Suppressing Cardiac Arrhythmia And Pump Dysfunction With Ischemia/Reperfusion And Failure

Brief Description

SUMO inhibitors offer a promising new therapy for protecting against cardiac rhythm disturbances and pump failure associated with heart attacks.

Full Description

Researchers at the University of California, Irvine have developed a technology involving SUMO inhibitors to prevent the abnormal opening of heart sodium channels during hypoxia, a condition leading to angina and heart attacks. The inhibitors work by blocking the attachment of SUMO proteins to the sodium channels, a process that is crucial for the development of late sodium current, which is implicated in cardiac dysfunction during heart attacks.

Suggested uses

• Pharmaceuticals for heart disease treatment. ·
• Preventive treatments for individuals at high risk of heart attacks.
• Therapeutic agents for managing angina and heart failure.

Advantages

• Prevents abnormal late sodium current in heart muscle cells. 
• Protects against cardiac rhythm disturbances. 
• Prevents pump failure during heart attacks. 
• Effective in both in vitro and mouse model studies. 
• Potential for human application to treat angina, heart attacks, and heart failure.

Patent Status

Patent Pending

State Of Development

In vitro and mouse model studies