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Chip-Based Detection Of Diabetes Related Biomarkers

A major goal in disease screening, diagnosis, and control has been to develop bioassay platforms capable of simultaneous measurements of different analytes in a single assay. Significant advances toward multiplexed biomarker detection chips based on either immunoassays or enzymatic bioassays have thus been reported. However, the combination of enzymatic and immunoassay sensing into a single disposable system has hitherto not been addressed.

Flexible, Biocompatible Microfluidics-inspired Micro-reference Electrodes for Sensing Applications

Researchers at UCI have created miniaturized, flexible, biocompatible reference electrode with a streamline design capable of being used in a variety of different laboratory and clinical environments.

A Wide Dynamic Range Current Measurement Front-End

Accurate current measurement is crucial in many biosensing applications, such as the detection of neurotransmitters and the monitoring of intercellular molecular dynamics. This need has become even more critical recently with single molecule biosensors where sub-pA signal currents are superimposed on a slowly varying nA to µA background current, as is the case with nanopores. As such, the readout circuitry requires wide dynamic range (>120dB) and high linearity (>14b) albeit often with low bandwidth (a few Hz to kHz).

An Injectable Biomote Biosensor

Brief description not available

Array Atomic Force Microscopy Enabling Simultaneous Multi-point and Multi-modal Nanoscale Analyses

Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale physical and biological systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and can be integrated seamlessly with disparate probe-based sensing and manipulation technologies. However, conventional AFMs only permit sequential single-point analysis. Widespread adoption of array AFMs for simultaneous multi-point study is still challenging due to the intrinsic limitations of existing technological approaches.

Low-noise Low-power ADC for Direct Biopotential Recording in Neuroscience Applications

High-density multi-channel neural recording is critical to driving advances in neuroscience and neuroengineering through increasing the spatial resolution and dynamic range of brain-machine interfaces.  Neural signal acquisition ICs have conventionally been designed composed of two distinct functional blocks per recording channel: a low-noise amplifier front-end (AFE), and an analog-digital converter (ADC).  Hybrid architectures utilizing oversampling ADCs with digital feedback have seen recent adoption due to their increased power and area efficiency. However, input dynamic range (DR) is still relatively limited due to aggressive supply voltage scaling and/or capacitive sampling noise.

Cloud- enabled Wireless pH Monitoring in Laboratory Sample Vials

A team of inventors at UCI have developed a miniaturized, wireless pH sensing system capable of monitoring the pH of laboratory samples in real-time with cloud-enabled connections for data collection. The sensor is designed to fit into the caps of standard sample vials, providing continuous measurements and eliminating the need to open vials during sensing.

Microfluidics Device and Methods of Detecting Airborne Agents

A microfluidic platform for real time sensing of volatile airborne agents.

Flexible Wearable Sensors for Non-invasive Continuous Blood Pressure Monitoring

Researchers at UCI have developed a wearable, wristband sensor that can detect the pressure of the body’s pulse from the surface of the skin at the wrist. They can correlate this measurement to blood pressure and subsequently use this device for long-term continuous monitoring.

Label-Free, Electrochemical Sensor for Detection of Antibiotics in Protein-based Substances

Researchers at the University of California, Davis have developed a highly sensitive immunosensor for the detection of chloramphenicol (CAP) residues in milk and other protein-based substances.

An Electrochemical CMOS Biosensor Array For Point-Of-Care Applications

Point-of-care (POC) testing is essential to halt the spread of deadly infectious diseases (e.g., Ebola, Zika, etc.) and is needed for rapid and accurate screening both in and outside of clinical settings. Label-free bioassays are desirable for POC testing as they have fewer reagents and assay steps resulting in lower cost and ease of use.   Biosensors based on electrochemical impedance spectroscopy (EIS), an ultra-sensitive, label-free sensing technique, are a promising technology for precise and rapid disease diagnosis at the point-of-care. However, EIS usually requires mixers and lock-in detection to measure both the magnitude and phase of the complex impedance.

Intravascular Ultrasound-guided Electrochemical Impedance Spectroscopy (IVUS-EIS) to Assess Lipid-Laden Plaques

UCLA researchers in the Department of Medicine have developed a novel intravascular ultrasound-guided electrochemical impedance spectroscopy (IVUS-EIS) system for the detection of oxLDL-laden plaques in arteries.

