UCLA researchers have developed a method and model to predict the placebo effect and placebo responsiveness using the 30-item baseline positive and negative syndrome scales (PANSS) scores, within both the medicated and unmedicated Schizophrenia patients.
The placebo effect is used to describe the effect of inert interventions to yield a positive treatment benefit. The placebo effect is greater in studies with a large number of trials, but was found to not be influenced by the frequency of clinician contact. The medication effect is larger in comparator studies than in placebo controlled studies, possibly because the patient realizes (s)he is guaranteed to receive an active medication. There is a need to predict both who will respond to a placebo treatment, and how strongly they will respond.
A model and method to predict who will respond to a placebo treatment, and how stronglySchizophrenia patients will respond.
Placebo effect, method, prediction model, placebo responsiveness, positive and negative syndrome scales, PANSS scores, Schizophrenia, placebo risk scores, responders, non responders