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Method for creating a macular/retinal degeneration animal model

Researchers at UCI have developed an animal model that mimics the onset and progression of age-related macular degeneration, an incurable disease that is the fourth-leading cause of blindness globally. The model serves as a means for testing the efficacy of possible treatments and cures.

Calcified Polymeric Valve and Vessels

A cast molded methodology for creating polymeric heart valves and vessels with calcium apatite inclusions. The heart valves and vessels can then be implanted in animals to test cardiovascular medical device efficacy.

Pathway-Dependent Inhibition Of Proteopathic Seed Transmission

UCLA researchers in the Department of Neurology have developed a novel approach to stop the propagation of proteopathic diseases, which could be applied to wide range of neurodegenerative disorders including Alzheimer’s disease and Parkinson’s disease.

Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Lipoplex-Mediated Efficient Single-Cell Transfection Via Droplet Microfluidics

The invention is an on-chip, droplet based single-cell transfection platform providing higher efficiency and consistency compared to conventional methods. Novel techniques following cell encapsulation yields uniform lipoplex formation, which increases the transfection accuracy. The invention solves the dilemma of the trade-off between efficiency and cell viability, and offers a safe, cell friendly and high transfection solution that is crucial for applications like gene therapy, cancer treatment and regenerative medicine.

Platform for predicting a compound’s cardioactivity

The invention is a platform that combines a screening system and machine learning algorithms to investigate and report the cardio-activity related information of a certain compound. Through screening cardiac tissue strips, the platform determines whether a compound is cardio-active or not, as well as the associated cardio-active mechanism based on a drug library that is automatically developed. Such information is crucial for the drug development process, especially for evidence based decisions.

Biomarkers for Port Wine Stain and Related Syndromes

Researchers at the University of California, Irvine (UC Irvine) have discovered specific biomarkers that will enable innovations in diagnosis, prognosis, monitoring, and therapy of PWS and other related syndromes.

Controlled 'One-Cell-One-Bead' Encapsulation in Droplets

Improving droplet encapsulation of a single-cell and single-bead to increase pharmacological assay throughput.

A Combined Microfluidic and Fluorescence Lifetime Imaging(FLIM) Platform to Identify Mammalian Circulating Cancer Cells in Whole Blood

Separating and classifying circulating cancer cells from whole blood using a single cell trap microfluidic platform coupled with label free fluorescence life time imaging.

A High Dynamic-Range Sensing Front-End For Neural Signal Recording Systems

UCLA researchers in the Department of Electrical Engineering have invented a novel neural recording chopper amplifier for neuromodulation systems that can simultaneously record and stimulate.

Epigenetic Target for HIV and Latent Virus Eradication

Researchers at the University of California, Davis, have identified a target for therapeutic intervention and agents that disrupt HIV latency in patients under suppressive HIV therapy. It amplifies the effects of other latency reversal agents and primes the cells harboring the virus for immune clearance and death.

Predictive Optimization Of Pharmeceutical Efficacy

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a machine learning platform to virtually screen combinatorial drug therapies.

Directed Editing Of Cellular RNA Via Nuclear Delivery Of CRISPR/Cas9

CRISPR-Cas9 technology has revolutionized the field of biological research through the introduction of sequence-specific genomic manipulation at the DNA level. It has also been reported that catalytically-dead Cas9 (dCas9) can successfully be localized to specific mRNAs within live cells. However, no system exists to perform Cas9-mediated sequence editing at the RNA level.

Generation of an Improved Synthetic Splice Modulator (FDGLY) That Mirrors the Structural Features of the Potential CLL In Vitro Inhibitor FD-895

 An increasing body of research has shown that alternations in RNA splicing are involved in a number of human diseases, particularly cancer. Drug regulation of splicing has become an interesting new target for therapeutic discovery. A number of drug discovery efforts aimed at developing splicing-modulating small-molecules are being tested in clinic trials for cancer.

Computational Sensing Using Low-Cost and Mobile Plasmonic Readers Designed by Machine Learning

UCLA researchers have developed a novel method for computational sensing using low-cost and mobile plasmonic readers designed by machine learning.

Single Fiber-Based Multimodal Biophotonic Imaging and Spectroscopy Platform

Researchers at the University of California, Davis have developed a highly flexible and reconfigurable optical imaging and spectroscopy platform.

The Use of Voltammetry Based Assessment of Neurotransmitters and Metabolites in Vivo

UCLA researchers in the Departments of Medicine, Radiology and Bioengineering have developed novel methods for monitoring cardiac autonomic function in vascular and tissue compartments by measuring neurotransmitters and metabolites in vivo.

Integrated Electrowetting Nanoinjector and Aspirator

Gene therapy applications necessitate cell transfection techniques for delivering biomaterial into multiple or a single cell(s). The global market for transfection technologies can be worth more than half a billion by 2017. Current viral and chemical transfection techniques have limited ease of fabrication, transfection efficiency, dosage control, and cell viability. The invention discloses a simple yet efficient technique for nanoinjection of material into a single cell with high transfection efficiency, controlled dosage delivery, and full cell viability.

Small Molecule Treatment for Androgen Inhibitor-Resistant Cancers

Researchers at the University of California, Davis have developed small molecule inhibitors of androgen receptor variants for the treatment of androgen inhibitor-resistant cancers.

A Way to Genetically Silence Calcium Signaling in Cells and Organisms and Derivates Thereof

UCLA researchers in the Department of Physiology have developed a method of genetically silencing calcium signaling in cells and organisms for use in studying aberrant calcium signaling in disease.

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.


96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} The CRISPR-Cas system is now understood to confer bacteria and archaea with acquired immunity against phage and viruses. CRISPR-Cas systems consist of Cas proteins, which are involved in acquisition, targeting and cleavage of foreign DNA or RNA, and a CRISPR array, which includes direct repeats flanking short spacer sequences that guide Cas proteins to their targets. The programmable nature of these systems has facilitated their use as a versatile technology that is revolutionizing the field of genome manipulation. There is a need in the art for additional CRISPR-Cas systems with improved cleavage and manipulation under a variety of conditions and ones that are particularly thermostable under those conditions.     UC researchers discovered a new type of RNA-guided endonuclease (GeoCas9) and variants of GeoCas9.  GeoCas9 was found to be stable and enzymatically active in a temperature range of from 15°C to 75°C and has extended lifetime in human plasma.  With evidence that GeoCas9 maintains cleavage activity at mesophilic temperatures, the ability of GeoCas9 to edit mammalian genomes was then assessed.  The researchers found that when comparing the editing efficiency for both GeoCas9 and SpyCas9, similar editing efficiencies by both proteins were observed, demonstrating that GeoCas9 is an effective alternative to SpyCas9 for genome editing in mammalian cells.  Similar to CRISPR-Cas9, GeoCas9 enzymes are expected to have a wide variety of applications in genome editing and nucleic acid manipulation.   

Rapid Screening and Identification of Antigenic Components in Tissues and Organs

Researchers at the University of California, Davis have developed an approach to rapidly screen and identify antigenic components in tissues and organs.

Novel Inhibitors of Mitochondrial Electron Transport

Researchers at the University of California, Davis have discovered a class of compounds that both bind to a unique newly-discovered binding site in respiratory complex III and act as inhibitors of electron transport for use as mitochondrial anti-cancer drugs.

Biologically Applicable Water-Soluble Heterogeneous Catalysts For Parahydrogen-Induced Polarization

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

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