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Water-Soluble Iron-Porphyrin Complexes Capable Of Acting As Antidotes For Carbon Monoxide Poisoning

CO poisoning is the most common form of poisoning worldwide. In the United States alone, over 50,000 emergency department visits each year are attributed to CO exposure. Despite the prevalence of CO poisoning, there is no clinically-approved antidote available.Current best practices involve placing the afflicted subject in fresh air, delivering 100% O2, or administering superatmospheric levels of O2 in a hyperbaric chamber. These treatments all serve to clear CO from the body by displacing it from metalloproteins with O2. The typical half-life of COHb in the bloodstream is 5.3 h, but hyperbaric O2 (1.5-3 atm) can decrease this half-life to < 1 h.Unfortunately, these large chambers are generally located in tertiary care centers to which patients must be transported. Moreover, hospitals typically house only a few such chambers, which would be rapidly overwhelmed in the event of a mass exposure.Although there are no clinically approved antidotes to CO poisoning, two strategies have been described: the creation of molecules that enhance the rate of release of CO from carboxyhemoglobin (formed during CO poisoning) and the creation of molecules that bind CO more strongly than physiologically important proteins such as hemoglobin.  

System Of Epicardial Sensing And Pacing For Synchronizing A Whole Heart Assist Device

See patent publication no. US20210128000A1. A network of electrodes configured to sense and/or pace the heart, wherein the network of electrodes are in contact with an epicardial surface of the heart, within a wrapping sleeve that assist the heart as a whole, wherein the network of electrodes sense the heart by quantifying intrinsic electrical activities of the heart, and wherein the network of electrodes pace the heart by inducing an electrical impulse to the heart to control its contractile activities. The network may be interfaced with a controller system, wherein the controller uses spatial and temporal electrical activities of the heart muscles to generate electrical impulse to synchronize the wrapping sleeve around the heart with the heart. Also disclosed is a system configured to construct space-time mapping of cardiac electrical activities and/or propagation, and sensing effects of a first assist event of a prior beat and controlling a second assist event.

Vascular Anastomosis Device

Researchers at the University of California, Davis have developed a surgical device to facilitate vascular anastomosis procedures with enhanced ease and speed.

Integrin Binding to P-Selectin as a Treatment for Cancer and Inflammation

Researchers at the University of California, Davis have developed a potential drug target for cancer and inflammation by studying the binding of integrins to P-selectin.

Motor Drive Unit for Combined Optical Coherence Tomography and Fluorescence Lifetime Imaging of Intraluminal Structures

Researchers at the University of California, Davis have designed a motor drive unit that enables combined fluorescence lifetime imaging and optical coherence tomography of luminal structures.

Subcutaneous and Continuous Blood Pressure Monitoring by PMUTS

Hypertension is a major precursor to cardiovascular disease and death. Current blood pressure (“BP”) monitoring systems based on cuff devices are cumbersome without the capability of continuously observing the BP.  It is estimated that 45% of all strokes are attributed to uncontrolled hypertension and adequate control of BP carries the highest benefit in reducing stroke burden. The average cost of a stroke hospitalization in the US is $21,000 and the ongoing 5-year costs post stroke is upwards of another $30,000.  However, despite the great importance of BP monitoring and considerable medical cost spent in hypertension and related disease, there has not yet been a reliable system for monitoring BP continuously and comfortably.    UC Berkeley researchers have developed a subcutaneous continuous BP monitor system and devices based on PMUTs for the first time, which is promising to provide remote, silent and continuous monitoring solutions for the BP management.

Growth-Accomodating Transcatheter Pulmonary Valve System

UCI researchers have developed a novel transcatheter pulmonary valve (TPV) that addresses the current lack of options for children with progressive pulmonary valve regurgitation (PVR), which may lead to right ventricular (RV) dysfunction and failure. This TPV allows for implantation into patients of a younger age, preventing the progression of PVR and the RV issues that follow, and can also expand to accommodate the need for a larger pulmonary valve as the patient grows.

