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Kelch Like Family Member 11 (Klhl11) Autoantibodies As Markers Of Seminoma Associated Paraneoplastic Encephalitis In Men

Researchers at UCSF and Chan Zuckerberg Biohub have discovered a novel biomarker for an autoimmune disease that affects patients with testicular cancer.  The disease, known as “testicular cancer-associated paraneoplastic encephalitis,” can cause severe neurological symptoms.  The symptoms include loss of limb control, eye movement, and in some cases, speech.  The disease begins with testicular cancer, which in some cases causes the immune system to attack the brain.  Affected patients are often misdiagnosed and appropriate treatment is delayed. 

Reacting Molecules and Colloids Electrophoretically

Researchers in UCLA's Department of Chemistry and Biochemistry have harnessed gel electrophoresis in order to direct and program controlled collisional reactions between pulse-like bands of molecules and/or colloidal reagent species.

A Wearable Platform for In-Situ Analysis of Hormones

UCLA researchers in the Department of Electrical and Computer Engineering have developed a highly sensitive, wearable hormone monitoring platform.

Urine Metabolomics For Identification Of Novel Biomarkers For Transplant Injury

This invention discloses a method for the non-invasive detection of renal allograft injuries–acute rejection, BK virus, and/or chronic allograft nephropathy–via a panel of novel biomarkers. 

Techniques for Improving Positron Emission Tomography Image Quality and Tracking Real-Time Biological Processes

Researchers at the University of California, Davis have developed methodologies that perform dynamic PET imaging and provide opportunities for tracing blood flow and other biological systems in real-time.

Stamping-based Method for Microwell Production and Cell Aggregate Formation

Researchers at the University of California, Davis have developed a 3-D printed stamping system (the “Aggrestamp”) with the capability for in-situ production of microwells that facilitate cell aggregate formation.

A Novel Device for the Measurement of the Strength of the Orbicularis Oculi Muscle

UCLA researchers in the Department of Ophthalmology have developed a novel device that measures the strength of the orbicularis oculi muscle.

Identification Of Pan-Cancer Small Cell Neuroendocrine Phenotypes And Vulnerabilities

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a classifier for the identification and treatment of small cell neuroendocrine cancers and small-round-blue cell tumors not previously identified.

Systems and Methods for Monodisperse Drop Generation and Use

UCLA researchers in the Department of Bioengineering have developed systems and methods to produce single particle, monodisperse droplets for use in digital assays, targeted drug delivery, and theranostics.

A Microfluidic Single-Cell Pairing Array for Studying Cell-Cell Interaction in Isolated Compartments

Cell interactions are fundamental to biological processes. Microfluidics provides a reliable platform to study these intricate phenomena. The researchers have developed a microfluidic trapping array which efficiently pairs single cells in isolated compartments in an easy to operate manner to study cell-cell interaction, especially at single-cell level.

cBCI: Method and System for Diagnosing and Training Cognitive Fitness and Targeted Neural Network Function Underlying Cognitive Fitness in an Integrated Digital Approach

The inventors have created a brain computer interface (BCI) that serves as a diagnostic and training tool of cognitive abilities and neural network function.

NOVEL ANTIBODIES AGAINST EPHA2 FOR RESEARCH, DIAGNOSIS, AND TREATMENT OF CANCER

A novel monoclonal human antibody specific to the cell-surface exposed protein EphA2, which is over-expressed in many forms of cancer and is a validated therapeutic target.

Low-Intrusion Plasma Probe

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an inexpensive and easily implemented plasma diagnostic tool, the Low-Intrusion Probe.

Continuous, Quantitative, Selective, Non-Enzymatic Glucose Monitoring Using Conductimetric Analysis

A new molecule that enables glucose monitoring using measurements of solution conductivity. 

Novel Biomarker For GI Diseases

UCLA researchers at the David Geffen School of Medicine have discovered a small antimicrobial peptide elafin to be used as a biomarker for evaluating inflammatory bowel disease activity and the development of intestinal fibrosis.

