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Fully Human Antibody Fragments Against Human N-Cadherin

UCLA researchers at the Department of Molecular & Medical Pharmacology have developed fully human antibody fragments against human N-cadherin that can potentially be used to evaluate EMT (epithelial-mesenchymal transition) status for diagnostic and prognostic purposes.

Bioorthogonal Ligation Mediated Rare-Cell Capture in Microfluidic Devices

Researchers at the UCLA Department of Molecular and Medical Pharmacology have developed a novel NanoVelcro microfluidic chip that is capable of not only effectively enriching circulating tumor cells (CTCs) but also quickly recovering CTCs with well-preserved mRNA and minimal level of white blood cell contamination.

Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a new type of fluorescent dermal pigment.

Guided Magnetic Nanospears For Targeted And High-Throughput Intracellular Delivery

UCLA researchers in the Department of Chemistry & Biochemistry and Department of Molecular & Medical Pharmacology have developed novel magnetic nanostructures that can be used to carry and/or deliver biomolecular cargo intracellularly to cells.

Airway Manikin With Realistic Mobility

Training for direct laryngoscopy relies heavily on practice with patients. The necessity for human practice might be supplanted to some extent by an intubation manikin with accurate airway anatomy, a realistic “feel” during laryngoscopy, the capacity to model many patient configurations, and a means to provide feedback to trainees and instructors. The realism and mobility of the anatomical features of current models limits the effectiveness of training intubation skills. Current models provide only one set of anatomic features, but patients present innumerable combinations of size, shape, proportion, and tissue stiffness. Thus, a novice who trains on a particular model merely learns how to intubate that particular model, but has minimal ability to transfer the learned skills to the multiplicity of anatomies in patients. Furthermore, most models approximate a normal anatomic configuration that poses no problem for intubation, so novices do not gain experience with difficult situations

Microfluidic Interfacial Magnetic Separation (MIMS)

UCLA researchers in the Department of Medicine and Bioengineering have developed a novel magnetic method for sorting cells.

Electrochemical Flash Fluorination and Radiofluorination

Researchers led by Saman Sadeghi from the Department of Molecular & Medical Pharmacology at UCLA have developed a new and simple process to make fluorinated organic compounds.

A Simple Integrated Device For Assessing Lung Health

Chronic lung diseases, like asthma, impose critical challenges on both the patients and the physicians due to the complexity of the diseases. Not only are these diseases tough to accurately assess, many of the diseases can be impacted by other physical and sociological factors. Perhaps a greater difficulty lies in measuring the effectiveness and compliance of the medications including inhaled medications. The invention discovered at the University of California, Irvine, is an “all-in-one,” portable device that offers complete assessment of lung health. It also incorporates a novel technology for monitoring the effectiveness and compliance of a medication, thereby, providing a personalized treatment and care plan for adults and children with asthma.

Physical Multi-Layer Arm Phantom For Body Area Networks

Researchers at UCI have developed an oil-based in vitro phantom that accurately mimics the electrical properties of the human arm. Due to the increased accuracy it affords, this phantom can be used to test the efficiencies of wireless medical devices in body area networks.

In vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy

Pelvic floor disorders (PFDs) afflict nearly 25% of all women and carry a host of symptoms that can drastically reduce quality of life. Despite their prevalence, the complex and varied nature of such PFDs make them difficult to diagnose and treat. Researchers at UCI have developed an entirely integrated system that, for the first time, provides real-time monitoring of the vaginal wall tissue during diagnosis and treatment, allowing for more thorough diagnoses and more effective treatment methods.

System and Methods for Efficient Collection of Single Cells and Colonies of Cells and Fast Generation of Stable Transfectants

A plate manufactured to enable samples of cells, microorganisms, proteins, DNA, biomolecules, transfectants, and other biological media to be positioned at specific sites. Some or all of the sites are built from removable material so that samples may be isolated.

Efficient Library Preparation for CRISPR Pooled Single-Guide RNAs Screens

There is great interest in both academic and commercial labs in performing pooled CRISPR screens for a variety of purposes, including identifying drug resistance and delivery mechanisms, genes essential for survival, death and disease phenotypes, differentiation, regulation of gene expression, and various other mechanisms.

Joint Pharmacophoric Space through Geometric Features

Pharmacophore analysis through examination of Joint Pharmacophore Space of chemical compounds, targets, and chemical/biological properties.

