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Seamless Ceramics for Biomedical Applications

Prof. Guillermo Aguilar-Mendoza and his colleagues from the University of California, Riverside (UCR) and Prof. Javier Garay and his colleagues from the University of California, San Diego have developed an all ceramic, biocompatible, hermetically sealed package for encapsulating electronics. This technology uses disparate transparent polycrystalline ceramics and is sealed by laser.  The laser directly joins the disparate surfaces, protecting the electronic device from damage while ensuring a high-quality seal. This state-of-the-art technology provides  superior packaging for biomedical implant devices that has long-term biocompatibility. It also provides safe and leak-proof seals. Fig 1: Picture of transparent ceramics fabricated at UCR.

Percutaneous Heart Valve Delivery System Enabling Implanted Prosthetic Valve Fracture

UCI researchers developed a percutaneous heart valve delivery system to deliver and implant a prosthetic valve. This system incorporates the means to fracture a previously implanted prosthetic valve in situ without interfering with the transcatheter valve to be implanted.

Novel Tunable Hydrogel for Biomedical Applications

Prof. Huinan Liu’s lab at the University of California, Riverside has developed a novel tunable hydrogel that achieves tunable crosslinking, reversible phase transition, and may be used as a 3DP scaffold. This new hydrogel utilizes dynamic coordination of its innate carboxylic groups and metal ions. Adding methylacrylate or other functional groups is not required for this technology and the resulting hydrogel is less toxic. Since the functionalization of this hydrogel is not required, it is less process-intensive and results in a more cost-effective hydrogel.  In addition, the UV curing is no longer needed since methylacrylate is no longer utilized to crosslink the hydrogel.   Fig 1: Optical micrographs of top view and cross-section of HyA hydrogels printed using cold-stage method and direct writing method. Hydrogels printed using direct writing method showed better structural integrity and stability.

Hemoglobin Carrying PEG Microspheres As Artificial Red Blood Cells

Researchers at the University of California, Irvine have developed artificial red blood cells consisting of hemoglobin that is tethered to polyethylene glycol (PEG) molecules and formed into microspheres.

Motion-Corrected, Optical Imaging of Biological Tissue

Researchers at the University of California, Davis have developed a system that displays a real-time image - generated from optical signals - of biological tissue.

Single Catheter System Combining Intravascular Ultrasound and Fiber-Based Fluorescence Lifetime Imaging

Researchers at the University of California, Davis have developed a catheter device that combines intravascular ultrasound with fluorescence lifetime imaging to better detect significant vascular conditions.

Novel Positron Emission Tomography Agents for Imaging Neurodegeneration

New positron emission tomography (PET) imaging agent developed that uniquely binds to synucleinopathies and tauopathies in the Parkinson’s brain and may therefore serve as an early diagnostic marker.

Photoacoustic Spectroscopy Detection Of HFA, NO, And C02 From Exhaled Breath

UCI researchers introduced a medical device which simultaneously detects hydrofluoroalkane (HFA), carbon dioxide (CO2), and nitrogen monoxide (NO) in exhaled breath for monitoring and improving treatment of asthma and chronic obstructive pulmonary disease (COPD).

High Efficiency Single Cell Indexing Of Droplets Via Interfacial Shearing With Downstream Droplet Sorting

The invention is an integrated device that provides a high efficiency single cell encapsulation solution. The two core modules of the invention are responsible for generating the cell encapsulating droplet, then sorting the generated droplets to eliminate the empty ones. Such a two-step process yields a high throughput, single cell indexed droplets, with an overall encapsulation efficiency reaching 80%, which is crucial for various applications ranging from genomics and proteomics to pharmacology.

Delivery System For Transcatheter Valves

Researchers at UCI have developed a novel medical device for use in transcatheter heart valve replacement surgeries. The device provides physicians with more careful control of the catheter insertion, minimizing complications and adverse effects.

SARS-CoV-2 Detection by Carbon Nanotube-Based Nanosensors

The inventors have developed a real-time optical nanosensor for detection of active SARS-CoV-2 infection, which includes a modular synthesis scheme that is amenable to detection of other viral infections. The nanosensor is constructed from near-infrared fluorescent single-walled carbon nanotube (SWCNT) substrates functionalized with biomolecules that have high binding affinity to viral proteins and viral genomic material. Virus binding to the nanosensor instantaneously changes the SWCNT fluorescence. This fluorescent readout serves as the optical signal that coronavirus is present in the clinical sample. The near-infrared fluorescence signal is detectable in biological samples, offering the prospect of detecting active SARS-CoV-2 in unprocessed, crude biofluid samples from individuals with readouts provided in tens of minutes. These SWCNT-based nanosensors are adaptable to point-of-care diagnostic devices to enable accessible, rapid testing of active SARS-CoV-2 infection. Furthermore, the reagents and detection devices would be sourced from different supply chains than existing tests and provide orthogonal advantages to such tests.

