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New 3D-Exoquant Method For The Analysis Of Surface Molecules And Quantification Of Tissue-Specific Exosomes In Biological Fluids

UCLA researchers in the Department of Neurology have developed a novel high sensitivity exosome and extracellular vesicle disease detection technology for use in the clinical and research setting. 

Patterning Silica Islands Onto Thermoplastic Shrink Film

Biosensors have a variety of applications from glucose monitoring to drug discovery. The ability to detect low concentration of analytes in biological samples is important for creating effective biosensors. Researchers at UCI have developed a novel lithographic method for capturing, concentrating, and identifying biological agents.

Controllable Emulsification And Point-Of-Care Assays Driven By Magnetic Induced Movement Of The Fluid

UCLA researchers in the department of Bioengineering have developed a novel microfluidic droplet generation technique, where instead of pumps, only magnetic force is used for controllable emulsification of ferrofluid containing solutions. 

Highly Wrinkled Metal Thin Films Using Lift-Off Layers

Wearable electronics are becoming a popular way of integrating personal healthcare with continuous, remote health monitoring, yet current devices are bulky and exhibit poor electronic performance. Wrinkled metal thin films can be utilized for their thin, flexible profiles, which conform well to the skin. Researchers at UCI have developed a novel method using specialized materials that results in wrinkled metal thin films that have enhanced mechanical and electrical performance.

Second Method For Nucleophilic Fluorination Of Aromatic Compounds With No-Carrier-Added [F-18] Fluoride Ion

UCLA researchers in the Department of Pharmacology have developed a novel aromatic nucleophilic fluorination reaction producing Fluorine-18 [F-18]-labeled aromatic compounds with extensive use in Positron Emission Tomography (PET).

Remotely-Activated Cell Therapy

The remote control of cellular activation in a controllable and reproducible fashion is a key tool for biological research, as well as for therapeutic uses. Cellular therapies are becoming well established within the medical community. However, the degree of cellular activation can be an unknown factor, and the risk of off-target effects remains. Cells may be delivered, but may not be therapeutically effective, or effective cells may elicit activity in an undesired location. The delivery of a cell therapy where a known quantity of cell activation occurs at a specific, selected site may therefore be advantageous. UC San Diego researchers have recently developed the methods and materials for remote control of cellular activation, to dynamically manipulate molecular events for therapeutic effect.

Safe And Targeted Electric Stimulation Of The Human Cranial Nerves

Neuromodulation (electrical stimulation of the nervous system) is used in cochlear and retinal implants, or deep brain stimulation devices to treat various neurological disorders (i.e. depression, Parkinson’s Disease). However, such approaches tend to be invasive and expensive. Researchers at UCI have developed a novel approach and device to stimulate the cranial nerves that is targeted, safe, and minimally-invasive for the treatment of diseases or the activation of senses.

Novel method for detection of O-Sulfonation sites on post-translationally modified proteins

Sulfonation of proteins and carbohydrates plays an important role in signaling, transport, and metabolism in the body. The degree to which a molecule is modified and at what positions dictates how that structure interacts within the body. UCI researchers have developed novel methods of detecting and mapping serine and threonine sulfonation of peptides and proteins.

CONTINUOUS, EFFICIENT PRODUCTION OF MEDICAL RADIOISOTOPES

The invention is a method for instantaneous and efficient extraction of radioactive isotopes with high specific activity, during continuous production at research reactors. The proposed method allows advantageous production of radioisotopes for various applications, including nuclear medicine uses (diagnostics, imaging, cancer treatments). In addition, the invention has the potential for applications related to isotopes used in thermoelectric generators (i.e. 238Pu) that power both medical devices, such as cardiac pacemakers, and deep space missions.

Reduced IP3 Signaling As A Diagnostic Tool For Autism Spectrum Disorders

The diagnosis of Autism Spectrum Disorder (ASD), and thus the development of therapies, is very challenging due to the lack of objective criteria and biomarkers. It is, however, a disease with a strong genetic component, and recent data has implicated new genes in the disease. Researchers at UC Irvine have developed a method to more reliably diagnose ASD with a laboratory test.

A non-destructive method of quantifying mRNA in a single living cell

The detection of levels of messenger RNA (mRNA), the molecule used by DNA to convey information about protein production, is a very important method in molecular biology. Current detection strategies, such as Northern Blotting and RT-PCR, require destruction of the cell to extract such information. Researchers at the University of California, Irvine have developed a method to non-destructively assess mRNA levels in a single living cell.

A Method For Accurate Parametric Mapping Based On Characterization Of A Reference Tissue Or Region

UCLA researchers in the Department of Radiological Sciences have developed a method to address the issue of B1+ field inhomogeneity that is becoming a persistent problem in higher field strengths. 

High-throughput planarian in vivo screening platform

UC San Diego investigators have developed a method of high-throughput screening (HTS) using freshwater planarians as a model. One use of this model is to screen chemical compounds. Conventional developmental toxicology testing is usually performed on mammals which is both expensive and low-throughput. A high-throughput inexpensive method capable of in vivo testing is highly desired whereby freshwater planarians could be used as an in vivo animal model.  Planarians are well suited to HTS, with their small size, sensitivity to chemicals, fast development and amenability to automated assays. These worms allow simultaneous assaying of adult and developing worms with the same assays, allowing direct comparison of the effects of chemicals on both populations. Furthermore, planarian brains are structurally similar to the mammalian brain, so that one can ascertain neurodevelopmental toxicity that is applicable to humans.

