Researchers at the University of California, Davis have cultured a titi monkey adenovirus (TMAdV,) and used the virus to develop a model of human respiratory disease.
Adenoviruses cause a variety of severe diseases in both humans and other primates. A joint research effort between the University of California, Davis and UCSF used a pan-viral microarray to identify the TMAdV adenovirus as the source of a pneumonia outbreak in titi monkeys. The team also determined that the virus could be transmitted to humans. The research further confirmed detailed characteristics of the virus.
The methods used to detect and characterize the virus are potentially applicable to the detection or mitigation of the transmissible spread of such viruses among humans or other primates. As an example, the virus was cultivated successfully in a human, lung adenocarcinoma, cell line. Such techniques can spur ongoing efforts to explore the potential of using adenovirus vectors to develop vaccines and gene therapies.
|United States Of America||Issued Patent||10,221,218||03/05/2019||2011-441|
|United States Of America||Issued Patent||9,267,112||02/23/2016||2011-441|
adenovirus, AAV's, cell-line cultivation, gene therapies, human diseases, microarray techniques, primate diseases, therapeutics, vaccines