Chip-Based Detection Of Diabetes Related Biomarkers

A major goal in disease screening, diagnosis, and control has been to develop bioassay platforms capable of simultaneous measurements of different analytes in a single assay. Significant advances toward multiplexed biomarker detection chips based on either immunoassays or enzymatic bioassays have thus been reported. However, the combination of enzymatic and immunoassay sensing into a single disposable system has hitherto not been addressed.

A Universal Method For Quantifying Proteins, Small Molecules, Lipids, And Electrolytes

UCLA scientists in the Departments of Psychiatry & Biobehavioral Sciences and Human Genetics have developed a novel method for the simultaneous quantification of proteins, small molecules, lipids, and electrolytes.

Predicting Cefixime Susceptiblity Using Molecular Genotyping

UCLA researchers in the David Geffen School of Medicine have developed a novel method to detect the susceptibility of Neisseria gonorrhoeae to the antibiotic cefixime.

Simple Imaging Tool for Oral Cancer Detection and Monitoring

UCI researchers have developed a miniature, flexible intra-oral probe with a camera that allows early detection of oral cancer lesions in difficult-to-see, high risk areas of the mouth and throat. The tool allows for a low cost, non-invasive procedure that can be easily adopted in non-specialist medical settings.

At Home Fetal Electrocardiogram/Heartrate Monitor for Congenital Heart Defect Diagnosis

Congenital heart defects affect >1% of babies born in the United States. These defects originate early on in fetal development. Inventors at UC Irvine have developed a flexible medical device that allows at home fetal electrocardiogram (ECG) monitoring to diagnosis congenital heart defects during development.

“Polyp-Print”: A Methodology To Identify Which Colon Polyps Are Likely To Proceed To Colorectal Cancers

Colorectal cancer (CRC) is the second leading cause of cancer deaths in men and women combined in the United States, according to the American Cancer Society. Every day, patients undergo routine screening colonoscopies around the world for assessment of their risk of CRC. CRCs always arise from precursor lesions, called polyps. Since most patients with polyps are asymptomatic, tracking these lesions through fecal occult blood, rectosigmoidoscopy and colonoscopy enables the suspicion, detection and removal of the lesion. Since 2000, colonoscopy has become the most important examination to track polyps and CRC. Nowadays, in the USA, one out of four colonoscopies aim to track polyps. Besides detecting polyps, their removal through endoscopic polypectomy has proved to be effective to reduce the incidence of this tumor. Anatomopathological analysis enables the histological classification of adenomas, and also allows checking for dysplasia or neoplasm, as well as vascular and/or lymphatic invasion. This assessment determines if polypectomy and/or mucosectomy were effective to heal the patient who presented with polyp or CRC, or if therapeutics will be necessary. Typically, screening colonoscopies begin at age 50, and are done every 10 years. If polyps are encountered, based on their size and number and location, the risk is determined to be high vs low (completely arbitrarily, with no molecular basis at all). Bottomline, right now, there is no way to tell which polyp will become a cancer and which will not. Hence, some patients may be receiving over Rx and some may be under Rx. Clearly, what is needed is an invention that can predict the timing and consequences of multiple host events during CRC initiation and progression.

Method for the detection of specific cells in bodily fluids with a small fluorescent probe

Using standard cellular biology techniques, researchers at UCI have developed a method for detecting the cellular components of blood easily, cheaply, and quickly with accurate quantification using fluorescence techniques.

Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel biomarker that can be used to diagnose prostate cancer patients for the presence of visceral metastasis with 54% sensitivity and 100% specificity.

Device and Method for Microscale Chemical Reactions

UCLA researchers in the Departments of Bioengineering and Molecular and Medical Pharmacology have developed a passive microfluidic reactor chip with a simplified design that is less costly than existing microfluidic chips.

An Algorithm For Automatic Histologic Grading Of Prostate Cancer

UCLA researchers in the Departments of Radiological Sciences and Pathology and Laboratory Medicine have developed a novel computer-aided diagnostic tool for histologic grading of prostate cancer.

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