A novel sensor device leveraging hydrogel and metallic structures for passive, wireless environmental monitoring.

An advanced geometric method for comprehensive 3D cardiac strain analysis, enhancing diagnosis and monitoring of myocardial diseases.

A novel device leveraging centrifugal microfluidics to accelerate bacterial growth and rapidly determine antibiotic susceptibility.

This technology enhances the sensitivity of sensors through exceptional points of degeneracy in various circuit configurations.

A revolutionary handheld force and load sensing device designed to measure and alert surgeons of critical force thresholds during surgical device deployment during flexible ureteroscopy, enhancing patient safety and surgical outcomes.

A novel circuit design promoting enhanced sensitivity for electromagnetic sensing through exceptional points of degeneracy.

An innovative technique for creating high-sensitivity Whispering Gallery Mode (WGM) sensors through advanced microbubble resonator fabrication.

A revolutionary approach to wearable sensors that significantly extends read-out distances and improves reliability without the need for microelectronics.

A novel diagnostic technology offering rapid, accurate, and inexpensive detection, genotyping, and quantification of viral RNA in patient-derived samples, enhancing public health capabilities.

Precise control of wound healing depends on physician’s evaluation, experience. Physicians provide conditions and time for body to either heal itself, or to accept and heal around direct transplantations, and their practice relies a lot on passive recovery. Slow healing of recalcitrant wounds is a known persistent problem, with incomplete healing, scarring, and abnormal tissue regeneration. 23% of military blast and burn wounds do not close, affecting a patient’s bone, skin, nerves. 64% of military trauma have abnormal bone growth into soft tissue. While newer static approaches have demonstrated enhanced growth of non-regenerative tissue, they do not adapt to the changing state of wound, thus resulting in limited efficacy.

X-radiation (X-ray) imaging is one of the most common imaging techniques in medicine. Presently, thin-film transistor flat panel detectors are the gold standard for X-ray detection; however, these detectors average across the absorbed X-ray spectrum and thus suffer from poor material decomposition and lesion differentiation. Modern efforts to address this focus on three methods of energy differentiation: dual-shot, photon counting, and dual-layer detectors. Dual-shot detection utilizes a single detector to image a patient with two shots of X-rays at low and high energies. While this has been shown to effectively differentiate between soft and hard tissues, (e.g., chest radiography) this results in a higher dose level to the patient and motion artifacts from slight movement between images. Photon counting detectors offer an alternative to multiple shots, providing high spatial resolution, low dose, and multiple energy binning with photon weighting. However, these detectors also require more complex circuit design for fast readout, have limited material options with great enough yield and detective quantum efficiency at low to mid energy ranges, and are limited in detective area. Dual-layer detectors that stack two detector layers to each process low and high energy X-rays remove motion artifacts by utilizing a single shot of polyenergetic X-rays. These most commonly employ two indirect detectors separated by a Cu filtering layer, which photon-starves the second higher energy detector. Unfortunately, this also requires a higher X-ray intensity, resulting in a higher dose level to the patient.

A groundbreaking non-pharmacological approach to controlling resistant hypertension through personalized, closed-loop neurostimulation.

In PET imaging, patient motion, such as respiratory and cardiac motion, are a major source of blurring and motion artifacts. Researchers at the University of California, Davis have developed a technology designed to enhance PET imaging resolution without the need for external devices by effectively mitigating these artifacts

This technology introduces a flexible, secure, and scalable approach to creating body area networks (BANs) using textile-integrated metamaterials for advanced healthcare monitoring.

Researchers at the University of California, Davis have developed method for separating quasi-periodic mixed-signals using a single data trace, enhancing wearable sensor applications.

An innovative air-based force sensor designed to enhance the safety and precision of surgical instrument insertions.

Sensors are used in a multitude of applications from molecular biology, chemicals detection to wireless communications. Researchers at the University of California Irvine have invented a new type of electronic circuit that utilizes exceptional points of degeneracy to improve the sensitivity of signal detection.

