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Cloud based platform for display and analysis of image time series

Current microscopy systems commonly used in biomedical research labs and companies generate large amounts of large data, known as image stacks. There is currently no easy, streamlined way to store, organize and analyze these datasets on a cloud. Researchers at UCI have developed a software consisting of a cloud-based data management and analysis platform that make visualization and analysis of large image stacks simpler and faster.

Fabrication Method for Side Viewing Miniature Optical Elements with Free-Form Surface Geometry

Researchers at the University of California, Davis have developed a fabrication method for free-form reflective side viewing miniature optical elements to focus and reflect light with minimal chromatic aberrations.

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

UCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K. This probe can also deliver drug molecules to bone resorption sites with high specificity.

High-Throughput Quantification of Nanoparticle Degradation using Computational Microscopy and its Application to Drug Delivery Nanocapsules

UCLA researchers in the Department of Bioengineering have developed a high-throughput imaging technique that monitors the degradation of nanoparticles in real time.

Frequency Doubled Pulsed Swept Laser

UCLA researchers in the Department of Electrical Engineering have invented a swept source laser that operates in the visible light range with a broad sweeping bandwidth.

The Brightest, Red-Shifted Luciferase-Luciferin Bioluminescent Pairs

Researchers at the University of California, Riverside, have developed several new luciferase-luciferin pairs that have superior brightness and excellent performance in vitro and in vivo. Through directed evolution of the existing NanoLuc Luciferase and the use of diphenylterazine (DTZ) as a substrate, the emission extensity is more than doubled compared to NanoLuc-furimazine. Moreover, red-shifted emission of teLuc-DTZ makes it an excellent tool for in vivo imaging. teLuc-DTZ streamlines a variety of applications to afford high sensitivity and reproducibility. Furthermore, fusing teLuc to a fluorescent protein creates the Antares2-DTZ pair, with emissions further red-shifted to the > 600 nm range and 65 times more photons emitted above 600 nm than FLuc-D-Luciferin. Fig. 1 shows the relative emission intensity and the range of emitted wavelengths of light  

Nondestructive System for Quantitative Evaluation of Cartilage Degradation and Regeneration

Researchers at the University of California, Davis, have developed a minimally invasive fluorescence based imaging system for the quantitative detection of cartilage health.

Simple All-in-One UV Waveguide Microscope with Illumination Sectioning for Surface Morphology and Fluorescence Imaging

Researchers at the University of California, Davis have developed an all-in-one microscope combining ultraviolet excitation light with a waveguide directly integrated onto a light microscope stage, capable of providing surface morphology and fluorescence information with minimal sample preparation.

Convex Optimized Diffusion Encoding (CODE) For Motion Compensated Diffusion Weighted Magnetic Resonance Imaging With Shortened Echo Times

UCLA researchers in the Department of Radiological Sciences have developed a novel method for diffusion weighted MRI that minimizes echo times and/or incorporates bulk motion compensation through application of a convex optimized diffusion encoding (CODE).

Focusing And Amplifying Reflectarray Metasurfaces For Stable Laser Cavities

UCLA researchers in the Department of Electrical Engineering have developed a novel design of reflectarray metasurface that focuses and amplifies THz laser beams with record high efficiency and stability.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Computational Out-Of-Focus Imaging Increases The Space-Bandwidth Product In Lens-Based Coherent Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a wide-field and high-resolution coherent imaging method that uses a stack of out-of-focus images to provide much better utilization of the space-bandwidth product (SBP) of an objective-lens.

Sparsity-Based Multi-Height Phase Recovery In Holographic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve more than 3-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality.

Single Fiber-Based Multimodal Biophotonic Imaging and Spectroscopy Platform

Researchers at the University of California, Davis have developed a highly flexible and reconfigurable optical imaging and spectroscopy platform.

A General Noise Suppression Scheme With A Reference Beam In Optical Heterodyne Spectroscopy

A methodology to suppress additive and convolved noise in optical heterodyne signals

Versatile Labeling of Protein N-Termini for Site-specific Bioconjugation

Improved subtiligase variants allow broad and versatile site-specific chemical modification or conjugation of proteins on their N-termini.

Fully Automated Synthesis Of 16B-[18F] Fluorodihydrotestosterone ([18F]-FDHT)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a method for the fully automated synthesis of 16β- 18F-fluorodihydrotestosterone (18F-FDHT), a probe to monitor prostate cancer.

Time-Resolved Fluorescence Imaging Without Lifetime Fitting

UCLA investigators have developed a novel method to obtain time-resolved fluorescence imaging (TRFI) without the need to extract a fluorescence lifetime. Compared to conventional TRFI, this novel method is reliable, simple, time-saving and can dramatically improve biomedical applications of TRFI.

Holographic Opto-Fluidic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a system for holographic opto-fluidic microscopy.

Single Molecule Imaging and Sizing of DNA on a Cell Phone

UCLA researchers in the Department of Electrical Engineering have developed a light-weight and cost-effective fluorescence microscope installed on a cell phone.

Live Cell Detection by Near-Infrared Fluorogenic Tetrazine Uncaging Oligo Probes

There is significant interest in developing methods that visualize and detect RNA in live cells. Bioorthogonal template driven tetrazine ligations are quickly becoming a powerful route to visualizing nucleic acids in native cells, yet past work has been limited with respect to the diversity of fluorogens and existing tetrazine-reactive fluorogenic probes are quenched by through‐bond energy transfer (TBET) or Fӧrster resonance energy transfer (FRET) between the donor fluorophore and acceptor tetrazine.

Label Free Assessment Of Embryo Vitality

Researchers at UC Irvine developed an independent non-invasive method to distinguish between healthy and unhealthy embryos.

Imaging Platform Based On Nonlinear Optical Microscopy For Rapid Scanning Large Areas Of Tissue

The present invention discloses a nonlinear optical microscopy (NLOM) instrument for rapid imaging of wide areas and large volumes of biological tissues or other materials, ex vivo or in vivo, at sub-micron resolution. The instrument allows much larger field of view (FOV) at the same time improves the scan speed.

Method and System for Ultra High Dynamic Range Nucleic Acid Quantification

Researchers at UC Irvine developed a device and method that combines the high dynamic range and high accuracy of digital PCR (dPCR) with the real-time analysis of quantitative PCR (qPCR) to achieve a ultra-high dynamic range PCR over 10 to 12 orders of magnitude. The present method is accomplished by a highly integrated design that optimally packs, thermocycles, and images as many as 1 million reaction vessels.

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