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The Use of Voltammetry Based Assessment of Neurotransmitters and Metabolites in Vivo

UCLA researchers in the Departments of Medicine, Radiology and Bioengineering have developed novel methods for monitoring cardiac autonomic function in vascular and tissue compartments by measuring neurotransmitters and metabolites in vivo.

Vagal Suppression Of Neurally-Induced Atrial Fibrillation

UCLA researchers in the Department of Cardiology have identified a novel mechanism for controlling atrial fibrillation via neuromodulation.

Vessel Cross-Sectional Area Measurements Using CT Angiography

A new approach to visualizing small and stenotic vasculature not readily visible with modern day diagnostic computed tomography angiography.

Single Ended Draw Lines For Medical Device Application

Minimizing the movement of deployed transcatheter heart valves and stents during detachment using single ended draw lines.

Ultrasound-Guided Delivery System For Accurate Positioning - Repositioning Of Transcatheter Heart Valves

Utilizing intravascular ultrasound for accurate placement of transcatheter heart valves to improve surgical outcomes.

Novel Nanoliposomal Nitroglycerin Formulation for Cardiovascular Therapies

    To address this major limitation, investigators at UCR have developed a nanoliposomal formulation of NTG, which achieves a 70-fold increase in the anti-inflammatory effect of NTG when compared to NTG. This increase in potency allows lower doses to be effective, which could mitigate the common issues seen with high clinical doses of NTG viz. loss of NTG sensitivity and endothelial toxicity. Fig. 1 Adhesion of U937 monocytes to NO-deficient (L-NIO-treated) ECs is significantly blocked by treating ECs with 5 ug/ml nanoliposomal nitroglycerin (NTG-NL). L-NIO is a selective eNOS inhibitor.  Remarkably, this anti-inflammatory dose of NTG in nanoliposomes is 70-fold lower than the dose of free NTG (5uM) required to achieve a similar effect

Automated Reconstruction Of The Cardiac Chambers From MRI

This is a fast, fully automated method to accurately model a patient’s left heart ventricle via machine learning algorithms.

A Method to Protect the Esophagus and Other Mediastinal Structures During Cardiac and Thoracic Interventions

UCLA researchers in the Division of Cardiology at the Geffen School of Medicine have developed a novel device that provides protection of esophagus and other surrounding mediastinal structures when the pericardial space is accessed by interventional catheters/probes.

A Novel Method and Apparatus to Access the Left Heart for Cardiac Interventions

UCLA researchers in the Division of Cardiology at the Geffen School of Medicine have developed novel devices and methods for allowing entirely intravascular access to the left ventricle, thereby precluding access via the apex of the heart percutaneously or by surgery.

Injectable Novel Therapeutic for Post-Myocardial Infarction Repair

Cardiovascular disease manifested as a myocardial infarction (MI) usually results in the irreversible death of heart muscle cells. While medical treatments can mitigate some symptoms, they often fail to prevent heart failure after a MI. The current standard of care for MI relies on surgical intervention via a coronary artery bypass. An alternative therapeutic approach has been taken in the last few years with the introduction of biomaterials designed to promote neovascularization after an MI and help prevent negative left ventricle remodeling by increasing infarct wall thickness and decreasing volume, fibrosis, and infarct size. 

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.

Monoclonal Antibodies to Oxidation-Specific Epitopes

The leading cause of death worldwide is cardiovascular disease, primarily atherosclerosis, which is recognized as a chronic inflammatory disease. This inflammation occurs within the arterial wall and is initiated in part by the oxidation of low-density lipoproteins (OxLDL), which in turn can stimulate both innate and adaptive immune responses. In cellular process of the oxidation of LDL, a number of oxidation-specific neo-epitopes are formed. One such product is malondialdehyde (MDA), produced by degradation by reactive oxygen species, which can further react with acetaldehyde and endogenous proteins, forming malondialdehyde-acetaldehyde (MAA) adducts. These MAA adducts are immunogenic and have proinflammatory properties. Furthermore, circulating levels of antibodies against MAA adducts have been shown to correlate with atherosclerotic disease and be involved in other diseases, such as liver and neurological diseases.

Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

Improved Free Fractional Flow Reserve (FFR) Measurement for Coronary Heart Disease Diagnosis

A free fractional flow reserve (FFR) measurement is a powerful tool for physicians to diagnose coronary heart disease. Adenosine or a related vasodilator agent is needed to prepare the patient for the procedure. Unfortunately, in addition to the cost, adenosine can cause debilitating side effects. The UCI inventors have developed a safer, less-expensive method of performing FFR.

Breast Lesion Characterization Using Contrast Mammography

Breast cancer is the most common cancer in women in the U.S. As with any cancer, early detection and treatment is critical in minimizing the severity of the tumor and risk of death. Researchers at UCI School of Medicine have developed a novel contrast-enhanced mammography technique capable of distinguishing between benign and malignant lesions in breast tissue.

Estimation Of Contrast Concentration From Angiograms In Presence Of Vessel Overlap

UCLA researchers have developed an image processing technique for quantitative measurement of brain hemodynamics using x-ray digital subtraction angiography (DSA) images. 

Non-Invasive Method For Determination Of Tissue Electrical Conductivity

UCLA researchers in the UCLA Semel Institutes of Neuroscience and Behavior have developed a non-invasive method to locate and estimate electrical currents in organs such as the brain and heart.

Small Molecule Inhibitors of Cardiovascular and Renal Ectopic Calcification

UCLA researchers in the Department of Medicine have discovered that administration of small molecule inhibitors of ENPP1 or functional antagonists of PPi can substantially attenuate ectopic calcification. This suggests that ENPP1 and PPi can be potential pharmacological targets when developing therapeutics for pathological ectopic calcification.

Microchambers With Solid-State Phosphorescent Sensor For Measuring Single Mitochondrial Respiration

The invention is a miniaturized device that assays the respiration of a single mitochondrion. Through a novel approach for measuring oxygen consumption rate, the device provides information on cell and tissue mitochondrial functional. This data is relevant for understanding human conditions associated with mitochondrial dysfunction, such as Alzheimer’s Disease and cancer.

A Novel Method to Generate Specific and Permanent Macromolecular Covalent Inhibitors

UCSF researchers have invented a novel method to generate covalent macromolecular inhibitors. This strategy allows a peptide inhibitor to bind to its target protein specifically and irreversibly through proximity-enabled bioreactivity.

Hybridoma Producing Antibodies To C1qRp

Individuals with genetic immunodeficiency, as well as patients with HIV, cancer, and those undergoing chemotherapy or high risk surgery, are at increased risk for infection. C1q, an important component of the immune system, is known to enhance phagocytosis (cell ingestion of harmful bacteria or other materials). Scientists at UCI have developed antibodies to the receptor for C1q, C1qRp, to be used as a target for prophylactic treatments in populations at high risk of infection.

An Endogenous Anti-angiogenic Protein (EAP) and its Derivatives for Treatment of Cerebral Cavernous Malformations (CCM)

Cerebral cavernous malformation (CCM) is a neurovascular disease that causes epilepsy and stroke for which there is no medical therapy. It has a prevalence of 5 per thousand in western populations and occurs in familial forms as a consequence of mutations in 3 CCM genes: CCM1/KRIT1, CCM2, CCM3/PCDC10 resulting in the formation of CCMs; mutations in the CCM1/KRIT1 gene account for 40% of the inherited cases. Once identified, CCM patients have a lifetime risk of CCM development and progression with increasing risk of stroke, epilepsy, or neurological impairment. 

Culturing More Mature iPSC-derived Cardiac Myocytes

Researchers at the University of California, Davis have developed a non-genetic, non-pharmacological method for culturing more mature induced pluripotent stem cell-derived cardiac myocytes.

Omnidirectional MRI Catheter Resonator for Interventional Procedures

This invention describes an orientation-independent device that can create bright and highly localized signal enhancement during magnetic resonance imaging.

A Method Of Computational Image Analysis For Predicting Tissue Infarction After Acute Ischemic Stroke

UCLA researchers in the Departments of Radiological Sciences and Neurology have designed an algorithm to predict tissue infarctions using pre-therapy magnetic resonance (MR) perfusion-weighted images (pre-PWIs) acquired from patients with acute ischemic stroke. The predictions generated by the algorithm provide information that may assist in physicians’ treatment decisions.

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