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Method for Early Detection of Edema and Intercranial Pressure

Researchers at UCR have developed a process that uses optical coherence tomography (OCT) on specific regions of the cranium to detect the onset of edema before severe damage can be done to the brain.  By scanning various regions of the brain with OCT, the early stages of cerebral edema may be visualized at a far earlier time point than otherwise possible.  The scattering pattern of reflected light changes in a predictable manner when brain water content increases.  This allows for a quick and accurate determination of a patient’s risk for developing dangerous ICP levels, thus eliminating the need for a invasive precautionary craniectomy. Fig. 1: diagram of the OCT apparatus being used to measure edema in a mouse brain Fig. 2: table demonstrating the time between OCT detection of artificially induced edema and onset of increased ICP  

Lensfree Tomographic Imaging

UCLA researchers in the Department of Electrical Engineering have developed a system for lens-free tomographic imaging.

Versatile III-Nitride VCSEL White Light Illumination System

A white light source with an RGB phosphor horizontally oriented on or above a VCSEL array.

Multifaceted III-Nitride Surface-Emitting Laser

Improved laser capability using III-Nitride VCSELs as the illumination source for sensing applications of a fluorescent sample.

Method for Removing Breathing Motion Artifacts in CT

UCLA researchers have developed a novel scanning and analysis method to remove breathing motion artifacts in CT scans by integrating motion modeling to the image reconstruction process.

Cloud based platform for display and analysis of image time series

Current microscopy systems commonly used in biomedical research labs and companies generate large amounts of large data, known as image stacks. There is currently no easy, streamlined way to store, organize and analyze these datasets on a cloud. Researchers at UCI have developed a software consisting of a cloud-based data management and analysis platform that make visualization and analysis of large image stacks simpler and faster.

Fabrication Method for Side Viewing Miniature Optical Elements with Free-Form Surface Geometry

Researchers at the University of California, Davis have developed a fabrication method for free-form reflective side viewing miniature optical elements to focus and reflect light with minimal chromatic aberrations.

Technique for Respiratory Gated Radiotherapy using Low Frame Rate MRI and a Breathing Motion Model

UCLA researchers in the Department of Radiation Oncology have developed a novel method to gate radiotherapy using low frame rate MRI sequences to reduce damage to adjacent tissues during radiotherapy.

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

UCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K. This probe can also deliver drug molecules to bone resorption sites with high specificity.

Frequency Doubled Pulsed Swept Laser

UCLA researchers in the Department of Electrical Engineering have invented a swept source laser that operates in the visible light range with a broad sweeping bandwidth.

Probability Map of Biopsy Site

UCLA researchers in the Department of Radiological Science have developed a technique for generating a probability map on an MRI that indicates the certainty of tissue sampling from a location, which could improve imaging-guided biopsies and their correlation with pathology.

A Method for Obtaining Depth of Interaction in Pixelated Scintillator Detectors

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a method to increase the spatial resolution for PET-based imaging.

Nondestructive System for Quantitative Evaluation of Cartilage Degradation and Regeneration

Researchers at the University of California, Davis, have developed a minimally invasive fluorescence based imaging system for the quantitative detection of cartilage health.

On-Chip Calibration And Control Of Optical Phased Arrays

Optimized on-chip control architecture and optimized phase shifter tuning strategy that scales to extremely large channel counts with significantly reduced on-chip footprint.

Method For Efficient Radiolabeling Of Biomolecules

UCLA researchers in the Department of Medical and Molecular Pharmacology have developed a method that enables efficient radiolabeling of small volumes / amounts of biomolecules.

Phase Recovery And Holographic Image Reconstruction Using Neural Networks

UCLA researchers from the Department of Electric Engineering have developed a novel microscopy approach that produces phase and intensity images using a single hologram acquired from a lens-free CMOS system with extremely fast deep neural network training algorithm.

Simple All-in-One UV Waveguide Microscope with Illumination Sectioning for Surface Morphology and Fluorescence Imaging

Researchers at the University of California, Davis have developed an all-in-one microscope combining ultraviolet excitation light with a waveguide directly integrated onto a light microscope stage, capable of providing surface morphology and fluorescence information with minimal sample preparation.

Convex Optimized Diffusion Encoding (CODE) For Motion Compensated Diffusion Weighted Magnetic Resonance Imaging With Shortened Echo Times

UCLA researchers in the Department of Radiological Sciences have developed a novel method for diffusion weighted MRI that minimizes echo times and/or incorporates bulk motion compensation through application of a convex optimized diffusion encoding (CODE).

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Single-Pixel Optical Technologies For Instantly Quantifying Multicellular Response Profiles

UCLA researchers in the Department of Mechanical & Aerospace Engineering and the Department of Pathology & Lab Medicine have proposed a new platform technology to actuate and sense force propagation in real-time for large sheets of cells.

Multi-Layer Electro-Textile MRI RF Coil Array

UCLA Researchers in the Department of Electrical Engineering have developed RF coils for MRI imaging made from ergonomic electro-textile materials.

Focusing And Amplifying Reflectarray Metasurfaces For Stable Laser Cavities

UCLA researchers in the Department of Electrical Engineering have developed a novel design of reflectarray metasurface that focuses and amplifies THz laser beams with record high efficiency and stability.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Automated Noninvasive Periodontal Depth Measurement Using Photoacoustic Imaging

Many people are familiar with the pocket depth measurements that occur in the dentist’s office. The dental technician pokes her periodontal probe into a patient’s gum line to measure how deep the probe will go. This is repeated tooth by tooth until the entire mouth is covered. Although inexpensive, probing depth measurements are error prone and suffer from poor reproducibility, largely due to variation in probing force. Indeed, a recent meta-analysis showed that a range of a variation of 20-fold. Other error sources include variation in the insertion point, probe angulation, the patient’s overall gingival health, and the presence of calculus. Thus, the examination is subject to large errors with inter-operator variation as high as 40%. These error sources can result in poor patient treatment and, hence, poor patient outcomes. This variation also compromises epidemiologic studies and makes it difficult to compare outcomes among dentists or among populations. Given these limitations, new tools are urgently needed to improve this procedure.

An Electro-Optical System with a Computation Model for Scanning Human Body

The invention describes an Electro-Optical instrument and a computational model for functional scanning of human body and recovering its chromophores (water, lipid, oxygenated hemoglobin, and deoxygenated hemoglobin). It is a low cost portable system that integrates frequency domain and continuous wave domain for real time spectroscopic imaging of human tissue.

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