Minimally Invasive Percutaneous Delivery System for a Whole-Heart Assist Device

Researchers at UCI have developed a minimally invasive mechanism to help deliver and implant a cardiac assist device inside the body to help patients with heart failure.

DNN-Assisted Sensor for ECG Monitoring

Inventors at UCI have developed a method of monitoring ECG signals from wearable devices while using artificial intelligence to only select the signals that are relevant to disease for further evaluation.

A Gene Therapy for treating Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a predominantly genetic-based heart disease characterized by right but also recently left ventricular dysfunction, fibrofatty replacement of the myocardium leading to fatal/severe ventricular arrhythmias leading to sudden cardiac death in young people and athletes. ARVC is responsible for 10% of sudden cardiac deaths in people ≥65 years of age and 24% in people ≤30 years of age. ARVC is thought to be a rare disease as it occurs in 1 in 1000-5000 people, although the prevalence may be higher as some patients are undiagnosed or misdiagnosed due to poor diagnostic markers. Growing evidence also reveals earlier onset since pediatric populations ranging from infants to children in their teens are also particularly vulnerable to ARVC, highlighting the critical need to identify and treat patients at an earlier stage of the disease. At present there are no effective treatments for ARVC nor has there been any randomized clinical trials conducted to examine treatment modalities, screening regimens, or medications specific for ARVC. As a result, treatment strategies for ARVC patients are directed at symptomatic relief of electrophysiological defects, based on clinical expertise, results of retrospective registry-based studies, and the results of studies on model systems. The current standard of care is the use of anti-arrhythmic drugs (sotalol, amniodarone and beta-blockers) that transition into more invasive actions, which include implantable cardioverter defibrillators and cardiac catheter ablation, if the patient becomes unresponsive or intolerant to anti-arrhythmic therapies. However, current therapeutic modalities have limited effectiveness in managing the disease, 40% of ARVC patients (a young heart disease) die within 10-11 years after initial diagnosis, highlighting the need for development of more effective therapies for patients with ARVC.

Percutaneous Heart Valve Delivery System Enabling Implanted Prosthetic Valve Fracture

UCI researchers developed a percutaneous heart valve delivery system to deliver and implant a prosthetic valve. This system incorporates the means to fracture a previously implanted prosthetic valve in situ without interfering with the transcatheter valve to be implanted.

Cardiac Energy Harvesting Device And Methods Of Use

This technology involves a medical device implanted in the heart’s ventricle that recharges leadless pacemakers. This device contains magnets and inductive coils whose motion is coupled to the contractions of the ventricles in order to create electricity.

Single Catheter System Combining Intravascular Ultrasound and Fiber-Based Fluorescence Lifetime Imaging

Researchers at the University of California, Davis have developed a catheter device that combines intravascular ultrasound with fluorescence lifetime imaging to better detect significant vascular conditions.

Delivery System For Transcatheter Valves

Researchers at UCI have developed a novel medical device for use in transcatheter heart valve replacement surgeries. The device provides physicians with more careful control of the catheter insertion, minimizing complications and adverse effects.

Esophageal Deflection Device

Cardiac ablations are common medical treatments for people with atrial fibrillation (Afib). During the ablation procedure, a cardiac electrophysiologist will thermally ablate, or burn off, defective heart tissue with radiofrequency or cryoablation technology. The esophagus is often in close proximity to the left atrium. Since the left atrial tissue is approximately 2mm thin, the heat can transfer through it to the esophagus in contact and cause thermal damage / lesions on the esophagus.  In worst-case rare scenarios, an atrio-esophageal fistula, or hole between the esophagus and the heart, can occur which has a ~75% mortality rate.  It would be ideal to move the esophagus away from the heart before or during the ablation procedure preventing thermal damage.

Polarization-Sensitive Optical Coherence Tomography Using a Polarization-Insensitive Detector

A polarization-sensitive optical coherence tomography (PS-OCT) is a common approach to non-invasively imaging in biomedical applications. The inventors have come up with a new way of creating a PS-OCT that is cheaper and simpler.

