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Engineering Human Proteases for Therapeutic Use

A methodology termed “protease evolution via cleavage of an intracellular substrate” (PrECISE) to enable engineering of human protease activity and specificity toward an arbitrary peptide target. 

Head tissue conductivity estimation from maximally independent brain EEG sources

Human electroencephalographic (EEG) source localization aims to reconstruct the current source distribution in the brain from one or more maps of potential differences measured noninvasively from electrodes on the scalp surface. An electric forward head model of the head plays a central role in accurate source localization. The volume conduction model must specify both the geometry and the conductivity distribution of the modeled tissue compartments (scalp, skull, cerebrospinal fluid, brain grey and white matter, etc.). While it is possible to extract head geometry information from magnetic resonance images (MRI) of the subject’s head, there has been no effective way to directly and non-invasively measure brain and skull tissue conductivities. Studies involving direct skull measurements have reported consistent conductivity values for scalp, brain, and cerebrospinal fluid. However, skull and therefore brain-to-skull conductivity ratio (BSCR) values reported in the literature have varied between 8 and 80 in adults. This presents a problem for accurate EEG source localization.

MicroRNA Fractionation

Background: The market landscape of the US global market for microRNA research tool, services, diagnostics and drug discovery is estimated to grow 13% annually and reach $1 billion in the next 4 years. The market continues to grow with many pharmaceutical and biotech companies becoming more and more involved in microRNA research to discover specific microRNA biomarkers for diagnostics and therapeutics. Current techniques are unable to identify which microRNA carriers are the most appropriate for disease diagnosis. In this regard, there are relationships between microRNA dysregulation and human disease in approximately 168 diseases, including cancers, heart disease, diabetes, alcoholism, and obesity.  Brief Description: UCR researchers have developed methods for rapid separation of different microRNA carriers in serum, using asymmetrical flow field flow fractionation or specially designed microchips. They have successfully identified microRNAs carriers as sensitive biomarkers, which will aid in the discovery of more effective therapeutic approaches. 

Adaptive optics with direct wavefront sensing for multi-photon microscope

Biological tissue are rarely transparent, presenting major challenges for deep tissue optical microscopy. With the advantages of high-resolution and viewing of live organisms, optical microscopy has become an important tool for biological research and continues to open new avenues in its capabilities. In recent years, image resolution and speed has been dramatically improved.  However the improvement of the resolution and penetration depth for optical microscopy is still in its infancy. As light passes through biological tissue, it can be absorbed, refracted and scattered, limiting the resolution and depth of optical imaging in biological tissues. Overcoming these challenges will benefit a wide range of applications from basic biological research to clinical investigations.

Simulation of Anchoring Bias in a Spatial Estimation Task

This system can automatically decide when it is best to update an old memory (anchor) or create a new memory (adjust). Such a system may be applicable to a computer system that needs to flexibly store and update incoming data, and alert users of anomalies.It features the ability to match and predict human cognitive performance.The mechanism is an algorithm that uses selective encoding of data, based on an encoding threshold.

Potential Driven Electrochemical Modification of Tissue

Researchers at UC Irvine have developed a minimally invasive technology that uses electrical potentials to perform a variety of to modify and reshape soft tissues such as cartilage

Apparatus for Growing a Heart Valve in 3D

This invention is a procedure and apparatus used to grow and shape three-dimensional heart valves tissues.

Markers to Identify Primary Cells from Tumor Biopsies

Researchers at UC Irvine have developed a novel immunofluorescent imaging strategy to identify cell subsets of interest, in particular cancer stem cells, endothelial progenitor cells, and other primary adherent cells from tumor biopsies.

Microfluidic System for Particle Trapping and Separation

<p>Researchers have developed a novel system and method to rapidly separate particles from liquid. This technology demonstrates lab-on-a-chip potential for particle separation and/or purification. This technology is capable of processing a wide variety of molecules, ranging from cells to smaller biomolecules such as proteins and nucleic acid. Applications of this technology include (but are not limited) use of it for particle separation and quantification for assays, cell preparation, and cell lysing and component separation.</p>

Multiplex Digital PCR

Researchers at the University of California, Irvine have developed methods to enable greater multiplexing abilities for digital polymerase chain reaction (PCR) so that up to 100 genetic targets may be analyzed. In the past multiplexing of digital PCR samples has been limited to only one probe per color. However multiple probes may be labeled by using combinatorial encoding of color, exploiting reaction rates of PCR cycles and modulating the intensity of Taqman and/or intercalating dyes therefore allowing a greater number of probes to be labeled.

