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Modular Wireless Large Bore Vacuum Universal Endoscope A.K.A. Vacuumscope

Though kidney stones are a prevalent problem that affect more than 10% of the population and cost the US economy upwards of $10 billion annually, the complete removal of stone fragments is difficult to achieve without surgical interventions. Researchers at UCI have developed a novel vacuum endoscope which, when combined with standard kidney stone ablation procedures, is capable of completely removing the resulting fragments.

Biosensors For Measuring The Metastatic Potential And Chemoresistance Of Single Cancer Cells

Metastasis is a complex process in which cancer cells migrate from the primary tumor, invade into the vasculature, and travel to distant parts of the body to establish secondary tumors. Cells with a greater metastatic potential have a proclivity for leading migration away from the primary tumor. Progress in identifying cells primed to metastasize and in assessing metastatic risk has been slow. This may be due in part to the lack of consistent molecular prognostic markers between cancer types and significant heterogeneity in metastatic potential within the tumor. Furthermore, not all tumors are metastatic and determining the metastatic proclivity of single tumor cells remains a major challenge. Another looming scientific question is estimating the metastatic “potential” because conventional techniques, e.g., Immunohistochemistry (IHC) are not capable of this and only molecular imaging can resolve these issues. So far, improved imaging platforms have helped detect established metastases and assessed tumor cell properties such as surrogate markers of metastatic potential. However, single cell-based assays to measure the dynamic pro-metastatic signaling programs that contribute to the 'potential' for metastasis remains a Holy Grail.

Simultaneous pH- And Oxygen-Weighted MRI Contrast Using Multi-Echo Chemical Exchange Saturation Transfer Imaging (ME-CEST)

UCLA researchers in the Department of Radiological Sciences have developed a magnetic resonance imaging (MRI) technique that simultaneously acquires acidic and hypoxic information often associated with brain tumors and traumatic brain injury (TBI).

Quantitative Multiparametric PET/CT Imaging for Nonalcoholic Fatty Liver Diseases

Researchers at the University of California, Davis have developed a quantitative imaging method to detect and characterize liver inflammation for diagnosing a wide spectrum of nonalcoholic fatty liver diseases (NAFLDs).

Histology Thin Sectioning Method for Soft, Unfixed Tissues

Before microscopic analysis, tissue specimens are typically prepared for sectioning by initial fixation, freezing, and/or embedding in a mounting medium. There have been no cutting blocks for vibratome that allow the use of fresh soft tissues into thin slices (with micrometer thickness) such as intestines and other soft tissues (brain, heart, blood vessels, liver, spleen, lung, skin etc.).These traditional techniques can limit the ability of scientists to carry out molecular analysis on the tissue.

Automatic Recognition Of Anatomical Coverage In Medical Images

UCLA researchers in the Department of Radiology have developed an algorithm for automated processing of medical images.

An Improved Phase-Contrast MRI Technique

UCLA researchers in the Department of Radiological Sciences have developed a phase-contrast MRI acquisition technique called Hybrid One- and Two-sided Flow Encoding Only (HOTFEO).

Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a new type of fluorescent dermal pigment.

Real-Time Motion Prediction for Dynamic MRI

UCLA researchers in the Department of Bioengineering and Department of Radiological Sciences have developed a novel motion prediction algorithm using MRI-based motion tracking to provide accurate and real-time motion information for dynamic MRI and MRI-guided interventions.

Integrative Leakage Correction For Contrast Agent Extravasation In Dynamic Susceptibility Contrast (DSC) - MRI

UCLA researchers in the Department of Radiological Sciences have developed a new technique for more accurately estimating relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC) perfusion MRI by improved modeling and correction of contrast agent leakage.

Multi-Frequency Harmonic Acoustography for Target Identification and Border Detection

UCLA researchers in the Department of Bioengineering, Electrical Engineering, and Head and Neck Surgery have developed a novel ultrasound-based imaging technique that can be used to analyze tumor margins during surgery.

