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All Microwave Stabilization Of Chip-Scale Frequency Combs

UCLA researchers in the Department of Electrical Engineering have developed an optical frequency comb technology using small, cheap components for high precision time, frequency, distance, and energy measurements.

All microwave stabilization of chip-scale frequency combs for high precision measurements

UCLA researchers in the Department of Electrical Engineering have developed an optical frequency comb technology using small, cheap components for high precision time, frequency, distance, and energy measurements.

Micro-preconcentrators for Gas Sampling

Researchers at the University of California, Davis have developed a miniature and low power concentration device for trace gas samples.

New label-free method for direct RNase activity detection in biological samples

Researchers at the University of California, Davis have developed a new and simple, label-free method to detect milligram levels of RNase activity in undiluted biological samples that is selective, accurate and scalable

Synthesis Technique to Achieve High-Anisotropy FeNi

Researchers at the University of California, Davis have developed an innovative synthesis approach to achieve high anisotropy L1 FeNi by combining physical vapor deposition and a high speed rapid thermal annealing (RTA).

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Continuous, enhanced detection of droplet contents in electrical impedance spectroscopy

The inventors at UCI have developed a method and system to make enhanced electrical impedance spectroscopy measurements in a continuously flowing train of microfluidic droplets. The technique increases the sensitivity of the electrical impedance spectroscopy measurements, lowering detection limits and increasing the frequency of continuous measurements.

Patterning Silica Islands Onto Thermoplastic Shrink Film

Biosensors have a variety of applications from glucose monitoring to drug discovery. The ability to detect low concentration of analytes in biological samples is important for creating effective biosensors. Researchers at UCI have developed a novel lithographic method for capturing, concentrating, and identifying biological agents.

Porous Membrane Integration In A Microfluidic Device For Controllable Release And Reaction

UCLA researchers have developed a solid-state, microfluidic device for high precision dispensation of small volumes of fluid.

Highly Wrinkled Metal Thin Films Using Lift-Off Layers

Wearable electronics are becoming a popular way of integrating personal healthcare with continuous, remote health monitoring, yet current devices are bulky and exhibit poor electronic performance. Wrinkled metal thin films can be utilized for their thin, flexible profiles, which conform well to the skin. Researchers at UCI have developed a novel method using specialized materials that results in wrinkled metal thin films that have enhanced mechanical and electrical performance.

A non-destructive method of quantifying mRNA in a single living cell

The detection of levels of messenger RNA (mRNA), the molecule used by DNA to convey information about protein production, is a very important method in molecular biology. Current detection strategies, such as Northern Blotting and RT-PCR, require destruction of the cell to extract such information. Researchers at the University of California, Irvine have developed a method to non-destructively assess mRNA levels in a single living cell.

Engineered-Microparticle-Based Cell Carriers For Culture And Adhesive Flow Cytometry

The Di Carlo group at UCLA has invented a microparticle that enables the analysis of adherent cells by flow cytometry. In addition, they have developed a high-throughput method to fabricate these microparticles.

Apparatus and Method for 2D-based Optoelectronic Imaging

The use of electric fields for signaling and manipulation is widespread, mediating systems spanning the action potentials of neuron and cardiac cells to battery technologies and lab-on-a-chip devices. Current FET- and dye-based techniques to detect electric field effects are systematically difficult to scale, costly, or perturbative. Researchers at the University of California Berkeley have developed an optical detection platform, based on the unique optoelectronic properties of two-dimensional materials that permits high-resolution imaging of electric fields, voltage, acidity, strain and bioelectric action potentials across a wide field-of-view.

Supermaneuverable Autonomous Swimmer

The most commonly used Autonomous underwater vehicles (AUVs) have shapes and structures similar to submarines and winged torpedoes, and maneuver using their fins, wings, stabilizers, and through changing the direction of their thrust vector. Existing systems have some disadvantages: (i) drag forces and torques exerted on the thrusters significantly affect the efficiency of reorientation maneuvers, (ii) since thrusters are operational during reorientation maneuvers, a substantial amount of power is consumed to pump the bulk fluid, wasting the precious power storage of the vehicle, and (iii) the translational and attitude dynamics of model submarines and torpedo-like AUVs are highly coupled, and therefore, the vehicle cannot perform in-place attitude maneuvers.  Also, biomimetic swimmers with flapping wings or tails are not energy-efficient.   To address these problems, UC Berkeley resesarchers have developed a new swimmer with high maneuverability. The swimmer has no external fins, wings, or appendages for attitude control or stabilization, and does not generate excess flows while maneuvering. The swimmer has two counter-rotating propellers only for forward propulsion.  The novel AUV experiences the least form drag, and can make rapid in-place turns without turning off its propellers.  

An Optical System for Parallel Acquisition of Raman Spectra from a 2-Dimensional Laser Beam Array

Researchers at the University of California, Davis have developed a method for acquiring Raman spectra from a plurality of laser interrogation spots in a two-dimensional array. This method can be used for parallel analysis of individual cells or for fast chemical imaging of specimens.

Ferromagnetic Infused Microstructure Arrays For Cell Sorting And Method Of Their Fabrication

Researchers at the University of California, Irvine have invented a system for biological cell sorting using ferromagnetic infused microstructure arrays. The invented system is an adherent cell sorting platform with individually addressable growth substrates for specified cell release and collection using integrated magnetic structures. Some previous cell sorting methods have sacrificed the image clarity of the samples that they have sorted due to the process by which they sort cells. The invented micro array platform allows for the capture of individual components while also maintaining ideal imaging conditions.

Monoclonal Antibody Against Cer164 (Clone 11)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against ATR-IP (Clone 5)

Mouse monoclonal antibody against the human ATR-interacting protein (ATR-IP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against Cer164 (Clone 26)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against PNPase (Clone 4C11)

Mouse monoclonal antibody against the human mitochondrial polyribonucleotide nucleotidyltransferase 1 (PNPase). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against Pnpase (Clone 2A2)

Mouse monoclonal antibody against the human mitochondrial polyribonucleotide nucleotidyltransferase 1 (PNPase). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibodies Against Spc24/25 (Clone 2A10)

Mouse hybridoma cell line secret antibody against the human Kinetochore protein Spc24 (SPC24) and Kinetochore protein Spc25 (SPC25). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibodies Against Spc24/25 (Clone 2C8)

Mouse hybridoma cell line secret antibody against the human Kinetochore protein Spc24 (SPC24) and Kinetochore protein Spc25 (SPC25). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Adaptive optics with direct wavefront sensing for multi-photon microscope

Biological tissue are rarely transparent, presenting major challenges for deep tissue optical microscopy. With the advantages of high-resolution and viewing of live organisms, optical microscopy has become an important tool for biological research and continues to open new avenues in its capabilities. In recent years, image resolution and speed has been dramatically improved.  However the improvement of the resolution and penetration depth for optical microscopy is still in its infancy. As light passes through biological tissue, it can be absorbed, refracted and scattered, limiting the resolution and depth of optical imaging in biological tissues. Overcoming these challenges will benefit a wide range of applications from basic biological research to clinical investigations.

Microfluidic System for Particle Trapping and Separation

<p>Researchers have developed a novel system and method to rapidly separate particles from liquid. This technology demonstrates lab-on-a-chip potential for particle separation and/or purification. This technology is capable of processing a wide variety of molecules, ranging from cells to smaller biomolecules such as proteins and nucleic acid. Applications of this technology include (but are not limited) use of it for particle separation and quantification for assays, cell preparation, and cell lysing and component separation.</p>

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