Prof. Guillermo Aguilar and his colleagues from the University of California, Riverside have developed a new approach to laser speckle imaging, called Laser Speckle Optical Flow Imaging (LSOFI) to be used for autonomous blood vessel detection and as a qualitative tool for blood flow visualization. LSOFI works by capturing the speckle displacement caused by different physical behavior and use the data to create a mapped image. It has been shown that LSOFI has many advantages over LSCI methods both in temporal and spatial resolution. Namely, LSOFI can be used to produce higher resolution images compared with the LSCI method using less frames. Combining this technology with Graphics Processing Unit (GPU) computation increases the speed of LSOFI, so GPU enabled LSOFI shows potential to create a fast and fully functional quasi-real time blood flow imaging system. Fig 1: Comparison of blood flow imaging techniques applied to the raw image. The shown results are for Laser Speckle Optical Flow Imaging (LSOFI) using the Farneback Optical Flow algorithm, traditional Laser Speckle Imaging (LSI), and Temporal Frame Averaging (sLASCA).