Superparamagnetic Magnetite Colloidal Nanocrystal Clusters

Tech ID: 32610 / UC Case 2007-505-0

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 10,118,834 11/06/2018 2007-505
 

Full Description

Background

Superparamagnetic nanocrystals are attractive for biomedical applications, as they are not subject to strong magnetic interactions in dispersion. Iron oxide nanocrystals have received the most attention for this purpose because of their biocompatibility and stability under physiological conditions. Robust approaches have been developed for synthesizing magnetic iron oxide (e.g., Fe2O3 or Fe3O4) nanocrystals with tightly controlled size distribution, typically by organometallic processes at elevated temperatures in nonpolar solvents. The challenges with these approaches are:

  • Nanocrystals of the order of 10 nanometers (nm) have a low magnetization per particle making it difficult to control their movement in blood using moderate magnetic fields limiting their usage in bio-separation or targeted delivery.
  • Increasing nanocrystal sizes induces paramagnetic-ferromagnetic transition making the crystals no longer dispersible in solution.

 

Current Invention

The current patented technology discloses the ability and the synthesis of highly water dispersible magnetite (Fe3O4) colloidal nanocrystal clusters (CNCs) with uniform size from about 30 to about 180nm, each of which is composed of many single magnetite crystallites approximately 10 nm in size.

TEM Image of CNCs of 31nm size

Representative TEM Image of Magnetite CNCs of average diameter 31nm.

 

Mass magnetization as a function of magnetic field

Mass Magnetization (M) as a function of applied magnetic field (H)  for 93 nm CNCs at 300 deg. K.

Advantages

The benefits of the current approach are:

  • The CNCs show superparamagnetic properties at room temperatures.
  • High magnetization enabling ease of separation and targeted delivery in bio-medical applications.
  • High water dispersability

Suggested uses

  • Targeted delivery
  • Bio-separation
  • Magnetic Resonance Imaging (MRI)

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Keywords

Biosensors, Chemical sensors, Bio-separation, Medical Imaging, Targeted delivery, Colloids, Nanocrystals, Superparamagnetic Colloids, Colloidal Nanocrystal Clusters, Magnetite

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