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Portable waterborne pathogen detector

The inventors at the University of California, Irvine, have developed an automated, easy-to-use digital PCR system that can be used at the time of sample collection, making it highly effective in microbial pathogen analysis in resource-limited settings and extreme conditions.

Automated Noninvasive Periodontal Depth Measurement Using Photoacoustic Imaging

Many people are familiar with the pocket depth measurements that occur in the dentist’s office. The dental technician pokes her periodontal probe into a patient’s gum line to measure how deep the probe will go. This is repeated tooth by tooth until the entire mouth is covered. Although inexpensive, probing depth measurements are error prone and suffer from poor reproducibility, largely due to variation in probing force. Indeed, a recent meta-analysis showed that a range of a variation of 20-fold. Other error sources include variation in the insertion point, probe angulation, the patient’s overall gingival health, and the presence of calculus. Thus, the examination is subject to large errors with inter-operator variation as high as 40%. These error sources can result in poor patient treatment and, hence, poor patient outcomes. This variation also compromises epidemiologic studies and makes it difficult to compare outcomes among dentists or among populations. Given these limitations, new tools are urgently needed to improve this procedure.

EpiSort: A Novel Method Using Deep Bisulfite Sequencing to Determine Immune Cell Types in Solid Tissue Samples

EpiSort is a novel method of using DNA methylation patterns to determine the proportion of immune cell populations in solid tissue samples.

An Electro-Optical System with a Computation Model for Scanning Human Body

The invention describes an Electro-Optical instrument and a computational model for functional scanning of human body and recovering its chromophores (water, lipid, oxygenated hemoglobin, and deoxygenated hemoglobin). It is a low cost portable system that integrates frequency domain and continuous wave domain for real time spectroscopic imaging of human tissue.

Active Nanoplatform with High Drug Loading Capacity for the Diagnosis and Treatment of Cancer

Researchers at the University of California, Davis have developed an active nanoplatform (F/HAPIN) for cancer diagnosis and therapy.

Deep Learning Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a novel microscopy analysis that improves resolution, field-of-view and depth-of-field in optical microscopy images.

Structurally Validated Anti-avß8 Antibodies for Targeting TGFß for Immunotherapy

This invention provides highly efficient antibodies whose epitopes and mechanism of action have been structurally defined against integrin αvβ8. These antibodies have been designed to be used as therapeutic for cancer. Other antibodies have been designed as companion diagnostic tools.

Nell-1 Regulates Neurogenesis And Nervous System Function

UCLA researchers in the Division of Plastic and Reconstructive Surgery at the Geffen School of Medicine and researchers at the School of Dentistry have identified neural EGFL Like 1 (Nell-1) protein as an essential molecule involved in neurogenic development and nervous system functional regulation.

The Use of Voltammetry Based Assessment of Neurotransmitters and Metabolites in Vivo

UCLA researchers in the Departments of Medicine, Radiology and Bioengineering have developed novel methods for monitoring cardiac autonomic function in vascular and tissue compartments by measuring neurotransmitters and metabolites in vivo.

METHOD FOR DETECTING AND TREATING NASAL AND LUNG DYSBIOSIS PATIENTS WITH MICROORGANISMS

This invention uses sequencing of microbiota community for diagnosis and treatment of lung and nasal dysbiosis.

Predicting, Diagnosing, And Treating Nausea And Vomiting Of Pregnancy And/Or Pregnancy Loss

UCLA researchers have identified genes associated with nausea and vomiting of pregnancy (NVP), which can be used to predict, diagnose and treat NVP and pregnancy loss.

A New Approach For Assessment Of Blood Coagulation

OCE (Optical Coherence Elastography) and ARF (Acoustic Radiation Force) for blood coagulation assessment. Diagnostic tool for assessing the clot formation/dissolution kinetics and strength.

High-Efficiency One-Cell-One-Bead Encapsulation In Droplets

A high-efficiency single-cell droplet encapsulation method to improve single cell pharmacological assay throughput.

Vessel Cross-Sectional Area Measurements Using CT Angiography

A new approach to visualizing small and stenotic vasculature not readily visible with modern day diagnostic computed tomography angiography.

Ultrasound-Guided Delivery System For Accurate Positioning - Repositioning Of Transcatheter Heart Valves

Utilizing intravascular ultrasound for accurate placement of transcatheter heart valves to improve surgical outcomes.