A revolutionary device for the diagnosis of cerebrospinal fluid (CSF) leaks with rapid, accurate, and low-volume sampling at the point of care.

This device offers a non-invasive solution for treating nasal airway obstructions, significantly improving recovery time and patient outcomes.

A novel method for predicting the effective lens position (ELP) in cataract surgery through pre-operative measurements of natural lens curvatures.

      Poorly designed healthcare environments can increase patient stress and delay recovery, particularly in pediatric settings (see, e.g., Devlin & Andrade 2017; Park et al. 2018; Jafarifiroozabadi et al. 2023). Traditional methods for gathering architectural design feedback, such as interviews, surveys, and focus groups, rely heavily on subjective user input, and often fail to capture the voices of children by relying on parent proxies. Physical mock-ups, a common alternative to traditional methods, provide a full-scale model of a room or space, often constructed from materials like cardboard or foam. While these mock-ups allow for some degree of spatial exploration, they are time-intensive, and limited in their ability to replicate real-world conditions; high-fidelity mock-ups which incorporate more realistic materials and finishes add expense and limit flexibility for testing multiple design iterations.       To overcome these challenges UC Berkeley researchers have developed an innovative participatory design methodology that leverages advanced virtual reality (VR), eye-tracking, and physiological/emotional biofeedback technologies to evaluate the design of pediatric healthcare environments. This comprehensive system is further enhanced by custom-developed workflows for creating dynamic, interactive room simulations that are randomized to ensure rigorous, unbiased data collection. The methodology is uniquely capable of gathering objective, quantifiable data on how pediatric patients and their families respond physiologically and emotionally to specific environmental design features.

Charge detection mass spectrometry (CDMS) measurements of individual ions using either Orbitrap or electrostatic ion trap-based instruments have heretofore been performed under ultra-high vacuum conditions (10-9 Torr or lower). The rationale for this expensive and often cumbersome requirement is that these measurements need to be performed in an environment where collisions with background gas do not adversely affect the measurements.  UC Berkeley researchers have developed systems and methods  that enable accurate CDMS mass measurements at pressures that are as high as 1 × 10−4 Torr, multiple orders of magnitude higher than previously demonstrated. Consistent, accurate masses were obtained for pentameric antibody complexes (~800 kDa), adeno-associated viruses (~4.8 MDa), and both ~50 and ~100 nm diameter polystyrene nanoparticles (~35 MDa and ~330 MDa, respectively) at pressures ranging from 1 × 10−8 Torr to 1 × 10−6 Torr. 

Precise control of wound healing depends on physician’s evaluation, experience. Physicians provide conditions and time for body to either heal itself, or to accept and heal around direct transplantations, and their practice relies a lot on passive recovery. Slow healing of recalcitrant wounds is a known persistent problem, with incomplete healing, scarring, and abnormal tissue regeneration. 23% of military blast and burn wounds do not close, affecting a patient’s bone, skin, nerves. 64% of military trauma have abnormal bone growth into soft tissue. While newer static approaches have demonstrated enhanced growth of non-regenerative tissue, they do not adapt to the changing state of wound, thus resulting in limited efficacy.

Precise control of wound healing depends on physician’s evaluation, experience. Physicians provide conditions and time for body to either heal itself, or to accept and heal around direct transplantations, and their practice relies a lot on passive recovery. Slow healing of recalcitrant wounds is a known persistent problem, with incomplete healing, scarring, and abnormal tissue regeneration. 23% of military blast and burn wounds do not close, affecting a patient’s bone, skin, nerves. 64% of military trauma have abnormal bone growth into soft tissue. While newer static approaches have demonstrated enhanced growth of non-regenerative tissue, they do not adapt to the changing state of wound, thus resulting in limited efficacy.

Researchers at the University of California, Davis have developed a technology involving statistically reconstructing positronium (or positron) lifetime imaging (PLI) for use with a positron emission tomography (PET) scanner, to produce images having resolutions better than can be obtained with existing time-of-flight (TOF) systems.