Esophageal Deflection Device

Cardiac ablations are common medical treatments for people with atrial fibrillation (Afib). During the ablation procedure, a cardiac electrophysiologist will thermally ablate, or burn off, defective heart tissue with radiofrequency or cryoablation technology. The esophagus is often in close proximity to the left atrium. Since the left atrial tissue is approximately 2mm thin, the heat can transfer through it to the esophagus in contact and cause thermal damage / lesions on the esophagus.  In worst-case rare scenarios, an atrio-esophageal fistula, or hole between the esophagus and the heart, can occur which has a ~75% mortality rate.  It would be ideal to move the esophagus away from the heart before or during the ablation procedure preventing thermal damage.

Sterilization of Face Masks and Respirators

Prof. Lorenzo Mangolini and his colleagues from the University of California, Riverside have developed an efficient and low-cost method to sterilize face masks and respirators with ozone. This novel design uses a flow through configuration where the ozone gas is directly flown through the fibers of the FPRs. The parts needed for construction of this system are widely available and small enough for the device to be easily portable. This approach can readily adapted for low-cost and simple sterilization of different FPRs to allow for them to be safely reused.  Fig 1: Picture of the dielectric barrier discharge reactor used in the mask sterilization experiments.

Particle-Sorting Device for Isolation, and Enrichment of Particles at Ultra-Low Concentrations

The ability to detect and sort particles by type is important to many fields, such as medical diagnostics, environmental monitoring, and food safety.UCI researchers have developed a platform to sort and isolate particles from a turbid medium with minimal pre-processing. The platform is very desirable for applications in which enrichment of particles or biological substances at low concentrations is necessary.

Device for Edema Reduction Following Spinal Cord Injury

Prof. Victor Rodgers and his colleagues from the University of California, Riverside have developed a method for effectively treating excess swelling from fluid, or edema, following a spinal cord injury. Following severe contusion to the spinal cord, edema accumulates and compresses the tissue against the surrounding dura mater. It is believed that this compression results in restricted flow of cerebrospinal fluid (CSF) and ultimately collapses local vasculature, exacerbating ischemia and secondary injury. This technology includes a surgically mounted osmotic transport device (OTD) that rests on the dura and can osmotically remove excess fluid at the injury site to reduce secondary injury. Fig 1: | Effects of OTD treatment on % water content after severe SCI. Percent (%) water content calculated SCI only, SCI + hydrogel (HG), and SCI + OTD following treatment. The figure shows a statistical reduction in % water content in tissue following OTD treatment  

Device and Method to Evaluate and Control the Therapeutic Effect of Tumor Treating Fields (TTFields)

Tumor Treating Fields (TTFields) is a tissue ablation technology that inhibits the uncontrolled growth of cells in the body, such as cancer cells, with non-contact electromagnetic fields. Electrodes attached to the skin, such as on a shaved skull, deliver the electromagnetic fields. In order to achieve a therapeutic effect, this minimally invasive cancer treatment must be delivered continuously, over a long period of time. The therapy is monitored with MRI imaging, every one to three months.In between MRI scans, the effects of treatment can be monitored through additional electrodes attached to precise locations on the skin. For example, when treating the brain, electrodes tightly attached to the skull can detect changes in the complex electrical impedance of the monitored tissue. Data collected from the electrodes can be also used to control and optimize treatment parameters. 

Mapping Ciliary Activity Using Phase Resolved Spectrally Encoded Interferometric Microscopy

Researchers at UCI have developed an imaging technique that can monitor and measure small mobile structures called cilia in our airways and in the oviduct. This invention will serve as a stepping stone for study of respiratory diseases, oviduct ciliary colonoscopy and future clinical translations.

Intraprocedural Grid Localization System

Brief description not available

Polarization-Sensitive Optical Coherence Tomography Using a Polarization-Insensitive Detector

A polarization-sensitive optical coherence tomography (PS-OCT) is a common approach to non-invasively imaging in biomedical applications. The inventors have come up with a new way of creating a PS-OCT that is cheaper and simpler.

The Uro-Wheel

Though guidewires are a common part of many endoscopic procedures as they help the scope reach its desired organ successfully, they are often difficult to maneuver due to their flexible and slippery construction. To combat this and assist physicians in rapid and effective endoscopic placement, researchers at UCI have developed a novel device which, by a simple turn of a finger wheel, allows the guidewires to be automatically and controllably advanced and retracted.

Personalized Oncology Drug Efficacy Monitoring Chip

Researchers at UCI have developed a novel microfluidic-based platform that enables personalized drug screening of patient-derived cancer cells. This versatile device features real-time, continuous screening of patient samples without the need for expensive labeling reagents, large sample sizes, or bulky readout equipment.

A Wearable Freestanding Electrochemical Sensing System

Researchers in the UCLA Department of Electrical and Computer Engineering have developed a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.

A Thin Film Nitinol Neurovascular Covered Stent For Small Vessel Aneurysms

UCLA researchers in the Department of Pediatrics have developed a thin and flexible stent that can be implanted in small vessels in the neurovascular system. Normal 0 false false false EN-US ZH-CN X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

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