Automated Reconstruction Of The Cardiac Chambers From MRI

This is a fast, fully automated method to accurately model a patient’s left heart ventricle via machine learning algorithms.

Hand Held Aerosol (HFA) Detector

The inventors have developed various devices, including in one embodiment, an inexpensive hand held device that can measure a wide range of HFA-134a levels in human breath. The present invention is also directed to a kit for detection of one or more halogenated organic compounds. The kit is useful for practicing the inventive method of measuring asthma inhaler compliance, for example.

Portable Breath Sampler for Diagnostic Testing

Researchers at the University of California, Davis have developed a portable, human exhaled breath sample collector for use in breath tests.

Endoscopic, Laparoscopic, Robotic And Minimally Invasive Force Sensor And Monitoring System

Minimally invasive ureteroscopy is a common procedure in adults, with over 10,000 procedures conducted annually in California alone. The ureteral access sheath (“UAS”), a highly effective device used to facilitate minimally invasive ureteroscopy, can injure the patient when excessive force is used during its placement. Inventors at UCI have developed a minimally invasive force sensor and monitoring system that measures force during UAS placement and can preclude injury by alerting the physician when the threshold for injury is being approached. It thus can be used for medical personnel safety training, quality control and standardization of minimally invasive ureteroscopy, as well as being applied to the passage of other catheters into natural orifices or channels./

Handled Blood-Flow Imaging Device

The invention is a medical handheld device that carries out skin visual inspection simultaneously with blood flow measurements through integrating a Laser Speckle Imaging (LSI) system within a handheld compact dermoscope. Combining both features in one compact, cheap and easy to use device will generate accurate and elaborative functional data that will improve the accuracy and detection of diseases such as cancer.

Biomarkers In Friedreich's Ataxia

UCLA researchers in the Department of Neurology have identified multiple biomarkers for Friedreich's Ataxia.

Monoclonal Antibodies to Oxidation-Specific Epitopes

The leading cause of death worldwide is cardiovascular disease, primarily atherosclerosis, which is recognized as a chronic inflammatory disease. This inflammation occurs within the arterial wall and is initiated in part by the oxidation of low-density lipoproteins (OxLDL), which in turn can stimulate both innate and adaptive immune responses. In cellular process of the oxidation of LDL, a number of oxidation-specific neo-epitopes are formed. One such product is malondialdehyde (MDA), produced by degradation by reactive oxygen species, which can further react with acetaldehyde and endogenous proteins, forming malondialdehyde-acetaldehyde (MAA) adducts. These MAA adducts are immunogenic and have proinflammatory properties. Furthermore, circulating levels of antibodies against MAA adducts have been shown to correlate with atherosclerotic disease and be involved in other diseases, such as liver and neurological diseases.

A Prognostic And Diagnostic Algorithm For Various Molecular Subtypes Of Breast Cancers, Including Her2 Positive And Triple Negative Breast Cancers (TNBCs)

Breast cancer is second leading cause of death among women in the United States in 2016 and It is estimated to be responsible for over 40,000 deaths in 2017 (ACS). The use of biomarkers plays a key role in the management of patients with breast cancer, especially in the decision process to select the appropriate systemic therapy to be administered. Furthermore, the discovery of new tissue-based and gene biomarkers has led to the development of a “molecular signature” for predicting patient outcome and treatment modalities. There are three subtypes of breast cancer that are determined by performing specific tests on a sample of the tumor. The first subtype is a tumor that is positive/negative for a hormone receptor, either estrogen (ER) and/or progesterone (PR); tumors without these receptors are classified “hormone receptor-negative”. The second subtype is characterized by the overexpression the human epidermal growth factor receptor 2 (HER2) protein on the tumor.  HER2 proteins are receptors on normal breast cells and help control the growth, but when overexpressed make the tumor grow faster and are designated HER2-positive tumors. The last subtype is designated triple-negative, since it does not express ER, PR, and/or HER2. 

System and Method for High Density Assembly and Packaging of Micro-Reactors

High density micro-reactors are fabricated to form an array of wells into a surface for use in high throughput microfluidic applications in biology and chemistry. Researchers at the University of California, Irvine developed a method for increasing micro-reactor densities per unit area using rapidly self-assembled three-dimensional crystalline formation droplet arrays, and a device for performing the same.

Test for Intestinal Permeability

Researchers from the Department of General Surgery at UCLA have developed an easy-to-use method to determine intestinal permeability that utilizes an FDA-approved non-absorbable dye.

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