Revolutionizing Micro-Array Technologies: A Microscopy Method and System Incorporating Nanofeatures

Tech ID: 27531 / UC Case 2009-454-0


UCLA researchers in the Department of Electrical Engineering have developed a novel lensfree incoherent holographic microscope using a plasmonic aperture.


Lensfree imaging has gained interest due to the potential to eliminate bulky optical components and to develop on-chip microscope systems, which would be beneficial for microfluidic systems used in medical diagnostics and cytometry applications. A lightweight and compact, lensfree-imaging modality would also be a cheaper alternative to conventional lens-based microscopy, especially for telemedicine applications. Current imaging modalities that are compact, cost-effective, and easy to use either have poor performance or low resolution, limiting their practical use.


Researchers led by Professor Aydogan Ozcan have invented a novel lensless incoherent holographic microscope with a resolution of ~500 nm over a field of view (FOV) of ~5 mm2 and can achieve subcellular resolution over a large FOV of 24 mm2. This compact and lightweight microscope does not require any lenses, lasers, or other bulky optical and mechanical components and instead, utilizes a simple light emitting diode and a compact optoelectronic sensor-array.


  • On-chip microscopy
  • Medical diagnostics
  • Cytometry
  • Telemedicine applications involving global health problems (i.e. malaria, TB, and HIV)


  • Minimally trained personnel to operate
  • Subcellular resolution with large FOV
  • Compact, cheap, and lightweight
  • Lensfree holographic imaging
  • Does not need lenses, lasers, or bulky components

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 9,202,835 12/01/2015 2009-454

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  • Ozcan, Aydogan

Other Information


Lensfree, incoherent, holographic, lensless microscope, holographic microscope, nanosurface, plasmonics, medical diagnostics, cytometry, on-chip microscope

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