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Distinct Metabolic States Guide Maturation of Inflammatory and Tolerogenic Dendritic Cells

Scientists at UCSF and the Parker Institute of Cancer Immunotherapy have developed methods for characterizing dendritic cells as well as methods for identifying a dendritic cell as either an inflammatory or a tolerogenic dendritic cell. Their results provide important insights into previously obscured metabolic heterogeneity impacting immune profiles of immunogenic and tolerogenic dendritic cells (DC).

A Broadly Neutralizing Molecule Against Clostridium Difficile Toxin B

Researchers at UCI have developed a family of recombinant protein therapeutics against Clostridium difficile designed to provide broad-spectrum protection and neutralization against all isoforms of its main toxin, TcdB. These antitoxin molecules feature fragments of TcdB’s human receptors (CSPG4 and FZD) which compete for TcdB binding, significantly improving upon existing antibody therapeutics for Clostridium difficile infections.

New Device to Test for Pulmonary Function for 21st Century Care

Prof. Mona Eskandari, whose research is known for seminal strides in experimental characterization and computational modeling of lung structural mechanics using novel techniques developed in her lab, has discovered a new method for measuring pulmonary function. It works by analyzing the change in temporal pressure while a patient is holding their breath. The measurement device is simple, comfortable and error-free for the patient to self-administer. Algorithms are used to transform the detailed lung data collection into actionable metrics for early detection capabilities for medical intervention and prevention. The discovery could provide more accessible, detailed, timely, and actionable data on lung function compared to conventional and currently used methods. Fig 1: The medical device prototype being tested in the laboratory  Fig 2: Preliminary data exhibiting detectable differences between several healthy and diseased mice lungs when utilizing the proposed new pulmonary function method

Compositions and Methods for Treating Viral Infections

Researchers at the University of California, Davis (“UC Davis”) have developed methods for screening and targeting regions of viral genomes to identify drugs that inhibit the replication of RNA viruses.

METHODS FOR PREDICTING THE RESPONSE TO METHOTREXATE AND TREATING RHEUMATOID ARTHRITIS

Researchers at UCSF have developed methods of treating Rheumatoid arthritis and for predicting the response of patients to methotrexate. 

AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1

Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common autoantibody targets in APS1 patients through proteome-wide programmable phage-display.

DETECTION ASSAY FOR SARS-COV-2 VIRUS

Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to detect SARS-CoV-2 virus.

BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES

Researchers at UCSF and the Chan Zuckerberg Biohub have developed a serological detection assay for anti-SARS-CoV-2 antibodies. 

Type III CRISPR-Cas System for Robust RNA Knockdown and Imaging in Eukaryotes

Type III CRISPR-Cas systems recognize and degrade RNA molecules using an RNA-guided mechanism that occurs widely in microbes for adaptive immunity against viruses. The inventors have demonstrated that this multi-protein system can be leveraged for programmable RNA knockdown of both nuclear and cytoplasmic transcripts in mammalian cells. Using single-vector delivery of the S. thermophilus Csm complex, RNA knockdown was achieved with high efficiency (90-99%) and minimal off-targets, outperforming existing technologies of shRNA- and Cas13-mediated knockdown. Furthermore, unlike Cas13, Csm is devoid of trans-cleavage activity and thus does not induce non-specific transcriptome-wide degradation and cytotoxicity. Catalytically inactivated Csm can also be used for programmable RNA-binding, which the inventors exploit for live-cell RNA imaging. This work demonstrates the feasibility and efficacy of multi-subunit CRISPR-Cas effector complexes as RNA-targeting tools in eukaryotes.

Methods To Rapidly Measure Antibodies And Other Biomolecules In Clinical Specimens Utilizing Biolayer Interferometry

The rapid spread of SARS-CoV-2 and associated declaration of a global pandemic in 2020 underscore the importance of rapid and accurate infectious disease testing. Serological tests,  which facilitate vaccine development and identification of population spread, are commonly used as countermeasures to infection. Existing serological testing methods, like lateral flow immunoassays, are not quantitative and reliably sensitive though. Other immunoassays have better sensitivity and specificity but require long incubation times and are labor-intensive.  

Leveraging microbiome bacteria, bacterial modulators, and novel microbial species for prevention, diagnosis, and treatment of inflammatory diseases, respiratory system infections, and premature birth

The following technologies encompass a portfolio of microbiome-centric inventions intended to address unmet diagnostic and treatment needs in the areas of inflammatory disease and respiratory system infections, including prevention in infants. 

Machine Learning Based Diagnostic for Identifying Sepsis

Researchers at the University of California, Davis, have developed a novel approach of identifying sepsis by employing custom machine learning models within a combination of known laboratory data.

(SD2021-335) Personalized Machine Learning of Depressed Mood using Wearables (software)

Depression is a multifaceted illness with genetic, behavioral, lifestyle, and interpersonal risk factors that may express as overlapping symptoms, which in turn leads to huge interindividual variability in clinical response to the same treatments or behavioral recommendations.In the era of digital medicine and precision therapeutics, new personalized treatment approaches are warranted for depression.

Modular Piezoelectric Sensor Array with Beamforming Channels for Ultrasound Imaging

Researchers at the University of California, Davis have developed a large area sensor array for ultrasound imaging systems that utilizes high-bandwidth piezoelectric sensors and modular design elements.

(SD2021-262) A wearable tool for colorimetric monitoring of proteases

Facemasks in congregate settings prevent the transmission of SARS-CoV-2 and help control the ongoing COVID-19 global pandemic because face coverings can arrest transmission of respiratory droplets. While many groups have studied face coverings as personal protective equipment, these respiratory droplets can also serve as a diagnostic fluid to report on health state; surprisingly, studies of face coverings from this perspective are quite limited.

Templated Synthesis Of Metal Nanorods

Brief description not available

Devices and Methods for Monitoring Respiration of a Tracheostomy Patient

Researchers at the University of California, Davis have developed a small device that attaches directly to the hub of a tracheostomy tube and enables the monitoring of respiratory function in tracheostomy patients during sleep studies.

Magnetically Responsive Photonic Nanochains

Brief description not available

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