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Tunable Thz Generation In Chip-Scale Graphene

UCLA researchers in the Department of Electrical Engineering have developed a novel tunable and efficient terahertz (THz) plasmon generation on-chip via graphene monolayers.

Broadband Absorbers Via Hyperbolic Metamaterial Particles

Broadband absorbers are essential components of many light detection, energy harvesting and camouflage schemes. Materials that “perfectly” absorb light already exist, but they are bulky and can break when bent. They also cannot be controlled to absorb only a selected range of wavelengths, which is a disadvantage for certain applications. In addition, transferring planar materials to flexible, thin or low-cost substrates poses a significant challenge.

Engineering the protein corona of a synthetic polymer nanoparticle for broad-spectrum sequestration and neutralization of venomous biomacromolecules

Antivenoms are created by harvesting antibodies from surrogate animals that are exposed to small amounts of specific venom. This process is very costly and sometimes ineffective due to variations even within a single species. The inventors at UCI have developed a broad spectrum antivenom using nanoparticles which absorb and sequester key proteins in the venom.

A Therapeutic Bandage For Treating Venom-Induced Tissue Necrosis

Snakebites affect 4.5 million people a year. Treatments that could save victim’s lives require capable medical facilities, which are not always within reach. Researchers at UCI have developed a therapeutic bandage for treating the tissue necrosis associated with snake bites. The invention can be applied in the field and has the potential to save many lives.

New Drug Formulations For Chemoembolization Treatment

Primary liver cancer is the 12th leading cause of death in the United States. This invention is a novel drug delivery system that involves use of liposomes for the binding of a systemic liver cancer drug. The disclosed formulation can be used as a chemoembolization treatment of hepatocellular carcinoma and liver cancer.

New Method For Determination Of Molecular Orientation At Interfaces

Sum frequency generation spectroscopy (SFG) is a technique used to analyze surfaces and interfaces. This nonlinear laser spectroscopy method can deduce the composition, orientation distributions, and some structural information of molecules at gas–solid, gas–liquid and liquid–solid interfaces. In a typical SFG setup, two laser beams mix at a surface and generate an output beam with a frequency equal to the sum of the two input frequencies. SFG has advantages in its ability to be monolayer surface sensitive, ability to be performed in situ (for example aqueous surfaces and in gases), and not causing much damage to the sample surface. SFG is comparable to second harmonic generation in Infrared and Raman spectroscopy. It is a challenge to measure orientation heterogeneity. For decades, surface-specific vibrational sum frequency generation spectroscopy (referred to as 1D VSFG hereafter) has been used to determine the mean tilt angle, under the assumption of a narrow orientational distribution. However, in this case, the knowledge of orientational distribution is lost, and the measured mean tilt angle can deviate from the real mean tilt angle when the orientational distribution is large, which is the well-known “magic angle” challenge.

Thermally Stable Silver Nanowire Transparent Electrode

UCLA researchers in the Department of Materials Science and Engineering have developed a novel transparent and flexible electrode material for optoelectronic device applications.

Growth-Factor Nanocapsules With Tunable Release Capability For Bone Regeneration

UCLA researchers in the Departments of Chemical Engineering and Orthopedic Surgery have developed a method to deliver therapeutic proteins directly to the tumor site using nanocapsules.

Protein Nanocapsules With Detachable Zwitterionic Coating For Protein Delivery

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a method to deliver therapeutic proteins directly to the tumor site using nanocapsules.

Efficient And Stable Of Perovskite Solar Cells With All Solution Processed Metal Oxide Transporting Layers

UCLA researchers in the Department of Materials Science and Engineering have developed a novel lead halide perovskite solar cell with a metal oxide charge transport layer.

Evaporation-Based Method For Manufacturing And Recycling Of Metal Matrix Nanocomposites

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a new method to manufacture and recycle metal matrix nanocomposites.

Design Of Semi-Transparent, Transparent, Stacked Or Top-Illuminated Organic Photovoltaic Devices

UCLA researchers in the Department of Materials Science and Engineering have developed novel tandem transparent and semi-transparent organic photovoltaic (OPV) devices.

Silver Nanowire-Indium Tin Oxide Nanoparticle As A Transparent Conductor For Optoelectronic Devices

UCLA researchers in the Department of Materials Science and Engineering have developed a novel composite material made of metal oxide nanoparticles (NPs) and silver nanowires (AgNWs).

