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Near-Realistic Sports Motion Analysis and Activity Monitoring

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise in video games.

The Method of Enhanced Pressure Sensing Performance for Pressure Sensors

UCLA Researchers in the Departments of Materials Science, Engineering, Chemistry, and Biochemistry have developed conductive microstructure air gaps for use in pressure sensors.

NOVEL BRAIN TECHNOLOGY FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS USING ELECTRICAL STIMULATIONS

This invention is a novel technology developed to treat a patient’s neurological and/or psychiatric conditions. It consists of a system of implantable devices and computational algorithms that not only has autonomous control in sensing and stimulation of electrical signals in the patient’s brain, but also enables interactions with the external environment, thereby enhancing training and learning.

Apparatus and Signal Processing Technique for Real-Time Label-Free High-Throughput Cell Screening

UCLA researchers in the Department of Bioengineering have invented a novel apparatus for real-time label-free high-throughput cell screening.

Biomarker of Dyskinesia to Customize Medication or Deep Brain Stimulation for Parkinson's Disease Patients

This invention has provided methods for detecting dyskinesia in Parkinson’s disease patients and provided a way to titrate current treatment to maximize benefits while minimizing side effects.

Technique for Respiratory Gated Radiotherapy using Low Frame Rate MRI and a Breathing Motion Model

UCLA researchers in the Department of Radiation Oncology have developed a novel method to gate radiotherapy using low frame rate MRI sequences to reduce damage to adjacent tissues during radiotherapy.

High-Throughput Intracellular Delivery of Biomolecular Cargos via Vibrational Cell Deformability within Microchannels

UCLA Researchers in the Departments of Chemistry and Materials Science & Engineering have developed a novel means of delivering intracellular cargo.

Plasmonic Nanoparticle Embedded PDMS Micropillar Array and Fabrication Approaches for Large Area Cell Force Sensing

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel cell force sensor platform with high accuracy over large areas.

Electrical Conduction In A Ceplhalopod Structural Protein

Fabricating materials from naturally occurring proteins that are inherently biocompatible enables the resulting material to be easily integrated with many downstream applications, ranging from batteries to transistors. In addition, protein-based materials are also advantageous because they can be physically tuned and specifically functionalized. Inventors have developed protein-based material from structural proteins such as reflectins found in cephalopods, a molluscan class that includes cuttlefish, squid, and octopus. In a space dominated by artificial, man-made proton-conducting materials, this material is derived from naturally occurring proteins.

Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

Modular Miniature Microscopy System

UCLA researchers have developed a modular miniature microscopy system for brain imaging in behaving animals.

A Novel Air/Water Retention Device for Improved Visibility in Colonoscopies

Colon cancer is the third most common cancer diagnosed in men and women in the United States. It is also the third leading cause of cancer-related death in women and the second leading cause in men. Fortunately, over the last 20 years the death rate for this cancer has been decreasing. There are two primary reasons for this decrease, improvements in therapy and the increase in screening for and removal of colorectal polyps. A colonoscopy is recommended for adults over the age of fifty in the US. It is an examination of the colon performed by a gastroenterologist whereby an endoscope is inserted through the anus and into the colon. Most endoscopes have a camera and a light for visualization of the colon. In order to clearly see within the colon, which is in a naturally collapsed state, air or water is used to inflate the organ. Normally, a tight seal is formed around the scope to retain pressure inside the colon. But in some patients, a tight seal is not possible and is not able to retain the pressure making the procedure difficult to perform. Currently, the standard practice in these occasions is for a technician to use a towel to hold the anus shut.

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Laser-Assisted Intraocular Surgical Alignment

UCLA researchers in the department of Mechanical Engineering have developed an automated procedure for aligning a remote center of motion to a surgical incision point for robot-assisted surgeries.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Non-Immunogenic Coating for Biomedical Devices

Fibrosis, an immune response that triggers fibroid encapsulation of the polymeric surface of an implant, is a leading cause of biomedical device and implant failure. Researchers at UCI have developed a new methodology for synthesizing polymers that, in addition to being inexpensive and simple to generate, uses unique structural features to discourage the immune response that leads to device failure.

Calcified Polymeric Valve and Vessels

A cast molded methodology for creating polymeric heart valves and vessels with calcium apatite inclusions. The heart valves and vessels can then be implanted in animals to test cardiovascular medical device efficacy.

Device for Manufacturing Intravascular Probes

A means of precisely positioning and joining two cylindrical bodies used in the construction of side-viewing rotational endoscopic imaging probes.

Cochlear Implant Enhanced by a Penetrating Auditory Nerve Electrode

State of the art cochlear implants improve hearing in deaf people, but show poor sensitivity to the fine timing of sounds. UCI researchers have developed a penetrating auditory nerve electrode which can directly stimulate the auditory nerve and increase the sensitivity of a cochlear implant.

Respiratory Monitor For Asthma And Other Pulmonary Conditions

A patch sensor that is able to continuously monitor breathing rate and volume to diagnose pulmonary function and possibly predict and possibly prevent fatal asthma attacks.

Lipoplex-Mediated Efficient Single-Cell Transfection Via Droplet Microfluidics

The invention is an on-chip, droplet based single-cell transfection platform providing higher efficiency and consistency compared to conventional methods. Novel techniques following cell encapsulation yields uniform lipoplex formation, which increases the transfection accuracy. The invention solves the dilemma of the trade-off between efficiency and cell viability, and offers a safe, cell friendly and high transfection solution that is crucial for applications like gene therapy, cancer treatment and regenerative medicine.

Platform for predicting a compound’s cardioactivity

The invention is a platform that combines a screening system and machine learning algorithms to investigate and report the cardio-activity related information of a certain compound. Through screening cardiac tissue strips, the platform determines whether a compound is cardio-active or not, as well as the associated cardio-active mechanism based on a drug library that is automatically developed. Such information is crucial for the drug development process, especially for evidence based decisions.

A Combined Microfluidic and Fluorescence Lifetime Imaging(FLIM) Platform to Identify Mammalian Circulating Cancer Cells in Whole Blood

Separating and classifying circulating cancer cells from whole blood using a single cell trap microfluidic platform coupled with label free fluorescence life time imaging.

Pressure Based Mechanical Feedback to Safely Insert Catheters

A pressure sensing device that provides feedback during the insertion of a ureteral access sheath to prevent unwanted damage to the wall of the ureter.

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