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Wearable Bioelectronics for Programmable Delivery of Therapy

Precise control of wound healing depends on physician’s evaluation, experience. Physicians provide conditions and time for body to either heal itself, or to accept and heal around direct transplantations, and their practice relies a lot on passive recovery. Slow healing of recalcitrant wounds is a known persistent problem, with incomplete healing, scarring, and abnormal tissue regeneration. 23% of military blast and burn wounds do not close, affecting a patient’s bone, skin, nerves. 64% of military trauma have abnormal bone growth into soft tissue. While newer static approaches have demonstrated enhanced growth of non-regenerative tissue, they do not adapt to the changing state of wound, thus resulting in limited efficacy.

Bioelectronic Smart Bandage For Controlling Wound pH through Proton Delivery

Precise control of wound healing depends on physician’s evaluation, experience. Physicians provide conditions and time for body to either heal itself, or to accept and heal around direct transplantations, and their practice relies a lot on passive recovery. Slow healing of recalcitrant wounds is a known persistent problem, with incomplete healing, scarring, and abnormal tissue regeneration. 23% of military blast and burn wounds do not close, affecting a patient’s bone, skin, nerves. 64% of military trauma have abnormal bone growth into soft tissue. While newer static approaches have demonstrated enhanced growth of non-regenerative tissue, they do not adapt to the changing state of wound, thus resulting in limited efficacy.

Inverse Design and Fabrication of Controlled Release Structures

Researchers at the University of California, Davis have developed an algorithm for designing and identifying complex structures having custom release profiles for controlled drug delivery.

Haptic Smart Phone-Cover: A Real-Time Navigation System for Individuals with Visual Impairment

Researchers at the University of California, Davis have developed a haptic interface designed to aid visually impaired individuals in navigating their environment using their portable electronic devices.

Silent Speech Interface Using Manifold Decoding Of Biosignals

Researchers at the University of California, Davis have developed a technology that provides a novel method for decoding biosignals into speech, enhancing communication for individuals with speech impairments.

Over-the-Counter (OTC) Hearing Aid Advancements

This technology introduces innovative methods to significantly improve the performance and accessibility of OTC hearing aids for individuals with mild-to-moderate hearing loss.

Heated Dynamic Headspace Sampling Device for Volatile Organic Compounds (VOCs) from a Surface

Researchers at the University of California, Davis have developed a technology that offers a sophisticated solution for collecting and measuring gas emissions from surfaces, particularly skin, with high sensitivity and specificity.

A Multi-Chip Module for Treatment of Ear/Brain Disorders

This unique device delivers electrical stimulation to the inner ear or cranial nerves to treat a panel of ear/brain disorders, including tinnitus.

Abnormal Heart Activity Monitoring Using Contact Doppler Radar

Researchers at the University of California, Davis have developed a device for non-invasive, simultaneous monitoring of fetal and maternal heart rates to enhance reproductive management and health monitoring.

Real-Time Virtual Histology Biopsy of Tissue

A revolutionary laser-based micro-biopsy tool designed for minimally invasive, precise tissue sampling and real-time histological analysis.

Non-invasive monitoring of hemodynamic parameters

This technology represents a breakthrough in non-invasive hemodynamic monitoring by utilizing coherent light to assess physiological parameters with high accuracy

A System And Method To Measure Intraocular Pressure

A novel non-invasive method to measure intraocular pressure (IOP), offering a significant advancement in glaucoma management.

Magnetic Device for Preventing Upper Gastrointestinal Luminal Device Migration

A novel magnetic device designed to prevent migration of upper gastrointestinal intraluminal devices, increasing their clinical functionality and patient safety.

Compact Series Elastic Actuator Integration

      While robots have proven effective in enhancing the precision and time efficiency of MRI-guided interventions across various medical applications, safety remains a formidable challenge for robots operating within MRI environments. As the robots assume full control of medical procedures, the reliability of their operation becomes paramount. Precise control over robot forces is particularly crucial to ensure safe interaction within the MRI environment. Furthermore, the confined space in the MRI bore complicates the safe operation of human-robot interaction, presenting challenges to maneuverability. However, there exists a notable scarcity of force-controlled robot actuators specifically tailored for MRI applications.       To overcome these challenges, UC Berkeley researchers have developed a novel MRI-compatible rotary series elastic actuator module utilizing velocity-sourced ultrasonic motors for force-controlled robots operating within MRI scanners. Unlike previous MRI-compatible SEA designs, the module incorporates a transmission force sensing series elastic actuator structure, while remaining compact in size. The actuator is cylindrical in shape with a length shorter than its diameter and integrates seamlessly with a disk-shaped motor. A precision torque controller enhances the robustness of the invention’s torque control even in the presence of varying external impedance; the torque control performance has been experimentally validated in both 3 Tesla MRI and non-MRI environments, achieving a settling time of 0.1 seconds and a steady-state error within 2% of its maximum output torque. It exhibits consistent performance across low and high external impedance scenarios, compared to conventional controllers for velocity-sourced SEAs that struggle with steady-state performance under low external impedance conditions.