Intraoperative Assessment Of Implant Positioning

Researchers from the Departments of Mechanical Engineering and Ophthalmology led by Dr. Jean-Pierre Hubschman have developed a modified intralocular lens (IOL) and surgical implantation procedure to treat cataract and refractive anomalies.

Label-Free Digital Bright Field Analysis of DNA Amplification

UCLA researchers in the department of Bioengineering have developed a novel method for quantitative analysis of DNA amplification products.

Quantitative Deformability Cytometry: Rapid, Calibrated Measurements Of Cell Mechanical Properties

UCLA researchers in the Department of Integrative Biology and Physiology have developed a novel microfluidic device that enables rapid measurement of cell mechanical properties.

In vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy

Pelvic floor disorders (PFDs) afflict nearly 25% of all women and carry a host of symptoms that can drastically reduce quality of life. Despite their prevalence, the complex and varied nature of such PFDs make them difficult to diagnose and treat. Researchers at UCI have developed an entirely integrated system that, for the first time, provides real-time monitoring of the vaginal wall tissue during diagnosis and treatment, allowing for more thorough diagnoses and more effective treatment methods.

Endoscopic Optical Coherence Tomography As A Minimally Invasive Lung Cancer Screening Tool To Guide Diagnosis And Therapy

Current diagnostic procedures for lung cancer are invasive, time-consuming, and subjective. UCI researchers have developed a quick, non-invasive lung cancer diagnostic device which uses optical coherence tomography (OCT) and can improve lung cancer diagnosis and outcomes.

Calcium Scoring Using Parallel Tomosynthesis

Researchers at UCLA in the Department of Radiology have developed a cheaper and safer way to measure coronary calcium levels to predict heart disease.

Method for Extending Depth of Field for Microscopy Images

Researchers at the University of California, Davis have developed a method to extend the depth of field of microscopy images by combining ultraviolet (UV) surface excitation and focal sweep imaging. This method provides high-resolution images processed in near- real-time.

Automated External Ventricular Drain Planning, Visualization And Placement

UCLA researchers in the Department of Neurosurgery have developed a computer algorithm that aids in the planning and placement of ventricular drains.

Ultra-Dense Electrode-Based Brain Imaging System With High Spatial And Temporal Resolution

UCLA researchers in the Department of Bioengineering have developed a novel integrated brain imaging system that utilizes an ultra-dense electrode-based device. This system provides high resolution of functional brain images spatially and temporally.

Systems And Methods For Real-Time Tracking Of Patient Anatomy Changes

Researchers in the Department of Radiation Oncology at UCLA have developed a system that enables physicians and radiology technicians to track a patient's posture and anatomical changes in real-time. This invention will enable healthcare providers to track physiological changes in a patient undergoing radiation therapy and give them the freedom to modify treatment to account for such changes.

Multi-Echo Spin-, Asymmetric Spin-, And Gradient Echo Echoplanar Imaging (Message-EPI) MRI

UCLA researchers in the Department of Radiological Sciences have developed a new MRI pulse sequence optimized for brain imaging.

Terahertz Endoscopy Through Laser-Driven Terahretz Sources And Detectors

UCLA researchers in the Department of Electrical Engineering have developed a miniaturized terahertz imaging system that can be integrated to the tip of commercially available endoscopes, with significantly larger detectable depths and faster image acquisition rates.

Method for Early Detection of Edema and Intercranial Pressure

Researchers at UCR have developed a process that uses optical coherence tomography (OCT) on specific regions of the cranium to detect the onset of edema before severe damage can be done to the brain.  By scanning various regions of the brain with OCT, the early stages of cerebral edema may be visualized at a far earlier time point than otherwise possible.  The scattering pattern of reflected light changes in a predictable manner when brain water content increases.  This allows for a quick and accurate determination of a patient’s risk for developing dangerous ICP levels, thus eliminating the need for a invasive precautionary craniectomy. Fig. 1: diagram of the OCT apparatus being used to measure edema in a mouse brain Fig. 2: table demonstrating the time between OCT detection of artificially induced edema and onset of increased ICP  

Lensfree Tomographic Imaging

UCLA researchers in the Department of Electrical Engineering have developed a system for lens-free tomographic imaging.

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