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Method For Retinal Layer Segmentation And Classification (San Diego Automated Layer Segmentation Algorithm (SALSA))

Imaging of the eye is routine in the diagnosis of glaucoma, but optic imaging is increasingly playing a role in the diagnosis and monitoring of neurodegenerative diseases, such as retina disease, multiple sclerosis (MS), Alzheimer’s disease, and Parkinson’s disease. Non-invasive imaging of the eye in a quantitative manner is now possible using OCT. Optical coherence tomography (OCT) imaging allows the visualization of biological tissues at high resolution, combined with ease of use, patient comfort, and low cost. This technology allows the discrimination of healthy from diseased tissue, and for the diagnosing and monitoring of disease. These benefits have made OCT the instrument of choice for imaging retinal cell layers in both ophthalmology and neurology imaging, including for monitoring neurodegenerative disease. Unfortunately, following imaging, manual segmentation of images of the optic nerve head (ONH) structures is a time-consuming process that is impractical for routine clinical use. A pressing challenge is to be able to quickly, effectively, and accurately, image the multiple layers of cells within the retina. 

Novel cyanobacteriochromes responsive to light in the far-red to near-infrared region

Researchers at the University of California, Davis have identified new cyanobacteriochromes (CBCRs) that detect and fluoresce in the far-red and near-infrared region of the electromagnetic spectrum.

An Accelerated Phase-Contrast MRI Technique

UCLA researchers in the Department Radiological Sciences have developed a technique for accelerated phase-contrast MRI, reducing total image acquisition time in the collection of high-resolution data.

Efficient Method to Improve the Temporal Signal-to-Noise of Arterial Spin Labeling for MRI

In conventional vessel encoded pseudo-continuous arterial spin labeling (PASL), the temporal signal to noise (tSNR) is improved by repeatedly applying pulsed labeling pulses in between Look-Locker readouts.  This works optimally when the temporal width of the tagged boluses matches the inter-pulse spacing. However, because the feeding arteries generally have different velocities and geometries, the conventional labeling slab fails to achieve desirable tSNR.  

Software for auto-generation of text reports from radiology studies

Imaging machines used for radiology studies often export data (such as vascular velocities, bone densitometry, radiation dose, etc.) as characters stored in image format. Radiologists are expected to interpret this data and also store it in their text-based reports of the studies. This is usually accomplished by dictating the data into the text report or copying it by typing it. However, these methods are error-prone and time-intensive.

A Real-time Intraoperative Fluorescent Imaging Device for Guided Surgical Excision of Microscopic Residual Tumors

This novel real-time imaging device can provide precise and rapid pathological imaging information of the tumor area by utilizing fluorescent or luminescent markers within the body to ensure complete surgical resection.

Patient-Specific Ct Scan-Based Finite Element Modeling (FEM) Of Bone

This invention is a software for calculating the maximum force a bone can support. The offered method provides an accurate assessment of how changes in a bone due to special circumstances, such as osteoporosis or a long duration space flight, might increase patient’s risk of fracture.

A Method For Determining Characteristic Planes And Axes Of Bones And Other Body Parts, And Application To Registration Of Data Sets

The invention is a method for deriving an anatomical coordinate system for a body part (especially bone) to aid in its characterization. The method relies on 3-D digital images of an anatomical object, such as CT- or MR-scans, to objectively, precisely, and reliably identify its geometry in a computationally efficient manner. The invention is a great improvement over the current practice of subjective, user-dependent manual data entry and visualization of bones and organs. The applications for well-defined anatomical coordinate systems include robotic surgeries, models for bone density studies, and construction of statistical anatomical data sets.

Monoclonal Antibody Against Cer164 (Clone 11)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against ATR-IP (Clone 5)

Mouse monoclonal antibody against the human ATR-interacting protein (ATR-IP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against Cer164 (Clone 26)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against PNPase (Clone 4C11)

Mouse monoclonal antibody against the human mitochondrial polyribonucleotide nucleotidyltransferase 1 (PNPase). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against Pnpase (Clone 2A2)

Mouse monoclonal antibody against the human mitochondrial polyribonucleotide nucleotidyltransferase 1 (PNPase). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibodies Against Spc24/25 (Clone 2A10)

Mouse hybridoma cell line secret antibody against the human Kinetochore protein Spc24 (SPC24) and Kinetochore protein Spc25 (SPC25). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Automated Liquid Volume Handler for Rapid Concentration of Radioisotopes

UCLA researchers in the Department of Pharmacology have developed a novel, rapid, and fully automated method of concentrating radioisotopes to allow production of PET imaging probes on a clinical scale.

