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Neural Modulation Of Autonomic Nervous System To Alter Memory And Plasticity Of The Autonomic Network

Researchers at UCLA from the Departments of Medicine and Bioengineering have created a device that modulates the autonomic nervous system to treat heart conditions like arrhythmias.

Gelatin Methacryloyl Based Microneedle

UCLA researchers in the Department of Bioengineering have developed gelatin methacryloyl microneedles (GelMA MN) for minimally invasive, sustained transdermal drug delivery.

Low-Intrusion Plasma Probe

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an inexpensive and easily implemented plasma diagnostic tool, the Low-Intrusion Probe.

A Method for Characterization of Device and Material and Communication at Thz Frequencies

UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel method for real-time detection and characterization of pulsed THz waveforms that features differential detection of high sensitivity, and phase diversity to overcome the dispersion penalty for wideband operation.

Apparatus and Methods for Stimulating DNA Repair Using Red Light Therapy

Red light exposure can have phototherapeutic effects on skin cells and other biological cells and tissues affected by UV damage. However, existing methods and devices using red light in DNA phototherapy have not identified the proper duration, intensity, or delivery mechanisms for optimal DNA repair. If the radiant intensity of the red light is too low, then exposure is inadequate and the repair biomarkers are not activated. Conversely, prolonged exposure to excessive electromagnetic radiation only furthers DNA damage. Moreover, in the context of skin treatment, excessive radiant intensity can burn tissue or have carcinogenic side effects. Thus, there is a need for a device and methods of use that provide safe, effective, and targeted red light DNA phototherapy.

Minimal Erythema Dose Testing Device

UCSF researchers have developed a novel device to deliver multiple UV doses simultaneously to perform testing of the optimal safe and effective dose of UV for treatment of patients.  

Polaris: Lifestyle Guide For Diabetes

Researchers at UCI have developed a comprehensive platform, Polaris, for personalized diabetes management. By combining standard blood glucose monitoring with activity tracking, Polaris provides users with real-time suggestions that encourage treatment adherence and promote healthy behaviors to better mitigate their symptoms.

Chip-Based Detection Of Diabetes Related Biomarkers

A major goal in disease screening, diagnosis, and control has been to develop bioassay platforms capable of simultaneous measurements of different analytes in a single assay. Significant advances toward multiplexed biomarker detection chips based on either immunoassays or enzymatic bioassays have thus been reported. However, the combination of enzymatic and immunoassay sensing into a single disposable system has hitherto not been addressed.

Simple Imaging Tool for Oral Cancer Detection and Monitoring

UCI researchers have developed a miniature, flexible intra-oral probe with a camera that allows early detection of oral cancer lesions in difficult-to-see, high risk areas of the mouth and throat. The tool allows for a low cost, non-invasive procedure that can be easily adopted in non-specialist medical settings.

At Home Fetal Electrocardiogram/Heartrate Monitor for Congenital Heart Defect Diagnosis

Congenital heart defects affect >1% of babies born in the United States. These defects originate early on in fetal development. Inventors at UC Irvine have developed a flexible medical device that allows at home fetal electrocardiogram (ECG) monitoring to diagnosis congenital heart defects during development.

Endoscopic ultrasound-guided fine needle injection

Endoscopic ultrasound-guided Fine Needle Aspiration (EUG-FNA) is a method by which tissue biospies are collected using a needle tip guided by real-time ultrasound imaging. UCI physicians propose a novel utility for EUS-FNA with enclosed fine needles that would allow the sterile injection of dyes, drugs and therapeutics to specific anatomical sites.

Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel biomarker that can be used to diagnose prostate cancer patients for the presence of visceral metastasis with 54% sensitivity and 100% specificity.

Microporous membranes for the separation of enantiomers

Current methods used to separate racemic compounds on a large scale have limitations in cost, energy efficiency, and discontinuous processing. UCI researchers have synthesized a membrane made of chiral porous polymers that can separate enantiomers from racemic mixtures through continuous processing.

Method for Concentration and Formulation of Radiopharmaceuticals

Researchers at the UCLA Department of Medical and Molecular Pharmacology have developed a compact microfluidic device that is able to achieve rapid concentration and/or reformulation of PET tracers after HPLC purification.

