Reducing Free Milk Glycan Monomers Generated by the Neonate Gut Microbiota Eliminates Colonization by Dysbiotic Microbiome Members

Tech ID: 24829 / UC Case 2015-193-0

Abstract

Researchers at the University of California, Davis have found a natural way to prevent the development of pig scour in nursing pigs.

Full Description

Pig scour, or collibacillosis, is a major cause of illness and death in nursing or weaning pigs worldwide. The US economic effect is estimated to be close to $236 million annually through death and disease. The disease itself is characterized by diarrhea that leads to dehydration and death among untreated animals and spreads rapidly within a facility. Dysbiosis in the gut microbiome of these animals has been identified as a primary driverfor Enterobactieriaceae and Clostridiaceae, the organisms primarily responsible for pig scour.

Current prophylactic treatments for pig scour includes vaccination, stringent sanitation procedures, and in-feed antibiotics for weaning animals. Despite these preventative strategies, pig scour remains a major economic cost to swine producers.

Researchers at the University of California, Davis have demonstrated a prophylactic treatment of pig scour in swine which is effective in reducing colonization by Enterobactieriaceae and Clostridiaceae in nursing pigs. 

Applications

  • Treatment of nursing and weaning pigs to prevent scour.

Features/Benefits

  • Does not increase risk of antibiotic resistant infection in swine. 
  • Cheap and effective preventative treatment. 
  • Easy to mass treat swine populations.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 11,633,461 04/25/2023 2012-346
United States Of America Issued Patent 11,285,182 03/29/2022 2015-193
United States Of America Issued Patent 11,000,576 05/11/2021 2012-346
United States Of America Issued Patent 10,780,136 09/22/2020 2015-193
United States Of America Issued Patent 10,688,160 06/23/2020 2012-346
United States Of America Issued Patent 10,639,357 05/05/2020 2012-346
United States Of America Issued Patent 10,471,134 11/12/2019 2012-346
United States Of America Issued Patent 10,350,249 07/16/2019 2015-193
United States Of America Issued Patent 10,165,788 01/01/2019 2013-877
United States Of America Issued Patent 10,071,142 09/11/2018 2012-346
United States Of America Issued Patent 9,327,016 05/03/2016 2012-346
United States Of America Issued Patent 8,425,930 04/23/2013 2009-110
 

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Inventors

  • Frese, Steven
  • Mills, David A.

Other Information

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