Fabrication of nano-structures on multiple sides of a non-planar surface

The invention is a breakthrough in the method of fabrication of biomedical devices, making them safer and less infectious. It allows the reproduction of nano-features to one or both side of non-planar biomedical devices. This would improve the cell motility and kill bacteria.

Artificial cornea implant using nanopatterned synthetic polymer

The device is an artificial corneal implant comprised of a single, nanopatterned material. The device is durable, easy to implant, and robust against bacterial infection and other problems associated with other state-of-the-art ocular devices.

Ultra Light Amphiphilic And Resilient Nanocellulose Aerogels And Foams

Researchers at the University of California, Davis have developed an energy efficient method of producing ultra-light aerogels with excellent dry compressive strength and tunable hydrophobicity by ambient drying of nanocellulose wet gels.

Preventing Protein Aggregation using Thermal Protectants

Protein aggregation in the brain are the causes of the neurodegenerative diseases Alzheimer’s and Parkinson’s. To study diseases and cellular mechanisms, biologists need to be able to efficiently synthesize, isolate and purify proteins. The invention herein is a synthetic nanoparticle (NP) that protects proteins from aggregation at temperatures, which normally cause aggregation. Furthermore, multiple stimuli can release the protein in high yield from the NPs.

Synthetic polymer nanoparticle hydrogels for drug screening

Synthetic polymer nanoparticle hydrogels and polymers can be designed to interact with and sequester targeted bio-macromolecules such as proteins, peptides, and carbohydrates. These relatively inexpensive and target specific polymers could potentially replace current antibody therapies and protein purification procedures.

Synthesis Technique to Achieve High-Anisotropy FeNi

Researchers at the University of California, Davis have developed an innovative synthesis approach to achieve high anisotropy L1 FeNi by combining physical vapor deposition and a high speed rapid thermal annealing (RTA).

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Enhancing Mechanical Properties of Nanostructured Materials with Interfacial Films

Nanostructured materials are a category of materials comprised of nanometer-scale crystals which exhibit order of magnitude higher strength when compared to their traditional counterparts with larger crystal sizes. The application of nanostructured materials has been limited due to seemingly inherent low ductility and high-temperature instability. The inventors at UCI have developed a nanostructured material that simultaneously exhibits increased ductility, strength, and thermal stability by the incorporation of amorphous intergranular films.

Shape Reconfigurable Materials And Structures For Shape Morphing, Energy Absorption And Tunable Phononic

The invention is a structured material that can be reshaped into multiple stable configurations. The material can be used to create highly adaptable components that can be reconfigured on demand, or absorb energy and vibrations.

Ultrafine Nanowires As Highly Efficient Electrocatalysts

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel process of synthesizing ultrafine jagged Pt nanowires with a record high utilization efficiency for fuel cell catalyst applications.

Highly Stable Nanoscale Disk Assemblies Of The Tobacco Mosaic Virus For Applications In Drug Delivery And Disease Imaging

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Self-assembling protein nanomaterials derived from viruses have properties that make them useful for applications in drug delivery, disease imaging and diagnostics. These properties include uniform sizes and shapes, biodegradability, and multiple sets of functional handles for chemical manipulation. Intact virus nanoparticles have been functionalized for applications in drug delivery in vivo, however, the injection of replication-competent viruses into subjects have limited their clinical appeal. The development of spherical and rod-shaped virus nanoparticles has in both cases resulted in differential tumor accumulation, demonstrating the need to further expand the shape library of protein nanomaterials. However, expressing non-spherical virus-based protein nanomaterials without the genetic material that functions as a backbone to the assembly architecture can lead to significant challenges including poly-diversity in size and shape, and change in assembly behavior in response to different conditions such as pH and ionic strength.   UC Berkeley researchers have developed a self-assembling nanoscale disk derived from a mutant of a recombinantly expressed viral coat protein. The disks display highly stable double-disk assembly states. The researchers functionalized the disks with the chemotherapy drug doxorubicin (DOX) and further modified the disks for improved solubility.  The functionalized disks displayed cytotoxic properties similar to those of DOX alone when incubated with U87MG glioblastoma cells, but the unmodified disks did not cause any cytotoxicity.

Novel Metal Chalcogenides For Pseudocapacitive Applications

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel metal chalcogenides for pseudocapacitive applications. 

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