Researchers at the University of California, Davis have developed small molecule inhibitors to prevent or reverse the progression of neurodegenerative diseases or symptoms.
Current diagnosis of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, has connections to the deposition of specific protein aggregates termed Lewy bodies. There are several PD symptoms commonly associated with these protein aggregates including palsy and dementia. Although there are multiple treatments for PD, these medications do not stop or reverse the progression of the disease.
Researchers at the University of California, Davis have developed soluble epoxide hydrolase (sEH) inhibitors for the treatment of neurodegenerative disorders. The inhibitors may block the phosphorylation of alpha-synuclein, which plays a key role in the pathogenesis of alpha-synuclein-related neurodegenerative diseases, reducing endoplasmic reticulum stress and possibly prevent the aggregation of Lewy bodies. The small molecule inhibitors are capable of preventing or reversing the progression of neurodegenerative diseases and symptoms.
small molecule, inhibitors, soluble epoxide hydrolase, sEH, alpha-synuclein, neurodegenerative disorders, parkinson's, lewy bodies, a-synuclein