Legionaminic Acid Glycosyltransferases for Chemoenzymatic Synthesis of Glycans and Glycoconjugates
Abstract
Researchers at the University of California, Davis have developed a method for preparing a glycan product containing a nonulosonic acid moiety by means of legionaminic acid transferase fusion proteins
Full Description
Researchers at the University of California Davis have developed a technology that revolves around the method of preparing a glycan product with a nonulosonic acid moiety. It involves the creation of a reaction mixture including a legionaminic acid transferase (LegT), a donor comprising a nonulosonic acid moiety, and a glycan acceptor. This process is performed under conditions for LegT-catalyzed transfer of the nonulosonic acid moiety from the donor to the glycan acceptor to create the glycan product.
Applications
- Pharmaceutical Industry
- Biotechnology
- Chemical Engineering
Features/Benefits
- Pharmaceutical Industry: Production of effective vaccines and drugs.
- Biotechnology: Advancements in glycan research.
- Chemical Engineering: Enhancement of existing chemical synthesis processes.
Patent Status
| Country | Type | Number | Dated | Case |
| Patent Cooperation Treaty | Reference for National Filings | WO 2023/183781 | 09/28/2023 | 2022-592 |
Patent Pending
Contact
- Victor Haroldsen
- haroldsen@ucdavis.edu
- tel: View Phone Number.
Inventors
- Chen, Xi
- Mishra, Bijoyananda
- Yang, Xiaohong
- Yu, Hai
Other Information
Keywords
biocatalysis, bacterial carbohydrate, polysaccharide, chemoenzymatic synthesis, glycosyltransferase, legionaminic acid, nonulosonic acid
Additional Technologies by these Inventors
- Purification of Glycosphingosines and Glycosphingolipids
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- Synthesis of Capsular Polysaccharides
- Using Escherichia coli to Produce Human Milk Oligosaccharide Lactodifucotetraose
- 4-N-Derivatized Sialic Acids and Related Sialosides
- Substrate And Process Engineering For Biocatalytic Synthesis And Facile Purification Of Human Milk Oligosaccharides (HMOs)
- O-Acetyl Glycosphingosines and Gangliosides, as well as Their N-Acetyl Analogs
- Stable N-acetylated analogs of Sialic Acids and Sialosides
- Alpha1–2-Fucosyltransferase for Enzymatic Synthesis of Alpha1–2-linked Fucosylated Glycans
- Engineering Pasteurella Multocida Heparosan Synthase 2 (Pmhs2) For Efficient Synthesis Of Heparosan Heparin And Heparan Sulfate Oligosaccharides
- One-Pot Multienzyme Synthesis of Sialidase Reagents, Probes and Inhibitors
- Novel Methods For Chemical Synthesis Of Lactosyl Sphingosines, Glucosylsphingosines, Galactosylsphingosines, And 3-O-Sulfogalactosylsphingosines
