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Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

Modular Miniature Microscopy System

UCLA researchers have developed a modular miniature microscopy system for brain imaging in behaving animals.

A Novel Air/Water Retention Device for Improved Visibility in Colonoscopies

Colon cancer is the third most common cancer diagnosed in men and women in the United States. It is also the third leading cause of cancer-related death in women and the second leading cause in men. Fortunately, over the last 20 years the death rate for this cancer has been decreasing. There are two primary reasons for this decrease, improvements in therapy and the increase in screening for and removal of colorectal polyps. A colonoscopy is recommended for adults over the age of fifty in the US. It is an examination of the colon performed by a gastroenterologist whereby an endoscope is inserted through the anus and into the colon. Most endoscopes have a camera and a light for visualization of the colon. In order to clearly see within the colon, which is in a naturally collapsed state, air or water is used to inflate the organ. Normally, a tight seal is formed around the scope to retain pressure inside the colon. But in some patients, a tight seal is not possible and is not able to retain the pressure making the procedure difficult to perform. Currently, the standard practice in these occasions is for a technician to use a towel to hold the anus shut.

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Laser-Assisted Intraocular Surgical Alignment

UCLA researchers in the department of Mechanical Engineering have developed an automated procedure for aligning a remote center of motion to a surgical incision point for robot-assisted surgeries.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Non-Immunogenic Coating for Biomedical Devices

Fibrosis, an immune response that triggers fibroid encapsulation of the polymeric surface of an implant, is a leading cause of biomedical device and implant failure. Researchers at UCI have developed a new methodology for synthesizing polymers that, in addition to being inexpensive and simple to generate, uses unique structural features to discourage the immune response that leads to device failure.

Calcified Polymeric Valve and Vessels

A cast molded methodology for creating polymeric heart valves and vessels with calcium apatite inclusions. The heart valves and vessels can then be implanted in animals to test cardiovascular medical device efficacy.

Device for Manufacturing Intravascular Probes

A means of precisely positioning and joining two cylindrical bodies used in the construction of side-viewing rotational endoscopic imaging probes.

Cochlear Implant Enhanced by a Penetrating Auditory Nerve Electrode

State of the art cochlear implants improve hearing in deaf people, but show poor sensitivity to the fine timing of sounds. UCI researchers have developed a penetrating auditory nerve electrode which can directly stimulate the auditory nerve and increase the sensitivity of a cochlear implant.

Respiratory Monitor For Asthma And Other Pulmonary Conditions

A patch sensor that is able to continuously monitor breathing rate and volume to diagnose pulmonary function and possibly predict and possibly prevent fatal asthma attacks.

Lipoplex-Mediated Efficient Single-Cell Transfection Via Droplet Microfluidics

The invention is an on-chip, droplet based single-cell transfection platform providing higher efficiency and consistency compared to conventional methods. Novel techniques following cell encapsulation yields uniform lipoplex formation, which increases the transfection accuracy. The invention solves the dilemma of the trade-off between efficiency and cell viability, and offers a safe, cell friendly and high transfection solution that is crucial for applications like gene therapy, cancer treatment and regenerative medicine.

Platform for predicting a compound’s cardioactivity

The invention is a platform that combines a screening system and machine learning algorithms to investigate and report the cardio-activity related information of a certain compound. Through screening cardiac tissue strips, the platform determines whether a compound is cardio-active or not, as well as the associated cardio-active mechanism based on a drug library that is automatically developed. Such information is crucial for the drug development process, especially for evidence based decisions.

A Combined Microfluidic and Fluorescence Lifetime Imaging(FLIM) Platform to Identify Mammalian Circulating Cancer Cells in Whole Blood

Separating and classifying circulating cancer cells from whole blood using a single cell trap microfluidic platform coupled with label free fluorescence life time imaging.

Pressure Based Mechanical Feedback to Safely Insert Catheters

A pressure sensing device that provides feedback during the insertion of a ureteral access sheath to prevent unwanted damage to the wall of the ureter.

Electrode Agnostic, Supply Variant Stimulation Engine For Implantable Neural Stimulation

UCLA researchers in the Department of Electrical Engineering have invented an innovative universal agnostic electrode for implantable neural stimulation and sensing.

Load Adaptive, Reconfigurable Active Rectifier for Multiple Input Multple Output (MIMO) Implant Power Management

UCLA researchers in the Department of Electrical Engineering have invented a novel full-fledged implant power management unit, which is highly programmable and can process multiple input power deliveries on-chip.

A High Dynamic-Range Sensing Front-End For Neural Signal Recording Systems

UCLA researchers in the Department of Electrical Engineering have invented a novel neural recording chopper amplifier for neuromodulation systems that can simultaneously record and stimulate.

Novel Methodology To Convert Magnetic Resonance Imaging Scan Data To Be Used In Proton Beam Therapy

This invention is a novel model that uses magnetic resonance imaging (MRI) information to more accurately determine the irradiation area using proton beam therapy (PBT) for oncological treatment.

An Electro-Optical System with a Computation Model for Scanning Human Body

The invention describes an Electro-Optical instrument and a computational model for functional scanning of human body and recovering its chromophores (water, lipid, oxygenated hemoglobin, and deoxygenated hemoglobin). It is a low cost portable system that integrates frequency domain and continuous wave domain for real time spectroscopic imaging of human tissue.

Percutaneous Arteriovenous Fistula For Dialysis Access

This implantable medical device can be used to create an arteriovenous fistula (AVF) percutaneously, in a clinic based procedure. The AVF improves clinical outcomes for  patients  on hemodialysis.

Computational Out-Of-Focus Imaging Increases The Space-Bandwidth Product In Lens-Based Coherent Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a wide-field and high-resolution coherent imaging method that uses a stack of out-of-focus images to provide much better utilization of the space-bandwidth product (SBP) of an objective-lens.

Sparsity-Based Multi-Height Phase Recovery In Holographic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve more than 3-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality.

Artificial Hair Transplantation

UCLA researchers in the Department of Head and Neck Surgery have developed a novel bio-inert scaffold with artificial hairs to be inserted in the scalp to artificially restore hair.

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These technologies are part of the UC QuickStart program.