Minimally invasive ureteroscopy is a common procedure in adults, with over 10,000 procedures conducted annually in California alone. The ureteral access sheath (“UAS”), a highly effective device used to facilitate minimally invasive ureteroscopy, can injure the patient when excessive force is used during its placement. Inventors at UCI have developed a minimally invasive force sensor and monitoring system that measures force during UAS placement and can preclude injury by alerting the physician when the threshold for injury is being approached. It thus can be used for medical personnel safety training, quality control and standardization of minimally invasive ureteroscopy, as well as being applied to the passage of other catheters into natural orifices or channels./

UCLA inventors have developed a new method for diagnosing PTSD using radiolabeled ligand targeting AMPA receptor as an imaging agent or tracer.

The invention is a multimodal imaging system that includes an optical coherence tomography device using a particular laser source for accurate and in-depth imaging. The new technology provides a more accurate and detailed imaging solution that aids in reaching a more accurate assessment for the patient’s condition, thus determining the adequate intervention method. Clearly, providing an accurate atherosclerotic plaque identification and treatment option will contribute significantly to treating cardiovascular diseases, which happens to be a leading cause of death in many countries.

High density micro-reactors are fabricated to form an array of wells into a surface for use in high throughput microfluidic applications in biology and chemistry. Researchers at the University of California, Irvine developed a method for increasing micro-reactor densities per unit area using rapidly self-assembled three-dimensional crystalline formation droplet arrays, and a device for performing the same.

Acute otitis media (AOM) is a painful ear infection with a high incidence rate in children. Despite its prevalence, it is commonly misdiagnosed especially in the youngest children, in part due to obstruction of the ear canal by earwax. Researchers at UCI have developed a compact, low-cost, adaptable device to diagnose otitis media through LED light absorption. The device is able to diagnose otitis media through earwax that could be obstructing the view of the eardrum.

Researchers at the University of California, Davis have developed a method to combine individual nanomaterial enhancements to achieve greater X-ray enhancement.

Near infrared (NIR) fluorescence imaging (FI) utilizing the fluorophore indocyanine green (ICG) has become more popular for use in medical diagnostics. It is useful for assessing tissue perfusion in a number of surgeries, particularly abdominal, heart, plastic, hepatic as well as other areas of medicine. The light needed for the excitation of the fluorescence is generated by a near infrared light source which is attached directly to a camera. A digital video camera allows the absorption of the ICG fluorescence to be recorded in real time, which means that perfusion can be assessed and documented. Currently, ICG provides a visual representation of tissue perfusion as a global view. Although some efforts have been put into density analysis, no device or software currently performs dynamic evaluation of blood flow for a surgeon. Without objective dynamic measurements, practitioners are only limited to snap shot view of the static environment. This is a problem because it is the dynamics of blood flow that determines tissue perfusion, not how much blood present at a stationary point in time. Furthermore, because there are no numerical evaluations out on the market that can capture this dynamic aspect of blood flow, practitioners are forced to use the naked eye to make a clinical decision that is not only subjective, but is difficult to assess between cases.

UCLA researchers in the Department of Radiation Oncology at the David Geffen School of Medicine have developed a new computational method to model head and neck movements during medical imaging/treatment procedures.

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a method for the fully automated synthesis of 16β- 18F-fluorodihydrotestosterone (18F-FDHT), a probe to monitor prostate cancer.

Breast cancer is the most common cancer in women in the U.S. As with any cancer, early detection and treatment is critical in minimizing the severity of the tumor and risk of death. Researchers at UCI School of Medicine have developed a novel contrast-enhanced mammography technique capable of distinguishing between benign and malignant lesions in breast tissue.

UCLA researchers have created a method that achieves uniform normal-incident illumination of a spherical surface by first projecting the sphere onto a Cartesian plane and then raster scanning it using an illuminating beam. This allows the scanned object, the illumination source, and the detector to remain stationary.

UCLA researchers in the Department of Bioengineering have developed an algorithm to assess the burn wound severity and predict its future outcomes using Terahertz imaging.

UCLA investigators have developed a novel method to obtain time-resolved fluorescence imaging (TRFI) without the need to extract a fluorescence lifetime. Compared to conventional TRFI, this novel method is reliable, simple, time-saving and can dramatically improve biomedical applications of TRFI.

UCLA researchers in the Departments of Radiological Sciences and Neurology have developed a novel algorithm for processing perfusion weighted magnetic resonance images.

UCLA researchers have developed an image processing technique for quantitative measurement of brain hemodynamics using x-ray digital subtraction angiography (DSA) images. 

UCLA researchers in the UCLA Semel Institutes of Neuroscience and Behavior have developed a non-invasive method to locate and estimate electrical currents in organs such as the brain and heart.

UCLA researchers in the Department of Electrical Engineering have developed a novel lensfree incoherent holographic microscope using a plasmonic aperture.

UCLA researchers have developed a compressive sampling algorithm for on-chip fluorescent imaging over an ultra-large field-of-view without the need for any lenses or mechanical scanning.

UCLA researchers in the Department of Electrical Engineering have developed a system for holographic opto-fluidic microscopy.

UCLA researchers in the Department of Electrical Engineering have developed a novel lensfree super-resolution holographic microscope using wetting films on a chip.

UCLA researchers in the Department of Electrical Engineering have developed a novel field portable fluorescence microscope that can be used as a smart phone accessory.

UCLA researchers in the Department of Electrical Engineering have developed a rapid, low-cost, and label-free methodology for nanoparticle sizing.

UCLA researchers have developed a novel way to significantly improve the resolution of an undersampled or pixelated image.

UCLA researchers in the Department of Electrical Engineering have developed a color calibration method for lens-free and mobile-phone microscopy images allowing for high resolution and accurate color reproduction.