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On-Chip Calibration And Control Of Optical Phased Arrays

Optimized on-chip control architecture and optimized phase shifter tuning strategy that scales to extremely large channel counts with significantly reduced on-chip footprint.

Method For Efficient Radiolabeling Of Biomolecules

UCLA researchers in the Department of Medical and Molecular Pharmacology have developed a method that enables efficient radiolabeling of small volumes / amounts of biomolecules.

Phase Recovery And Holographic Image Reconstruction Using Neural Networks

UCLA researchers from the Department of Electric Engineering have developed a novel microscopy approach that produces phase and intensity images using a single hologram acquired from a lens-free CMOS system with extremely fast deep neural network training algorithm.

Simple All-in-One UV Waveguide Microscope with Illumination Sectioning for Surface Morphology and Fluorescence Imaging

Researchers at the University of California, Davis have developed an all-in-one microscope combining ultraviolet excitation light with a waveguide directly integrated onto a light microscope stage, capable of providing surface morphology and fluorescence information with minimal sample preparation.

Convex Optimized Diffusion Encoding (CODE) For Motion Compensated Diffusion Weighted Magnetic Resonance Imaging With Shortened Echo Times

UCLA researchers in the Department of Radiological Sciences have developed a novel method for diffusion weighted MRI that minimizes echo times and/or incorporates bulk motion compensation through application of a convex optimized diffusion encoding (CODE).

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Single-Pixel Optical Technologies For Instantly Quantifying Multicellular Response Profiles

UCLA researchers in the Department of Mechanical & Aerospace Engineering and the Department of Pathology & Lab Medicine have proposed a new platform technology to actuate and sense force propagation in real-time for large sheets of cells.

Multi-Layer Electro-Textile MRI RF Coil Array

UCLA Researchers in the Department of Electrical Engineering have developed RF coils for MRI imaging made from ergonomic electro-textile materials.

Focusing And Amplifying Reflectarray Metasurfaces For Stable Laser Cavities

UCLA researchers in the Department of Electrical Engineering have developed a novel design of reflectarray metasurface that focuses and amplifies THz laser beams with record high efficiency and stability.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Automated Noninvasive Periodontal Depth Measurement Using Photoacoustic Imaging

Many people are familiar with the pocket depth measurements that occur in the dentist’s office. The dental technician pokes her periodontal probe into a patient’s gum line to measure how deep the probe will go. This is repeated tooth by tooth until the entire mouth is covered. Although inexpensive, probing depth measurements are error prone and suffer from poor reproducibility, largely due to variation in probing force. Indeed, a recent meta-analysis showed that a range of a variation of 20-fold. Other error sources include variation in the insertion point, probe angulation, the patient’s overall gingival health, and the presence of calculus. Thus, the examination is subject to large errors with inter-operator variation as high as 40%. These error sources can result in poor patient treatment and, hence, poor patient outcomes. This variation also compromises epidemiologic studies and makes it difficult to compare outcomes among dentists or among populations. Given these limitations, new tools are urgently needed to improve this procedure.

An Electro-Optical System with a Computation Model for Scanning Human Body

The invention describes an Electro-Optical instrument and a computational model for functional scanning of human body and recovering its chromophores (water, lipid, oxygenated hemoglobin, and deoxygenated hemoglobin). It is a low cost portable system that integrates frequency domain and continuous wave domain for real time spectroscopic imaging of human tissue.

Active Nanoplatform with High Drug Loading Capacity for the Diagnosis and Treatment of Cancer

Researchers at the University of California, Davis have developed an active nanoplatform (F/HAPIN) for cancer diagnosis and therapy.

Deep Learning Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a novel microscopy analysis that improves resolution, field-of-view and depth-of-field in optical microscopy images.

Computational Out-Of-Focus Imaging Increases The Space-Bandwidth Product In Lens-Based Coherent Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a wide-field and high-resolution coherent imaging method that uses a stack of out-of-focus images to provide much better utilization of the space-bandwidth product (SBP) of an objective-lens.

Sparsity-Based Multi-Height Phase Recovery In Holographic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve more than 3-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality.

Single Fiber-Based Multimodal Biophotonic Imaging and Spectroscopy Platform

Researchers at the University of California, Davis have developed a highly flexible and reconfigurable optical imaging and spectroscopy platform.

Selective Plane Illumination for throughput three-dimensional time course imaging

The invention is a novel arrangement that provides high throughput 3D time coursing imaging solution. The setup, simply applied to the conventional inverted microscope, not only improves the imaging speed, resolution and field view, but also provides new capabilities for monitoring a much broader range of samples with various thicknesses and nature. These features combined open new frontiers for imaging applications, including tracking the development of cells in tissues, one of the ultimate goals for imaging.

A New Approach For Assessment Of Blood Coagulation

OCE (Optical Coherence Elastography) and ARF (Acoustic Radiation Force) for blood coagulation assessment. Diagnostic tool for assessing the clot formation/dissolution kinetics and strength.

A General Noise Suppression Scheme With A Reference Beam In Optical Heterodyne Spectroscopy

A methodology to suppress additive and convolved noise in optical heterodyne signals

Vessel Cross-Sectional Area Measurements Using CT Angiography

A new approach to visualizing small and stenotic vasculature not readily visible with modern day diagnostic computed tomography angiography.

Ultrasound-Guided Delivery System For Accurate Positioning - Repositioning Of Transcatheter Heart Valves

Utilizing intravascular ultrasound for accurate placement of transcatheter heart valves to improve surgical outcomes.

Automated Reconstruction Of The Cardiac Chambers From MRI

This is a fast, fully automated method to accurately model a patient’s left heart ventricle via machine learning algorithms.

Endoscopic, Laparoscopic, Robotic And Minimally Invasive Force Sensor And Monitoring System

Minimally invasive ureteroscopy is a common procedure in adults, with over 10,000 procedures conducted annually in California alone. The ureteral access sheath (“UAS”), a highly effective device used to facilitate minimally invasive ureteroscopy, can injure the patient when excessive force is used during its placement. Inventors at UCI have developed a minimally invasive force sensor and monitoring system that measures force during UAS placement and can preclude injury by alerting the physician when the threshold for injury is being approached. It thus can be used for medical personnel safety training, quality control and standardization of minimally invasive ureteroscopy, as well as being applied to the passage of other catheters into natural orifices or channels./

Handled Blood-Flow Imaging Device

The invention is a medical handheld device that carries out skin visual inspection simultaneously with blood flow measurements through integrating a Laser Speckle Imaging (LSI) system within a handheld compact dermoscope. Combining both features in one compact, cheap and easy to use device will generate accurate and elaborative functional data that will improve the accuracy and detection of diseases such as cancer.

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