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Synergistic Enzyme Mixtures to Realize Near-Complete Depolymerization in Blends

In this technology, the inventors introduce additives to purposely change the morphology of polycaprolactone (PCL) by increasing the bending and twisting of crystalline lamellae. These morphological changes immobilize chain-ends preferentially at the crystalline/amorphous interfaces and limit chain-end accessibility by the embedded processive enzyme. This chain end redistribution reduces the polymer-to-monomer conversion from >95% to less than 50%, causing formation of highly crystalline plastic pieces including microplastics. By synergizing both random chain scission and processive depolymerization, it is feasible to navigate morphological changes in polymer/additive blends and to achieve near complete depolymerization. The random scission enzymes in the amorphous domains create new chain ends that are subsequently bound and depolymerized by processive enzymes. Present studies further highlight the importance to consider host polymer morphological effects on the reactions catalyzed by embedded catalytic species.This is part of a patent family in compostable plastics.  

Modified Bauxite for Phosphate Recovery and Recycling

This technology shows three different forms of bauxite to be effective adsorbents for phosphate ions. 1. Mildly processed bauxite (MPB), which is essentially ball-milled raw bauxite ore, 2. Thermally activated bauxite (TAB), which is ball-milled bauxite ore subjected to 300 C roasting, and 3. Acid treated thermally activated bauxite (ATAB), which is ball-milled bauxite ore subjected to 300 C roasting and subsequent acid treatment using 5M HCl.  These three different forms of bauxite are shown to adsorb phosphate in high amounts from solutions containing a range of initial phosphate concentrations, 5 ppm to 631 ppm.  ATAB shows the highest adsorption density, demonstrating a value of 50 mg of PO4-/g ATAB at pH=6TAB shows an adsorption density of 25 mg PO4-/g TAB at pH=6  There are two industry standard materials for phosphate adsorption, activated magnesia (MgO), and activated alumina (Al2O3). For comparison, activated magnesia (MgO) demonstrates an adsorption capacity of 25 mg PO4-/g at pH=6. Activated alumina (Al2O3) shows an adsorption capacity of 11 mg PO4-/g at pH=6 (reference: Journal of Environmental Chemical Engineering 5 C(2017) 3181–31893183).  Phosphate, a finite and dwindling resource mined from phosphate rock, is a critical nutrient in modern agriculture, which is applied as fertilizer to ensure adequate plant growth. The inventors provide a cost-effective, environmentally-friendly method for recovering phosphate from agricultural runoff and other wastewater and delivering the recovered phosphate in a targeted and controlled manner to agriculture and farm sectors.

Milk Fat Globules As A Universal Delivery System

Researchers at the University of California, Davis have developed methods that utilize molecules encapsulated in milk fat globules and plant oleosomes to deliver bioactive compounds for a variety of applications.

Breast Milk as a Source, Incubation/Storage Medium, and Delivery System for Infant Mucosal Immunity Bacteriophage

Researchers at the University of California, Davis have developed a method to harvest and enrich symbiotic bacteriophage to promote bacterial immunity.

Update To Degradable Trehalose Glycopolymers

UCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.

