Method And Materials For Modification Of Serum Albumin

Patent Status

Brief Description

Serum albumin is an abundant and long-lived blood protein. These characteristics as well as the localization of albumin within the body make it a promising component of diagnostic and therapeutic applications. For example, bioconjugation to albumin has been used to extend the half-life of short-lived therapeutics in serum.

Researchers at UC Berkeley have developed a novel technology to selectively modify albumin.  These methods were superior to other albumin modification methods in their hydrolytic stability, solubility, and ease of synthesis.

Suggested uses

-       Extending serum half-life of therapeutic molecules

-       Use of albumin in an adjuvant or vaccine

-       Diagnostic biomedical imaging

-       Analytical tool for basic research 

Advantages

-       Ability to use short-lived therapeutics

-       Easy synthesis

-       Improved hydrolytic stability

-       Improved solubility

-       Superior selectivity of modification

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