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Novel NMR Tube for In-Situ Photochemical Reactions Under Inert and Controlled Atmospheres
Dr. René Riedel and Stephen Lepore from the University of California, Riverside have developed an NMR tube/reactor that enables in-situ irradiation to photo-initiate reactions in an inert or controlled atmosphere. It allows for the data acquisition of air, moisture, and temperature-sensitive liquid samples by nuclear magnetic resonance (NMR) spectroscopy without needing to remove the sample from the spectrometer for irradiation. This technology is advantageous because it makes photochemical reactions and kinetic measurements of sensitive samples more reproducible, and it enables the previously impossible maintenance of a controlled environment during photochemical NMR investigations.
Safer and Efficient Schrock Catalysts
Professors Richard Schrock, Matthew Conley, and colleagues from the University of California, Riverside have developed a new Schrock catalysts for olefin metathesis that can be produced in fewer synthetic steps, activated with perfluorinated alcohols, and reactivated using light or heat. The method provides a more convenient route to a variety of Schrock catalysts that avoid corrosive triflic acid and reactive Grignard reagents to yield Schrock catalysts, which can then be converted readily into other catalyst variations. This technology is advantageous because it is a safer and less expensive way to synthesize and activate Schrock catalysts for industrial and research applications.
High-Fidelity Cas13a Variants
Professor Giulia Palermo and colleagues from the University of California, Riverside and the University of Rochester have developed high-fidelity Cas13a variants with increased sensitivity for base pair mismatches.The activation of these Cas13a variants can be inhibited with a single mismatch between guide-RNA and target-RNA, a property that can be used for the detection of SNPs associated with diseases or specific genotypic sequences.
Handheld Device For Quick DNA Extraction
Professor Hideaki Tsutsui and colleagues from the University of California, Riverside have developed a portable handheld device for nucleic acid extraction. With its high-speed motor, knurled lysis chamber for rapid sample lysis, and quick nucleic acid extraction using paper disks, this device can yield ready-to-use extracts in just 12 minutes, significantly reducing the time required for sample preparation. This technology is advantageous over current methods as it can be expedited without the need for cumbersome specimen collection, packaging, and submission, shortening the turnaround time.
The Poor Man’s Trough: A Bench Top Motor Free Method To 3D Langmuir-Blodgett Films
Brief description not available
Improved p38 MAPK Assay
Professor Thomas Kuhlman and colleagues from the University of California, Riverside have developed a novel method named “Chemical Selectivity Readouts” and FRET sensor that can be used to identify new p38 MAPK inhibitors for development. Chemical Selectivity Readouts work by measuring p38 MAPK inhibition through the detection of resonance selectivity by Fourier transform. This technology is advantageous because it can enable the research and development of new and improved drugs targeting p38 MAPK for specific diseases like cancer and neurological disorders. Past clinical development roadblocks can be overcome with this new assay by developing more specific and less toxic drugs.
ShowMEPATH: Automated Multi-Omics Comparative Analysis Tool Revealing Hidden Patterns in Large-Scale Fold-Change Data
The University of California, Riverside has developed a new omics software named, ShowMEPATH, employing a faster and easier approach to compare changes in metabolites within multiple sample groups, along with an automated algorithm to facilitate the process. The software introduces a novel tool to visualize volcano plots, called Parallel Fold Change (PFC) plot. Unlike current software solutions, PFC enables researchers to easily process their large omics data sets to compare various biological networks. The PFC plot is an efficient tool for analyzing and interpreting complex biological comparisons and it helps researchers to efficiently map omics pathways. Fig 1: This figure illustrates a Parallel Fold Change (PFC) plot and demonstrates the parallel comparison of multiple samples in metabolomics. The tool examines the fold-change patterns of 45 metabolites across 16 scenarios involving 8 genotypes and 3 treatments. Using ShowMEPATH, researchers can identify detailed patterns within biological experiments, with the ability to hover over lines in the PFC plots for seamless access to KEGG modules or pathways, thereby streamlining the exploration of related biological information
Efficient Method with Less Caustic Reagents to Synthesize Schrock Catalysts
Professors Richard Schrock, Matthew Conley, and colleagues from the University of California, Riverside have developed new Schrock catalysts in the form of tungsten cyclohexylidenes that can be produced in as few as three synthetic steps, using inexpensive and non-corrosive reagents. This technology forms metathesis-relevant alkylidenes from an olefin through a novel thermal mechanism that avoids a protonation/deprotonation mechanism. This technology is advantageous because it can enable a cost-effective access to metathesis active Schrock catalysts for industrial and research applications.
Aerobic Biotransformation and Defluorination of ether PFAS
Substantial defluorination of chlorinated PFCAs
Strain Gated Molybdenum Disulfide Field Effect Transistor With Edge Contacts
Fabrication And Capillary Flow In Microporous Wick For Non-Thermal Solar Desilanation
Self-Regenerative Ni-Doped Catio3/Cao For Co2 Capture And Utilization
A General Magnetic Assembly Approach To Chiral Superstructures At All Scales
Daily Move© - Infant Body Position Classification
Prof. John Franchak and his team have developed a prototype system that accurately classifies an infant's body position.
Tungsten and Molybdenum Alkylidene Catalysts for Olefin Metathesis
Professors Richard Schrock and Matthew Conley from the University of California, Riverside have developed new W and Mo based alkylidene olefin metathesis catalysts that can be produced by activation of metathesis-inactive precursors, accessible from metal chloride precursors via as few as three synthetic steps, using visible light. ??,??'disubstituted tungsten cyclopentane complexes can be prepared in the dark and form alkylidenes through irradiation. This technology is advantageous because it can potentially regenerate used catalysts by irradiation with visible light, offering a sustainable and cost-effective approach for industrial and research applications. Fig 1: Synthetic scheme of alkylidenes from tungstacyclopentane complexes upon exposure to violet or blue light (405-445 nm). A number of tungstacyclopentanes have been prepared from W(NR)OR’)2Cl2 complexes through alkylation and reduction with diethylzinc in the presence of an olefin.
Method for High-Yield Chemical Recycling of Plastic Waste
Professor Matthew Conley from the University of California, Riverside has discovered that catalysts used to generate polyolefin plastics also perform well in hydrotreatment reactions of plastic waste. This method works by treating plastic materials with known catalysts at 200⁰C to degrade polymers into smaller alkanes in the presence of hydrogen. This technology is advantageous compared to existing methods since it does not require high temperatures, has a relatively high yield (+80%), and can be applied to a variety of plastics to generate a feedstock of smaller polymers and monomers for further processing.
Next Generation Led-Chemical Home Drinking Water Purifier For Removal Of Organic Contaminants, Pathogens And Lead
Phosphorus Pentoxide Additive for Lithium-ion Batteries
Catalysts For Aqueous Contaminant Reduction
An Electrochemical Switch For Controlling The Flammability Of Liquid Fuels
Magnesium Enhanced Reactivity of High Energy Composites
Unzipping Polymers For Enhanced Energy Release
Smart Insulin Leak Detector
New Recycling Methods For Li-Ion Batteries
Prof. Juchen Guo and his research team have discovered novel methods that use a liquid reagent to extract close to 100% of the metals lithium (Li), cobalt (Co), nickel (Ni) and manganese (Mn) from LiCoO2 (LCO) and LiNixMnyCo(1-x-y)O2 (NMC) cathodes, efficiently. This low cost process is easy to implement, scale up, low cost and is environmentally friendly.