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Proteoglycan Mimetics For Enhanced Wound Healing Angiogenesis And Vascular Repair

Researchers at the University of California, Davis We have developed proteoglycan mimetics that alters the extracellular environment to promote local vascular repair and wound healing.

Synaptic Resistor With Signal Processing, Memory, And Learning Functions

Researchers led by Yong Chen from the Department of Mechanical and Aerospace Engineering have developed an artificial synapse for neuromorphic chips that have integrated logic, memory, and learning capabilities.

Pain Assessment Method And Apparatus For Patients Unable To Self Report Pain

Though pain assessment is a crucial part of many medical treatment plans, most physicians rely on patients self-reporting their own pain levels. This self-reporting strategy may be convenient to some patients trying to determine whether the patient should get to a doctor, but in some situations, especially where a patient is non-communicative or incapacitated, these patients may be unable to clearly express themselves to a medical professional. As such, researchers at UCI have developed a novel device that automatically and objectively monitors a patient’s pain levels by tracking/monitoring subconscious facial movements in real-time.

Membrane Insertion of Potential Sensing Nanorods

UCLA researchers in the Department of Chemistry have developed inorganic semiconductor nanosensors that measure membrane voltage.

Histology Thin Sectioning Method for Soft, Unfixed Tissues

Before microscopic analysis, tissue specimens are typically prepared for sectioning by initial fixation, freezing, and/or embedding in a mounting medium. There have been no cutting blocks for vibratome that allow the use of fresh soft tissues into thin slices (with micrometer thickness) such as intestines and other soft tissues (brain, heart, blood vessels, liver, spleen, lung, skin etc.).These traditional techniques can limit the ability of scientists to carry out molecular analysis on the tissue.

Multi-Arm Block-Copolymers for Multifunctional Self-Assembled Systems

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel polymer that can be used as an antimicrobial coating on surgical implants.

Methods And Devices for Continuous Analyte Sensing with Microporous Annealed Particle Gels

UCLA researchers in the Department of Bioengineering have developed novel microporous annealed particle gels for long-term continuous monitoring of blood metabolites.

Wearable Real-Time Gait Analysis And Sensory Feedback System For Gait Rehabilitation And Biomechanical Optimization

UCLA researchers in the Department of Bioengineering have developed a wearable sensory feedback system that provides instructive tactile feedback to guide the user towards biomechanical gait improvements, based on real-time motion analysis derived from wearable sensor data.

Airway Manikin With Realistic Mobility

Training for direct laryngoscopy relies heavily on practice with patients. The necessity for human practice might be supplanted to some extent by an intubation manikin with accurate airway anatomy, a realistic “feel” during laryngoscopy, the capacity to model many patient configurations, and a means to provide feedback to trainees and instructors. The realism and mobility of the anatomical features of current models limits the effectiveness of training intubation skills. Current models provide only one set of anatomic features, but patients present innumerable combinations of size, shape, proportion, and tissue stiffness. Thus, a novice who trains on a particular model merely learns how to intubate that particular model, but has minimal ability to transfer the learned skills to the multiplicity of anatomies in patients. Furthermore, most models approximate a normal anatomic configuration that poses no problem for intubation, so novices do not gain experience with difficult situations

The Use Of Magnetic Sensors To Prevent Femoral Posterior Wall Blowout During ACL Reconstruction

Researchers led by Andrew Palosaari from the Department of Chemistry and Biochemistry at UCLA have developed a novel way to guide ACL grafts and prevent femoral wall blowout during ACL reconstruction.

Development of a Microfluidic Adhesion Assay for the Isolation of Weakly Adherent Metastatic Cancer Cells

Metastasis is a complex process in which cancer cells migrate from the primary tumor, invade into the vasculature, and travel to distant parts of the body to establish secondary tumors. Cells with a greater metastatic potential have a proclivity for leading migration away from the primary tumor. Progress in identifying cells primed to metastasize and in assessing metastatic risk has been slow. This may be due in part to the lack of consistent molecular prognostic markers between cancer types and significant heterogeneity in metastatic potential within the tumor. However, all metastatic cells – independent of tumor type or heterogeneity within the tumor – must detach from the tumor, migrate through the surrounding tissue, and invade the blood stream. This process involves a significant change in adhesion, which can be quantified in a heterogeneous population of cancer cells.