Ultra-low Voltage EDA Acquisition Circuits with an Adaptive Feedback System

Researchers at the University of California, Davis have developed a system that significantly improves the accuracy and efficiency of stress detection through electrodermal activity monitoring.

3D Bioprinting Epithelial Organoids

Researchers at the University of California, Davis have developed a novel 3D printing approach to culture and construct epithelial tubular mini-tissues.

Dissolvable Calcium Alginate Microfibers via Immersed Microfluidic Spinning

A novel method for producing dissolvable alginate microfibers critical for advanced tissue engineering and microfluidic network fabrication.

Spatial Analysis of Multiplex Immunohistochemical Tissue Images

Researchers at the University of California, Davis have developed a semiautomated solution for identifying differences in tissue architectures or cell types as well as visualizing and analyzing cell densities and cell-cell associations in a tissue sample.

Training Swimwear Garment to Address Injury Risk Factors

Researchers at the University of California, Davis (“UC Davis”) have developed a unisex swimwear garment designed to prevent swimming-related injuries and to assist in injury recovery during training.

High-Speed, High-Memory NMR Spectrometer and Hyperpolarizer

         Recent advancements in nuclear magnetic resonance (NMR) spectroscopy have underscored the need for novel instrumentation, but current commercial instrumentation performs well primarily for pre-existing, mainstream applications. Modalities involving, in particular, integrated electron-nuclear spin control, dynamic nuclear polarization (DNP), and non-traditional NMR pulse sequences would benefit greatly from more flexible and capable hardware and software. Advances in these areas would allow many innovative NMR methodologies to reach the market in the coming years.          To address this opportunity, UC Berkeley researchers have developed a novel high-speed, high-memory NMR spectrometer and hyperpolarizer. The device is compact, rack-mountable and cost-effective compared to existing spectrometers. Furthermore, the spectrometer features robust, high-speed NMR transmit and receive functions, synthesizing and receiving signals at the Larmor frequency and up to 2.7GHz. The spectrometer features on-board, phase-sensitive detection and windowed acquisition that can be carried out over extended periods and across millions of pulses. These and additional features are tailored for integrated electron-nuclear spin control and DNP. The invented spectrometer/hyperpolarizer opens up new avenues for NMR pulse control and DNP, including closed-loop feedback control, electron decoupling, 3D spin tracking, and potential applications in quantum sensing.

SPECTRAL DOMAIN FUNCTIONAL OCT and ODT

This technology revolves around Optical Coherence Tomography (OCT), a noninvasive imaging method that provides detailed cross-sectional images of tissue microstructure and blood flow. OCT utilizes either time domain (TDOCT) or Fourier domain (FDOCT) approaches, with FDOCT offering superior sensitivity and speed. Doppler OCT combines Doppler principles with OCT to visualize tissue structure and blood flow concurrently. Additionally, polarization-sensitive OCT detects tissue birefringence. Advanced methods aim to enhance the speed and sensitivity of Doppler OCT, crucial for various clinical applications such as ocular diseases and cancer diagnosis. Swept source FDOCT systems further improve imaging capabilities by increasing range and sensitivity. Overall, this technology represents significant advancements in biomedical imaging, offering insights into both structural and functional aspects of tissue physiology.

Electricity enhanced delivery of drugs into the ureter, renal pelvis, and renal parenchyma

The invention entails a unique catheter device utilizing electromotive drug administration (EMDA) to enhance drug penetrance into tissues of the ureter, renal pelvis, and calyces. By incorporating a conductive wire and fluid delivery system, the catheter enables targeted drug delivery, potentially revolutionizing the treatment of kidney stones, urothelial carcinoma, infections, and inflammation without systemic side effects.

Implantable Prosthetic Valves

The invention pertains to a prosthetic valve featuring a saddle-shaped annulus that synchronously transforms between concave and convex configurations, facilitating seamless opening and closure synchronized with cardiac cycles. Comprising leaflets and support elements, the valve mimics natural heart valve function, enabling effective blood flow regulation and offering versatile deployment options for cardiac and vascular applications.

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