Methods Of Use Of Cas12L/CasLambda In Plants
Tech ID: 32524 / UC Case 2022-026-0
Patent Status
Patent Pending
Brief Description
UC researchers have discovered a novel use of proteins denoted CasLamda/Cas12L
within the Type V CRISPR Cas superfamily distantly related to CasX, CasY and other published type V sequences. These CasLamda/Cas12L proteins utilize a guide RNA to perform RNA-directed cleavage of DNA. The researchers have developed compounds and structures for use in in editing plant cells.
Suggested uses
- Targeted genome editing of plant cells
- Targeting of proteins bound to CasLamda/Cas12L to a specific locus of a genome
Contact
- Terri Sale
- terri.sale@berkeley.edu
- tel: View Phone Number.
Inventors
- Doudna, Jennifer A.
Other Information
Keywords
CRISPR, Cas12L, CasLambda
Additional Technologies by these Inventors
- COMPOSITIONS AND METHODS FOR IDENTIFYING HOST CELL TARGET PROTEINS FOR TREATING RNA VIRUS INFECTIONS
- Lentivirus-like Particle Delivery of CRISPR-Cas9 & Guide RNA for Gene Editing
- Type III CRISPR-Cas System for Robust RNA Knockdown and Imaging in Eukaryotes
- Cas12-mediated DNA Detection Reporter Molecules
- Improved guide RNA and Protein Design for CasX-based Gene Editing Platform
- Cas13a/C2c2 - A Dual Function Programmable RNA Endoribonuclease
- CasX Nickase Designs, Tans Cleavage Designs & Structure
- A Dual-RNA Guided CasZ Gene Editing Technology
- CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF (“Cas-VariPhi”)
- Modifications To Cas9 For Passive-Delivery Into Cells
- A Protein Inhibitor Of Cas9
- Split-Cas9 For Regulatable Genome Engineering
- NANOPORE MEMBRANE DEVICE AND METHODS OF USE THEREOF
- Optimized Virus-like Particles for Cas9 RNPs & Transgene/HDR Template Delivery
- Protein Inhibitor of Type VI-B CRISPR-Cas System
- COMPOSITIONS AND METHODS FOR INCREASING HOMOLOGY-DIRECTED REPAIR
- CRISPR CASY COMPOSITIONS AND METHODS OF USE
- Single Conjugative Vector for Genome Editing by RNA-guided Transposition
- Improved Cas12a Proteins for Accurate and Efficient Genome Editing
- CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF
- Engineered/Variant Hyperactive CRISPR CasPhi Enzymes And Methods Of Use Thereof
- Engineering Cas12a Genome Editors with Minimized Trans-Activity
- Type V CRISPR/CAS Effector Proteins for Cleaving ssDNA and Detecting Target DNA
- THERMOSTABLE RNA-GUIDED ENDONUCLEASES AND METHODS OF USE THEREOF (GeoCas9)
- Structure-Guided Methods Of Cas9-Mediated Genome Engineering
- Endoribonucleases For Rna Detection And Analysis
- Efficient Site-Specific Integration Of New Genetic Information Into Human Cells
- Class 2 CRISPR/Cas COMPOSITIONS AND METHODS OF USE
- Compositions and Methods of Use for Variant Csy4 Endoribonucleases
- Identification Of Sites For Internal Insertions Into Cas9
- Chimeric Cas9 Variants With Novel Engineered Enzymatic Activities
- Small Molecule Assisted Cell Penetrating Cas9 RNP Delivery
- Methods and Compositions for Controlling Gene Expression by RNA Processing
