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Endoscopic ultrasound-guided fine needle injection

Endoscopic ultrasound-guided Fine Needle Aspiration (EUG-FNA) is a method by which tissue biospies are collected using a needle tip guided by real-time ultrasound imaging. UCI physicians propose a novel utility for EUS-FNA with enclosed fine needles that would allow the sterile injection of dyes, drugs and therapeutics to specific anatomical sites.

Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel biomarker that can be used to diagnose prostate cancer patients for the presence of visceral metastasis with 54% sensitivity and 100% specificity.

Microporous membranes for the separation of enantiomers

Current methods used to separate racemic compounds on a large scale have limitations in cost, energy efficiency, and discontinuous processing. UCI researchers have synthesized a membrane made of chiral porous polymers that can separate enantiomers from racemic mixtures through continuous processing.

Method for Concentration and Formulation of Radiopharmaceuticals

Researchers at the UCLA Department of Medical and Molecular Pharmacology have developed a compact microfluidic device that is able to achieve rapid concentration and/or reformulation of PET tracers after HPLC purification.

Augmented Reality For Time-Delayed Telsurgical Robotics

Teleoperation brings the advantage of remote control and manipulation to distant locations or harsh or constrained environments. The system allows operators to send commands from a remote console, traditionally called a master device, to a robot, traditionally called a slave device, and offers synchronization of movements. This allows the remote user to operate as if on-site, making teleoperational systems an ideal and often only solution to a wide range of applications such as underwater exploration, space robotics, mobile robots, and telesurgery. The main technical challenge in realizing remote telesurgery (and similarly, all remote teleoperation) is the latency from the communication distance between the master and slave. This delay causes overshoot and oscillations in the commanded positions, and are observable and statistically significant in as little as 50msec of round trip communication delay. Predictive displays are virtual reality renderings, generally designed for space operations, that show a prediction of the events to follow in a short amount of time. It can be used to overcome the negative effects of delay by giving the operator immediate feedback from a predicted environment. Furthermore, it does not suffer stability issues that arise with delayed haptic feedback. Early predictive displays included manipulation of the Engineering Test Satellite 7 from ground control where the round trip delay can be up to 7sec and Augmented Reality (AR) rendering where the prediction is overlaid on raw image data. These strategies can be applied to telesurgery, but require overcoming the unique challenges in calculating and tracking the 3D environment for a full environment prediction, which includes non-rigid material such as tissue. Furthermore, prior work in the surgical robotics community highlights the need for active tracking rather than only relying on kinematic calibrations to localize the slave due to the millimeter scale of a surgical operation and the often utilized cable driven actuation.

Microfluidics Device and Methods of Detecting Airborne Agents

A microfluidic platform for real time sensing of volatile airborne agents.

Atrial Cage For Placement, Securing And Anchoring Of Atrioventricular Valves

A collapsible heart valve supporting structure that securely anchors and prevents unwanted valvular dislodgment post implantation.

Electrical Charge Balancing Scheme For Functional Stimulation Using Pulse Width Compensation

UCLA researchers in the Department of Bioengineering have developed a novel electrical charge cancellation scheme to effectively remove residual charge on an electrode, achieving greater precision for lesser hardware cost, while maintaining a surgically implantable small size without extra pulse insertion.

Massively Parallel High Throughput Single Cell Electroporation (MSEP)

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.

Mobile Microscopy Camera

A portable camera device that combines fluorescent imaging with optical sectioning capability of microscopic samples and wireless data transfer. This 3D sectioning imaging system and fluorescent detection will detect bacteria for ease use in remote areas for on-site diagnosis and will connect to a smartphone. The technology will lead to significant improvements in public health.

Flexible Wearable Sensors for Non-invasive Continuous Blood Pressure Monitoring

Researchers at UCI have developed a wearable, wristband sensor that can detect the pressure of the body’s pulse from the surface of the skin at the wrist. They can correlate this measurement to blood pressure and subsequently use this device for long-term continuous monitoring.