Intelligent Flexible Spinal Cord Stimulators For Pain And Trauma Management Through Neuromodulation

UCLA researchers in the Department of Neurosurgery and Electrical Engineering have developed a novel closed-loop spinal cord stimulator device that is small and flexible.

Flexible And Stretchable Interconnects For Flexible Systems And Flextrate(Tm)

Researchers led by Professor Subramanian Iyer from the Department of Electrical Engineering at UCLA have developed a novel fabrication technique to create stretchable electronics.

Docking System To Stabilize Eyeball During Intraocular Surgery

UCLA researchers in the Department of Mechanical Engineering have designed a docking system to secure the eyeball relative to the imaging-system probe, allowing for the use of surgical instruments or tools, and facilitate real-time image acquisition during intraocular surgery.

System And Method For Automated Image Guided Robotic Intraocular Surgery

UCLA researchers in the Departments of Mechanical Engineering and Ophthalmology have developed a system and method for automated optical surgery.

Rapid And Precise Tool Exchange Mechanism For Intraocular Robotic Surgical Systems

UCLA researchers from the Department of Mechanical Engineering have developed a rapid, precise, and repeatable tool exchange mechanism for intraocular surgical procedures. This mechanism reduces surgery time, undesirable surgical tool movements, complications, and recovery time.

A Simple Integrated Device For Assessing Lung Health

Chronic lung diseases, like asthma, impose critical challenges on both the patients and the physicians due to the complexity of the diseases. Not only are these diseases tough to accurately assess, many of the diseases can be impacted by other physical and sociological factors. Perhaps a greater difficulty lies in measuring the effectiveness and compliance of the medications including inhaled medications. The invention discovered at the University of California, Irvine, is an “all-in-one,” portable device that offers complete assessment of lung health. It also incorporates a novel technology for monitoring the effectiveness and compliance of a medication, thereby, providing a personalized treatment and care plan for adults and children with asthma.

Intraoperative Assessment Of Implant Positioning

Researchers from the Departments of Mechanical Engineering and Ophthalmology led by Dr. Jean-Pierre Hubschman have developed a modified intralocular lens (IOL) and surgical implantation procedure to treat cataract and refractive anomalies.

Dextrous Hand Exoskeleton

Researchers led by Professor Jacob Rosen from the Department of Mechanical and Aerospace Engineering at UCLA have developed a novel hand exoskeleton that provides sensory information to the user.

Graphene Nanomesh As A Glucose Sensor

UCLA researchers in the Departments of Chemistry & Biochemistry and of Materials Science & Engineering have developed a glucose sensor based on a graphene nanomesh (GNM) material. The nanoscale GNM glucose sensor provides the potential for in vivo glucose sensing with high selectivity and high sensitivity.

A Novel Way To Enhance Soft Tissue Integration And Seal Around Prosthetic Devices

A UCLA researcher from the Weintraub Center at the Department of Dentistry has developed a method to treat prosthetics allowing them to better integrate with the body.

Physical Multi-Layer Arm Phantom For Body Area Networks

Researchers at UCI have developed an oil-based in vitro phantom that accurately mimics the electrical properties of the human arm. Due to the increased accuracy it affords, this phantom can be used to test the efficiencies of wireless medical devices in body area networks.

Functionalized Titanium Implants And Related Regenerative Materials

UCLA researchers in the Department of Dentistry have developed novel titanium surfaces with enhanced bioactivity in implants and tissue regeneration.

Innovation of the Non-Obstructive Cerebral Shunt System

Dr. Subramaniam from the UCLA Department of Neurosurgery has developed a novel cerebral shunt design that allows self-clearing of shunt obstruction. This innovation reduces complications caused by cerebral shunt blockage and prolongs the lifetime of shunt implants.

In vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy

Pelvic floor disorders (PFDs) afflict nearly 25% of all women and carry a host of symptoms that can drastically reduce quality of life. Despite their prevalence, the complex and varied nature of such PFDs make them difficult to diagnose and treat. Researchers at UCI have developed an entirely integrated system that, for the first time, provides real-time monitoring of the vaginal wall tissue during diagnosis and treatment, allowing for more thorough diagnoses and more effective treatment methods.

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