Multi-Echo Spin-, Asymmetric Spin-, And Gradient Echo Echoplanar Imaging (Message-EPI) MRI

UCLA researchers in the Department of Radiological Sciences have developed a new MRI pulse sequence optimized for brain imaging.

Biomarkers Based On Molecular Composition Of Cells

UCLA researchers in the Department of Materials Science and Engineering have developed a novel biomarker based on spectroscopic analysis of proteins in cell membranes.

Antisense Oligonucleotide Therapy for B Cell Mediated Cancers

Researchers at the University of California, Davis have developed a targeted therapy using an antisense oligonucleotide (ASO) to treat precursor B cell (pre-B) acute lymphoblastic leukemia (ALL).

Automatic Personal Daily Activity Tracking

Researchers at UCI have developed an entirely unobtrusive method for chronicling and analyzing an individual’s daily activities over time, which relies on tracking user activity via their smartphone. This technology has important applications in health and behavior monitoring, where it can be used to signal the early stages of various diseases and disorders.

Spatio-Temporal Pacing and Recording for Evaluation, Induction, and Mapping of Arrhythmias

Researchers led by Marmar Vaseghi from the School of Medicine at UCLA have developed a high density electrode array to evaluate, induce, and map arrhythmias.

A Cell-Based Seeding Assay for Huntingtin Aggregation

UCLA researchers from the Department of Psychiatry has created a novel cell-based seeding assay for sensitive, specific and high throughput detection of mutant Huntingtin proteins in biological samples.

Hydrostatic pressure-driven passive micropumps

Researchers at UCI have developed an inexpensive and entirely passive pump for microfluidic devices, which yields steady, controllable, and long-lived fluid flow through the device.

Methods for Enhancing Cell Populations for Articular Cartilage Repair

Cartilage lesion treatments require expanding cells from healthy donor cartilage which have limited availability and restricted potential to produce cartilage. This invention overcomes these challenges, presenting chemical and physical methods for enhancing cell populations capable of producing neocartilage. According to a 2015 global market report, tissue engineering technologies are expected to reach over 94B USD by 2022.

Methods for Producing Neocartilage with Functional Potential

Cell expansion for cartilage tissue production usually leads to loss of the potential to produce cartilage, which impedes uses for cartilage repair. This invention features methods and systems for producing highly expanded primary cells to construct functional neocartilage and other neotissue. According to a 2015 global market report, tissue engineering technologies are expected to reach over 94B USD by 2022.

Endoribonucleases For Rna Detection And Analysis

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Bacteria and archaea possess adaptive immune systems that rely on small RNAs for defense against invasive genetic elements. CRISPR (clustered regularly interspaced short palindromic repeats) genomic loci are transcribed as long precursor RNAs, which must be enzymatically cleaved to generate mature CRISPR-derived RNAs (crRNAs) that serve as guides for foreign nucleic acid targeting and degradation. This processing occurs within the repetitive sequence and is catalyzed by a dedicated CRISPR-associated (Cas) family member in many CRISPR systems.  Endoribonucleases that process CRISPR transcripts are bacterial or archaeal enzymes capable of catalyzing sequence- and structure- specific cleavage of a single- stranded RNA. These enzymes cleave a specific phosphodiester bond within a specific RNA sequence.  UC Berkeley researchers discovered variant Cas endoribonucleases, nucleic acids encoding the variant Cas endoribonucleases, and host cells genetically modified with the nucleic acids that can be used, potentially in conjunction with Cas9, to detect a specific sequence in a target polyribonucleotide and of regulating production of a target RNA in a eukaryotic cell.  For example, it was found that the variant Cas endoribonuclease has an amino acid substitution at a histidine residue such that is is enzymatically inactive in the absence of imidazole and is activatable in the presence of imidazole.  

Preconditioned Human Mesenchymal Stem Cells (hMSCs) for Musculoskeletal Tissue Repair

Researchers at the University of California, Davis have developed a preconditioning treatment and delivery method for human mesenchymal stem cell (hMSC) for enhanced bone healing.

Sonification-Facilitated Cognitive Training System to Enhance Visual Learning and Memory

UCLA researchers in the Department of Psychology have developed a new cognitive training tool to enhance visual learning and memory using sound.

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