Infant Movement Diagnostics (IMD)

Researchers at UC Irvine have developed a non-invasive wireless method to measure, quantify and analyze infant movement to identify preterm infants at risk for neurological disorders such as cerebral palsy, mental retardation, autism, or intraventricular hemorrhage.

Three-Dimensional Reconstruction of Cardiac Flows Based on Multi-Planar Velocity / Multi-Plane Method for Three-Dimensional Particle Image Velocimetry

Measurement of three-dimensional (3D) flow field inside cardiac chambers has proven to be a challenging task. Researchers at UC Irvine have developed a multi-planar velocity reconstruction approach that is able to characterize 3D incompressible flows based on the reconstruction of 2D velocity fields.

Immunomodulary Materials for Implantable Medical Devices

The host response to biomaterials is a huge challenge for the design of medical devices. Researchers at UC Irvine have created an extremely biocompatible material that can escape inflammatory immune attack.

Cell Identification Strategy Using Functionalized Micropallet Arrays

Cell identification is an important procedure for many applications. Current processing methods for single cell identification from a large heterogeneous population face drawbacks such as loss of cell morphology, removal of surface markers, damage to the membrane, and loss of cell viability.Therefore, an improved method for single cell identification that preserves cell viability and overcomes the previously mentioned limitations is desired. Researchers at UC Irvine have invented a method to identify and collect single adherent cells from a mixed population using an existing micropallet array platform. This allows users to identify and extract single cells from a mixed population for subsequent studies or processing.

Lateral Cavity Acoustic Transducer Based Microfluidic Switch

The ability for on-chip particle/cell manipulation is important for microfluidic applications. Researchers at UC Irvine have developed a technology that exploits the phenomenon of acoustic microstreaming to manipulate fluid flow and suspended cells/particles in a microfluidic environment.

Real-Time, Label-Free Detection of Nucleic Acid Amplification in Droplets Using Impedance Spectroscopy and using Solid-Phase Substrates

Researchers at UC Irvine have developed a technology to detect the presence of nucleic acid amplification in a droplet. This technology yields real time detection of DNA or RNA amplication in a high throughput integrated microfluidic platform.

Dielectrophoresis-Based Cell Destruction to Eliminate/Remove Unwanted Subpopulations of Cells

This invention allows for label free cell separations and cell enrichment.

Multilayer High Density Microwells

Researchers at UC Irvine have developed high density, three dimensional (3D) micro-reactors for digital biology applications. The high-density imaging arrays overcome drawbacks associated with existing high density arrays fabricated on a single surface and the more recent 3D droplet emulsion arrays.

Design and Synthesis of Fluoroalkylpyridyl Ethers as Potential Pet Radioligands for A4B2 Nicotinic Acetylcholine / Labeled A4B2 Ligands and Methods Therefor

Researchers have developed compounds to bind to α4β2 nicotinic acetylcholine receptors to evoke antagonistic effects both in vitro and in vivo environments.

New Indication for Use of Niacin (Nicotinic Acid) for Treatment, Prevention and Reversal of Fatty Liver Disease

Non alcoholic fatty liver disease (NAFLD) is a health problem that affects approximately 30% of the population, and the up to 75% of people afflicted with obesity and type 2 diabetes. Currently, no therapeutic agent for the prevention or treatment of fatty liver disease exists. Researchers at UC Irvine have developed a strategy that suggests treatment for fatty liver disease and/or NAFLD using niacin and/or its metabolites.

Microfluidic System for Particle Trapping and Separation

Researchers have developed a novel system and method to rapidly separate particles from liquid. This technology demonstrates lab-on-a-chip potential for particle separation and/or purification. This technology is capable of processing a wide variety of molecules, ranging from cells to smaller biomolecules such as proteins and nucleic acid. Applications of this technology include (but are not limited) use of it for particle separation and quantification for assays, cell preparation, and cell lysing and component separation.

Monoclonal Antibody against ATR-IP (Clone 11)

Mouse monoclonal antibody against the human ATR-interacting protein (ATR-IP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against CEP164 (Clone 13)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against CEP164 (Clone 17)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunoprecipitation and western blot.

Monoclonal Antibodies Against Chk2 (Clone 4B8)

Mouse monoclonal antibody (clone 4B8) against the human Serine/threonine-protein kinase Chk2. This antibody has been tested for use in immunoprecipitation and western blot.

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