Browse Category: Medical > Research Tools

Categories

[Search within category]

Lensfree Wide-Field Fluorescent Imaging On A Chip Using Compressive Decoding

UCLA researchers have developed a compressive sampling algorithm for on-chip fluorescent imaging over an ultra-large field-of-view without the need for any lenses or mechanical scanning.

High-Throughput And Label-Free Single Nanoparticle Sizing Based On Time-Resolved On-Chip Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a rapid, low-cost, and label-free methodology for nanoparticle sizing.

Single Molecule Imaging and Sizing of DNA on a Cell Phone

UCLA researchers in the Department of Electrical Engineering have developed a light-weight and cost-effective fluorescence microscope installed on a cell phone.

Compound Library Made Through Phosphine-Catalyzed Annulation/Tebbe/Diels-Alder Reaction

UCLA researchers in the Department of Chemistry and Biochemistry have developed a small molecule library consisting of a large variety stereochemical variants.

Microbial Mediators Of The Beneficial Effects Of The Ketogenic Diet

UCLA researchers have identified a strategy to manipulate the gut microbiome to mimic the effects of a ketogenic diet, as a treatment for CNS disorders and metabolic diseases.

Live Cell Detection by Near-Infrared Fluorogenic Tetrazine Uncaging Oligo Probes

There is significant interest in developing methods that visualize and detect RNA in live cells. Bioorthogonal template driven tetrazine ligations are quickly becoming a powerful route to visualizing nucleic acids in native cells, yet past work has been limited with respect to the diversity of fluorogens and existing tetrazine-reactive fluorogenic probes are quenched by through‐bond energy transfer (TBET) or Fӧrster resonance energy transfer (FRET) between the donor fluorophore and acceptor tetrazine.

Process For Sorting Dispersed Colloidal Structures

Researchers from the Chemistry and Biochemistry department at UCLA have developed method of separating and/or sorting specific target structures from other non-target structures in a complex mixture using custom-made target-specific colloidal particles.

Polycytotoxic T Cells

UCLA researchers in the Department of Dermatology have characterized a novel subset of CD8+ T cells, termed polycytotoxic, that mediate killing of intracellular pathogens.

Derivation Of A Human Neuroendocrine Prostate Cancer Cell Line With Defined Oncogenic Drivers

Researchers at UCLA have developed a malignant neuroendocrine prostate cancer cell line that was derived from benign human prostate tissue and transformed with the oncogenes MYCN and myristoylated AKT1.

Nucleic Acid Tetramers For High Efficiency Multiplexed Cell Sorting

UCLA researchers in the Departments of Medicine and Pharmacology have a highly specific method of sorting cells by using multiplexed tetramers with unique DNA-oligomer signatures.

Xenobiotic-Free Culture System To Expand Human Limbal Stem Cells

UCLA researchers in the Departments of Opthalmology have developed a xenobiotic-free manufacturing process to produce transplantable human limbal stem cells for use in treating limbal stem cell deficiency.

Homogenous Entropy-Driven Biomolecular Assay (HEBA)

Professors in the UCLA Department of Bioengineering have developed a novel short oligonucleotide assay to fluorescently detect biomolecules.

Drop-Carrier Particles For Digital Assays

UCLA researchers in the Department of Bioengineering have developed a novel drop-carrier particle for single cell or single molecule assays.

Label Free Assessment Of Embryo Vitality

Researchers at UC Irvine developed an independent non-invasive method to distinguish between healthy and unhealthy embryos.

Low Cost Wireless Spirometer Using Acoustic Modulation

The present invention relates to portable Spirometry system that uses sound to transmit pulmonary airflow information to a receiver.

Microfluidic Component Package

The present invention describes a component package that enables a microfluidic device to be fixed to a Printed Circuit Board (PCB) or other substrate, and embedded within a larger microfluidic system.

Imaging Platform Based On Nonlinear Optical Microscopy For Rapid Scanning Large Areas Of Tissue

The present invention discloses a nonlinear optical microscopy (NLOM) instrument for rapid imaging of wide areas and large volumes of biological tissues or other materials, ex vivo or in vivo, at sub-micron resolution. The instrument allows much larger field of view (FOV) at the same time improves the scan speed.

Microchambers With Solid-State Phosphorescent Sensor For Measuring Single Mitochondrial Respiration

The invention is a miniaturized device that assays the respiration of a single mitochondrion. Through a novel approach for measuring oxygen consumption rate, the device provides information on cell and tissue mitochondrial functional. This data is relevant for understanding human conditions associated with mitochondrial dysfunction, such as Alzheimer’s Disease and cancer.

Immortalized Human Epidermal Cell Lines

Researchers at the University of California, Davis have developed several immortalized human epidermal cell lines.

Novel Method to Identify Unknown Viruses

Prof. Shou-wei Ding and colleagues at UCR have developed a new method for virus discovery that is independent of either amplification or purification of viral particles. Virus-derived siRNAs and piRNAs are produced by the host immune system as an antiviral response to viral infection. These viral siRNAs and piRNAs are overlapping in sequence and can be assembled back into long continuous fragments of the infecting viral RNA genome. A researcher may sequence the total small RNAs of 18 to 29 nucleotides in length in a disease sample and search a public database of viral sequences using the contiguous sequences assembled from the small RNAs to identify a new or known virus with homology to all or part of a known viral genome in the database.

Somatic loss of Mgat1 as a potential risk factor for Multiple Sclerosis (MS)

Researchers at UCI report the incidence of somatic mutation/ loss in a human gene to increase the risk of some types of Multiple Sclerosis (MS).

Genetically Encoded Fluorescent Sensors for Probing the Action of G-Protein Coupled Receptors (GPCRs)

Researchers at the University of California, Davis have developed a genetically encoded fluorescent sensor toolbox for the probing of G-protein coupled receptors.

Culturing More Mature iPSC-derived Cardiac Myocytes

Researchers at the University of California, Davis have developed a non-genetic, non-pharmacological method for culturing more mature induced pluripotent stem cell-derived cardiac myocytes.

Wireless Implantable System To Restore Memory

UCLA researchers have developed a wireless implantable deep brain stimulation system to restore memory in individuals with traumatic brain injury.

Small Molecule Generation of Multinucleated and Striated Myofibers from Human Pluripotent Stem Cells Equivalent to Adult Skeletal Muscle

Researchers in the UCLA Department of Microbiology, Immunology and Molecular Genetics have developed a novel means of generating adult skeletal muscle-equivalent myofibers from human pluripotent stem cells.

  • Go to Page: