Human Respiratory Disease Model Developed from Titi Monkey Adenovirus

Abstract

Researchers at the University of California, Davis have cultured a titi monkey adenovirus (TMAdV,) and used the virus to develop a model of human respiratory disease.

Full Description

Adenoviruses cause a variety of severe diseases in both humans and other primates. A joint research effort between the University of California, Davis and UCSF used a pan-viral microarray to identify the TMAdV adenovirus as the source of a pneumonia outbreak in titi monkeys. The team also determined that the virus could be transmitted to humans. The research further confirmed detailed characteristics of the virus.

The methods used to detect and characterize the virus are potentially applicable to the detection or mitigation of the transmissible spread of such viruses among humans or other primates. As an example, the virus was cultivated successfully in a human, lung adenocarcinoma, cell line. Such techniques can spur ongoing efforts to explore the potential of using adenovirus vectors to develop vaccines and gene therapies.

Applications

• Improved detection techniques for zoonotic viruses that can be transmitted to humans
• Potential development of human and other primate therapeutics and vaccines

Features/Benefits

• Techniques can be used for epidemiological screening, clinical diagnostics, and outbreak investigation

Related Materials

• Yu G, Yagi S, Carrion R Jr, et al. Experimental cross-species infection of common marmosets by titi monkey adenovirus. PLoS One 2013; 8(7) e68558. doi: 10.1371/journal.pone.006558. - 07/24/2013
• Chen EC, Yagi S, Kelly KR, et al. Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony. Nemerow GR, ed. PLoS Pathogens. 2011;7(7):e1002155. doi:10.1371/journal.ppat.1002155. - 07/14/2011

Patent Status