Xylosyl-Xylitol Oligomers And Their Microbial And Enzymatic Productions

Lignocellulosic biomass derived from plant cell walls is the most abundant raw material for biofuels and renewable chemicals production.  Hemicellulose comprises about 30% of the total weight of lignocellulosic biomass. In contrast to cellulose, hemicellulose components are readily depolymerized into short oligomers and released into the liquid phase during pretreatment.  It is of great interest to convert the released hemicellulose components into fuels or other value-add chemicals for building an economical biomass conversion process. There are ten times more microorganisms than human cells in a healthy adult.  The symbiosis between the microbiome and human organs is increasingly recognized as a major player in health and well-being.  Xylooligosaccharides and xylitol, both derived from hemicellulose, can benefit gut flora and oral flora, respectively. Xylooligosaccharides (XOS, also called xylodextrins) are naturally occurring oligosaccharides, found in bamboo shoots, fruits, vegetables, milk and honey.  Industrial scale production of XOS can be carried out with much less expensive lignocellulosic materials by hydrothermal treatment or enzymatic hydrolysis.  A broad range of applications of XOS have been demonstrated, including as functional food, prevention and treatment of gastrointestinal infections, animal feed for fish and poultry, agricultural yield enhancer and ripening agent, and as active agents against osteoporosis, pruritus cutaneous, otitis, and skin and hair disorders.  In the current market, the most important applications of XOS correspond to ingredients for functional foods as a prebiotic, or formulated as synbiotics. XOS has been shown to promote beneficial bacteria Bifidobacterium adolescentis growth in vitro and in vivo.  It has been estimated that the prebiotics market will reach $4.8 billion by 2018. Xylitol is another hemicellulose-derived compound beneficial to human health.  For many bacteria and yeasts, the uptake of non-utilizable xylitol interferes with hexose utilization, which helps the human body to rebuild a healthy microbiome.  Xylitol has been used to prevent middle ear infections and tooth decay.  In addition, xylitol possesses 33% fewer calories but similar sweetness compared to sucrose and has been widely used as a substitute sweetener.  While chemical hydrogenation of xylose remains the major industrial method of xylitol production, microbial fermentation has become more popular in the newly built plants due to lower conversion cost. There exists a need for improved methods of producing xylooligosaccharides and related compounds, such as xylooligosaccharides with xylitol components.    UC researchers discovered a new set of fungal metabolic intermediates, named xylosyl-xylitol oligomers and developed the enzymatic and microbial fermentation method to produce such compounds. The detection and purification methods have also been developed.

Preparation of Furan Fatty Acids from 5-(Chloromethyl) Furfural

Researchers at the University of California, Davis have developed a novel, efficient route to a new class of dietary supplements with antioxidant, anti-inflammatory, and possible cardioprotective properties.

Gluten Digesting Bacterial Strains

Over the last few years Celiac disease and gluten intolerance has been on the rise. Currently, the only treatment is a gluten free diet, which is very difficult to follow. Cross contamination of gluten free products is common and many food items that seemingly contain no wheat contain gluten-derived products. Here we describe several bacterial strains isolated from humans for their gluten degrading activities. These bacteria may be used to eliminate trace amounts of wheat contaminants from gluten free products or as probiotic therapy.

Method for Efficient Loading of Bioactives into Lipid Membrane Microcapsules

Researchers at the University of California, Davis have developed a method of delivering targeted bioactives that is applicable to the agricultural, food processing, cosmetic, veterinary and medical industries.

PolyProtek: Platform for Delivering and Stabilizing Therapeutic Biologics, Vaccines, and Industrial Enzymes

UCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.

Fermented Wheat Germ Extract And Its Purified Low Molecular Weights Proteins For Treatment Of Lung Cancer

Researchers at the University of California, Davis have demonstrated biologic activities of Fermented wheat germ extract (FWGE) against lung cancer cells in tissue culture and in mice.

Edible Oils to Enhance the Absorption of Orally Administered Steroids Including Neurosteroids

Researchers at the University of California, Davis have developed a formulation of steroids, including neurotsteroids in edible oils to enhance their absorption orally or transmucosally.

Application of Topical Resveratrol in the Treatment of Acne

Researchers in UCLA Department of Dermatology have demonstrated through in vitro experiments that resveratrol, an ingredient in antioxidants and anti-aging products, generates sustained bactericidal and anti-inflammatory effects against P. acnes, the bacteria involved in the pathogenesis of acne.

Curcumin as a Treatment for Pancreatitis

Brief description not available

Rumen-Protection System for Feed Ingredients

Delivery system for protecting feed ingredients passing through the rumen of cattle.

Phaff Yeast Culture Collection

Phaff yeast culture collection.

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