Monoclonal Antibodies Against Spc24/25 (Clone 2C8)

Mouse hybridoma cell line secret antibody against the human Kinetochore protein Spc24 (SPC24) and Kinetochore protein Spc25 (SPC25). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Versatile, Modular and Affordable Microwave and Radiofrequency Magnetic Resonance Setup for Dynamic Nuclear Polarization

A DNP setup operating at a magnetic field at or above 5 Tesla, powered by a solid state microwave source, transmitted using low loss quasi optics and utilizes an externally tunable, inductively coupled radio frequency probe integrated into part of the waveguide to provide efficient microwave transmission to the sample while maintaining good NMR performance and complete hardware modularity.

Bio-Imaging Of Aldehyde Dehydrogenase Activity

Aldehyde Dehydrogenase (ALDH) activity is essential for generating cancer stem cells and drug resistance in cancer stem cells, which are the primary cause of treatment failure in oncology. Similarly, ALDH activity also plays a therapeutic role in a variety of inflammatory diseases and is needed for tissue regeneration and wound healing after a myocardial infarct, the detoxification of xenobiotics in the liver, the alleviation of pain, and the prevention of Parkinson’s disease. There is therefore great interest in developing small molecules that can inhibit or activate ALDH activity, however, this is currently challenging because of the inability to measure ALDH activity in cells.  The current method measures ALDH in cells indirectly, via ALDH substrates that are unable to distinguish between non-specific accumulation and genuine ALDH activity, and can only indirectly measure ALDH activity via flow cytometry.  UC Berkeley researchers have developed bio-imaging agents to image ALDH activity in cells. The new agents can spectrally distinguish between the small electronegativity differences between an aldehyde and a carboxylate and are exceptionally sensitive to changes in electronegativity.   

UCLA Inventors Create Platform Technology to Create Customizable Materials for Imaging and Detection

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in imaging and detection.The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic and hydrophilic payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing nanoparticles.

Measurement Of Blood Flow Dynamics With X-Ray Computed Tomography: Dynamic Ct Angiography

This invention identifies a method to accurately measure flow dynamics, such as velocity and volume, from Computed Tomography scans of blood vessels in a patient.

Adaptive optics with direct wavefront sensing for multi-photon microscope

Biological tissue are rarely transparent, presenting major challenges for deep tissue optical microscopy. With the advantages of high-resolution and viewing of live organisms, optical microscopy has become an important tool for biological research and continues to open new avenues in its capabilities. In recent years, image resolution and speed has been dramatically improved.  However the improvement of the resolution and penetration depth for optical microscopy is still in its infancy. As light passes through biological tissue, it can be absorbed, refracted and scattered, limiting the resolution and depth of optical imaging in biological tissues. Overcoming these challenges will benefit a wide range of applications from basic biological research to clinical investigations.

Beta-Amyloid Plaque Imaging Agents

Current imaging agents for labelling β-amyloid plaques and neurofibrillary tangles (NFT), which are indicators for Alzheimer’s disease, suffer from drawbacks such as (but not limited to) non-specific binding, low target to non-target ratio, instability, and inefficient labelling. Researchers at UC Irvine have developed an imaging agent and its derivatives for labelling β-amyloid plaques and NFTs that overcome these problems and also provide therapeutic properties in vivo for the neural tissues. The labelling agent also binds to norepinephrine transporters (NET) and are taken up into the cells via the NET, therefore serving as suitable agents for diagnostic and/or therapeutic purposes involving disorders or conditions associated with NET.

Design and Synthesis of Fluoroalkylpyridyl Ethers as Potential Pet Radioligands for A4B2 Nicotinic Acetylcholine / Labeled A4B2 Ligands and Methods Therefor

Researchers have developed compounds to bind to α4β2 nicotinic acetylcholine receptors to evoke antagonistic effects both in vitro and in vivo environments.

Novel Radiotracer for Solid Tumor Detection Using Positron Emission Tomography Imaging

A novel pH-dependent radiotracer improves solid tumor detection using positron emission tomography (PET), especially in organs with high metabolic rate.

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