Non-Human Primate Adenovirus Model of Human Respiratory Disease

Tech ID: 27612 / UC Case 2011-441-0

Abstract

Researchers at the University of California, Davis have developed a model of human respiratory disease using a titi monkey adenovirus.

Full Description

Adenoviruses, or double-stranded DNA viruses that naturally infect vertebrates, have been associated with clinical syndromes including conjunctivitis, hepatitis, and diarrhea. Conventionally, these viruses are thought to be species specific. A high degree of sequence relatedness however suggests that at least some adenoviral strains may be capable of infecting both human and nonhuman primates. These adenovirus can then be used to create models of human diseases in nonhuman primates.

Researchers at the University of California, Davis have discovered an adenovirus from titi monkeys with the potential to infect both human and non-human primates, including both titi monkeys and common marmosets. The researchers have developed methods to detect the adenovirus infection. Furthermore, the virus has been successfully cultivated in a human lung adenocarcinoma cell line and a primary titi monkey cell line, presenting a potential human lung disease model in nonhuman primates.

Applications

  • Detect, treat, prevent, and modulate adenovirus infection

Features/Benefits

  • Model for respiratory disease
  • Cross-species adenovirus
  • Novel viral species

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 9,267,112 02/23/2016 2011-441
United States Of America Published Application 20160264629 09/15/2016 2011-441
 

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Inventors

  • Bales, Karen L.
  • Chen, Eunice
  • Chiu, Charles
  • Lerche, Nicholas W.

Other Information

Keywords

adenovirus, titi monkeys, zoonotic transmission, cross-species transmission, lung disease

Categorized As