CHEMICAL INDUCTION OF A PAUSED PLURIPOTENT STATE

This invention identifies a mechanism for pausing development of pre-implantation embryos while retaining viability.

Combined Optical Micromanipulation & Interferometric Topography

Background: Optical tweezers (OTs) is a commonly used light-based technology with a broad range of applications in studying mechanobiology. While OTs are capable of making force measurements at the pico-Newton level, they cannot be used to provide size and structural information on the object being investigated. The platform technology developed at UCR provides simultaneous measurements of force and physical dimensions. Currently, many leading manufacturers for nanoanalytic instruments are expanding their operations in North America and Asia to support the growth of its application in the scientific community.   Brief Description: UCR researchers have developed COMMIT, an all-optical platform, by combining optical tweezers and a novel microscopy method. COMMIT allows for simultaneous measurement of nano-sized objects and pN forces. Existing methods call for fluorescent labels and lack high resolution in imaging. This platform facilitates dynamic measurement of transient nanomechanical properties of cells in real-time.

Functionally Selective Ligands for Study and Inhibition of Inflammation

Background: Due to the complexity of the complement system cascade, biological roles of many signaling receptors are unknown. Additionally, biased ligand binding to cell-bound receptors may lead to selective intracellular effector binding and ligand-specific pathway activation and function. Mechanistic knowledge forms the basis for assay development to explore pharmacology against complement-mediated inflammatory diseases.   Brief Description: A multidisciplinary team of researchers from UCR, Texas A&M, Sheffield, and Queensland have discovered the first functionally selective peptide ligands for a complement system receptor that is involved in inflammation. The peptides are functionally selective ligands of C5aR2 but not C5aR1 or C3aR, and they have been characterized in vitro and in vivo. These peptides are novel tools that can modulate the activity of the receptor in vitro and in vivo, and interrogate the function of the receptor and its implication in inflammatory diseases.

Silent Small Scale Magnetic Resonance Imaging (MRI)

This technology is a novel magnetic resonance imaging (MRI) spatial encoding method to afford a completely silent MRI. In addition, this technology allows miniaturization and is complimentary to both high field and low field designs.

Sensitive, Specific Ratiometric Fluorescence-based DNA Detection

Fluorescent silver nanoclusters for nucleic acid detection. 

Fusion Protein For Anti-Cd19 Chimeric Antigen Receptor Detection

Researchers at UCLA have developed a fusion protein that can detect immune cells expressing anti-CD19 chimeric antigen receptors with higher specificity and lower background than existing antibodies.

Engineered-Microparticle-Based Cell Carriers For Culture And Adhesive Flow Cytometry

The Di Carlo group at UCLA has invented a microparticle that enables the analysis of adherent cells by flow cytometry. In addition, they have developed a high-throughput method to fabricate these microparticles.

Novel cyanobacteriochromes responsive to light in the far-red to near-infrared region

Researchers at the University of California, Davis have identified new cyanobacteriochromes (CBCRs) that detect and fluoresce in the far-red and near-infrared region of the electromagnetic spectrum.

Treatment of spinal cord injury, traumatic brain injury, stroke and neurodegenerative disorders with a monoclonal antibody

Most people who suffer traumatic spinal cord injuries have incomplete lesions of neural circuits whose function can be partially restored from the reconfiguration of the spared circuits with rehabilitative training. Methods for improving nerve regeneration after spinal cord injury or nerve transplantation are needed for improved patient outcome. Also, neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer’s Disease and Parkinson’s Disease negatively impact quality of life. 

Versatile Cas9-Mediated Integration Technology

Many advancements to the Cas9 system (both the Cas9 nuclease and the sgRNA sequence) have been made to increase and optimize its efficiency and specificity.  Since many diseases and traits in humans have a complex genetic basis, multiple genomic targets must be simultaneously edited in order for diseases to be cured or for traits to be impacted.  Thus in order for CRISPR/Cas9 to be an effective gene therapeutic technology, huge swathes of the genome must be edited simultaneously, efficiently, and accurately. To address many of these issues, UC Berkeley researchers have developed a system method to rapidly manipulate multiple loci. This system allows for either sequential (maintaining inducible Cas9 present in the genome) or simultaneous (scarless excision) manipulation of Cas9 itself and can be applied to any organism currently utilizing the CRISPR technology.  The system can also be applied conveniently to create genomic libraries, artificial genome sequences, and highly programmable strains or cell lines that can be rapidly (and repeatedly) manipulated at multiple loci with extremely high efficiency.  

Deriving Human Naïve Pluripotent Stem Cells by Modifying the Hippo Pathway Using Genetic or Chemical Approaches

This invention identifies a method of generating naïve pluripotent stem cells for subsequent use in research or for regenerative medicine.

Use of Embryonic Stem Cell-Specific microRNAs to Safely Promote Induced Pluripotency

Novel use of a family of microRNAs to promote the de-differentiation of somatic cells to induce pluripotent stem cells (iPS cells) for use as therapeutic agents or research tools.

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