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Improved Method for Data Collection during Clinical Imaging

Researchers at the University of California, Davis have developed a patient-friendly method for compiling accurate, real-time, imaging data – without requiring often-needed, additional, monitoring devices.

(SD2019-220) Spatiotemporal resolution enhancement of biomedical images

Cardiac MRI is the clinical reference standard for visual and quantitative assessment of heart function. Specifically, cine balanced steady-state free precession (SSFP) can yield cardiac images with high myocardium–blood pool contrast for evaluation of left ventricular (LV) function. However, MRI suffers from long acquisition times, often requiring averaging across multiple heartbeats, and necessitates a trade-off among spatial resolution, temporal resolution, and scan time. Clinically, radiologists are forced to balance acquisition time with resolution to fit clinical needs, and certain applications such as real-time imaging may require small acquisition matrices. Image scaling is typically performed by using conventional upscaling methods, such as Fourier domain zero padding and bicubic interpolation. These methods, however, do not readily recover spatial detail, such as the myocardium–blood pool interface or delineation of papillary muscles.

Fetal Oximetry Measurement via Maternal Transabdominal Spectroscopy

Researchers at the University of California, Davis have developed a non-invasive, near-infrared, spectroscopy technique that measures fetal oxygen saturation via the maternal abdomen.

High-Frequency Imaging and Data Transmission Using a Re-configurable Array Source with Directive Beam Steering

Researchers at the University of California, Davis have developed a reconfigurable radiator array that produces a high frequency directed beam via uninterrupted, scalable, electronic beam steering.

Motor Drive Unit for Combined Optical Coherence Tomography and Fluorescence Lifetime Imaging of Intraluminal Structures

Researchers at the University of California, Davis have designed a motor drive unit that enables combined fluorescence lifetime imaging and optical coherence tomography of luminal structures.

2-D Polymer-Based Device for Serial X-Ray Crystallography

Researchers at the University of California, Davis have developed a single-use chip for the identification of protein crystals using X-ray based instruments.

(SD2021-402) Fully Automated Deep Learning‐Based Background Phase Error Correction for Abdominopelvic 4D Flow MRI

4D Flow MRI has become increasingly valuable for the qualitative and quantitative assessment of cardiovascular disease. Since all measurements can be obtained following image acquisition without the need for targeted ultrasonographic windows or placement of 2D phase contrast planes at the time of the exam, 4D Flow provides versatility that can be essential in the diagnostic process.However, the correction of magnetic eddy current-related background phase error remains a critical bottleneck in abdominal applications.

(SD2021-221) Automated deep correction of MRI phase‐error

Time-resolved 3D phase-contrast MRI with three-dimensional velocity encoding (4D Flow MRI) has become increasingly valuable for the evaluation of cardiovascular disease. While cardiothoracic and neurovascular applications have grown rapidly, a limiting factor for abdominal applications is the correction of magnetic eddy current-related background phase error, which can be more challenging to reliably correct in abdominopelvic regions due to complex vascular and soft tissue geometry. Phase-error correction is essential for both quantification of blood flow as well as for visualization.

(SD2021-401) Automated Correction of Background Phase Error for Cerebrovascular 4D Flow MRI

Currently, there are no automated solutions for phase‐error correction that are effective for brain imaging.

Improving Perfusion Magnetic Resonance Imaging Using Ultra-Fast Arterial Spin Labeling

Prof. Jia Guo and colleagues from the University of California, Riverside have developed a method for improving perfusion Magnetic Resonance Imaging (MRI) using Velocity Selective Arterial Spin Labeling (VSASL). This method uses VS labeling pulses that are capable to only label the blood that is moving within a narrow band of velocities and keep the blood moving at higher velocities unperturbed. This creates a small bolus of label that can be detected readily and quickly. This method provides MRI imaging that is far superior than conventional ASL MRI techniques with a doubled temporal resolution, improved signal-to-noise ratio (SNR) efficiency and quantification accuracy. Fig 1: Schematics showing how UCR’s narrow-band velocity selectivity enables ultra-fast perfusion imaging  

Protein Inhibitor of Type II-A CRISPR-Cas System

The inventors have discovered three protein inhibitors of the type II-A CRISPR-Cas system that specifically inhibit Cas9 from staphylococcus aureus. This finding is of potential importance to many companies in the CRISPR space. 

Advanced Imaging By LASER-Trained Algorithms Used To Process Broad-Field Light Photography and Videography

Diagnosing retinal disease, which affects over 200 million people worldwide, requires expensive and complicated analysis of the structure and function of retinal tissue. Recently, UCI developed a training algorithm which, for the first time, is able to assess tissue health from images collected using more common and less expensive optics.

Method for Motion Sensing in MRI Using Preamplifier RF Intermodulation

The inventors have developed a new flexible motion sensing method that exploits nonlinear intermodulation of MRI receiver coil preamplifiers to sense the motion of a subject in an MRI scanner without on-subject hardware. The method transmits two tones at two different frequencies, f1 and f2, designed to be received at frequency f_BPT by the receiver via intermodulation, where f1 and f2 are much greater than the MRI center frequency. These signals are picked up by the receiver coils, mixed at the pre-amplification stage by intermodulation, then digitized by the receiver chain. The method is 20 times more sensitive to motion than the state-of-the-art Pilot Tone (PT) method of motion sensing. The inventors have demonstrated the method with second order intermodulation. Additionally, more transmitters can be used, each with a different set of frequencies. Higher frequency tones enable greater sensitivity to subject motion. This method enables the detection of motion at multiple temporal and spatial scales, for example, breathing and rigid motion of the head. The method is used simultaneously with conventional MR imaging and does not adversely impact the signal-to-noise ratio (SNR) of the acquired MR image. The method has been demonstrated using inexpensive consumer grade hardware for the 2.4GHz ISM band as a proof-of-concept. Since the MR signal is small (< -30dBm), little transmit power is necessary to induce an intermodulation signal similar in amplitude to the MR signal.

