Prof. Changcheng Zhou and colleagues from the University of California, Riverside (UCR) have developed an antisense oligonucleotide to knockdown tsRNA-Glu-CTC, which is an abundant tsRNA in the liver and a critical regulator of cholesterol homeostasis. This specific tsRNA is cholesterol responsive and interacts with the master lipid regulator SREBP2. In vivo studies in mice demonstrated that the treatment reduces hypercholesterolemia and hepatic steatosis (fatty liver) in mice fed a high-cholesterol diet. This treatment is advantageous because it may open new therapeutic avenues for cardiometabolic conditions and liver disease.  

A novel high-affinity peptide selectively inhibits the human Kv1.5 channel to safely treat and prevent atrial fibrillation by targeting atrial electrophysiology.

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Researchers at the University of California, Davis have developed a computer-implemented method for accurately classifying congenital heart defects in newborns using pulse oximetry and machine learning.

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A mechanically adaptive hydrogel that changes color in response to force exerted by living cells, enabling force sensing through optical signals.

Researchers at the University of California, Davis have demonstrated that THR-β agonists such as resmetirom, when repurposed, can effectively treat heart failure with preserved ejection fraction (HFpEF), addressing unmet clinical needs.

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This invention introduces a groundbreaking Foundation Model that achieves expert-level accuracy in ECG diagnostics across 68 conditions, leveraging deep learning to overcome the need for extensive labeled data and enabling advanced predictions in data-scarce environments.

An advanced AI-driven system for synthetic medical data generation and precise segmentation of cardiac MRI to enhance accuracy and efficiency in cardiovascular health.

A real-time, ultrasound-based imaging modality that improves intracardiac irreversible electroporation accuracy by visualizing electric field distribution during cardiac ablation.

This invention introduces a novel approach to cardiac tissue stimulation and maturation through the use of photoactive organic and biological material blends.

An advanced geometric method for comprehensive 3D cardiac strain analysis, enhancing diagnosis and monitoring of myocardial diseases.

Stability issues in membrane-free coacervates have been addressed with coating strategies, but these approaches often compromise the permeability of the coacervate. Researchers from UC San Diego have invented a facile approach to maintain both stability and permeability using tannic acid and then demonstrate the value of this approach in enzyme-triggered drug release. First, the researchers developed size-tunable coacervates via self-assembly of heparin glycosaminoglycan with tyrosine and arginine-based peptides. A thrombin-recognition site within the peptide building block results in heparin release upon thrombin proteolysis. Notably, polyphenols are integrated within the nano-coacervates to improve stability in biofluids. Phenolic crosslinking at the liquid-liquid interface enables nano-coacervates to maintain exceptional structural integrity across various environments. The UCSD scientists discovered a pivotal polyphenol threshold for preserving enzymatic activity alongside enhanced stability. The disassembly rate of the nano-coacervates increases as a function of thrombin activity, thus preventing a coagulation cascade. This polyphenol-based approach not only improves stability but also opens the way for applications in biomedicine, protease sensing, and bio-responsive drug delivery. 

A groundbreaking non-pharmacological approach to controlling resistant hypertension through personalized, closed-loop neurostimulation.

SUMO inhibitors offer a promising new therapy for protecting against cardiac rhythm disturbances and pump failure associated with heart attacks.

Researchers at the University of California, Davis and Cardiac Motion LLC have collaborated to develop a method for monitoring heart failure using contact Doppler radar.

Researchers at the University of California, Davis, have developed a device to monitor the heart using radiofrequency signals to improve the detection and diagnosis of various cardiovascular conditions. The device can integrate with existing mobile products, which is particularly helpful for older adults and those with limited access to adequate medical facilities.

Researchers at UC Irvine have developed a novel biomaterial to heal and regenerate tissues for chronic wounds. The biomaterial, referred to as GelMA-AN, has immunomodulating properties engineered for complete incorporation into injured tissue while enhancing the regenerative healing activities of immune and stromal cells. It is based on a gelatin scaffold supplemented with Methacrylic Anhydride and immunomodulating apoptotic neutrophil cells. All components have high biocompatibility due to structural and biochemical similarities to the host wound environment. This combination of the hydrogel scaffold and apoptotic neutrophils has uncovered a wound healing mechanism that acts through immunomodulation to enhance regenerative healing. The mechanism works by modulating immune cells to drive them from inflammatory to healing activities that in turn stimulate stromal cells to repair the skin and regenerate health skin appendages such as vasculature.

Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. Every year, more that 14 million people are affected by stroke, and over 6 million stroke patients die from this condition and associated complications. 2-(2,3,5-trisubstituted phenyl)oxazole compounds potently inhibit 12/15-LOX. Hence, the compounds of this disclosure are advantageously useful to treat or prevent various disorders where 12/15-LOX is implicated in the pathology of the disorder (e.g.,stroke). 

Human Platelet-type 12-(S)-lipoxygenase (12-LOX) is a non-heme iron-containing oxygenase that catalyzes the regio- and stereo-specific addition of molecular oxygen to polyunsaturated fatty acids (PUFA). 12-LOX belongs to a family of enzymes that also include 5- LOX and 15-LOX, which oxygenate arachidonic acid (AA) at their corresponding carbon positions. The hydroperoxyeicosatetraenoic acid (HPETE) product is subsequently reduced by cellular peroxidases to form the hydroxyeicosatetraenoic acid (HETE), which in the case of 12- LOX is 12-(S)-HETE.Although 12-LOX expression is predominantly restricted to platelets (~14,000 molecules per platelet), it is also expressed in some hematopoietic and solid tumors. To date, 12-LOX is the only LOX isoform identified to be present in platelets, and its activity is part of a number of platelet functions, including granule secretion, platelet aggregation, and normal adhesion through specific agonist-mediated pathways, such as collagen and the thrombin receptor, PAR4. Normal platelet activation plays a central role in the regulation of hemostasis, but uncontrolled activation can lead to pathologic thrombotic events, such as ischemic coronary heart disease.

The invention pertains to a prosthetic valve featuring a saddle-shaped annulus that synchronously transforms between concave and convex configurations, facilitating seamless opening and closure synchronized with cardiac cycles. Comprising leaflets and support elements, the valve mimics natural heart valve function, enabling effective blood flow regulation and offering versatile deployment options for cardiac and vascular applications.

This technology describes a prosthetic heart valve system designed to accommodate the growth of children.