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Antimicrobial and Osteoinductive Hydrogel for Dental Applications

UCLA researchers in the Department of Chemical & Biomolecular Engineering developed osteoinductive and antimicrobial hydrogel adhesives for dental applications.

Deconstructive Diversification Of Cyclic Amines Useful For Proline Tagging

A deconstructive strategy to transform saturated nitrogen heterocycles such as piperidines and pyrrolidines into halogen-containing acyclic amine derivatives through sequential Csp3–N/Csp3–Csp3 single bond cleavage followed by Csp3–halogen bond formation. The resulting acyclic haloamines serve as versatile intermediates that are expediently transformed into a variety of structural motifs through substitution reactions. In this way, skeletal remodeling, which constitutes a scaffold hop, can be achieved. The value of this deconstructive strategy has been demonstrated through the late-stage diversification of proline-containing peptides, thus achieving late-stage proline tagging.

Colorimetric Detoxifying Sensors for Fumigants and Aerosol Toxicants

Researchers at the University of California, Davis have developed a colorimetric sensor than can detect and detoxify fumigants simultaneously. 

Deconstructive Fluorination Of Cyclic Amines

Cyclic amines bearing an optimal substituent on the nitrogen atom can be converted to value-added linear fluorinated products. Many of these fluorinated amine products are not known and even the ones that are known are prohibitively expensive. This new method accesses these fluorinated building blocks. The chemistry can also be used to achieve late-stage skeletal diversification of interest to the pharmaceutical and agrochemical fields and possibly materials applications.

Ambient Methane Functionalization Initiated by d0 Metal-Oxo Electrocatalyst

UCLA researchers in the Department of Chemistry and Biochemistry have developed a new strategy to electrochemically functionalize methane at low activation energies under ambient conditions.

Hydrodealkenylative C(Sp3)–C(Sp2) Bond Scission

UCLA researchers in the Department of Chemistry and Biochemistry have developed a new chemical reaction that combines ozone, an iron salt, and a hydrogen atom donor to enable hydrodealkenylative cleavage of C(sp3)–C(sp2) bonds in a widely applicable manner.

A Sustainable Alternative Route to Produce Methyl Methacrylate

A sustainable alternative route to produce Methyl methacrylate (MMA) in an engineered yeast strain.

Device and Method for Accurate Sample Injection in Analytical Chemistry

Researchers in the UCLA Departments of Bioengineering and Medical and Molecular Pharmacology and the UCSF Department of Bioengineering and Therapeutic Sciences have developed a novel microvalve injector for capillary electrophoresis (CE) that improves injection repeatability and consistency.

Method For Mitigation Of Alkali-Silica Reaction In Concrete Using Chemical Additives

UCLA researchers in the Department of Civil and Environment Engineering have developed a new alkali-silica reaction (ASR) mitigation method using calcium nitrate, which is an abundant, cost-effective alternative to current approaches.

Drug Combinations For Treatment Of Tinnitus, Vertigo, and Headache

UC Irvine researchers propose various combinations of medications for treatment of tinnitus and vertigo.

Synthesis Of Heteroatom Containing Polycyclic Aromatic Hydrocarbons

UCLA researchers in the Department of Chemistry & Biochemistry have developed an approach for synthesizing nitrogen-containing polycyclic aromatic hydrocarbons with high yield.

Nanocellulose-Assisted Exfoliation of Graphite to Few Layer Graphene

Researchers at the University of California, Davis have developed a high-yield method that utilizes the unique properties of cellulose nanofibrils (CNFs) to fabricate high-quality graphene from bulk graphite. This graphene can then be fabricated into graphene nanopapers, which have unique moisture and heat-sensing capabilities for applications in “smart” electronic devices and other uses.

