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Method to Identify Vomocytosis Events via Time-Lapse Fluorescence Microscopy

Researchers at the University of California, Davis have developed a method to identify vomocytosis events in time-lapse microscopy videos.

Neuro-Swarm3: System-On-A-Nanoparticle For Wireless Recording Of Brain Activity

A fundamental limitation for the implantable brain-machine interfaces (BMI) is the wiring requirements for power transfer and signal transmission. Microelectrode arrays (MEAs), the workhorse technology in neuroscience, offer multiplexed electrophysiological recordings with high temporal resolution. However, their use is inherently limited to a few hundred electrodes as direct electronic measurements suffer from complex wiring requirements and inherent bandwidth (spatial multiplexing) limitations due to electron-electron interactions within conductors. Moreover, electrode arrays can only record from small sections of the brain and require invasive cranial surgical operations. The recent discovery of genetically encoded voltage sensitive fluorescence indicators (GEVI) has created tremendous excitement as light offers unparalleled multiplexing and information carrying capabilities. However, GEVI cannot be used in humans as it requires expression of voltage sensitive molecules by neurons and therefore genetic manipulation. In addition, attenuation of visible light in biological tissue renders much of the brain inaccessable to fluorescence based techniques.  


Target biomarkers are often found at low levels (e.g., attomolar to picomolar scale) in the early stages of disease. Current biosensor technologies are limited by their ability to simply and precisely detect target biomarkers at very low concentrations though. Typical biomedical samples, like blood or urine, can also compromise the specificity and sensitivity of common diagnostic platforms without extensive sample processing to remove background contaminants.

Magnetochromatic Spheres

Brief description not available

Systems and Methods for Scaling Electromagnetic Apertures, Single Mode Lasers, and Open Wave Systems

The inventors have developed a scalable laser aperture that emits light perpendicular to the surface. The aperture can, in principal, scale to arbitrarily large sizes, offering a universal architecture for systems in need of small, intermediate, or high power. The technology is based on photonic crystal apertures, nanostructured apertures that exhibit a quasi-linear dispersion at the center of the Brillouin zone together with a mode-dependent loss controlled by the cavity boundaries, modes, and crystal truncation. Open Dirac cavities protect the fundamental mode and couple higher order modes to lossy bands of the photonic structure. The technology was developed with an open-Dirac electromagnetic aperture, known as a Berkeley Surface Emitting Laser (BKSEL).  The inventors demonstrate a subtle cavity-mode-dependent scaling of losses. For cavities with a quadratic dispersion, detuned from the Dirac singularity, the complex frequencies converge towards each other based on cavity size. While the convergence of the real parts of cavity modes towards each other is delayed, going quickly to zero, the normalized complex free-spectral range converge towards a constant solely governed by the loss rate of Bloch bands. The inventors show that this unique scaling of the complex frequency of cavity modes in open-Dirac electromagnetic apertures guarantees single-mode operation of large cavities. The technology demonstrates scaled up single-mode lasing, and confirmed from far-field measurements. By eliminating limits on electromagnetic aperture size, the technology will enable groundbreaking applications for devices of all sizes, operating at any power level. BACKGROUND Single aperture cavities are bounded by higher order transverse modes, fundamentally limiting the power emitted by single-mode lasers, as well as the brightness of quantum light sources. Electromagnetic apertures support cavity modes that rapidly become arbitrarily close with the size of the aperture. The free-spectral range of existing electromagnetic apertures goes to zero when the size of the aperture increases. As a result, scale-invariant apertures or lasers has remained elusive until now.  Surface-emitting lasers have advantages in scalability over commercially widespread vertical-cavity surface-emitting lasers (VCSELs). When a photonic crystal is truncated to a finite cavity, the continuous bands break up into discrete cavity modes. These higher order modes compete with the fundamental lasing mode and the device becomes more susceptible to multimode lasing response as the cavity size increases. 

Templated Synthesis Of Metal Nanorods

Brief description not available

Magnetically Responsive Photonic Nanochains

Brief description not available

Medical Device: Electrode for Wearable Point-of-Care Health Monitoring

Researchers at the University of California, Irvine have fabricated a flexible and unobtrusive wearable electrode that can detect glucose at a very low limit of detection.In fact, the detection limits are the lowest ever reported for an enzyme-free sensor. This sensor is applicable for detecting glucose levels in saliva, sweat or tears, and can safely be used at home, especially by diabetic patients without the need to frequently draw blood.

Inter-Brain Measurements for Matching Applications

This technology utilizes inter-subject measurement of brain activity for the purpose of matching individuals. In particular, the invention measures the similarity and differences in neural activity patterns between interacting individuals (either in person or online) as a signature measurement for their matching capabilities. Relevant applications can be in the world of human resources (e.g., building collaborative teams), patient-therapist matching and others. The application relies on the utilization of both custom and commercial devices for measuring brain activity.

Flexthrough: A Recirculation Mechanism In Point Of Care CD Microfluidic Using Elastic Membrane

Researchers from the University of California, Irvine have developed a new method and device to efficiently mix and analyze liquid samples on CD-based point of care devices.