Flexible Balloon-Inflatable Electrochemical Impedance Spectroscopy To Assess Endoluminal Lipid-Rich Lesions

UCLA researchers have developed a novel flexible balloon-inflatable electrochemical impedance spectroscopy to facilitate the diagnosis of metabolically active atherosclerotic lesions.

Machine-Learning-Based Denoising Of Doppler Ultrasound Blood Flow And Intracranial Pressure Signal

UCLA researchers in the Department of Neurosurgery have developed a novel framework to constrain noises in the measurements of vital physiological signals from neurosurgical patients.

Method For Indefinite Storage And Preservation Of Membrane Precursors

UCLA researchers in the Department of Bioengineering have developed a novel strategy for the creation of biomimetic lipid bilayer membrane using a high freezing point lipid-containing solvent.  Using this method, the membrane precursor is frozen/immobilized prior to the completion of the spontaneous process of bilayer self-assembly, and the process can be resumed later by simply thawing and allowing membrane formation to resume.

Ultrafast Differential Interference Contrast Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a novel instrument that can image unstained transparent objects with high speeds.

A Method and Device for the Estimation of Blood Glucose Concentration from Signals of Sensors Implanted in Tissues

Diabetes is a major disease affecting all populations and age groups, and society as a whole. All therapies for diabetes are based on achieving close glucose control. Close glucose control achieved by sufficient and timely administration of therapy has been shown to reduce the destructive “long-term complications” of diabetes, such as retinal damage, kidney failure, amputations, and cardiovascular damage, as well as debilitating and life-threatening short-term hypoglycemia. However, attainment of close control requires a means of glucose monitoring and means for correction of glucose imbalances such as administration of insulin, pharmaceuticals, diet adjustment, and exercise, based on the monitored glucose concentration.

A Device, Methodology And System For Monitoring, Classifying And Encouraging Activity

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise.

A Bio-Impedance Measurement Technique Using Biphasic Current Stimulus Excitation for Implantable Stimulators

UCLA researchers from the Department of Bioengineering have developed a novel efficient, low-cost, low-power technique for measuring the bio-impedance at the electrode-tissue interface, which can be incorporated into implantable stimulators.

A 3D Microfluidic Actuation and Sensing Wearable Technology for In-Situ Biofluid Processing and Analysis

UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel wearable biosensor capable of measuring biomarkers in real time through biofluids like sweat.

Nano Biosensing System

Metabolites can provide real-time information about the state of a person’s health. Devices that can detect metabolites are commercially available, but are unable to detect very low concentrations of metabolites. Researchers at UCI have developed surfaces that use nanosensors to detect much lower concentrations of such metabolites.

Membrane Insertion of Potential Sensing Nanorods

UCLA researchers in the Department of Chemistry have developed inorganic semiconductor nanosensors that measure membrane voltage.

Wearable Real-Time Gait Analysis And Sensory Feedback System For Gait Rehabilitation And Biomechanical Optimization

UCLA researchers in the Department of Bioengineering have developed a wearable sensory feedback system that provides instructive tactile feedback to guide the user towards biomechanical gait improvements, based on real-time motion analysis derived from wearable sensor data.

A Simple Integrated Device For Assessing Lung Health

Chronic lung diseases, like asthma, impose critical challenges on both the patients and the physicians due to the complexity of the diseases. Not only are these diseases tough to accurately assess, many of the diseases can be impacted by other physical and sociological factors. Perhaps a greater difficulty lies in measuring the effectiveness and compliance of the medications including inhaled medications. The invention discovered at the University of California, Irvine, is an “all-in-one,” portable device that offers complete assessment of lung health. It also incorporates a novel technology for monitoring the effectiveness and compliance of a medication, thereby, providing a personalized treatment and care plan for adults and children with asthma.

Highly Sensitive, Conformal And Wearable In2O3 Nanoribbon Transistor Biosensors With Integrated On Chip Side Gate For Glucose Monitoring In Body Fluid

UCLA researchers in the Department of Electrical Engineering have invented a novel wearable sensor that is capable of measuring glucose levels in bodily fluids.

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