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SFK Covalent Protein Genetic Engineering Platform: Unlocking Potent Therapeutics for Undruggable Targets

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Rapid Diagnostic Platform for Stratifying Cancer Patients with Immunoresponsive ‘Cold’ Tumors via TGFß Signaling and DNA Damage Response

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A Fluorescent-Labeled Phage Display Platform: RAPID and BIAS Technologies Transform Antibody Discovery for Therapeutic Development

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Protein Engineering with Phosphorus Fluoride Exchange (PFEx): A Novel Click Chemistry Approach for Biotherapeutics and Proteomics

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Novel Molecular Glues Targeting 14-3-3/ER for Treatment-Resistant ER+ Breast Cancer

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Next-Generation CRISPR-Barcoded Organoid-Mouse Models for Prostate Cancer Drug Discovery and Immunotherapy Research

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RocASO: A Breakthrough Platform to Silence Undruggable RNA Targets and Transform Therapeutics

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Precision Oncology Diagnostic: Epithelial-to-Mesenchymal Transition Gene Signature Technology for Metastasis Prediction and Personalized Cancer Care

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Epipangi-Dx: A Cell-Free Dna Methylation Fingerprint For The Early Detection Ofgastrointestinal Cancers

A novel method for detecting, diagnosing, monitoring, and treating gastrointestinal cancers by analyzing DNA methylation levels in patient samples.

Cell Type-Selective, Potent Signaling Pathway Modulation Using A Guide-Effector Bispecific Design

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Manipulation Of Internalization Property Of Cell Surface Molecules Using A Guide-Effector Bispecific Design

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Immune Impact Of Cyclic STAT3 Decoy Therapy

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Covalent Chemical Inhibitors Of The Oncoprotein K-Ras (G12R)

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Discovery Of Kras G12c Inhibitor-Specific Antibodies For Oncogene-Specific Chemically-Directed Immune Targeting

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Collimated Compton Camera

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Induced Synthetic Intracellular Cytokine And Growth Factor Circuits For Cell Autonomous Control Of Cell Signaling, Proliferation, Survival And Cell State

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A Predictive ML Model For Cancer Early Relapse

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Methods Of Treating Stat1 Dependent Cancer

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Inhibitors Of P90 Rsk

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Autologous Irradiated Whole Cell Tumor Vaccines Lentivirally Engineered To Express Cd-80, Il-15 And Il-15 Receptor Alpha

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Identification Of Selective Regulators Of Oncogene Translation

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CAPTaINs: Capped And Protected Targeted Immunoproteasome N-End Degrons

CAPTaINs provide a novel, selective, and stable method for selective degradation of protein targets.

The Isolated Heparin-binding Domain (HBD) of VEGF165 and the Isolated D1 Domain of VEGFR2 (KDR)

Researchers at the University of California, Davis have developed recombinant fusion protein compositions that inhibit pathological angiogenesis by targeting VEGF165-KDR interactions to treat cancers and related diseases.

Methods of Improving Cancer Immunotherapy

Researchers at the University of California, Davis have developed methods that combine immunotherapeutic agents with dual inhibitors to enhance cancer treatment efficacy and prolong patient survival.

Programmable Peptide Nucleic Acid-Based Nanoplatform for Customizable Drug Delivery

Researchers at the University of California, Davis have developed a peptide nucleic acid-based system enabling precise and customizable delivery of antigens, adjuvants, and targeting molecules for improved cancer immunotherapy.

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