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Automated Drosophila Maintenance System

Drosophila spp., also known as fruit flies, are widely used in genetic research. Drosophila lines (e.g. flies with a particular mutation) can only be stored as live animals – they cannot be frozen and remain viable. So to maintain the stocks, the live flies are manually transferred from an old vial to a new vial on a regular basis (every 1-2 weeks). Some Drosophila labs maintain hundreds or even thousands of individual lines and so maintenance of these lines can be very time consuming. A UC Santa Cruz Drosophila researcher has developed a simpler and more efficient method of transferring the flies that requires significantly less hands-on work.

Heart Assist Device for Patients

Researchers at UCI have developed a cardiac assist device for patients with failing heart functions. The device contracts and expands the heart with the help of a pacemaker to help restore natural heart pace and blood flow. 

New Classes Of Cage And Polyhedron And New Classes Of Nanotube And Nanotube With Planar Faces

UCLA researchers have developed a novel algorithm that can be used to design unique self-assembled molecules and nanostructures.

New Substrate to Enhance Catalytic Activity

Researchers at UCR have developed a sulfated zirconium oxide substrate containing strong Lewis acid sites to enhance the activity and selectivity of heterogeneous catalysts. As seen in Fig 1, this new heterogeneous catalyst significantly increases catalyst activity compared to a known olefin metathesis catalyst in homogeneous solution. Fig. 1 shows the catalytic activity for the UCR supported catalyst (red dots) at ~0.001 mol % loading in the metathesis of 1-decene. The black dots are metathesis activity of the same catalyst unsupported catalyst in solution at 0.1 mol%.  

Material For Thermal Regulation

Researchers at UCI have developed a lightweight, flexible thermal material that, due to the extent that it is stretched, allows for tunable control of heat flow.

Lower Cost Method for Fabricating Porous Metal Oxide Composites

Researchers at the University of California, Riverside have developed lower cost methods to synthesize metal oxide composites. The metal organic particles are fabricated by first dispersing a metal oxide precursor with a dispersing agent. The pH of the dispersing agent is set between 7.8 and 11. These conditions promote binding of the metal oxide and dispersing agent in solution. The resulting mixture is then heated at lower temperatures than current processes and subsequently extruded to form the desired geometry. The nanoparticles can be recovered and reused for further treatment. Metal oxides can also be fabricated into stand-alone structures, eliminating the need for nanoparticle recovery. Fig. 1 Continuous stirred tank reactor (CSTR) fabrication method for the metal oxide particles. Metal oxide is mixed with the dispersing agent, then washed, heat-treated and finally extruded into the desired geometry   Fig. 2 Dried cubes of TiO2 mixed with PVA dispersing agent  

Chromantium: New Alloy with Very High Hardness

Researchers in Prof. Reza Abbaschian’s High-Pressure High-Temperature Materials Processing Laboratory (HPHT Lab) have developed a new multiprincipal element  alloy (MPEA) consisting of near equal parts Co, Cr, Cu, Mn, and Ti that combines strength and fracture toughness due to its hard intermetallic microstructure encapsulated in a Cu-rich matrix (Fig. 1). HPHT Lab refers to this alloy as Chromantium. Additional alloying elements such as iron, carbon, boron, magnesium, or any of the rare earth elements may be added to this mixture to achieve similar microstructure and properties. Refining the amounts of the elements in the composition leads to a more uniform microstructure shown in Figure 2. Unlike most commercial alloys, Chromantium has primary dendrites that have Hexagonal Close Packed (HCP) crystalline structure. As such, these extremely hard dendrites are embedded in a softer cubic Cu-rich matrix. The Vickers hardness values of the dendrites is 1000 HV, while the softer matrix is around 460 HV. The overall hardness encompassing both regions is 480 HV. While precise conversion from HV to Rockwell C is not available, the above numbers show hardness values in excess of 68 HRC for dendrites and around 46 HRC for the matrix. Direct measurement of HRC for the as-cast microstructure of the refined material composition in Fig. 2 has bulk Rockwell hardness of 43 HRC. For comparison, H13 tool steel has hardness ranging from 360 HV to 490 HV depending on composition and heat treatment. These extreme hardness values make Chromantium desirable for applications that require hard materials and good wear properties.  Fig. 1 Dendritic microstructure of equiatomic CoCrCuMnTi Fig. 2 Dendritic microstructure of refined Chromantium displaying a much more uniform microstructure when compared to the equiatomic composition in Fig. 1.  

Variable Friction Shoe

The Variable Friction Shoe, which ameliorates the effects of drop foot.