A High Potency CYP3A4 Inhibitor for Pharmacoenhancement of Drugs

      CYP3A4 is the most clinically relevant drug metabolizing enzyme in the body, as it is responsible for the oxidation and breakdown of ~60% of current drugs on the market.  Researchers at UCI have developed novel CYP3A4 inhibitors, that are highly potent and more specific, exhibit fewer side effects, and are both cheaper, and easier to-synthesize than current commercially available CYP3A4 inhibitors. 

Combination of a drug with low level light therapy (LLT) for treatment of wounds

This is a combination of a drug and light technology for the purpose of accelerating the healing of wounds on the skin, ulcers, and elsewhere in the body. Both methods have been shown to accelerate wound healing, and combining the two will potentially result in more rapid healing than either would alone.  

Metal Triazolites

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel metal-organic framework (MOF) using triazole ligands that allows for facile modification with a variety of metals, which has unique gas separation and adsorption properties.

Isobutanol Production Using Metabolically Engineered Escherichia Coli

UCLA researchers at the Department of Chemical and Biomolecular Engineering have engineered Escherichia coli bacteria to produce isobutanol from glucose.

Novel Synthesis of Streptogramin A Antibiotics

A modular, scalable, chemical synthesis platform that produces new Streptogramin A class antibiotic candidates.

One Step Process of Forming Complex Coacervation During Spray Drying

Researchers at the University of California, Davis have developed a formation of complex coacervate microparticles by spray drying.

Catechol Functionalized Elastin-Like Polypeptide Adhesives

Reliably reconnecting severed tissues is a critical part of any invasive medical procedure. Although, sutures and staples are ideal choices due to their effectiveness, adhesives hold great promise as alternatives for bonding tissues. Although many bio-adhesives are commercially available, no product yet combines all desirable properties such as consistent adhesion to wet surfaces, mechanical durability, molecular-level customizability and biocompatibility. UC Berkeley research have developed a recombinant protein-based adhesive by chemically functionalizing elastin-like polypeptides (ELPs).  These ELPs form stable and flexible hydrogels de-swell in aqueous conditions. An additional strength of using recombinant proteins is exhibited by significantly enhancing cell binding to this ELP by a simple modular addition of an engineered protein with ‘RGD’ peptides. 

Complex Mixed Ligand Open Framework Materials

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel multifarious mixed functionalized metal-organic framework (MOF), which has been demonstrated to be successful in gas storage and separation.

Preparation Of Functionalized Polypeptides, Peptides, And Proteins By Alkylation Of Thioether Groups

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering Department, have developed new methods for adding different functional groups on polypeptides.  The UCLA researchers have used this method to create a platform to create and modify nanoscale vesicles and hydrogels for use in nanoscale drug delivery particles, injectable drug depots, imaging and detection, industrial biomaterials, and wound management.

New Form Of Hybrid Materials

Advances in science are driven by new discoveries which can pave the way to new create new research directions. For example, crystals by the nature of their order in three-dimensional space, cannot flex or expand, but with the integration of macromolecular ferritin crystals with hydrogel polymers can change their dimensions.

Development of an Antidote for Cyanide and Sulfide Poisoning

Cyanide is a rapidly acting poison, which, along with carbon monoxide, is the major cause of death from smoke inhalation. For treating a large number of casulaties in the field, the best mode of treatment would be intramuscular injection of antidote, preferably by an autoinjector. The two treatments currently approved for cyanide poisoning— hydroxocobalamin (Cyanokit) and the combination of sodium nitrite and sodium thiosulfate (Nithiodote)—must be administered by intravenous injection. Thus, no agent currently exists for rapidly treating a large number of cyanide poisoned persons. Another rapidly acting poison similar to cyanide, is hydrogen sulfide. People are exposed to hydrogen sulfide gas in a variety of occupations, most notably wastewater processing, and agriculture and petroleum industries. Up to 30% of oil workers have been exposed to sufficient amounts of hydrogen sulfide to have symptoms, and fatalities are not uncommon. No specific treatment currently exists for sulfide poisoning, and treatment consists of general supportive care.

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