Learn more about UC TechAlerts – Subscribe to categories and get notified of new UC technologies

Browse Category: Medical > Devices

Categories

[Search within category]

Reducing Risk Of Aerosol-Transmitted Infection From Dental Ultrasonic Instrumentation

Pathogenic transmission of dental aerosol created by ultrasonic scaling is considered a major concern during dental procedures. Researchers at UC Irvine have developed a novel tool/method to address this concern by removing the created aerosol at the source.

New Device to Test for Pulmonary Function for 21st Century Care

Prof. Mona Eskandari, whose research is known for seminal strides in experimental characterization and computational modeling of lung structural mechanics using novel techniques developed in her lab, has discovered a new method for measuring pulmonary function. It works by analyzing the change in temporal pressure while a patient is holding their breath. The measurement device is simple, comfortable and error-free for the patient to self-administer. Algorithms are used to transform the detailed lung data collection into actionable metrics for early detection capabilities for medical intervention and prevention. The discovery could provide more accessible, detailed, timely, and actionable data on lung function compared to conventional and currently used methods. Fig 1: The medical device prototype being tested in the laboratory  Fig 2: Preliminary data exhibiting detectable differences between several healthy and diseased mice lungs when utilizing the proposed new pulmonary function method

(SD2022-122) Unsupervised channel compression method for low power neural prostheses

Brain machine interfaces (BMIs) have the potential to help individuals with functional impairments, such as loss of motor control, due to neurological disease or spinal cord injury. BMIs map brain signals acquired in relevant brain regions to patient intent to enable functional restoration. In previous studies, BMIs have enabled patients to control robotic arm movements, and type by translating brain signals directly into text.  Intracortical BMIs record and sample brain signals from relevant regions of the brain at rates high enough to process both local field potentials (LFP) and action potentials (spikes).The development of high performance brain machine interfaces (BMIs) requires scaling recording channel count to enable simultaneous recording from large populations of neurons. Unfortunately, proposed implantable neural interfaces have power requirements that scale linearly with channel count. 

System Of Epicardial Sensing And Pacing For Synchronizing A Whole Heart Assist Device

See patent publication no. US20210128000A1. A network of electrodes configured to sense and/or pace the heart, wherein the network of electrodes are in contact with an epicardial surface of the heart, within a wrapping sleeve that assist the heart as a whole, wherein the network of electrodes sense the heart by quantifying intrinsic electrical activities of the heart, and wherein the network of electrodes pace the heart by inducing an electrical impulse to the heart to control its contractile activities. The network may be interfaced with a controller system, wherein the controller uses spatial and temporal electrical activities of the heart muscles to generate electrical impulse to synchronize the wrapping sleeve around the heart with the heart. Also disclosed is a system configured to construct space-time mapping of cardiac electrical activities and/or propagation, and sensing effects of a first assist event of a prior beat and controlling a second assist event.

Ultrasound-Guided Delivery System For Accurate Positioning/Repositioning Of Transcatheter Heart Valves

See patent publication below. Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.

Percutaneous Heart Valve Delivery System

See patent information below. Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.

Skin Optical Clearing Technique And Device Using Mechanical Compression

See patent information below. Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated.

Frequency-Amplitude-Modulation-Encoding (Fame) Strategies For Cochlear Implants And Audio Compression

See patent information below. A method of improving sound quality of audio signals that are digitally processed includes steps of extracting amplitude and frequency modulations from one or more narrow bands of the audio signal, and filtering and compressing those modulations to produce amplitude and frequency modulated audio signals that are digitally processed to provide an acoustic signal similar to the original audio signal. The methods may be used in auditory prostheses and telecommunication systems.

Safety Scalpel for Removal of Gastrostomy Tubes

A researcher at the University of California, Davis has developed a safety scalpel for mitigating the challenges associated with the removal of certain types of percutaneous implants, such as gastrostomy tubes having difficult to reduce anchoring elements.

Systems and Methods for Scaling Electromagnetic Apertures, Single Mode Lasers, and Open Wave Systems

The inventors have developed a scalable laser aperture that emits light perpendicular to the surface. The aperture can, in principal, scale to arbitrarily large sizes, offering a universal architecture for systems in need of small, intermediate, or high power. The technology is based on photonic crystal apertures, nanostructured apertures that exhibit a quasi-linear dispersion at the center of the Brillouin zone together with a mode-dependent loss controlled by the cavity boundaries, modes, and crystal truncation. Open Dirac cavities protect the fundamental mode and couple higher order modes to lossy bands of the photonic structure. The technology was developed with an open-Dirac electromagnetic aperture, known as a Berkeley Surface Emitting Laser (BKSEL).  The inventors demonstrate a subtle cavity-mode-dependent scaling of losses. For cavities with a quadratic dispersion, detuned from the Dirac singularity, the complex frequencies converge towards each other based on cavity size. While the convergence of the real parts of cavity modes towards each other is delayed, going quickly to zero, the normalized complex free-spectral range converge towards a constant solely governed by the loss rate of Bloch bands. The inventors show that this unique scaling of the complex frequency of cavity modes in open-Dirac electromagnetic apertures guarantees single-mode operation of large cavities. The technology demonstrates scaled up single-mode lasing, and confirmed from far-field measurements. By eliminating limits on electromagnetic aperture size, the technology will enable groundbreaking applications for devices of all sizes, operating at any power level. BACKGROUND Single aperture cavities are bounded by higher order transverse modes, fundamentally limiting the power emitted by single-mode lasers, as well as the brightness of quantum light sources. Electromagnetic apertures support cavity modes that rapidly become arbitrarily close with the size of the aperture. The free-spectral range of existing electromagnetic apertures goes to zero when the size of the aperture increases. As a result, scale-invariant apertures or lasers has remained elusive until now.  Surface-emitting lasers have advantages in scalability over commercially widespread vertical-cavity surface-emitting lasers (VCSELs). When a photonic crystal is truncated to a finite cavity, the continuous bands break up into discrete cavity modes. These higher order modes compete with the fundamental lasing mode and the device becomes more susceptible to multimode lasing response as the cavity size increases. 