FlexThrough: a recirculation mechanism in point of care CD microfluidic using elastic membrane

Researchers from the University of California, Irvine have developed a new method and device to efficiently mix and analyze liquid samples on CD-based point of care devices.

Gas Sensors For Hazardous Chemical Detection

Prof. Nosang Myung and colleagues from the University of California, Riverside have developed state-of-the-art gas sensors that may be used to create an electronic nose. This device is known as ChromaNose. ChromaNose is capable of sensing carbon monoxide, hydrogen sulfide, hydrogen gas, oxygen gas, nitrogen dioxide, and ammonia at room temperature. This technology may be used in various applications to detect harmful chemicals that people cannot see or smell. For example, ChromaNose may detect cleaning solvent residue left in masks worn by Air Force personnel. The inhalation of cleaning solvent residue causes the wearer to become ill. It would be desirable to detect and remove any cleaning solvents remaining in a mask to prevent illness. Fig 1: Image of the UCR Pt/SnO2/SWNT hybrid nanostructure sensors.

Deep Learning Techniques For In Vivo Elasticity Imaging

Imaging the material property distribution of solids has a broad range of applications in materials science, biomechanical engineering, and clinical diagnosis. For example, as various diseases progress, the elasticity of human cells, tissues, and organs can change significantly. If these changes in elasticity can be measured accurately over time, early detection and diagnosis of different disease states can be achieved. Elasticity imaging is an emerging method to qualitatively image the elasticity distribution of an inhomogeneous body. A long-standing goal of this imaging is to provide alternative methods of clinical palpation (e.g. manual breast examination) for reliable tumor diagnosis. The displacement distribution of a body under externally applied forces (or displacements) can be acquired by a variety of imaging techniques such as ultrasound, magnetic resonance, and digital image correlation. A strain distribution, determined by the gradient of a displacement distribution, can be computed (or approximated) from measured displacements. If the strain and stress distributions of a body are both known, the elasticity distribution can be computed using the constitutive elasticity equations. However, there is currently no technique that can measure the stress distribution of a body in vivo. Therefore, in elastography, the stress distribution of a body is commonly assumed to be uniform and a measured strain distribution can be interpreted as a relative elasticity distribution. This approach has the advantage of being easy to implement. The uniform stress assumption in this approach, however, is inaccurate for an inhomogeneous body. The stress field of a body can be distorted significantly near a hole, inclusion, or wherever the elasticity varies. Though strain-based elastography has been deployed on many commercial ultrasound diagnostic-imaging devices, the elasticity distribution predicted based on this method is prone to inaccuracies.To address these inaccuracies, researchers at UC Berkeley have developed a de novo imaging method to learn the elasticity of solids from measured strains. Our approach involves using deep neural networks supervised by the theory of elasticity and does not require labeled data for the training process. Results show that the Berkeley method can learn the hidden elasticity of solids accurately and is robust when it comes to noisy and missing measurements.

Compositions and Methods of Isothermal Nucleic Acid Detection

An improved method for isothermal nucleic acid detection based on a loop mediated isothermal amplification (LAMP) technique that can be broadly applied for nucleic acid diagnostics.LAMP is an isothermal amplification method that amplifies DNA or RNA. This iteration of LAMP allows for the integration of any short DNA sequence, including tags, restriction enzyme sites, or promoters, into an isothermally amplified amplicon. The technique presented by the inventors allows for the insertion of sequence tags up to 35 nt into the flanking regions of the LAMP amplicon using the forward and backward inner primers (FIP and BIP), and loop primers. The inventors have demonstrated insertion of sequence fragments into the 5’ and middle regions of the FIP and BIP primers, and the 5’ region of the loop primers. In some embodiments, the sequence tag comprises a T7 RNA polymerase promoter, which is then incorporated into the LAMP amplicon (termed RT-LAMP/T7). With the addition of T7 polymerase, the amplicon can be in vitro transcribed, leading to additional amplification of the target molecule into an RNA substrate. This improves the efficiency of the amplification reaction and enables substrate conversion into different nucleic acid types.In other embodiments, the amplified RNA sequence can be detected by CRISPR enzymes, such as RNA-targeting Cas13 systems. 

Personalized Oncology Drug Efficacy Monitoring Chip

Researchers at UCI have developed a novel microfluidic-based platform that enables personalized drug screening of patient-derived cancer cells. This versatile device features real-time, continuous screening of patient samples without the need for expensive labeling reagents, large sample sizes, or bulky readout equipment.

A Wearable Freestanding Electrochemical Sensing System

Researchers in the UCLA Department of Electrical and Computer Engineering have developed a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.

A Fully Integrated Stretchable Sensor Arrays for Wearable Sign Language Translation To Voice

UCLA researchers in the Department of Bioengineering have developed a novel machine learning assisted wearable sensor system for the direct translation of sign language into voice with high performance.

Unobtrusive Fetal Heartrate Monitoring In The Daily Life

A novel wearable, unobtrusive flexible patch designed to facilitate continuous monitoring of fetal heart rate (fHR) and ECG by pregnant women in a home setting.

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