is a rare metabolic disease that causes loss of vision. Researchers at UCI have developed a nanowafer drug delivery system that has demonstrated twice the therapeutic efficacy during in vivo studies in mice.

Active Nanoplatform with High Drug Loading Capacity for the Diagnosis and Treatment of Cancer

Researchers at the University of California, Davis have developed an active nanoplatform (F/HAPIN) for cancer diagnosis and therapy.

Sealed Nanostraw Microdevices For Oral Drug Delivery

This invention is a nanostraw device that is built upon microdevice technology for oral drug delivery. It is the first example of a microdevice for oral drug delivery, with the drug sealed in by a semi-permeable membrane for (1) in-solution drug loading, and tunable drug release, (2) increased bioadhesion for prolonged drug exposure, and (3) protection of drug from outside biomolecules.

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