|United States Of America||Issued Patent||10,118,834||11/06/2018||2007-505|
Superparamagnetic nanocrystals are attractive for biomedical applications, as they are not subject to strong magnetic interactions in dispersion. Iron oxide nanocrystals have received the most attention for this purpose because of their biocompatibility and stability under physiological conditions. Robust approaches have been developed for synthesizing magnetic iron oxide (e.g., Fe2O3 or Fe3O4) nanocrystals with tightly controlled size distribution, typically by organometallic processes at elevated temperatures in nonpolar solvents. The challenges with these approaches are:
The current patented technology discloses the ability and the synthesis of highly water dispersible magnetite (Fe3O4) colloidal nanocrystal clusters (CNCs) with uniform size from about 30 to about 180nm, each of which is composed of many single magnetite crystallites approximately 10 nm in size.
Representative TEM Image of Magnetite CNCs of average diameter 31nm.
Mass Magnetization (M) as a function of applied magnetic field (H) for 93 nm CNCs at 300 deg. K.
The benefits of the current approach are:
Biosensors, Chemical sensors, Bio-separation, Medical Imaging, Targeted delivery, Colloids, Nanocrystals, Superparamagnetic Colloids, Colloidal Nanocrystal Clusters, Magnetite