Legionaminic Acid Glycosyltransferases for Chemoenzymatic Synthesis of Glycans and Glycoconjugates

Tech ID: 33435 / UC Case 2022-592-0

Abstract

Researchers at the University of California, Davis have developed a method for preparing a glycan product containing a nonulosonic acid moiety by means of legionaminic acid transferase fusion proteins

Full Description

Researchers at the University of California Davis have developed a technology that revolves around the method of preparing a glycan product with a nonulosonic acid moiety. It involves the creation of a reaction mixture including a legionaminic acid transferase (LegT), a donor comprising a nonulosonic acid moiety, and a glycan acceptor. This process is performed under conditions for LegT-catalyzed transfer of the nonulosonic acid moiety from the donor to the glycan acceptor to create the glycan product.

Applications

  • Pharmaceutical Industry
  • Biotechnology
  • Chemical Engineering

Features/Benefits

  • Pharmaceutical Industry: Production of effective vaccines and drugs. 
  • Biotechnology: Advancements in glycan research. 
  • Chemical Engineering: Enhancement of existing chemical synthesis processes.

Patent Status

Country Type Number Dated Case
Patent Cooperation Treaty Reference for National Filings WO 2023/183781 09/28/2023 2022-592
 

Patent Pending

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Inventors

  • Chen, Xi
  • Mishra, Bijoyananda
  • Yang, Xiaohong
  • Yu, Hai

Other Information

Keywords

biocatalysis, bacterial carbohydrate, polysaccharide, chemoenzymatic synthesis, glycosyltransferase, legionaminic acid, nonulosonic acid

Categorized As