CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF

Tech ID: 30175 / UC Case 2019-102-0

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 11,739,309 08/29/2023 2019-102
United States Of America Issued Patent 11,685,909 06/27/2023 2019-102
Japan Issued Patent 7239725 03/06/2023 2019-102
United States Of America Issued Patent 11,578,313 02/14/2023 2019-102
United States Of America Issued Patent 11,530,398 12/20/2022 2019-102
United Kingdom Issued Patent 2595606 09/21/2022 2019-102
United States Of America Issued Patent 11,377,646 07/05/2022 2019-102
Germany Issued Patent 212020000516.8 01/17/2022 2019-102
United States Of America Published Application 20240026321 01/25/2024 2019-102
United States Of America Published Application 20230332123 10/19/2023 2019-102
United States Of America Published Application 20230323321 10/12/2023 2019-102
United States Of America Published Application 20230287375 09/14/2023 2019-102
China Published Application CN116732004A 09/12/2023 2019-102
European Patent Office Published Application 4219700 A1 08/02/2023 2019-102
Japan Published Application 2023-071855 05/23/2023 2019-102
Mexico Published Application MX/A/23/003255 05/15/2023 2019-102
United States Of America Published Application 20220340889 10/27/2022 2019-102
Hong Kong Published Application 40064319 A 06/30/2022 2019-102
European Patent Office Published Application 3935156 A0 01/12/2022 2019-102
Mexico Published Application MX/A/21/010559 01/12/2022 2019-102
China Published Application CN113811607A 12/17/2021 2019-102
United States Of America Published Application 20210324356 10/21/2021 2019-102
United States Of America Published Application 20210324358 10/21/2021 2019-102
United States Of America Published Application 20210254038 08/19/2021 2019-102
Australia Published Application 2019-102
Canada Published Application 2019-102
 

Additional Patent Pending

Brief Description


The CRISPR-Cas system is now understood to confer bacteria and archaea with acquired immunity against phage and viruses. CRISPR-Cas systems consist of Cas proteins, which are involved in acquisition, targeting and cleavage of foreign DNA or RNA, and a CRISPR array, which includes direct repeats flanking short spacer sequences that guide Cas proteins to their targets.  Class 2 CRISPR-Cas are streamlined versions in which a single Cas protein bound to RNA is responsible for binding to and cleavage of a targeted sequence. The programmable nature of these minimal systems has facilitated their use as a versatile technology that is revolutionizing the field of genome manipulation.  Current CRISPR Cas technologies are based on systems from cultured bacteria, leaving untapped the vast majority of organisms that have not been isolated.  There is a need in the art for additional Class 2 CRISPR/Cas systems (e.g., Cas protein plus guide RNA combinations).

 

 

UC Berkeley researchers discovered a new type of Cas 12 protein.  Site-specific binding and/or cleavage of a target nucleic acid (e.g., genomic DNA, ds DNA, RNA, etc.) can occur at locations (e.g., target sequence of a target locus) determined by base-pairing complementarity between the Cas12 guide RNA (the guide sequence of the Cas12 guide RNA) and the target nucleic acid.  Similar to CRISPR Cas9, Cas12 enzymes are expected to have a wide variety of applications in genome editing and nucleic acid manipulation.  

 


Suggested uses


  • Genome editing
  • Gene therapy
  • Diagnostic assays
  • Research tools

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Inventors

  • Doudna, Jennifer A.

Other Information

Keywords

CRISPR, Cas 12, Cas12J

Categorized As

Additional Technologies by these Inventors