Nanoparticles With Enhanced Fluorescence for Medical Imaging and Research Purposes
Tech ID: 33854 / UC Case 2024-710-0
Background
Currently, fluorescent dyes are used for image-guided surgery and other clinical applications. It would be ideal for fluorescent organic dyes, like the US FDA–approved indocyanine green (ICG), to have stronger fluorescence emission. Alternative dyes with improved emission characteristics would be useful in various imaging applications in the clinic and in research.
Brief Description
Professor Bahman Anvari and colleagues from the University of California, Riverside and the University of Maryland have developed nanoparticle systems with greater fluorescence emission when compared to known dyes. These nanoparticles incorporate dual near infrared fluorescence (NIR) and magnetic resonance (MR) dyes for improved fluorescence. The nanoparticles encapsulate brominated carbocyanine dyes with MR qualities and ICG with NIR properties. This technology is advantageous because these nanoparticles containing these dyes exhibit greater fluorescence emission when compared to the individual dyes. This presents a promising dual-mode platform with high optical sensitivity and clinical diagnostic and research applications.
Suggested uses
- For use in various imaging applications such as deep tissue imaging, tumor staging and mapping, and small tumor nodules visualization for resection.
- For integration into various theranostic treatments like chemotherapy, phototherapy, and dual therapy, as nanovaccines and as theranostic agent.
Patent Status
Patent Pending
Related Materials
Contact
- Grace Yee
- grace.yee@ucr.edu
- tel: View Phone Number.
Other Information
Keywords
biomimetics, fluorescence, halogenated dyes, nanoparticles, near infrared, red blood cells, spectroscopy, ICG