Protein Inhibitor of Type VI-B CRISPR-Cas System

The inventors have discovered the first protein inhibitor of the type VI-B CRISPR-Cas system. By controlling this CRISPR system, one could possibly ameliorate the toxicity and off-target cleavage activity observed with the use of the type VI CRISPR system. Moreover, these proteins can also serve as an antidote for instances where the use of CRISPR-Cas technology poses a safety risk. Additionally, this technology can also be used for engineering genetic circuits in mammalian cells. This finding is of potential importance to many companies in the CRISPR space. 

Facile, Excitation-Based Spectral Microscopy For Fast Multicolor Imaging And Quantitative Biosensing

The number of color channels that can be concurrently probed in fluorescence microscopy is severely limited by the broad fluorescence spectral width. Spectral imaging offers potential solutions, yet typical approaches to disperse the local emission spectra notably impede the attainable throughput.    UC Berkeley researchers have discovered methods and systems for simultaneously imaging up to 6 subcellular targets, labeled by common fluorophores of substantial spectral overlap, in live cells at low (~1%) crosstalks and high temporal resolutions (down to ~10 ms), using a single, fixed fluorescence emission detection band. 

Single Catheter System Combining Intravascular Ultrasound and Fiber-Based Fluorescence Lifetime Imaging

Researchers at the University of California, Davis have developed a catheter device that combines intravascular ultrasound with fluorescence lifetime imaging to better detect significant vascular conditions.

Novel Positron Emission Tomography Agents for Imaging Neurodegeneration

New positron emission tomography (PET) imaging agent developed that uniquely binds to synucleinopathies and tauopathies in the Parkinson’s brain and may therefore serve as an early diagnostic marker.

Improved guide RNA and Protein Design for CasX-based Gene Editing Platform

The inventors have developed two new CasX gene-editing platforms (DpbCasXv2 and PlmCasXv2) through rationale structural engineering of the CasX protein and gRNA, which yield improved in vitro and in vivo behaviors. These platforms dramatically increase DNA cleavage activity and can be used as the basis for further improving CasX tools.The RNA-guided CRISPR-associated (Cas) protein CasX has been reported as a fundamentally distinct, RNA-guided platform compared to Cas9 and Cpf1. Structural studies revealed structural differences within the nucleotide-binding loops of CasX, with a compact protein size less than 1,000 amino acids, and guide RNA (gRNA) scaffold stem. These structural differences affect the active ternary complex assembly, leading to different in vivo and in vitro behaviors of these two enzymes.

Elastography based on X-Ray Ct and Sound Wave Integration

Researchers at UCI have created an elastography technique, which combines X-ray computed tomography (CT) and sound wave integration.  This adapted elastographic technique avoids the issues faced by ultrasound alone and permits medical imaging of deep tissue and measures the mechanical properties of materials.

Photoacoustic Spectroscopy Detection Of HFA, NO, And C02 From Exhaled Breath

UCI researchers introduced a medical device which simultaneously detects hydrofluoroalkane (HFA), carbon dioxide (CO2), and nitrogen monoxide (NO) in exhaled breath for monitoring and improving treatment of asthma and chronic obstructive pulmonary disease (COPD).

Automated Histological Image Processing tool for Identifying and Quantifying Tissue Calcification

Researchers at UCI have developed a method of identifying, quantifying, and visualizing tissue with calcification. The image processing tool can automatically characterize calcium deposits in CT images histological tissue, especially when it has accumulated in unusual places in the body.

Mapping Ciliary Activity Using Phase Resolved Spectrally Encoded Interferometric Microscopy

Researchers at UCI have developed an imaging technique that can monitor and measure small mobile structures called cilia in our airways and in the oviduct. This invention will serve as a stepping stone for study of respiratory diseases, oviduct ciliary colonoscopy and future clinical translations.

Polarization-Sensitive Optical Coherence Tomography Using a Polarization-Insensitive Detector

A polarization-sensitive optical coherence tomography (PS-OCT) is a common approach to non-invasively imaging in biomedical applications. The inventors have come up with a new way of creating a PS-OCT that is cheaper and simpler.

Novel Reflective Microscope Objective Lens For All Colors

The researchers at the University of California, Irvine (UCI) have developed a microscopic lens, made entirely of reflective curved surface, where all the light wavelengths are focused at the same time for better resolution and larger field view of the image.

Low-Dose Ct Perfusion Technique

Coronary atherosclerosis (a thickening of the arterial wall) is correlated to the occurrence of cardiac events; therefore, its correct and early diagnosis is paramount in the prevention and treatment of coronary artery disease. Researchers at UCI have developed an innovative method for assesses coronary artery stenosis and microvascular disease that is both accurate and non-invasive.

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