New Catalysts for Perchlorate Reduction in Water

Prof. Jinyong Liu’s lab at UCR has developed a new family of catalysts that reduce perchlorate in contaminated water and wastewater. The catalyst rapidly and completely reduces the toxic ClO4- into the innocuous chloride (Cl -) by breaking down the bonds between the central chlorine atom and all surrounding oxygen atoms. The reduction is a green process because no byproducts are produced in the water. The catalyst completely reduces perchlorate in a very wide concentration range, and retains high activity even in brine with concentrated salts. The catalyst using earth-abundant and non-toxic metal provides sustainable solutions to the perchlorate issues in terms of water and wastewater treatment, ion-exchange resin regeneration, and old munition/explosive disposal. Not only can this new catalyst reduce perchlorate but it may also be used to reduce other drinking water contaminants such as chlorate, chlorite, nitrate, nitrite, bromate, and iodate in a variety of environmental remediation scenarios.  Fig. 1 shows the reduction profiles of 1, 10, and 100 mM ClO4− (corresponding to 100,000 to 10,000,000 ppb) by the UCR catalyst at a loading of only 0.2 g/L. The reactions were conducted at 25 oC and under 1 atm H2. Fig. 2 shows the high activity for the catalytic reduction of 1 mM ClO4− by the UCR catalyst (just 0.2 g/L) in the typical resin generation wastes containing chloride and sulfate.

Iii-N Transistor With Stepped Cap Layers

A new structure for III-N transistors that is able to maintain a high breakdown and operating voltage while improving the gain of the device.

Device and Method for Microscale Chemical Reactions

UCLA researchers in the Departments of Bioengineering and Molecular and Medical Pharmacology have developed a passive microfluidic reactor chip with a simplified design that is less costly than existing microfluidic chips.

Device and Method for Accurate Sample Injection in Analytical Chemistry

Researchers in the UCLA Departments of Bioengineering and Medical and Molecular Pharmacology and the UCSF Department of Bioengineering and Therapeutic Sciences have developed a novel microvalve injector for capillary electrophoresis (CE) that improves injection repeatability and consistency.

Engineered Biomaterial to Prevent Endothelial Inflammation

Researchers at the University of California, Davis have developed a biocompatible material to mimic the glycocalyx, the natural layer of molecules that coats the outside of endothelial cells. This technology can be used to treat inflammation in diseases characterized by dysfunction in leukocyte-endothelial cell interactions.

Continuously Variable Inverse Harmonic Drive

A transmission that uses a variable sized drum, a rotating tensioner arm, and a dry adhesive band to create a compact, continuously-variable transmission that behaves like an inside-out harmonic drive.

Massively Parallel High Throughput Single Cell Electroporation (MSEP)

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.

High Pressure, Laser Floating Zone Crystal Growth Furnace

A furnace that allows for the growth of crystalline material under applied gas pressures of up to 1000atm.

Selective Deposition Of Diamond In Thermal Vias

UCLA researchers in the Department of Materials Science & Engineering have developed a new method of diamond deposition in integrated circuit vias for thermal dissipation.

Combination of a drug with low level light therapy (LLT) for treatment of wounds

This is a combination of a drug and light technology for the purpose of accelerating the healing of wounds on the skin, ulcers, and elsewhere in the body. Both methods have been shown to accelerate wound healing, and combining the two will potentially result in more rapid healing than either would alone.  

Metal Triazolites

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel metal-organic framework (MOF) using triazole ligands that allows for facile modification with a variety of metals, which has unique gas separation and adsorption properties.

Soft Burrowing Robot for Simple & Non-Invasive Subterranean Locomotion

A soft robot that can successfully burrow through sand and dirt, similar to a plant root.

Complex Mixed Ligand Open Framework Materials

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel multifarious mixed functionalized metal-organic framework (MOF), which has been demonstrated to be successful in gas storage and separation.

Micro- and Nanocomposite Support Structures for Reverse Osmosis Thin Film Membranes

UCLA researchers in the Department of Civil and Environmental Engineering have invented a novel nanofiltration (NF) and reverse osmosis (RO) composite membrane for water desalination applications.

Actively Controlled Microarchitectures with Programmable Bulk Material Properties

Professor Jonathan Hopkins and colleagues have developed amechanical programmable metamaterial consisting of an array of actively, independently controlled micro-scale unit cells. This technology allows for the application of materials which have instantly changeable, programmable properties that can exceed those of conventional, existing materials.

Novel Multi-Scale Pre-Assembled Phases of Matter

UCLA researchers from the Departments of Chemistry and Physics have developed a novel method for creating multi-scale pre-assembled phases of matter with customizable symmetries, topologies, and degrees of order and disorder.

Controlling Magnetization Using Patterned Electrodes on Piezoelectrics

UCLA researchers in the Department of Materials Science and Engineering have developed a novel piezoelectric thin film that can control magnetic properties of individual magnetic islands.

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