(SD2021-314) MULTI-THOUSAND CHANNEL ELECTROPHYSIOLOGY ARRAYS

Electrophysiological devices are critical for mapping eloquent and diseased brain regions and for therapeutic neuromodulation in clinical settings and are extensively utilized for research in brain-machine interfaces. However, the existing devices are often limited in either spatial resolution or cortical coverage, even including those with thousands of channels used in animal experiments.

Vascular Anastomosis Device

Researchers at the University of California, Davis have developed a surgical device to facilitate vascular anastomosis procedures with enhanced ease and speed.

Devices and Methods for Monitoring Respiration of a Tracheostomy Patient

Researchers at the University of California, Davis have developed a small device that attaches directly to the hub of a tracheostomy tube and enables the monitoring of respiratory function in tracheostomy patients during sleep studies.

(SD2020-421) Virtual Electrodes for Imaging of Cortex-Wide Brain Activity: Decoding of cortex-wide brain activity from local recordings of neural potentials

As an important tool for electrophysiological recordings, neural electrodes implanted on the brain surface have been instrumental in basic neuroscience research to study large-scale neural dynamics in various cognitive processes, such as sensorimotor processing as well as learning and memory. In clinical settings, neural recordings have been adopted as a standard tool to monitor the brain activity in epilepsy patients before surgery for detection and localization of epileptogenic zones initiating seizures and functional cortical mapping. Neural activity recorded from the brain surface exhibits rich information content about the collective neural activities reflecting the cognitive states and brain functions. For the interpretation of surface potentials in terms of their neural correlates, most research has focused on local neural activities.   From basic neuroscience research to clinical treatments and neural engineering, electrocorticography (ECoG) has been widely used to record surface potentials to evaluate brain function and develop neuroprosthetic devices. However, the requirement of invasive surgeries for implanting ECoG arrays significantly limits the coverage of different cortical regions, preventing simultaneous recordings from spatially distributed cortical networks. However, this rich information content of surface potentials encoded for the large-scale cortical activity remains unexploited and little is known on how local surface potentials are correlated with the spontaneous neural activities of distributed large-scale cortical networks. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0in; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

(SD2022-014) Neural Signal Detection of Immune Responses: miniaturized wireless data streaming system to detect early infection

A promising area of clinical research has been growing in wearable diagnostics that has proven to be a powerful tool in healthy physiological as well as disease diagnostics. As the field grows and develops, a number of specializations are already emerging including diagnostics focused on: cardiac dysfunction, epilepsy, and most recently infectious disease detection.

Digital Microfluidic Plasmonic Polymerase Chain Reaction (PCR) Device

This technology automates the polymerase chain reaction (PCR) process using digital microfluidics for droplet manipulation. The invention also increases PCR speed and efficiency by combining electrowetting and plasmonic heating in a single device.PCR tests have a wide variety of applications, including the diagnosis of infectious organisms such as viruses and bacterias, as well as cloning, mutagenesis, sequencing, gene expression, and more. The test has become a gold standard for detecting SARS-CoV-2, the virus that causes COVID-19. In the PCR process, a gene or part of the DNA of the infecting organism is amplified exponentially to the extent that it can be detected using conventional methods like gel electrophoresis. This invention addresses the following challenges in current PCR methods: a long sample to answer time; and manual manipulation by humans, which increases the error rate in the tests.  

Medical/Surgical Instrument-Bending Device

Researchers at the University of California, Davis have developed a device that allows needles to be reliably and easily bent to a range of specified and reproducible angles. The device also enables protection of the needle tip and the maintenance of needle sterility during bending.

Fetal Oximetry Measurement via Maternal Transabdominal Spectroscopy

Researchers at the University of California, Davis have developed a non-invasive, near-infrared, spectroscopy technique that measures fetal oxygen saturation via the maternal abdomen.

Laser Photocoagulation To Stabilize Collector Channels To Enhance Aqueous Flows

Inventors at the University of California, Irvine have developed a laser-emitting device that treats glaucoma by enlarging and stabilizing collector channels in order to enhance aqueous outflow and reduce intraocular pressure (IOP).

Growth-Accomodating Transcatheter Pulmonary Valve System

UCI researchers have developed a novel transcatheter pulmonary valve (TPV) that addresses the current lack of options for children with progressive pulmonary valve regurgitation (PVR), which may lead to right ventricular (RV) dysfunction and failure. This TPV allows for implantation into patients of a younger age, preventing the progression of PVR and the RV issues that follow, and can also expand to accommodate the need for a larger pulmonary valve as the patient grows.

Simple, User-friendly Irrigator Device for Cleaning the Upper Aerodigestive Tract and Neighboring Areas

Researchers at UCI have developed a user-friendly consumer medical device capable of cleaning and removing food particles and bacteria that accumulate in and around the back of the throat. Without removal, this accumulation may lead development of halitosis (bad breath) or inflammation that may require more serious medical intervention.

  • Go to Page: