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Browse Category: Sensors & Instrumentation > Biosensors

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Personalized Oncology Drug Efficacy Monitoring Chip

Researchers at UCI have developed a novel microfluidic-based platform that enables personalized drug screening of patient-derived cancer cells. This versatile device features real-time, continuous screening of patient samples without the need for expensive labeling reagents, large sample sizes, or bulky readout equipment.

A Wearable Freestanding Electrochemical Sensing System

Researchers in the UCLA Department of Electrical and Computer Engineering have developed a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.

A Fully Integrated Stretchable Sensor Arrays for Wearable Sign Language Translation To Voice

UCLA researchers in the Department of Bioengineering have developed a novel machine learning assisted wearable sensor system for the direct translation of sign language into voice with high performance.

A Wireless Textile Based Sensor System for Self-Powered Personalized Health Care

UCLA researchers in the Department of Bioengineering have developed a textile-based sensor system (TS system) for wireless, wearable biomonitoring.

Unobtrusive Fetal Heartrate Monitoring In The Daily Life

A novel wearable, unobtrusive flexible patch designed to facilitate continuous monitoring of fetal heart rate (fHR) and ECG by pregnant women in a home setting.

Wireless and Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans Immersed in Virtual, Augmented or Real-World Environments

UCLA researchers in the Department of Psychiatry and Biobehavioral Sciences have a designed a lightweight, highly mobile deep brain activity measuring platform that elucidates neural mechanisms for neuropsychiatric disorders.

Smart Dialysis Catheter

UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.

Low-Cost Paper-Based Microfluidic Diagnostic Device

Prof. Mulchandani and his colleagues from the University of California, Riverside have developed a new paper-based microfluidic platform for the simple and low-cost fabrication of single-walled carbon nanotube (SWNT)-based chemiresistive nanobiosensor arrays for multianalyte sensing from a single small volume sample that may be used as point-of-care diagnostic for a variety of purposes, including healthcare, food safety, environment, etc. This device is created by utilizing a wax printer to construct well-defined hydrophobic barriers for equal splitting and delivery of fluid and an inkjet printer to fabricate chemiresistors using a water-based SWNT ink on a paper substrate. Currently, the quantitative and selective detection of both human serum albumin (HSA) and human immunoglobulin G (hIgG) simultaneously in urine has been demonstrated by UCR. This paper-based chemiresistive biosensor is easy to fabricate, and designed for cost-effective, rapid, sensitive and selective detection of  analyte(s) of interest. This technology provides a platform for automated, disposable paper-based point-of-care diagnostics with multiplexed detection capability and microfluidic controls. Fig 1: A 3D microfluidic multiplexed paper-based biosensor array device.

Mechanisms and Devices Enabling Arbitrarily Shaped, Deep-Subwavelength, Acoustic Patterning

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a Compliant Membrane Acoustic Patterning (CAMP) technology capable of patterning cells in an arbitrary pattern at a high resolution over a large area.

Liquid Metal Enabled Multi-Functional Neural Probes with Ultra-Large Tunable Stiffness

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel multi-functional neural probe with ultra-large tunable stiffness for electrochemical sensing and chemical delivery in the brain.

Development Of Biosensors For Drought Stress In Plants

Researchers at the University of California, Davis have developed a prototype biosensor that can monitor detectable levels of hormones present in plants experiencing drought or other environmental stress.

Colorimetric Detoxifying Sensors for Fumigants and Aerosol Toxicants

Researchers at the University of California, Davis have developed a colorimetric sensor than can detect and detoxify fumigants simultaneously. 

A Wearable Platform for In-Situ Analysis of Hormones

UCLA researchers in the Department of Electrical and Computer Engineering have developed a highly sensitive, wearable hormone monitoring platform.

Ultra-Low Cost, Transferrable and Thermally Stable Sensor Array Patterned on Conductive Substrate for Biofluid Analysis

UCLA researchers from the Department of Electrical Engineering have invented a novel biosensor array that is ultra-low cost and thermally stable. It prolongs the lifetime of electrode modules of sensor products and allows for extended sensing operation in uncontrolled environments.

In-Situ Sweat Rate Monitoring For Normalization Of Sweat Analyte Concentrations

UCLA researchers in the Department of Electrical Engineering have developed a method of in-situ sweat rate monitoring, which can be integrated into wearable consumer electronics for physiological analyses.

Multiplexed Sweat Extraction And Sensing Wearable Interface For Normalized And Periodic Analysis

UCLA researchers from the Department of Electrical Engineering have developed a novel sweat induction and sensing platform to achieve personalized physiological monitoring non-invasively.

Chip-Based Detection Of Diabetes Related Biomarkers

A major goal in disease screening, diagnosis, and control has been to develop bioassay platforms capable of simultaneous measurements of different analytes in a single assay. Significant advances toward multiplexed biomarker detection chips based on either immunoassays or enzymatic bioassays have thus been reported. However, the combination of enzymatic and immunoassay sensing into a single disposable system has hitherto not been addressed.

Flexible, Biocompatible Microfluidics-inspired Micro-reference Electrodes for Sensing Applications

Researchers at UCI have created miniaturized, flexible, biocompatible reference electrode with a streamline design capable of being used in a variety of different laboratory and clinical environments.

A Wide Dynamic Range Current Measurement Front-End

Accurate current measurement is crucial in many biosensing applications, such as the detection of neurotransmitters and the monitoring of intercellular molecular dynamics. This need has become even more critical recently with single molecule biosensors where sub-pA signal currents are superimposed on a slowly varying nA to µA background current, as is the case with nanopores. As such, the readout circuitry requires wide dynamic range (>120dB) and high linearity (>14b) albeit often with low bandwidth (a few Hz to kHz).

An Injectable Biomote Biosensor

Brief description not available

Array Atomic Force Microscopy Enabling Simultaneous Multi-point and Multi-modal Nanoscale Analyses

Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale physical and biological systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and can be integrated seamlessly with disparate probe-based sensing and manipulation technologies. However, conventional AFMs only permit sequential single-point analysis. Widespread adoption of array AFMs for simultaneous multi-point study is still challenging due to the intrinsic limitations of existing technological approaches.

Low-noise Low-power ADC for Direct Biopotential Recording in Neuroscience Applications

High-density multi-channel neural recording is critical to driving advances in neuroscience and neuroengineering through increasing the spatial resolution and dynamic range of brain-machine interfaces.  Neural signal acquisition ICs have conventionally been designed composed of two distinct functional blocks per recording channel: a low-noise amplifier front-end (AFE), and an analog-digital converter (ADC).  Hybrid architectures utilizing oversampling ADCs with digital feedback have seen recent adoption due to their increased power and area efficiency. However, input dynamic range (DR) is still relatively limited due to aggressive supply voltage scaling and/or capacitive sampling noise.

Cloud- enabled Wireless pH Monitoring in Laboratory Sample Vials

A team of inventors at UCI have developed a miniaturized, wireless pH sensing system capable of monitoring the pH of laboratory samples in real-time with cloud-enabled connections for data collection. The sensor is designed to fit into the caps of standard sample vials, providing continuous measurements and eliminating the need to open vials during sensing.

Tracking Diet And Nutrition with a Wearable Bio-Iot

Faculty at UC Irvine have invented a wearable biosensor that quantifies macronutrients such as sugar, salt, fat, protein, and water consumed by the wearer.  It may be used much like a fitness tracker for self-monitoring and promotion of healthy dietary choices.

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