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Adaptive optics with direct wavefront sensing for multi-photon microscope

Biological tissue are rarely transparent, presenting major challenges for deep tissue optical microscopy. With the advantages of high-resolution and viewing of live organisms, optical microscopy has become an important tool for biological research and continues to open new avenues in its capabilities. In recent years, image resolution and speed has been dramatically improved.  However the improvement of the resolution and penetration depth for optical microscopy is still in its infancy. As light passes through biological tissue, it can be absorbed, refracted and scattered, limiting the resolution and depth of optical imaging in biological tissues. Overcoming these challenges will benefit a wide range of applications from basic biological research to clinical investigations.

Microfluidic System for Particle Trapping and Separation

<p>Researchers have developed a novel system and method to rapidly separate particles from liquid. This technology demonstrates lab-on-a-chip potential for particle separation and/or purification. This technology is capable of processing a wide variety of molecules, ranging from cells to smaller biomolecules such as proteins and nucleic acid. Applications of this technology include (but are not limited) use of it for particle separation and quantification for assays, cell preparation, and cell lysing and component separation.</p>

Microfluidic System for Particle Trapping and Separation

Researchers have developed a novel system and method to rapidly separate particles from liquid. This technology demonstrates lab-on-a-chip potential for particle separation and/or purification. This technology is capable of processing a wide variety of molecules, ranging from cells to smaller biomolecules such as proteins and nucleic acid. Applications of this technology include (but are not limited) use of it for particle separation and quantification for assays, cell preparation, and cell lysing and component separation.

Monoclonal Antibody against ATR-IP (Clone 11)

Mouse monoclonal antibody against the human ATR-interacting protein (ATR-IP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against CEP164 (Clone 13)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against CEP164 (Clone 17)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunoprecipitation and western blot.

Monoclonal Antibodies Against Chk2 (Clone 4B8)

Mouse monoclonal antibody (clone 4B8) against the human Serine/threonine-protein kinase Chk2. This antibody has been tested for use in immunoprecipitation and western blot.

Monoclonal Antibodies Against Mtpap (Clone 1D3)

Mouse monoclonal antibody against the human Poly (A) RNA polymerase, mitochondrial (mtPAP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Methods and Compositions for Determining Differences in Taste Perception

People vary dramatically in their taste perception. What one person perceives as mild and pleasant, another will perceive as aversively spicy. Perception of piquancy, sweetness, sourness, temperature, bitterness, and other components of taste all vary across individuals in this way. Some substances, such as cilantro and phenylthiocarbamide, are famously polarizing, producing perceptual experiences that differ radically across individuals. Yet there is no universal system for measuring taste perception; people have a sense for what they like, but they cannot measure it or communicate it to others precisely. This means, for example, that food providers are left almost entirely in the dark, forced to cater to the average and not the individual. To address this need, researchers at the University of California, Berkeley, have created methods and compositions for consumable products to measure individual differences in taste perception. This innovative approach could lead to new products in support of a universal system for measuring taste perception, with an opportunity for consumers and retailers to understand food and beverage preferences in more precise, quantitative terms.

Design for Particle Manipulation using Complex Flow Profiles

Researchers in UCLA Department of Bioengineering demonstrated the theoretical foundations of how inflection points of complex flow velocity profile can be used to create attractors in designed locations.

Monoclonal Antibody Against mtPAP (Clone 3D2)

Mouse monoclonal antibody against the human Poly (A) RNA polymerase, mitochondrial (mtPAP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot. .

Monoclonal Antibody Against PNPase (Clone 3H5)

Mouse monoclonal antibody against the human mitochondrial polyribonucleotide nucleotidyltransferase 1 (PNPase). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Methods for Fabrication of Electric Propulsion Tips

The technology is a method for fabrication of silicon microfabricated emitter tips.This process has two-step etching process which utilizes field emission electric propulsion (FEEP) and indium propellant.

Microfabrication of High Quality 3-D Structures Using Wafer-Level Glassblowing of Fused Quartz and Ultra Low Expansion Glasses

Micro-glassblowing MEMS fabrication process for low expansion and low loss materials

Lever Mechanisms for Anti-phase Mode Isolation in MEMS Tuning-fork Structures

The technology is a design structures for mode isolation in tuning fork structures on MEMS vibratory sensors.It features two coupling design structures added to tuning fork structure.The device separates in-phase and anti-phase mode tuning fork resonances by raising the in-phase resonance over the anti-phase resonance.

Carbon Sequestration Using a Magnetic Treatment System

The technology is a technique for the capture and removal of carbonates in natural water sources.It features the use of an alternating electromagnetic field (AMF) to induce the formation of calcium carbonate or other carbonate compounds in suspension in water source. Additionally, carbonate compounds are removed using filtration device.

Thermal Devices for Controlling Heat Transfer

The technology is a heat transfer device. The key properties are a unidirectional heat flow, thin, sandwich structure, and a T-dependent thermal resistance. The technology functions via the heat pipe effect. The purpose of the technology is to provide a one-way heat flow in a compact form (in a thin layer) with T-dependent thermal resistance.

Referenceless Clock Recovery Circuit with Wide Frequency Acquisition Range

The technology is a circuit that recovers a full-rate clock signal from a random digital data signal. Properties include: achieves frequency and phase locking in a single loop and a wide acquisition range.

A Neuromorphic Robot that Interacts with People Through Tactile Sensing and Bi-directional Learning

The device is an interactive neuromorphic robot, using to mimic neuro-biological architectures and learning.Properties include:a spiking neural network to control robot behavior, inexpensive parts which are easily available, and two-way learning and behavior shaping.The technology is autonomous, highly mobile, and includes on-board measurement equipment.

Cacophony: A Framework for Next Generation Software Sensors

The technology is a software architecture for providing robust predictions for software systems from cloud sourced data points. Properties include:the ability to “wrap” existing software sensors with additional services. The technology is used by executing software on a cloud based server and manipulating data points from user update systems, such as Waze, and provide predictive services around these data points.

Precise Neural Circuit Probe with Reversible Functionality

A neural circuit probe microscope attachment that uses atomic force microscope technology to apply tiny, precisely controlled forces to axons or axon bundles to interfere reversibly with neural transmission on a multielectrode array.

Ferrofluid Droplets to Locally Measure the Mechanics of Soft Materials

A technique and apparatus that can measure the mechanical properties of any kind of soft material, including complex fluids, living embryonic and adult tissues (such as skin), as well as tumors. 

High-Throughput Lensfree 3D Tracking of Human Sperms

UCLA researchers have developed a lensfree technique to track three-dimensional trajectories of individual human sperms.

System for Patterned Illumination Microscopy

Existing structured illumination microscopy can increase the resolution of an image by a factor of 2, however, it requires expensive optical or mechanical devices (e.g., spatial light modulators, digital micromirror devices, or piezo translation stages).  Also, the existing movable patterned mask generated by the light interference using SLM or DMD suffers from hysteresis and repeatability problems due to mechanical motion.  UC Berkeley researchers have developed a computational illumination hardware and software system that can achieve pattern-shift on the object plane without mechanically switching the patterns and therefore without movement of any component.  The lensless system can be easily implemented into existing microscopes without extra hardware can can be extremely fast and suitable for real-time imaging applications.     

System and Method for Electrical Conductivity and Permittivity Measurement of Droplets in Digital Microfluidics

Researchers at UCLA have developed a system for measuring the electrical conductivity and permittivity of microliter to nanoliter droplets. This technology enables the analysis of microscale samples and permits real-time, quantitative analyses of on-chip processes in digital microfluidic platforms.

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