Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Separating and classifying circulating cancer cells from whole blood using a single cell trap microfluidic platform coupled with label free fluorescence life time imaging.

UCLA researchers in the Department of Materials Science and Engineering have developed highly transparent, photoluminescent nanocomposites containing record-high levels of quantum dots.

Researchers at the University of California, Davis, have identified a target for therapeutic intervention and agents that disrupt HIV latency in patients under suppressive HIV therapy. It amplifies the effects of other latency reversal agents and primes the cells harboring the virus for immune clearance and death.

This invention is a novel model that uses magnetic resonance imaging (MRI) information to more accurately determine the irradiation area using proton beam therapy (PBT) for oncological treatment.

Researchers at the University of California, Davis have developed an active nanoplatform (F/HAPIN) for cancer diagnosis and therapy.

UCLA researchers in the Department of Electrical Engineering have developed a novel microscopy analysis that improves resolution, field-of-view and depth-of-field in optical microscopy images.

UCLA researchers have developed a novel method for computational sensing using low-cost and mobile plasmonic readers designed by machine learning.

UCLA researchers in the Department of Electrical Engineering have developed a wide-field and high-resolution coherent imaging method that uses a stack of out-of-focus images to provide much better utilization of the space-bandwidth product (SBP) of an objective-lens.

UCLA researchers in the Department of Electrical Engineering have developed a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve more than 3-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality.

Researchers at the University of California, Davis have developed a highly flexible and reconfigurable optical imaging and spectroscopy platform.

The invention is a novel arrangement that provides high throughput 3D time coursing imaging solution. The setup, simply applied to the conventional inverted microscope, not only improves the imaging speed, resolution and field view, but also provides new capabilities for monitoring a much broader range of samples with various thicknesses and nature. These features combined open new frontiers for imaging applications, including tracking the development of cells in tissues, one of the ultimate goals for imaging.

OCE (Optical Coherence Elastography) and ARF (Acoustic Radiation Force) for blood coagulation assessment. Diagnostic tool for assessing the clot formation/dissolution kinetics and strength.

A methodology to suppress additive and convolved noise in optical heterodyne signals

A new approach to visualizing small and stenotic vasculature not readily visible with modern day diagnostic computed tomography angiography.

Utilizing intravascular ultrasound for accurate placement of transcatheter heart valves to improve surgical outcomes.

This is a fast, fully automated method to accurately model a patient’s left heart ventricle via machine learning algorithms.

Minimally invasive ureteroscopy is a common procedure in adults, with over 10,000 procedures conducted annually in California alone. The ureteral access sheath (“UAS”), a highly effective device used to facilitate minimally invasive ureteroscopy, can injure the patient when excessive force is used during its placement. Inventors at UCI have developed a minimally invasive force sensor and monitoring system that measures force during UAS placement and can preclude injury by alerting the physician when the threshold for injury is being approached. It thus can be used for medical personnel safety training, quality control and standardization of minimally invasive ureteroscopy, as well as being applied to the passage of other catheters into natural orifices or channels./

The invention is a medical handheld device that carries out skin visual inspection simultaneously with blood flow measurements through integrating a Laser Speckle Imaging (LSI) system within a handheld compact dermoscope. Combining both features in one compact, cheap and easy to use device will generate accurate and elaborative functional data that will improve the accuracy and detection of diseases such as cancer.

The invention is a multimodal imaging system that includes an optical coherence tomography device using a particular laser source for accurate and in-depth imaging. The new technology provides a more accurate and detailed imaging solution that aids in reaching a more accurate assessment for the patient’s condition, thus determining the adequate intervention method. Clearly, providing an accurate atherosclerotic plaque identification and treatment option will contribute significantly to treating cardiovascular diseases, which happens to be a leading cause of death in many countries.

High density micro-reactors are fabricated to form an array of wells into a surface for use in high throughput microfluidic applications in biology and chemistry. Researchers at the University of California, Irvine developed a method for increasing micro-reactor densities per unit area using rapidly self-assembled three-dimensional crystalline formation droplet arrays, and a device for performing the same.

Acute otitis media (AOM) is a painful ear infection with a high incidence rate in children. Despite its prevalence, it is commonly misdiagnosed especially in the youngest children, in part due to obstruction of the ear canal by earwax. Researchers at UCI have developed a compact, low-cost, adaptable device to diagnose otitis media through LED light absorption. The device is able to diagnose otitis media through earwax that could be obstructing the view of the eardrum.

Researchers at the University of California, Davis have developed a method to combine individual nanomaterial enhancements to achieve greater X-ray enhancement.

Near infrared (NIR) fluorescence imaging (FI) utilizing the fluorophore indocyanine green (ICG) has become more popular for use in medical diagnostics. It is useful for assessing tissue perfusion in a number of surgeries, particularly abdominal, heart, plastic, hepatic as well as other areas of medicine. The light needed for the excitation of the fluorescence is generated by a near infrared light source which is attached directly to a camera. A digital video camera allows the absorption of the ICG fluorescence to be recorded in real time, which means that perfusion can be assessed and documented. Currently, ICG provides a visual representation of tissue perfusion as a global view. Although some efforts have been put into density analysis, no device or software currently performs dynamic evaluation of blood flow for a surgeon. Without objective dynamic measurements, practitioners are only limited to snap shot view of the static environment. This is a problem because it is the dynamics of blood flow that determines tissue perfusion, not how much blood present at a stationary point in time. Furthermore, because there are no numerical evaluations out on the market that can capture this dynamic aspect of blood flow, practitioners are forced to use the naked eye to make a clinical decision that is not only subjective, but is difficult to assess between cases.

UCLA researchers in the Department of Radiation Oncology at the David Geffen School of Medicine have developed a new computational method to model head and neck movements during medical imaging/treatment procedures.