Low-Dose Ct Perfusion Technique

Coronary atherosclerosis (a thickening of the arterial wall) is correlated to the occurrence of cardiac events; therefore, its correct and early diagnosis is paramount in the prevention and treatment of coronary artery disease. Researchers at UCI have developed an innovative method for assesses coronary artery stenosis and microvascular disease that is both accurate and non-invasive.

Early Detection Of Diabetic And Decubitus Ulcers

Pressure ulcers and diabetic foot ulcers are a pervasive and expensive health care challenge. They are debilitating and can significantly impair quality of life, as they are associated with loss of pain sensation and disordered circulation. The gold standard to preventing pressure ulcers include regular patient  turning/repositioning. However, there are relatively few tools for molecular-level insight into when to reposition and who to reposition.

A Thin Film Nitinol Neurovascular Covered Stent For Small Vessel Aneurysms

UCLA researchers in the Department of Pediatrics have developed a thin and flexible stent that can be implanted in small vessels in the neurovascular system. Normal 0 false false false EN-US ZH-CN X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

Oxime Crosslinked Hydrogels To Prevent Postsurgical Cardiac Adhesions

Although a wide variety of hydrogels have been developed for a multitude of uses, various functional characteristics have been hard to capture in a controllable manner. A significant feature is the ability to ‘tune’ the gel so its gelling time can be controlled in a manner suitable to its application. In this disclosure, because the gel is both tunable and its composition allows it to bond to tissue, the inventors believe it can be used to address an unmet medical need – the formation of adhesions after cardiac surgery. Current methods used are either drug therapy or various physical barriers but their success is limited.

Zinc Nanocomposites And Stents For Functional Applications

UCLA researchers in the Department of Mechanical Engineering have developed a method to manufacture zinc-based metal matrix nanocomposites (MMNCs) for functional applications, such as stents.

Method for Synchronizing a Pulsatile Cardiac Assist Device with the Heart

Patients with severe heart failure can require both a cardiac pacemaker to help the timing of the heart and a ventricular assist device (VAD) to physically help pump blood. UCI researchers have developed a method to synchronize the actions of a pulsatile VAD with a pacemaker in order to reduce heart stress and improve treatment effectiveness.

Drug Repurposing for Treatment of Fatty Liver Disease and Diabetes

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat is stored in the liver, though not caused by heavy alcohol use. NAFLD is one of the most common causes of liver disease in the United States. NAFLD it typically asymptomatic but when NAFLD advances, it can result in the development of NASH (Nonalcoholic steatohepatitis) where inflammation and fibrosis are widespread in the liver, resulting in nonalcoholic steatohepatitis and liver cirrhosis. Mechanisms of NAFLD progression are poorly understood. Experts estimate that about 20% of people with NAFLD have NASH. Between 30% and 40% of adults in the United States have NAFLD. About 3% to 12% of adults in the United States have NASH. There are no existing FDA‐approved therapies for nonalcoholic fatty liver disease (NAFLD). NAFLD it typically asymptomatic but it can progress to nonalcoholic steatohepatitis and liver cirrhosis. Mechanisms of NAFLD progression are poorly understood. There are many FDA‐approved therapies for type 2 diabetes, including metformin, insulin, sulfonylureas, Glp‐1 receptor agonists, Dpp‐4 inhibitors, and Sglt2 inhibitors. These drugs work through diverse mechanisms such as increasing insulin secretion (sulfonylureas, Glp‐1 receptor agonists, Dpp‐4 inhibitors), direct insulin replacement (insulin), reducing glucose production by the liver (metformin), and stimulating excretion of glucose into urine (Sglt2 inhibitors).

Novel Mixtures For Synergistic Activation Of M-Channels

Epilepsy is a seizure causing neurological disorder that affects over 50 million people, and it is estimated that half are ineffectively treated with current therapeutic options. Researchers at UCI have isolated components of a plant extract used to treat epilepsy in Africa and discovered that, when combined with an existing epilepsy medication, the mixture greatly decreases epileptic episodes and significantly increases survival rates in rodent models of epilepsy.

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