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CAPTaINs provide a novel, selective, and stable method for selective degradation of protein targets.

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Researchers at the University of California, Davis have developed a system of reusable, sterilizable 3D-printed surgical tools that enables safe, precise intraoperative deployment of Neuropixels probes within standard neurosurgical workflows.

A breakthrough one-wire EEG cap with embedded electrode chips provides ultra-sensitive, noise-immune, wide-band brain signal acquisition. It enables non-invasive, real-time, high-resolution recording using dry electrodes, ideal for wearable and clinical neuro-technology applications.

An innovative non-invasive device that accurately determines the age of bruises for all skin types and tones, designed to assist in forensic investigations and medical diagnostics.

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Researchers at UC Santa Cruz have expanded the knowledge on the rippled β-sheet, a protein structural motif formed by certain racemic peptides. Rippled β-sheets already show potential for Alzheimer’s research and drug delivery and leads to formation of hydrogels with enhanced properties. Researchers at UC Santa Cruz have further added to the structural foundation of rippled β-sheets, better understanding how rippled β-sheet formation can be controlled at the molecular level.

An advanced AI-driven system for synthetic medical data generation and precise segmentation of cardiac MRI to enhance accuracy and efficiency in cardiovascular health.

Researchers at the University of California, Davis have developed an AI-powered framework that bridges the gap between predictive feature analysis and actionable interventions by extracting evidence-based recommendations from scientific literature.

Researchers at the University of California, Davis have developed a nanoparticle system combining photothermal therapy and chemotherapy for enhanced cancer treatment.

Amyloid-β (Aβ) is a protein that is implicated in Alzheimer’s disease. Aβ oligomers aggregate to form amyloid plaques, which are found in the brains of individuals with Alzheimer’s disease. These plaques have high polydispersity; they vary in shape and size. Previously, researchers at UC Santa Cruz demonstrated that using a racemic mixture of Aβ promoted fibril formation, an aggregation that is less neurotoxic than plaques of high polydispersity. Furthermore, these racemic counterparts form rippled β-sheets.

Nucleic acids such as DNA and RNA find many different applications in research. They can act as research reagents, diagnostic agents, therapeutic agents, and more. Nucleic acids are made by enzymes, which are macromolecules that catalyze reactions. Since nucleic acids are so frequently used in research, there is continued interest in finding new and improved ways to synthesize them. Researchers at UC Santa Cruz have developed ways to continuously synthesize nucleic acids without the use of enzymes.

Researchers at the University of California, Davis have engineered dominant negative CD40L mutant polypeptides that inhibit CD40/CD40L-mediated signaling, offering therapeutic potential for inflammatory, immune disorders, and cancer with improved safety profiles.

Researchers at the University of California, Davis have developed a computer-implemented method to identify viral mutations that enhance transmission and predict their prevalence in populations over time.

Clustered regularly interspaced short palindromic repeats (CRISPR) screening is a cornerstone of functional genomics, enabling genome-wide knockout studies to identify genes involved in specific cellular processes or disease pathways. The success of CRISPR screens depends critically on the design of effective guide RNA (gRNA) libraries that maximize on-target activity while minimizing off-target effects. Current CRISPR screening lacks tools that can natively integrate next-generation sequencing (NGS) data for context-specific gRNA design, despite the wealth of genomic and transcriptomic information available from modern sequencing approaches. Traditional gRNA design tools have relied on static libraries with limited genome annotations and outdated scoring methods, lacking the flexibility to incorporate context-specific genomic information. Off-target effects are also a concern, with CRISPR-Cas9 systems tolerating up to three mismatches between single guide RNA (sgRNA) and genomic DNA, potentially leading to unintended mutations that could disrupt essential genes and compromise genomic integrity. Additionally, standard CRISPR library preparation methods can introduce bias through PCR amplification and cloning steps, resulting in non-uniform gRNA representation.