Researchers at the University of California, Davis have developed isolated peptides that selectively bind M1 and M2 macrophages to enable precise diagnosis and targeted treatment of macrophage-associated diseases, including cancer.

Researchers at the University of California, Davis have developed a nanoparticle system combining photothermal therapy and chemotherapy for enhanced cancer treatment.

Researchers at the University of California, Davis have developed an advanced multi x-ray source array system employing dual cathode designs that enhance computed tomography (“CT”) imaging by enabling pulsed, spatially multiplexed x-ray emission with reduced artifacts.

A medical device that uses machine learning and augmented reality to project precise surgical guides onto 3D patient anatomy, enabling real-time surgical guidance and remote expert collaboration.

A novel protoacoustic imaging method and apparatus providing affordable, real-time verification of proton range and quantification of radiation dose during proton therapy to improve treatment precision and patient outcomes.

An advanced geometric method for comprehensive 3D cardiac strain analysis, enhancing diagnosis and monitoring of myocardial diseases.

This technology leverages X-ray-induced acoustic phenomena for real-time, in-line verification of photon beam location and dose during cancer radiotherapy.

Researchers at the University of California, Davis have developed a microscopy system combining optical coherence and confocal fluorescence microscopy for accurate Dry Eye Disease diagnosis.

A novel technology for real-time, non-invasive monitoring and adaptive control of electron radiotherapy treatments using acoustic signals.

X-radiation (X-ray) imaging is one of the most common imaging techniques in medicine. Presently, thin-film transistor flat panel detectors are the gold standard for X-ray detection; however, these detectors average across the absorbed X-ray spectrum and thus suffer from poor material decomposition and lesion differentiation. Modern efforts to address this focus on three methods of energy differentiation: dual-shot, photon counting, and dual-layer detectors. Dual-shot detection utilizes a single detector to image a patient with two shots of X-rays at low and high energies. While this has been shown to effectively differentiate between soft and hard tissues, (e.g., chest radiography) this results in a higher dose level to the patient and motion artifacts from slight movement between images. Photon counting detectors offer an alternative to multiple shots, providing high spatial resolution, low dose, and multiple energy binning with photon weighting. However, these detectors also require more complex circuit design for fast readout, have limited material options with great enough yield and detective quantum efficiency at low to mid energy ranges, and are limited in detective area. Dual-layer detectors that stack two detector layers to each process low and high energy X-rays remove motion artifacts by utilizing a single shot of polyenergetic X-rays. These most commonly employ two indirect detectors separated by a Cu filtering layer, which photon-starves the second higher energy detector. Unfortunately, this also requires a higher X-ray intensity, resulting in a higher dose level to the patient.

In PET imaging, patient motion, such as respiratory and cardiac motion, are a major source of blurring and motion artifacts. Researchers at the University of California, Davis have developed a technology designed to enhance PET imaging resolution without the need for external devices by effectively mitigating these artifacts

      Optical tweezers generated with light modulation devices have great importance for highly precise laser imaging and addressing systems e.g. excitation and readout of single atoms, imaging of interactions between molecules, or highly precise spatial trapping and movement of particles. To generate dynamic optical tweezers adjustable at the microsecond scale, acousto-optic deflectors (AOD) are commonly used to modulate the spatial profile of laser light. Dynamic optical tweezers are increasingly relevant for emerging technologies such as neutral atom quantum computers, and tightly focused laser spot arrays may enable advanced imaging and/or semiconductor processing applications. However, dynamic optical tweezer systems capable of rapid, aberration-free movement of one or multiple atoms in independent, arbitrary three-dimensional trajectories with minimal aberration have not yet been realized.      UC Berkeley researchers have developed a dynamic optical tweezer system that overcomes significant defects such as limited 2D motion and optical aberration present in existing art. Carefully designed waveform modulation of one or more acousto-optic deflector lenses (AODLs) enables atomic addressing and rapid tweezer motions while minimizing significant optical aberrations present in prior methods. The invention is capable of microsecond scale single or multi tweezer motion in arbitrary three-dimensional trajectories without the use of translation stages. The invention can flexibly address one atom, multiple atoms, or the entire array.

A novel method using Diffusion Tensor Imaging (DTI) combined with Statistical Parametric Mapping (SPM) as an effective diagnostic tool for Traumatic Brain Injury.

A breakthrough imaging technique that provides high-resolution visualization of optically transparent materials at a low cost.

A novel method for predicting the effective lens position (ELP) in cataract surgery through pre-operative measurements of natural lens curvatures.

An innovative technology that uses dual energy CT to measure blood flow in organs, offering a non-invasive, accurate assessment of diseases like INOCA.

Professor Bahman Anvari and colleagues from the University of California, Riverside and the University of Maryland have developed nanoparticle systems with greater fluorescence emission when compared to known dyes. These nanoparticles incorporate dual near infrared fluorescence (NIR) and magnetic resonance (MR) dyes for improved fluorescence.  The nanoparticles encapsulate brominated carbocyanine dyes with MR qualities and ICG with NIR properties. This technology is advantageous because these nanoparticles containing these dyes exhibit greater fluorescence emission when compared to the individual dyes.  This presents a promising dual-mode platform with high optical sensitivity and clinical diagnostic and research applications.  

Researchers at the University of California, Davis have developed a large-scale, energy-efficient, high-throughput, and compact tensorized optical neural network (TONN) exploiting the tensor-train decomposition architecture on an integrated III–V-on-silicon metal–oxide–semiconductor capacitor (MOSCAP) platform.

Researchers at the University of California, Davis have developed a technology involving statistically reconstructing positronium (or positron) lifetime imaging (PLI) for use with a positron emission tomography (PET) scanner, to produce images having resolutions better than can be obtained with existing time-of-flight (TOF) systems.

Researchers at the University of California, Davis, have developed a novel imaging system that improves the diagnostic accuracy of PET imaging. The system combines machine learning and computed tomography (CT) imaging to reduce noise and enhance resolution. This novel technique can integrate with commercial PET imaging systems, improving diagnostic accuracy and facilitating superior treatment of various diseases.

Researchers at the University of California, Davis have developed a solid-state device that uses Cherenkov Radiation to emit light at a tunable wavelength in the THz to IR range.

Researchers at the University of California, Davis, have developed a headset (e.g., virtual reality headset) in which two imaging modalities, optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), are incorporated with automated eye tracking and optical adjustment capabilities providing a fully automated imaging system in which patients are unaware that images of the retina are being acquired. Imaging takes place while the patient watches a soothing or entertaining video.

Researchers at the University of California, Davis have developed an optical lens module that uses a metalens or a metalens array having a controllable angular field-of-view.

Researchers at the University of California, Davis, have developed a positron emission tomography (PET) medical imaging system that allows for higher 3D position resolution, eliminates radiation background, and holds a similar production cost to existing technologies.

Researchers at the University of California, Davis have developed a novel cell segmentation technology for accurate analysis of non-spherical cells and that offers a comprehensive, high-throughput approach for analyzing the transcriptomic and metabolomic data to study complex biological processes at the single-cell level.