A Method For Digital Pathology Using Augmented Reality

UCLA researchers in the Departments of Electrical Engineering and Computer Engineering have developed a novel method for automated image analysis of digital pathology slides.

Methods Of Fabricating A Multi-Electrode Array For Spinal Cord Epidural Stimulation

UCLA researchers in the Department of Bioengineering and Department of Integrated Biology & Physiology have developed a novel array for spinal cord epidural stimulation.

Use of a Radiation Detector that Combines Virtual Frisch Grid and Cerenkov Readouts

Researchers at the University of California, Davis have developed a radiation detector for high energy photons that employs a transparent semiconductor with a high index of refraction to combine benefits of Virtual Frisch Grid devices and the readout of Cerenkov light.

An Electrochemical CMOS Biosensor Array For Point-Of-Care Applications

Point-of-care (POC) testing is essential to halt the spread of deadly infectious diseases (e.g., Ebola, Zika, etc.) and is needed for rapid and accurate screening both in and outside of clinical settings. Label-free bioassays are desirable for POC testing as they have fewer reagents and assay steps resulting in lower cost and ease of use.   Biosensors based on electrochemical impedance spectroscopy (EIS), an ultra-sensitive, label-free sensing technique, are a promising technology for precise and rapid disease diagnosis at the point-of-care. However, EIS usually requires mixers and lock-in detection to measure both the magnitude and phase of the complex impedance.

Multimodal food journaling

Researchers at UCI have developed a hands-free, unobtrusive smartphone-based application for automatic food journaling. The app, which operates via voice command, is interactive and highly engaging thereby encouraging long-term user participation.  

Breathing Motion Artifact Reduction In CT

UCLA researchers have developed a novel scanning and analysis method for breathing motion-correlated CT that can provide breathing motion-artifacts free images for subsequent use in biomechanical modeling for COPD diagnosis and radiation therapy treatment planning.

Intravascular Ultrasound-guided Electrochemical Impedance Spectroscopy (IVUS-EIS) to Assess Lipid-Laden Plaques

UCLA researchers in the Department of Medicine have developed a novel intravascular ultrasound-guided electrochemical impedance spectroscopy (IVUS-EIS) system for the detection of oxLDL-laden plaques in arteries.

A Method To Determine Cause Of A Cardiac Arrest And Provide Cause-Specific Decision Support In Real-Time Using Continuous Electrocardiography

Researchers led by Duc Hong Do from the Department of Cardiology at UCLA have developed an algorithm to detect the cause of cardiac arrest in a hospital setting.

Stereo Image Acquisition By Lens Translation

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel single-objective lens stereo imaging setup for endoscopic applications.

Flexible Balloon-Inflatable Electrochemical Impedance Spectroscopy To Assess Endoluminal Lipid-Rich Lesions

UCLA researchers have developed a novel flexible balloon-inflatable electrochemical impedance spectroscopy to facilitate the diagnosis of metabolically active atherosclerotic lesions.

Real-Time Tomosynthesis For Radiation Therapy Guidance

UCLA researchers in the Department of Radiological Sciences and Department of Radiation Oncology have developed a real-time tomosynthesis design that can produce sufficient contrast to guide radiation therapy of small lung tumors.

Systems And Methods For Therapeutic Agent Delivery

UCLA researchers at the Department of Physics have developed a system that is capable of delivering a therapeutic agent to a specifically targeted tissue using ultrasound.

Load-Induced Frequency-Shift-Keying: A New Modulation Scheme That Enables Simultaneous Near-Field Wireless Power And Data Transmission Through A Single Set of Inductive Coils

UCLA researchers in the Department of Electrical Engineering have developed the first modulation system that allows simultaneous wireless power and data transmission through a single pair of inductive coils.

Immersive Virtual Reality To Manage Pain

Researchers led by Mark Cohen from the Department of Psychiatry at UCLA have developed a virtual reality-based therapy to manage chronic pain.

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