Augmented Reality For Time-Delayed Telsurgical Robotics

Teleoperation brings the advantage of remote control and manipulation to distant locations or harsh or constrained environments. The system allows operators to send commands from a remote console, traditionally called a master device, to a robot, traditionally called a slave device, and offers synchronization of movements. This allows the remote user to operate as if on-site, making teleoperational systems an ideal and often only solution to a wide range of applications such as underwater exploration, space robotics, mobile robots, and telesurgery. The main technical challenge in realizing remote telesurgery (and similarly, all remote teleoperation) is the latency from the communication distance between the master and slave. This delay causes overshoot and oscillations in the commanded positions, and are observable and statistically significant in as little as 50msec of round trip communication delay. Predictive displays are virtual reality renderings, generally designed for space operations, that show a prediction of the events to follow in a short amount of time. It can be used to overcome the negative effects of delay by giving the operator immediate feedback from a predicted environment. Furthermore, it does not suffer stability issues that arise with delayed haptic feedback. Early predictive displays included manipulation of the Engineering Test Satellite 7 from ground control where the round trip delay can be up to 7sec and Augmented Reality (AR) rendering where the prediction is overlaid on raw image data. These strategies can be applied to telesurgery, but require overcoming the unique challenges in calculating and tracking the 3D environment for a full environment prediction, which includes non-rigid material such as tissue. Furthermore, prior work in the surgical robotics community highlights the need for active tracking rather than only relying on kinematic calibrations to localize the slave due to the millimeter scale of a surgical operation and the often utilized cable driven actuation.

Microfluidics Device and Methods of Detecting Airborne Agents

A microfluidic platform for real time sensing of volatile airborne agents.

Atrial Cage For Placement, Securing And Anchoring Of Atrioventricular Valves

A collapsible heart valve supporting structure that securely anchors and prevents unwanted valvular dislodgment post implantation.

Electrical Charge Balancing Scheme For Functional Stimulation Using Pulse Width Compensation

UCLA researchers in the Department of Bioengineering have developed a novel electrical charge cancellation scheme to effectively remove residual charge on an electrode, achieving greater precision for lesser hardware cost, while maintaining a surgically implantable small size without extra pulse insertion.

Massively Parallel High Throughput Single Cell Electroporation (MSEP)

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.

Mobile Microscopy Camera

A portable camera device that combines fluorescent imaging with optical sectioning capability of microscopic samples and wireless data transfer. This 3D sectioning imaging system and fluorescent detection will detect bacteria for ease use in remote areas for on-site diagnosis and will connect to a smartphone. The technology will lead to significant improvements in public health.

Flexible Wearable Sensors for Non-invasive Continuous Blood Pressure Monitoring

Researchers at UCI have developed a wearable, wristband sensor that can detect the pressure of the body’s pulse from the surface of the skin at the wrist. They can correlate this measurement to blood pressure and subsequently use this device for long-term continuous monitoring.

A Method For Digital Pathology Using Augmented Reality

UCLA researchers in the Departments of Electrical Engineering and Computer Engineering have developed a novel method for automated image analysis of digital pathology slides.

Methods Of Fabricating A Multi-Electrode Array For Spinal Cord Epidural Stimulation

UCLA researchers in the Department of Bioengineering and Department of Integrated Biology & Physiology have developed a novel array for spinal cord epidural stimulation.

Use of a Radiation Detector that Combines Virtual Frisch Grid and Cerenkov Readouts

Researchers at the University of California, Davis have developed a radiation detector for high energy photons that employs a transparent semiconductor with a high index of refraction to combine benefits of Virtual Frisch Grid devices and the readout of Cerenkov light.

An Electrochemical CMOS Biosensor Array For Point-Of-Care Applications

Point-of-care (POC) testing is essential to halt the spread of deadly infectious diseases (e.g., Ebola, Zika, etc.) and is needed for rapid and accurate screening both in and outside of clinical settings. Label-free bioassays are desirable for POC testing as they have fewer reagents and assay steps resulting in lower cost and ease of use.   Biosensors based on electrochemical impedance spectroscopy (EIS), an ultra-sensitive, label-free sensing technique, are a promising technology for precise and rapid disease diagnosis at the point-of-care. However, EIS usually requires mixers and lock-in detection to measure both the magnitude and phase of the complex impedance.

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